KR890001965A - 스퍼구알린 관련 유도체 - Google Patents

스퍼구알린 관련 유도체 Download PDF

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Publication number
KR890001965A
KR890001965A KR870006966A KR870006966A KR890001965A KR 890001965 A KR890001965 A KR 890001965A KR 870006966 A KR870006966 A KR 870006966A KR 870006966 A KR870006966 A KR 870006966A KR 890001965 A KR890001965 A KR 890001965A
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KR
South Korea
Prior art keywords
formula
pharmaceutically acceptable
group
compound
spurgualine
Prior art date
Application number
KR870006966A
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English (en)
Other versions
KR940007743B1 (ko
Inventor
하마오 우메자와
도미오 다께우찌
데쓰시 사이노
마사오 요시다
가쓰도시 다까하시
데루야 나까무라
Original Assignee
이찌가와 도꾸지
자이단호오진 비세이부쓰 가가꾸 겡뀨우가이
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Application filed by 이찌가와 도꾸지, 자이단호오진 비세이부쓰 가가꾸 겡뀨우가이 filed Critical 이찌가와 도꾸지
Publication of KR890001965A publication Critical patent/KR890001965A/ko
Application granted granted Critical
Publication of KR940007743B1 publication Critical patent/KR940007743B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

내용 없음

Description

스퍼구알린 관련 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식(I)의 스퍼구알린 관련 유도체 또는 약제학적으로 허용되는 그 염
    위의 일반식에서, X는 -(CH₂)₃이고, R은 -H 또는 -CH2OH이고, R1은 -H,R2는 아미노산 또는 팹타이드의 카르복실기로부터 하이드록실기를 제거한 잔기를 나타내는데, R₁이 수소 이외의 기일 경우에는 R₂는 R₁과 같다.
  2. 제 1 항에 있어서, 일반식(I)의 R₂가 다음기와 같은 화합물 또는 약제학적으로 허용되는 그 염.
    위의 기에서, n은 0 또는 1이고, X₁은 -H 또는 -OH 이고, X₂는 -H 또는 -CH₂OH이고, m은 0 또는 1 내지 4의 정수이고, X₃은 -H, -COOH, -OH, -NH₂또는 -CONH₂이고, X₄는 -H 또는 -NH₂인데 X₃과 X₄가운데 적어도 하나는 -NH₂이고, Y는 1 또는 2이고, A는또는인데 두 A는 펩타이드 결합을 이룬다.
  3. 제 1 항에 있어서, 일반식(I)의 X가 -(CH₃)- 또는인 화합물 또는 약제학적으로 허용되는 그 염.
  4. 제 1 항에 있어서, 일반식(I)에서, X는이고, R이 -CH₂OH이고 R₁은 -H 또는이고 R2는 (L또는D)
    인 화합물 또는 약제학적으로 허용되는 그 염.
  9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870006966A 1986-04-04 1987-07-01 스퍼구알린(Spergualin) 관련 유도체 KR940007743B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP86-77747 1986-04-04
JP7774786 1986-04-04

Publications (2)

Publication Number Publication Date
KR890001965A true KR890001965A (ko) 1989-04-06
KR940007743B1 KR940007743B1 (ko) 1994-08-24

Family

ID=13642505

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019870003206A KR940006768B1 (ko) 1986-04-04 1987-04-04 스퍼구알린(Spergualin)관련 유도체의 제조방법
KR1019870006966A KR940007743B1 (ko) 1986-04-04 1987-07-01 스퍼구알린(Spergualin) 관련 유도체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019870003206A KR940006768B1 (ko) 1986-04-04 1987-04-04 스퍼구알린(Spergualin)관련 유도체의 제조방법

Country Status (17)

Country Link
US (1) US4956504A (ko)
EP (1) EP0241797B1 (ko)
JP (1) JPH0745460B2 (ko)
KR (2) KR940006768B1 (ko)
CN (1) CN1016341B (ko)
AT (1) ATE64378T1 (ko)
AU (1) AU599092B2 (ko)
CA (1) CA1305827C (ko)
DE (1) DE3770680D1 (ko)
DK (2) DK171487A (ko)
ES (1) ES2039213T3 (ko)
FI (1) FI86546C (ko)
GR (1) GR3002660T3 (ko)
HU (1) HU204069B (ko)
IE (1) IE60077B1 (ko)
PT (1) PT84620B (ko)
ZA (1) ZA872440B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100604206B1 (ko) * 2005-12-01 2006-07-24 박현미 배선용 단자

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0794424B2 (ja) * 1987-09-30 1995-10-11 財団法人微生物化学研究会 新スパガリン関連化合物およびその製造法
US5770625A (en) * 1988-02-08 1998-06-23 The Trustees Of Columbia University In The City Of New York Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
DE69104291T2 (de) * 1990-07-20 1995-05-18 Nippon Kayaku Kk Spergulinähnliche Verbindungen und ihre Verwendung.
WO1992018117A1 (en) * 1991-04-11 1992-10-29 Rhone-Poulenc Rorer International (Holdings), Inc. Anti-thrombotic peptide and pseudopeptide derivatives
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
FR2698628B1 (fr) * 1992-12-02 1995-02-17 Fournier Ind & Sante Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
GB9726569D0 (en) * 1997-12-16 1998-02-11 Univ Southampton Neuroprotective agents
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same
JPS60104099A (ja) * 1983-11-09 1985-06-08 Nippon Kayaku Co Ltd スパガリン関連化合物の新規製造法
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
EP0298135A1 (en) * 1987-03-30 1989-01-11 Shosuke Okamoto Phenylalanine derivative and proteinase inhibitor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100604206B1 (ko) * 2005-12-01 2006-07-24 박현미 배선용 단자

Also Published As

Publication number Publication date
PT84620B (pt) 1989-11-30
ZA872440B (en) 1987-12-30
DK171487A (da) 1987-10-05
IE870864L (en) 1987-10-04
CA1305827C (en) 1992-07-28
ES2039213T3 (es) 1993-09-16
GR3002660T3 (en) 1993-01-25
EP0241797A2 (en) 1987-10-21
AU599092B2 (en) 1990-07-12
KR870009989A (ko) 1987-11-30
JPS6345247A (ja) 1988-02-26
DK102792D0 (da) 1992-08-18
IE60077B1 (en) 1994-06-01
FI871445A (fi) 1987-10-05
FI871445A0 (fi) 1987-04-02
PT84620A (en) 1987-05-01
ATE64378T1 (de) 1991-06-15
CN1016341B (zh) 1992-04-22
KR940006768B1 (ko) 1994-07-27
KR940007743B1 (ko) 1994-08-24
JPH0745460B2 (ja) 1995-05-17
EP0241797A3 (en) 1988-07-20
DK102792A (da) 1992-08-18
FI86546B (fi) 1992-05-29
CN87102538A (zh) 1987-11-18
HU204069B (en) 1991-11-28
AU7107587A (en) 1987-10-08
US4956504A (en) 1990-09-11
FI86546C (fi) 1992-09-10
EP0241797B1 (en) 1991-06-12
DE3770680D1 (de) 1991-07-18
HUT44577A (en) 1988-03-28
DK171487D0 (da) 1987-04-03

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