KR890002077A - 하이드로퀴논일페닐 부티르산 아미드 유도체 - Google Patents

하이드로퀴논일페닐 부티르산 아미드 유도체 Download PDF

Info

Publication number
KR890002077A
KR890002077A KR1019880008566A KR880008566A KR890002077A KR 890002077 A KR890002077 A KR 890002077A KR 1019880008566 A KR1019880008566 A KR 1019880008566A KR 880008566 A KR880008566 A KR 880008566A KR 890002077 A KR890002077 A KR 890002077A
Authority
KR
South Korea
Prior art keywords
phenyl
group
hydroquinoneylphenyl
acid amide
butyric acid
Prior art date
Application number
KR1019880008566A
Other languages
English (en)
Inventor
토시오 타쯔오까
켄지 스즈끼
후미오 사또
세이지 미야노
쿠니히로 스모또
Original Assignee
원본미기재
산토리가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 산토리가부시끼가이샤 filed Critical 원본미기재
Publication of KR890002077A publication Critical patent/KR890002077A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

하이드로퀴논일페닐 부티르산 아미드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(I)의 하이드로퀴논일페닐 부티르산 아미드 유도체 또는 약학적으로 무독한 이의 염.
    상기식에서, R1은 치환될 수 있는 방향족 또는 헤테로사이클릭 그룹이고, R2는 수소원자, 치환될 수 있는 저급 알킬카보닐 그룹, 방향족 카보닐 또는 헤테로사이클릭 카보닐 그룹이며, X는 산소원자 또는 황원자이다.
  2. 제1항에 있어서, 일반식(I)에서 R2가 수소원자이고, R1이 페닐 그룹 또는 피리딜 그룹인 하이드로 퀴논일페닐 브티르산 아미드 유도체.
  3. 제1항에 있어서, 일반식(I)에서 R2가 아세틸 그룹이고, R1이 페닐 그룹 또는 피리딜 그룹인 하이드로퀴논일페닐 브티르산 아미드 유도체.
  4. 제1항에 있어서, 일반식(I)에서 R2가 벤조일 그룹 또는 니코티노일 그룹이고, R1이 페닐 그룹 또는 피리딜 그룹인 하이드로퀴논일페닐 부티르산 아미드 유도체.
  5. 제1항에 있어서, 유도체가 4-(3,4-디메톡시-2-하이드록시-6-메틸-5-니코티노일옥시)페닐-4-페닐-1-티오모르폴리노-1-옥소부탄;4-(3,4-디메톡시-2-하이드록시-5-이소니코티노일옥시6-메틸)페닐-4-페닐-1-티오모르폴리노-1-옥소부탄; 4-(5-벤조일옥시-3,4-디메톡시,-2-하이드록시-6-메틸)페닐-4-페닐-1-티오모르폴리노-1-옥수부탄; 4-(5-벤조일옥시-3,4-디메톡시-2-하이드록시-6-메틸)페닐-4-페닐-1-모르폴리노-1-옥소부탄 ; 4-(2,5-디벤조일옥시-3,4-디메톡시-6-메틸)페닐-4-페닐-1-티오모르폴리노-1-옥소부탄; 4(2-아세톡시-5-벤조일옥시-3,4-디메톡시-6-메틸)페닐-4-페닐-1-티오모르폴리노-1-옥소부탄; 및 4-(2-아세톡시-5-벤조일옥시-3,4-디메톡시-6-메틸)페닐-4-페닐-1-모르폴리노-1-옥소부탄으로 이루어진 그룹으로부터 선택된 하나 이상의 화합물인 하이드로퀴논일페닐 부티르산 아미드 유도체.
  6. 활성 성분으로 일반식(I)의 하이드로퀴논일페닐 부티르산 아미드 유도체 또는 약학적으로 무독한 이의 염의 약제학적 유효량을 함유함을 특징으로 하는, 뇌부전증 증진 활성이 있는 약제학적 조성물.
    상기식에서, R1은 치환될 수 있는 방향족 또는 헤테로사이클릭 그룹이고, R2는 수소원자, 치환될 수도 있는 저급 알킬카보닐 그룹, 방향족 카보닐 또는 헤테로사이클릭 카보닐 그룹이며 X는 산소원자 또는 황원자이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008566A 1987-07-09 1988-07-09 하이드로퀴논일페닐 부티르산 아미드 유도체 KR890002077A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62-169683 1987-07-09
JP62169683A JPH062755B2 (ja) 1987-07-09 1987-07-09 ヒドロキノニルフェニル酪酸アミド誘導体

Publications (1)

Publication Number Publication Date
KR890002077A true KR890002077A (ko) 1989-04-07

Family

ID=15890972

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880008566A KR890002077A (ko) 1987-07-09 1988-07-09 하이드로퀴논일페닐 부티르산 아미드 유도체

Country Status (7)

Country Link
US (1) US4889853A (ko)
EP (1) EP0298758B1 (ko)
JP (1) JPH062755B2 (ko)
KR (1) KR890002077A (ko)
AU (1) AU614757B2 (ko)
CA (1) CA1320725C (ko)
DE (1) DE3854064T2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
US11103159B2 (en) * 2016-03-04 2021-08-31 United States Of America As Represented By The Secretary Of The Air Force Exhaled breath hypoxia biomarkers
US20180353520A1 (en) * 2017-06-12 2018-12-13 Arjil Biotech Holding Company Limited Method for treating stroke or reducing nerve injury

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640651A (en) * 1979-09-12 1981-04-16 Takeda Chem Ind Ltd Quinone compound and its preparation
DE3164894D1 (en) * 1980-10-02 1984-08-23 Ciba Geigy Ag Hydroquinone derivatives and their preparation and use in photographic materials
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
JPH064582B2 (ja) * 1986-03-29 1994-01-19 サントリー株式会社 ベンゾキノニルフエニル酪酸アミド誘導体
JP2628967B2 (ja) * 1992-11-11 1997-07-09 関東電化工業株式会社 マグネタイト粒子粉末及びその製造方法

Also Published As

Publication number Publication date
DE3854064D1 (de) 1995-08-03
AU1865588A (en) 1989-01-12
DE3854064T2 (de) 1995-11-02
US4889853A (en) 1989-12-26
EP0298758B1 (en) 1995-06-28
CA1320725C (en) 1993-07-27
JPH01272576A (ja) 1989-10-31
EP0298758A3 (en) 1989-11-23
JPH062755B2 (ja) 1994-01-12
EP0298758A2 (en) 1989-01-11
AU614757B2 (en) 1991-09-12

Similar Documents

Publication Publication Date Title
KR880009951A (ko) N-인단일 카르복시아미드 유도체 및 이 유도체를 활성성분으로 함유하는 농업/원예용 살진균제
KR950016738A (ko) 알쯔하이머 질병의 억제 방법
DK338187D0 (da) 13beta-milbemycinderivater samt deres fremstillingog anvendelse
KR950010892A (ko) 자궁 섬유증 억제 방법
KR940005274A (ko) 쇼그렌(Sjoegren)증후군 치료제
KR900015718A (ko) 골관절염 치료제
KR880007085A (ko) 고지질혈증 치료용의 약학 조성물
KR900004331A (ko) 활성물질로서의 질산염 에스테르를 포함하고, 이완활성을 가진 약제조성물
KR950010887A (ko) 연골 퇴화 억제 방법
KR950702530A (ko) 프로스타글란딘 유도체
KR890002077A (ko) 하이드로퀴논일페닐 부티르산 아미드 유도체
FR2660657B1 (fr) Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2085930T3 (es) Pirazolcarboxamida, composicion insecticida y acaricida, y composicion fungicida para uso en agricultura y horticultura.
FR2763335B1 (fr) Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR900701262A (ko) 췌장염 등에 대한 치료제
KR900018128A (ko) 카르복스아미드 유도체
KR960702458A (ko) 퀴놀린 유도체 또는 그의 염 및 이를 함유 하는 항균제
KR870006035A (ko) 신규 항균제 1-티에닐-4-옥소퀴놀린-3-카복실산 화합물의 제법
KR890001540A (ko) 심부전증 치료제
KR980002033A (ko) 트리아졸 유도체 또는 그 염
KR890001543A (ko) 당뇨병 치료제
DK270889D0 (da) Cytostatisk virksomme anthracyclinderivater, deres fremstilling og anvendelse
KR920019349A (ko) 불안을 치료하기 위한 r(+)-3-아미노-1-하이드록시-피롤리딘-2-온의 용도
KR890009270A (ko) 식물 보호용 살균제
KR920007626A (ko) 벤조[b]티오펜-2-카르복시이미드아미드 유도체의 사용방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application