KR890014534A - 혈당 감소제로서 티아졸리딘디온 유도체 - Google Patents
혈당 감소제로서 티아졸리딘디온 유도체 Download PDFInfo
- Publication number
- KR890014534A KR890014534A KR1019890002788A KR890002788A KR890014534A KR 890014534 A KR890014534 A KR 890014534A KR 1019890002788 A KR1019890002788 A KR 1019890002788A KR 890002788 A KR890002788 A KR 890002788A KR 890014534 A KR890014534 A KR 890014534A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- group
- alkyl
- oxazol
- bond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 구조식(I)의 화합물, 또는 이 화합물이 염기성 질소를 포함한 경우 그의 제약상 허용되는 산 부가염.상기식중, 점선은 결합이거나 결합이 아니고, V는 - CH=CH-, -N=CH, -CH=N-, S, O 또는 NR이고, W는 S, SO, SO2, SO2NR1, NR1SO2, CONR1또는 NR1CO이고, X는 S, O, NR2, -CH=N- 또는 -N=CH-이고, Y는 CH 또는 N이고, Z는 수소, (C1-C7)알킬, (C3-C7)시클로알킬, 페닐, 피리딜, 푸릴, 티에닐, 또는 페닐(이 기는 (C1-C3)알킬, 트리플루오로메틸, (C1-C3)알콕시, 플루오로, 클로로 또는 브로모인 동일하거나 상기한 기에 의해 일치환 또는 이치환됨)이고, Z1은 수소 또는 (C1-C3)알킬이고, R, R1및 R2은 각각 독립적으로 수소 또는 (C1-C4)알킬이고, n은 1,2 또는 3임.
- 제1항에 있어서, 점선이 결합이 아니고, V가 -CH=CH-이고, n이 1 또는 2인 화합물.
- 제2항에 있어서, n이 1이고, W가 CONR1이고, X가 0이고, Y가 옥사졸-4-일기를 형성하는 N인 화합물.
- 제2항에 있어서, n이 1이고, W가 NR1CO이고, X가 0이고, Y가 옥사졸-4-일기를 형성하는 N인 화합물.
- 제2항에 있어서, n이 2이고, W가 S 또는 SO2이고, X가 0이고, Y가 옥사졸-4-일기를 형성하는 N인 화합물.
- 제3항, 제4항 또는 제5항에 있어서, Z가 2-페닐기이고, Z1이 5-메틸기인 화합물.
- 제1항의 화합물 혈당 감소량 및 제약상 허용되는 담체로 되는, 과혈당증 포유 동물에서 사용하기 위한 제약 조성물.
- 제1항의 화합물 혈중 콜레스테롤 감소량 및 제약상 허용되는 담체로 되는, 과콜레스테롤혈증 포유 동물에서 사용하기 위한 제약 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US88/00745 | 1988-03-08 | ||
PCT/US1988/000745 WO1989008652A1 (en) | 1988-03-08 | 1988-03-08 | Thiazolidinedione derivatives as hypoglycemic agents |
US8800745 | 1988-03-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890014534A true KR890014534A (ko) | 1989-10-24 |
KR910000734B1 KR910000734B1 (ko) | 1991-02-06 |
Family
ID=22208591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890002788A KR910000734B1 (ko) | 1988-03-08 | 1989-03-07 | 혈당 감소제로서 티아졸리딘디온 유도체 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0389699B1 (ko) |
JP (1) | JPH01299289A (ko) |
KR (1) | KR910000734B1 (ko) |
CN (1) | CN1026234C (ko) |
AU (1) | AU594899B2 (ko) |
CA (1) | CA1328265C (ko) |
DK (1) | DK108789A (ko) |
ES (3) | ES2052906T3 (ko) |
FI (1) | FI92696C (ko) |
HU (1) | HU217432B (ko) |
IL (1) | IL89481A (ko) |
MY (1) | MY103837A (ko) |
NO (1) | NO178068C (ko) |
NZ (1) | NZ228247A (ko) |
PT (1) | PT89922B (ko) |
WO (1) | WO1989008652A1 (ko) |
ZA (1) | ZA891681B (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989008651A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
GB8919417D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
AU645112B2 (en) * | 1990-08-23 | 1994-01-06 | Pfizer Inc. | Hypoglycemic hydroxyurea derivatives |
FR2696743B1 (fr) * | 1992-10-12 | 1994-12-23 | Adir | Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
DE4317320A1 (de) * | 1993-05-25 | 1994-12-01 | Boehringer Mannheim Gmbh | Neue Thiazolidindione und diese enthaltende Arzneimittel |
JPH08157473A (ja) * | 1994-10-06 | 1996-06-18 | Nissan Chem Ind Ltd | ピラゾール系チアゾリジン類 |
US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
JP3906935B2 (ja) * | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
AU2231397A (en) * | 1996-03-08 | 1997-09-22 | Torii Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives |
DE19711616A1 (de) | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
US6355672B1 (en) * | 1998-08-07 | 2002-03-12 | Takeda Chemical Industries, Ltd. | Benzothiepin derivatives, process for the preparation of the same and uses thereof |
AU6023300A (en) * | 1999-07-26 | 2001-02-13 | Shionogi & Co., Ltd. | Drug compositions exhibiting thrombopoietin agonism |
JP4316787B2 (ja) * | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
DE10029077A1 (de) | 2000-06-13 | 2001-12-20 | Bayer Ag | Thiazolylsubstituierte Heterocyclen |
CA2435143A1 (en) * | 2001-01-26 | 2002-08-01 | Shionogi & Co., Ltd. | Halogen compounds having thrombopoietin receptor agonism |
US20040077697A1 (en) * | 2001-02-02 | 2004-04-22 | Hiroyuki Koshio | 2-Acylaminothiazole derivative or its salt |
DE10331675A1 (de) | 2003-07-14 | 2005-02-10 | Bayer Cropscience Ag | Hetarylsubstituierte Pyrazolidindion-Derivate |
WO2008051197A2 (en) | 2005-09-20 | 2008-05-02 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
GB2465890A (en) * | 2008-12-05 | 2010-06-09 | Scynexis Inc | 2-Arylazole derivatives as antiprotozoal agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
HU210339B (en) * | 1985-05-21 | 1995-03-28 | Pfizer | Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
-
1988
- 1988-03-08 HU HU181/88A patent/HU217432B/hu not_active IP Right Cessation
- 1988-03-08 WO PCT/US1988/000745 patent/WO1989008652A1/en active IP Right Grant
-
1989
- 1989-03-03 IL IL89481A patent/IL89481A/xx not_active IP Right Cessation
- 1989-03-06 CA CA000592859A patent/CA1328265C/en not_active Expired - Fee Related
- 1989-03-06 ZA ZA891681A patent/ZA891681B/xx unknown
- 1989-03-06 MY MYPI89000272A patent/MY103837A/en unknown
- 1989-03-07 NZ NZ228247A patent/NZ228247A/xx unknown
- 1989-03-07 PT PT89922A patent/PT89922B/pt not_active IP Right Cessation
- 1989-03-07 CN CN89101214A patent/CN1026234C/zh not_active Expired - Fee Related
- 1989-03-07 KR KR1019890002788A patent/KR910000734B1/ko not_active IP Right Cessation
- 1989-03-07 AU AU31077/89A patent/AU594899B2/en not_active Ceased
- 1989-03-07 DK DK108789A patent/DK108789A/da not_active Application Discontinuation
- 1989-03-08 JP JP1055973A patent/JPH01299289A/ja active Granted
- 1989-03-22 ES ES89302872T patent/ES2052906T3/es not_active Expired - Lifetime
- 1989-03-29 EP EP89303086A patent/EP0389699B1/en not_active Expired - Lifetime
- 1989-03-29 ES ES89303086T patent/ES2052907T3/es not_active Expired - Lifetime
- 1989-04-13 ES ES89303667T patent/ES2052910T3/es not_active Expired - Lifetime
-
1990
- 1990-09-05 NO NO903863A patent/NO178068C/no not_active IP Right Cessation
- 1990-09-07 FI FI904413A patent/FI92696C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1026234C (zh) | 1994-10-19 |
ES2052906T3 (es) | 1994-07-16 |
ES2052907T3 (es) | 1994-07-16 |
HU882181D0 (en) | 1991-01-28 |
MY103837A (en) | 1993-09-30 |
NO903863L (no) | 1990-09-05 |
IL89481A0 (en) | 1989-09-10 |
KR910000734B1 (ko) | 1991-02-06 |
CN1036572A (zh) | 1989-10-25 |
EP0389699B1 (en) | 1994-05-11 |
WO1989008652A1 (en) | 1989-09-21 |
AU3107789A (en) | 1989-09-14 |
DK108789D0 (da) | 1989-03-07 |
JPH0585551B2 (ko) | 1993-12-07 |
HU217432B (hu) | 2000-01-28 |
NO178068C (no) | 1996-01-17 |
JPH01299289A (ja) | 1989-12-04 |
NO903863D0 (no) | 1990-09-05 |
FI904413A0 (fi) | 1990-09-07 |
NZ228247A (en) | 1990-05-28 |
ZA891681B (en) | 1990-10-31 |
FI92696B (fi) | 1994-09-15 |
PT89922B (pt) | 1995-03-01 |
IL89481A (en) | 1993-02-21 |
DK108789A (da) | 1989-09-09 |
EP0389699A1 (en) | 1990-10-03 |
NO178068B (no) | 1995-10-09 |
ES2052910T3 (es) | 1994-07-16 |
FI92696C (fi) | 1994-12-27 |
PT89922A (pt) | 1989-11-10 |
AU594899B2 (en) | 1990-03-15 |
CA1328265C (en) | 1994-04-05 |
HUT54680A (en) | 1991-03-28 |
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