KR910000748A - 결정성 세펨산 부가염 및 이의 제조 방법 - Google Patents
결정성 세펨산 부가염 및 이의 제조 방법 Download PDFInfo
- Publication number
- KR910000748A KR910000748A KR1019900008498A KR900008498A KR910000748A KR 910000748 A KR910000748 A KR 910000748A KR 1019900008498 A KR1019900008498 A KR 1019900008498A KR 900008498 A KR900008498 A KR 900008498A KR 910000748 A KR910000748 A KR 910000748A
- Authority
- KR
- South Korea
- Prior art keywords
- addition salt
- acid addition
- cefeic
- crystalline
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 일반식(Ⅱ)의 결정성 세펨산 부가염.상기식에서 R은 수소 또는 C1-C4-알킬이고, 그룹 =N-OH는 syn-위치에 존재한다.
- 제1항에 있어서, α-(2, 2-디메틸프로파노일옥시)에틸7-〔2-(2-아미노티아졸-4-일)-2-(Z)-하이드록시이미노-아세트아미도〕-3-메톡시메틸-3-세펨--카르복실레이트 벤젠설포네이트인 결정성 세펨산 부가염.
- 제1항에 있어서, α-(2, 2-디메틸프로파노일옥시)에틸7-〔2-(2-아미노티아졸-4-일)-2-(Z)-하이드록시이미노-아세트아미도〕-3-메톡시메틸-3-세펨--카르복실레이트 톨루엔설포네이트인 결정성 세펨산 부가염.
- 제1항에 있어서, α-(2, 2-디메틸프로파노일옥시)에틸7-〔2-(2-아미노티아졸-4-일)-2-(Z)-하이드록시이미노-아세트아미도〕-3-메톡시메틸-3-세펨--카복실레이트p-에틸벤젠셀포네이트인 결정성 세펨산 부가염.
- 일반식(Ⅰ)의 비결정성 세펨을 유기 용매중에서 일반식(Ⅲ)의 산과 반응시킨 다음 생성된 산 부가염을 직접 또는 다른 유기용매 또는 물을 첨가하여 결정화시킴을 특징으로 하여, 일반식(Ⅱ)의 결정성 세펨산 부가염을 제조하는 방법.상기식에서 R은 수소 또는 C1-C4-알킬이고, 그룹 =N-OH는 syn-위치에 존재한다.
- 일반식(Ⅱ)의 세펨산 부가염을 함유하는, 세균감염에 대해 효과적인 약제.
- 통상적인 약제학적 부형제 또는 희석제를 사용하여 일반식(Ⅱ)의 세펨산 부가염을 약제학적 투여에 적합한 형태로 하여, 세균 감염에 효과적인 약제를 제조하는 방법.
- 세균감염을 억제하기 위한 일반식(Ⅱ)의 세펨산 부가염의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3919259.8 | 1989-06-13 | ||
DE3919259A DE3919259A1 (de) | 1989-06-13 | 1989-06-13 | Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910000748A true KR910000748A (ko) | 1991-01-30 |
KR0158883B1 KR0158883B1 (ko) | 1998-12-01 |
Family
ID=6382651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900008498A KR0158883B1 (ko) | 1989-06-13 | 1990-06-11 | 결정성 세펨산 부가염 및 이의 제조방법 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5409918A (ko) |
EP (1) | EP0402806B1 (ko) |
JP (1) | JPH0730085B2 (ko) |
KR (1) | KR0158883B1 (ko) |
CN (1) | CN1043043C (ko) |
AT (1) | ATE95185T1 (ko) |
AU (1) | AU645254B2 (ko) |
CA (1) | CA2018794C (ko) |
DE (2) | DE3919259A1 (ko) |
DK (1) | DK0402806T3 (ko) |
ES (1) | ES2045653T3 (ko) |
FI (1) | FI96424C (ko) |
HU (1) | HU207087B (ko) |
IE (1) | IE64076B1 (ko) |
IL (1) | IL94701A (ko) |
NO (1) | NO174258C (ko) |
NZ (1) | NZ234004A (ko) |
PT (1) | PT94347B (ko) |
ZA (1) | ZA904526B (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU48484B (sh) * | 1991-05-24 | 1998-09-18 | Hoechst Aktiengesellschaft | Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline |
US5589593A (en) * | 1991-11-11 | 1996-12-31 | Biochimica Opos Spa | Crystalline form of a cephalosporin antibiotic |
TW212181B (ko) * | 1992-02-14 | 1993-09-01 | Hoechst Ag | |
ES2117066T3 (es) * | 1992-05-21 | 1998-08-01 | Hoechst Ag | Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico. |
LT3871B (en) | 1993-11-30 | 1996-04-25 | Hoechst Ag | Additive crystalline salts of pure diastereomers of 1-cefem-4-carboxylic acid 1-(2,2-dimethyl-propionyloxy)ethyl esters, process for the preparation thereof, pharmaceutical compositions and process for the preparation thereof |
AT401651B (de) * | 1994-06-14 | 1996-11-25 | Biochemie Gmbh | 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4- |
AT408226B (de) * | 1999-05-05 | 2001-09-25 | Biochemie Gmbh | Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2 |
US7842791B2 (en) | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
JP4749194B2 (ja) * | 2006-03-28 | 2011-08-17 | ジャパンパイル株式会社 | オーガー削孔装置における土質試料採取具 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4203899A (en) * | 1974-12-19 | 1980-05-20 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
US4668783A (en) * | 1974-12-19 | 1987-05-26 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido cephalosporin compounds |
US4298606A (en) * | 1974-12-19 | 1981-11-03 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
JPS5760345B2 (ko) * | 1974-12-19 | 1982-12-18 | Takeda Chemical Industries Ltd | |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
JPS523091A (en) * | 1975-06-23 | 1977-01-11 | Takeda Chem Ind Ltd | A prcess for preparing cephalosporins |
DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
IT1101437B (it) * | 1978-11-28 | 1985-09-28 | Proter Spa | Procedimento per il recupero di cefaloridina da soluzione acquosa nella quale e'stata prodotta |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
FR2476087A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4486425A (en) * | 1980-09-30 | 1984-12-04 | Sankyo Company Limited | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
JPS5759894A (en) * | 1980-09-30 | 1982-04-10 | Sankyo Co Ltd | Cephalosporin for oral administration |
FR2532315A1 (fr) * | 1982-08-27 | 1984-03-02 | Rhone Poulenc Sante | Formes cristallisees de sels d'addition avec des acides, de l'((amino-2-thiazolyl-4)-2 methoxyimino-2 acetamido)-7 carboxy-2 (dioxo-5,6 formylmethyl-4 tetrahydro-1,4,5,6 triazine-1,2,4 yl-3) thio-2 vinyl)-3 oxo-8 thia-5 aza-1 bicyclo(4.2.0) octene-2 isomere syn, forme e et leur preparation |
US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
DE3804841A1 (de) * | 1988-02-17 | 1989-08-31 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
DE3809561A1 (de) * | 1988-03-22 | 1989-10-05 | Hoechst Ag | Ester der 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroxyiminoacetamido)-3-methoxymethyl-3-cephem-4-carbonsaeure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
US5063224A (en) * | 1990-07-09 | 1991-11-05 | Eli Lilly And Company | R-cefuroxime axetil |
-
1989
- 1989-06-13 DE DE3919259A patent/DE3919259A1/de not_active Withdrawn
-
1990
- 1990-06-09 ES ES90110945T patent/ES2045653T3/es not_active Expired - Lifetime
- 1990-06-09 DK DK90110945.4T patent/DK0402806T3/da active
- 1990-06-09 EP EP90110945A patent/EP0402806B1/de not_active Expired - Lifetime
- 1990-06-09 DE DE90110945T patent/DE59002880D1/de not_active Expired - Lifetime
- 1990-06-09 AT AT90110945T patent/ATE95185T1/de not_active IP Right Cessation
- 1990-06-11 FI FI902900A patent/FI96424C/fi active IP Right Grant
- 1990-06-11 CN CN90104242A patent/CN1043043C/zh not_active Expired - Lifetime
- 1990-06-11 IL IL9470190A patent/IL94701A/en unknown
- 1990-06-11 KR KR1019900008498A patent/KR0158883B1/ko not_active IP Right Cessation
- 1990-06-11 NZ NZ234004A patent/NZ234004A/en unknown
- 1990-06-12 CA CA002018794A patent/CA2018794C/en not_active Expired - Lifetime
- 1990-06-12 PT PT94347A patent/PT94347B/pt not_active IP Right Cessation
- 1990-06-12 NO NO902607A patent/NO174258C/no not_active IP Right Cessation
- 1990-06-12 IE IE211590A patent/IE64076B1/en not_active IP Right Cessation
- 1990-06-12 ZA ZA904526A patent/ZA904526B/xx unknown
- 1990-06-12 JP JP2153825A patent/JPH0730085B2/ja not_active Expired - Lifetime
- 1990-06-12 AU AU56976/90A patent/AU645254B2/en not_active Expired
- 1990-06-13 HU HU903828A patent/HU207087B/hu unknown
-
1992
- 1992-08-21 US US07/931,505 patent/US5409918A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI96424B (fi) | 1996-03-15 |
IE64076B1 (en) | 1995-07-12 |
NO174258C (no) | 1994-04-06 |
ZA904526B (en) | 1991-03-27 |
JPH0730085B2 (ja) | 1995-04-05 |
NO902607D0 (no) | 1990-06-12 |
EP0402806B1 (de) | 1993-09-29 |
KR0158883B1 (ko) | 1998-12-01 |
US5409918A (en) | 1995-04-25 |
NO902607L (no) | 1990-12-14 |
CA2018794A1 (en) | 1990-12-13 |
IL94701A (en) | 1994-11-28 |
HUT56375A (en) | 1991-08-28 |
PT94347B (pt) | 1997-01-31 |
NZ234004A (en) | 1992-07-28 |
JPH0324086A (ja) | 1991-02-01 |
ES2045653T3 (es) | 1994-01-16 |
CA2018794C (en) | 2000-05-16 |
DE3919259A1 (de) | 1990-12-20 |
EP0402806A1 (de) | 1990-12-19 |
PT94347A (pt) | 1991-02-08 |
CN1048042A (zh) | 1990-12-26 |
DE59002880D1 (de) | 1993-11-04 |
IE902115L (en) | 1990-12-13 |
AU5697690A (en) | 1990-12-20 |
IE902115A1 (en) | 1991-01-02 |
HU903828D0 (en) | 1990-11-28 |
FI902900A0 (fi) | 1990-06-11 |
HU207087B (en) | 1993-03-01 |
NO174258B (no) | 1993-12-27 |
DK0402806T3 (da) | 1994-01-17 |
CN1043043C (zh) | 1999-04-21 |
AU645254B2 (en) | 1994-01-13 |
ATE95185T1 (de) | 1993-10-15 |
FI96424C (fi) | 1996-06-25 |
IL94701A0 (en) | 1991-04-15 |
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