KR900000329A - 신규한 요오드화 비이온성 트리요오드 벤젠 화합물과 이를 함유하는 조영제 - Google Patents
신규한 요오드화 비이온성 트리요오드 벤젠 화합물과 이를 함유하는 조영제 Download PDFInfo
- Publication number
- KR900000329A KR900000329A KR1019890006875A KR890006875A KR900000329A KR 900000329 A KR900000329 A KR 900000329A KR 1019890006875 A KR1019890006875 A KR 1019890006875A KR 890006875 A KR890006875 A KR 890006875A KR 900000329 A KR900000329 A KR 900000329A
- Authority
- KR
- South Korea
- Prior art keywords
- hydroxy
- alkyl
- compound
- triiodine
- hydroxyalkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 다음 일반식(Ⅰ)으로 표시되는 화합물 :상기식에서 R1은 일반식(여기서 R5는 C1-C4알킬, C1-C4히드록시알킬 또는 C1-C4폴리히드록시알킬이고, R6는 수소, C1-C4알킬, C1-C4히드록시알킬 또는 C1-C4폴리히드록시알킬이다)의 기 또는 일반식(여기서 R7은 C1-C4히드록시알킬 또는 C1-C4폴리히드록시알킬이고, R8은 수소 또는 알킬이다)이고, R2는 수소, C1-C4히드록시알킬 또는 C1-C4폴리히드록시 알킬이고, R3는 수소 또는 C1-C4알킬이고, R4는 수소, C1-C4알킬, C1-C4히드록시알킬 또는 C1-4폴리히드록시알킬이다.
- 제1항에 있어서, 다음 일반식(Ⅱ)으로 포시되는 화합물 :(상기식에서 R2, R3와 R4는 제1항에서와 같은 의미를 갖는다.)
- 제1항에 있어서 5[3-히드록시-2-(히드록시메틸)-N-(2,3-디히드록시프로필)프로피온아미드]-N',N''-비스-(2-히드록시에틸)-2,4,6-트리요오드이소프탈아미드인 화합물.
- 제1항에 있어서, 5-글리콜아미드-3-[3-히드록시-2-(히드록시메틸)-N-(2,3-디히드록시프로필)프로피온아미드]-2,4,6-트리요오드-N-히드록시에틸 벤즈아미드인 화합물.
- 제1항에 있어서, 3,5-비스-(3-히드록시-2-히드록시메틸-프로피온아미드-2,4,6-트리요오드-N-(2,3-디히드록시프로필)벤즈아미드인 화합물
- 제1항에 있어서, 5-[3-히드록시-2-(히드록시메틸)-N-(2-히드록시에틸)-프로피온아미드]-N-(2-히드록시에틸)-N'-(2,3-디하드록시프로필)-2,4,6-트리요오드-이소프탈아미드인 화합물.
- 제1항에 내지 제6항중 어느 한 항에 따른 유효량의 하나 이상의 화합물로 이루어짐을 특징으로 하는 조영제
- 제7항에 있어서, 화합물의 수용액으로 이루어짐을 특징으로 하는 조영제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8807369 | 1988-06-02 | ||
FR8807369A FR2632304B1 (fr) | 1988-06-02 | 1988-06-02 | Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant |
FR8900672 | 1989-01-23 | ||
FR8900762A FR2643077B1 (fr) | 1989-01-23 | 1989-01-23 | Nouveaux composes non ioniques iodes et produits de contraste les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900000329A true KR900000329A (ko) | 1990-01-30 |
KR0148358B1 KR0148358B1 (ko) | 1998-08-17 |
Family
ID=26226693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890006875A KR0148358B1 (ko) | 1988-06-02 | 1989-05-23 | 신규한 요오드화 비이온성 트리요오드 벤젠 화합물과 이를 함유하는 조영제 |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0357467B1 (ko) |
JP (1) | JPH07100684B2 (ko) |
KR (1) | KR0148358B1 (ko) |
CN (1) | CN1021440C (ko) |
AT (1) | ATE98220T1 (ko) |
AU (1) | AU617810B2 (ko) |
CA (1) | CA1339665C (ko) |
CZ (1) | CZ277984B6 (ko) |
DE (1) | DE68911237T2 (ko) |
DK (1) | DK175034B1 (ko) |
DZ (1) | DZ1341A1 (ko) |
EG (1) | EG19008A (ko) |
ES (1) | ES2060800T3 (ko) |
FI (1) | FI102745B (ko) |
GE (1) | GEP19960460B (ko) |
HR (1) | HRP920498B1 (ko) |
HU (1) | HU201732B (ko) |
IL (1) | IL90326A (ko) |
LV (1) | LV10234B (ko) |
MA (1) | MA21565A1 (ko) |
NO (1) | NO177461C (ko) |
PT (1) | PT90696B (ko) |
RU (1) | RU1833365C (ko) |
SI (1) | SI8911042A (ko) |
YU (1) | YU48318B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2656865B1 (fr) * | 1990-01-05 | 1993-03-26 | Guerbet Sa | Compose non ionique iode, son procede de preparation et produit de contraste le contenant. |
FR2673180B1 (fr) * | 1991-02-25 | 1994-03-04 | Guerbet Sa | Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant. |
DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
FR2695125B1 (fr) * | 1992-08-25 | 1994-12-23 | Guerbet Sa | Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant. |
US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
US5705692A (en) * | 1996-09-27 | 1998-01-06 | Abbott Laboratories | Process for the preparation of iohexol |
CN110903275A (zh) * | 2018-09-14 | 2020-03-24 | 苏州科伦药物研究有限公司 | 制备碘比醇的方法、其中间体及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2909439A1 (de) * | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
DE3429949A1 (de) * | 1984-08-10 | 1986-02-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel |
ES2006951A6 (es) * | 1987-05-22 | 1989-05-16 | Bracco Ind Chimica Spa | Un procedimiento para la preparacion de derivados de acido 5-acilamino-2,4,6-triyodo o tribromo-benzoico. |
FR2632304B1 (fr) * | 1988-06-02 | 1991-05-17 | Guerbert Sa | Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant |
-
1989
- 1989-05-17 IL IL90326A patent/IL90326A/xx not_active IP Right Cessation
- 1989-05-21 DZ DZ890079A patent/DZ1341A1/fr active
- 1989-05-22 SI SI8911042A patent/SI8911042A/sl not_active IP Right Cessation
- 1989-05-22 YU YU104289A patent/YU48318B/sh unknown
- 1989-05-23 KR KR1019890006875A patent/KR0148358B1/ko not_active IP Right Cessation
- 1989-05-26 AU AU35235/89A patent/AU617810B2/en not_active Ceased
- 1989-05-26 DK DK198902595A patent/DK175034B1/da not_active IP Right Cessation
- 1989-05-30 RU SU894614183A patent/RU1833365C/ru not_active IP Right Cessation
- 1989-05-31 NO NO892189A patent/NO177461C/no not_active Application Discontinuation
- 1989-05-31 CZ CS893291A patent/CZ277984B6/cs not_active IP Right Cessation
- 1989-06-01 DE DE89401509T patent/DE68911237T2/de not_active Expired - Fee Related
- 1989-06-01 CN CN89103735A patent/CN1021440C/zh not_active Expired - Lifetime
- 1989-06-01 CA CA000601412A patent/CA1339665C/en not_active Expired - Fee Related
- 1989-06-01 EP EP89401509A patent/EP0357467B1/fr not_active Expired - Lifetime
- 1989-06-01 ES ES89401509T patent/ES2060800T3/es not_active Expired - Lifetime
- 1989-06-01 MA MA21817A patent/MA21565A1/fr unknown
- 1989-06-01 JP JP1140222A patent/JPH07100684B2/ja not_active Expired - Fee Related
- 1989-06-01 EG EG26789A patent/EG19008A/xx active
- 1989-06-01 AT AT89401509T patent/ATE98220T1/de not_active IP Right Cessation
- 1989-06-01 FI FI892681A patent/FI102745B/fi not_active IP Right Cessation
- 1989-06-01 PT PT90696A patent/PT90696B/pt not_active IP Right Cessation
- 1989-06-02 HU HU892826A patent/HU201732B/hu not_active IP Right Cessation
-
1992
- 1992-09-25 HR HRP-1042/89A patent/HRP920498B1/xx not_active IP Right Cessation
-
1993
- 1993-03-11 GE GEAP1993599A patent/GEP19960460B/en unknown
- 1993-05-25 LV LVP-93-404A patent/LV10234B/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB9416897D0 (en) | Metalloproteinase inhibitors | |
KR920018029A (ko) | 신규한 카복실산 아미드 | |
PT100673A (pt) | Processo para a preparacao de intermediarios de sertralina e compostos assim obtidos | |
KR960034164A (ko) | 스틸벤 유도체 및 이를 함유하는 약제학적 조성물 | |
BR8307166A (pt) | Composicao microbicida,processo para o combate de microorganismos e emprego | |
KR890003720A (ko) | 벤조티아졸 및 그를 유효성분으로 함유하는 항류머티스제 | |
DK0612723T3 (da) | Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf | |
DK0659174T3 (da) | Derivater af valproinsyre og 2-valproensyreamider samt deres anvendelse som antikonvulsive midler | |
KR900000329A (ko) | 신규한 요오드화 비이온성 트리요오드 벤젠 화합물과 이를 함유하는 조영제 | |
KR870010864A (ko) | O/w 형 에멀젼 조성물 | |
FI920271A (fi) | Polyamintioler som straolningsskyddande aemnen. | |
PT90938A (pt) | Processo para a preparacao de novas sulfonamidas e de composicoes farmaceuticas que as contem | |
NO880995L (no) | Nye 5-alkoxy-2,4-diaminoalkylbenzener saavel som haarfarvemiddel med 5-alkoxy-2,4-diamino-alkylbenzen. | |
KR900011754A (ko) | (디-3급-부틸히드록시페닐)티오 유도체 | |
MX9102103A (es) | Compuestos de contraste para diagnosticos con rayos x, procedimiento para su preparacion y composiciones que los contienen. | |
KR950002588A (ko) | 과산화수소 조성물 | |
SE8301899L (sv) | Fenoxialkylkarboxylsyraderivat | |
KR910002774A (ko) | 2-아미노펜탄 산 화합물 및 면역 억제제로 그들을 사용하는 방법 | |
KR940003542A (ko) | 피부외용제 | |
NO904774D0 (no) | Ikke-ionisk roentgenkontrastmiddel med hoeyt jodinnhold. | |
ES2133511T3 (es) | Composicion tintorea que contiene p-fenilendiaminas con azufre, p-fenilendiaminas con azufre y su procedimiento de preparacion. | |
MX9306588A (es) | Compuesto de acilo antirretrovirales. | |
KR950013509A (ko) | 비동기화 장애의 치료에 유용한 멜라토닌 유도체 | |
KR880002822A (ko) | 뇌허혈증 예방 치료제 | |
KR920007995A (ko) | 벤즈아미드 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20060517 Year of fee payment: 9 |
|
LAPS | Lapse due to unpaid annual fee |