KR890004689A - 니트로글리세린 스프레이 - Google Patents

니트로글리세린 스프레이 Download PDF

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Publication number
KR890004689A
KR890004689A KR1019880012583A KR880012583A KR890004689A KR 890004689 A KR890004689 A KR 890004689A KR 1019880012583 A KR1019880012583 A KR 1019880012583A KR 880012583 A KR880012583 A KR 880012583A KR 890004689 A KR890004689 A KR 890004689A
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KR
South Korea
Prior art keywords
solution
nitroglycerin
spray
total amount
ethanol
Prior art date
Application number
KR1019880012583A
Other languages
English (en)
Inventor
유끼오 아오우다
히로시 니노미야
겐이찌 이즈
유이찌 야자와
메구미 다찌바나
Original Assignee
사까노 쯔네카즈
니뽄 카야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사까노 쯔네카즈, 니뽄 카야꾸 가부시끼가이샤 filed Critical 사까노 쯔네카즈
Publication of KR890004689A publication Critical patent/KR890004689A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

니트로글리세린 스프레이
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 니트로글리세린, 에탄올 및 물로 이루어지고 pH가 약 0.4 내지 약 6.7인 용액을 액체 가압된 용기 내에 충전시켜 제조한 니트로글리세린 스프레이.
  2. 제1항에 있어서, 용액중의 니트로글리셀린 함량이 용액의 총 양을 기준으로 하여 약 0.05 내지 약 2W/V%인 니트로글리세린 스프레이.
  3. 제1항에 있어서, 용액중의 에탄올 함량이 용액의 총 양을 기준으로 하여 약 10 내지 약 85W/V%인 니트로글리셀린 스프레이.
  4. 제1항에 있어서, 용액이 니트로글리세린, 에탄올 및 물 이외의 성분을 거의 함유하지 하는 니트로글리세린 스프레이.
  5. (a)용액의 총 양을 기준으로 하여 약 0.3 내지 약 1.2W/V%의 니트로글리세린. (b) 용액의 총 양을 기준으로 하여 약 30 내지 75W/V%의 에탄올 및, (c) 잔여량의 물로 이루어지며 pH가 약 2.4 내지 약6.7인 용액을 액체가압된 용기 내에 충전시켜 제조한 니트로 글리세린 스프레이.
  6. 제5항에 있어서, 용액의 pH가 약 3.0 내지 약 6.5인 니트로글리세린 스프레이.
  7. (a) 용액의 총 양을 기준으로 하여 약 0.5 내지 약 1W/V%의 니트로글리세린, (b)용액의 총 양을 기준으로 하여 약 50 내지 70W/V%의 에탄올 및 (c)잔여량의 물로 이루어지고 pH가 약 3.5 내지 약 6.0인 용액을 용기 내에 충전시켜 제조한 니트로글리세린 스프레이.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880012583A 1987-09-30 1988-09-29 니트로글리세린 스프레이 KR890004689A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62-244259 1987-09-30
JP62244259A JPH0645538B2 (ja) 1987-09-30 1987-09-30 ニトログリセリンスプレー剤

Publications (1)

Publication Number Publication Date
KR890004689A true KR890004689A (ko) 1989-05-09

Family

ID=17116090

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880012583A KR890004689A (ko) 1987-09-30 1988-09-29 니트로글리세린 스프레이

Country Status (4)

Country Link
US (1) US4919919A (ko)
EP (1) EP0310910A1 (ko)
JP (1) JPH0645538B2 (ko)
KR (1) KR890004689A (ko)

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DE4007705C1 (ko) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
US5370862A (en) * 1990-06-13 1994-12-06 Schwarz Pharma Ag Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina
DE4026072A1 (de) * 1990-08-17 1992-02-20 Sanol Arznei Schwarz Gmbh Nitroglycerinhaltiger, hydrophiler, waessriger pumpspray
GB2285921A (en) * 1994-01-31 1995-08-02 Leilani Lea Sublingual administration of medicaments
IL122752A (en) * 1995-06-27 2001-07-24 Boehringer Ingelheim Kg Stable preparations for creating propellant-free sprays
US20030215396A1 (en) 1999-09-15 2003-11-20 Boehringer Ingelheim Pharma Kg Method for the production of propellant gas-free aerosols from aqueous medicament preparations
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20040141923A1 (en) * 1997-10-01 2004-07-22 Dugger Harry A. Buccal, polar and non-polar spray containing alprazolam
US20030077229A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US20030095927A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20050180923A1 (en) * 1997-10-01 2005-08-18 Dugger Harry A.Iii Buccal, polar and non-polar spray containing testosterone
US7632517B2 (en) * 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20050002867A1 (en) * 1997-10-01 2005-01-06 Novadel Pharma Inc. Buccal, polar and non-polar sprays containing propofol
US20040136913A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing sumatriptan
US20050287075A1 (en) * 1997-10-01 2005-12-29 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20030095926A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
US20090162300A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing alprazolam
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US20030185761A1 (en) * 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
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US20030190286A1 (en) * 1997-10-01 2003-10-09 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma
US20050163719A1 (en) * 1997-10-01 2005-07-28 Dugger Harry A.Iii Buccal, polar and non-polar spray containing diazepam
US20050281752A1 (en) * 1997-10-01 2005-12-22 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
DE69738333T2 (de) * 1997-10-01 2008-11-27 Novadel Pharma Inc. Nichtpolares Spray zur bukkalen Verabreichung
US20030077228A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders
US20040136915A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing atropine
JP4786041B2 (ja) * 2001-03-02 2011-10-05 丸善製薬株式会社 渋味、収斂味を低減する方法および渋味、収斂味低減ハス胚芽抽出物製剤
AU2006214166B2 (en) 2005-02-17 2011-09-29 Zoetis Belgium S.A. Transmucosal administration of drug compositions for treating and preventing disorders in animals
GB0602224D0 (en) * 2006-02-03 2006-03-15 Futura Medical Dev Ltd Composition for promoting vascular smooth muscle relaxation
WO2007123955A2 (en) * 2006-04-19 2007-11-01 Novadel Pharma Inc. Stable hydroalcoholic oral spray formulations and methods
EP2124897A4 (en) * 2006-12-22 2012-05-09 Novadel Pharma Inc SPRAYING, ORAL, STABLE, SPRAY PREPARATIONS AND ASSOCIATED METHODS
US20080280947A1 (en) * 2007-05-10 2008-11-13 Blondino Frank E Anti-insomnia compositions and methods
US7985325B2 (en) * 2007-10-30 2011-07-26 Novellus Systems, Inc. Closed contact electroplating cup assembly
US20100184870A1 (en) * 2008-03-14 2010-07-22 Rolf Groteluschen Long-term stable pharmaceutical preparation containing the active ingredient glycerol trinitrate
WO2010011650A1 (en) * 2008-07-21 2010-01-28 Imi International Medical Innovations (D/B/A Procris Pharmaceuticals) Stable water-based topical pharmaceutical creams and methods of making and using same
EP2990032A1 (en) * 2010-08-03 2016-03-02 G. Pohl-Boskamp GmbH & Co. KG Use of glyceryl trinitrate for treating traumatic edema
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US9248099B2 (en) 2012-05-31 2016-02-02 Desmoid Aktiengesellschaft Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
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US4615699A (en) * 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes

Also Published As

Publication number Publication date
JPH0645538B2 (ja) 1994-06-15
EP0310910A1 (en) 1989-04-12
US4919919A (en) 1990-04-24
JPS6490123A (en) 1989-04-06

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