KR880701719A - 아자인돌 및 인돌리진 유도체, 이들의 제조방법 및 이들 약제로서의 용도 - Google Patents

아자인돌 및 인돌리진 유도체, 이들의 제조방법 및 이들 약제로서의 용도

Info

Publication number
KR880701719A
KR880701719A KR1019880700517A KR880700517A KR880701719A KR 880701719 A KR880701719 A KR 880701719A KR 1019880700517 A KR1019880700517 A KR 1019880700517A KR 880700517 A KR880700517 A KR 880700517A KR 880701719 A KR880701719 A KR 880701719A
Authority
KR
South Korea
Prior art keywords
azaindole
pharmaceuticals
preparation
methods
indolizine derivatives
Prior art date
Application number
KR1019880700517A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/945,750 external-priority patent/US4751235A/en
Application filed filed Critical
Publication of KR880701719A publication Critical patent/KR880701719A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019880700517A 1986-09-10 1988-05-10 아자인돌 및 인돌리진 유도체, 이들의 제조방법 및 이들 약제로서의 용도 KR880701719A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90589786A 1986-09-10 1986-09-10
US06/945,750 US4751235A (en) 1986-12-23 1986-12-23 Anti-atherosclerotic indolizine derivatives
PCT/EP1987/000511 WO1988001997A2 (en) 1986-09-10 1987-09-09 Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
KR880701719A true KR880701719A (ko) 1988-11-04

Family

ID=27129444

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880700517A KR880701719A (ko) 1986-09-10 1988-05-10 아자인돌 및 인돌리진 유도체, 이들의 제조방법 및 이들 약제로서의 용도

Country Status (12)

Country Link
EP (1) EP0265640A3 (ko)
JP (1) JPH01500834A (ko)
KR (1) KR880701719A (ko)
AU (1) AU606621B2 (ko)
DK (1) DK254488A (ko)
FI (1) FI882160A0 (ko)
HU (1) HU200769B (ko)
IL (1) IL83821A0 (ko)
NZ (1) NZ221717A (ko)
PL (1) PL267646A1 (ko)
PT (1) PT85662B (ko)
WO (1) WO1988001997A2 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352575A3 (de) * 1988-07-28 1991-08-21 Bayer Ag Substituierte anellierte Pyrrole
EP0363934B1 (en) * 1988-10-13 1993-12-29 Sandoz Ag Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof
JPH04270285A (ja) * 1988-11-14 1992-09-25 Nissan Chem Ind Ltd ピラゾロピリミジン系メバロノラクトン類
US5124453A (en) * 1990-03-02 1992-06-23 E. R. Squibb & Sons, Inc. Process for preparing certain 5,6,7,8-tetrahydroindolizinyl (ethyl or ethynyl)-hydroxy or methoxy-phosphinyl-3-hydroxy-butanoates and derivatives thereof
US5025000A (en) * 1990-03-02 1991-06-18 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitor compounds
WO1992019240A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Treatment of aberrant cellular states with biomodulators
WO1992019239A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Treatment of aberrant cellular states with biomodulators
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
EP1535922A4 (en) 2002-07-11 2006-10-04 Takeda Pharmaceutical PYRROLOPYRIDINE DERIVATIVE AND ITS USE
EP1730146B1 (en) 2004-03-30 2011-05-04 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
CA2636189A1 (en) 2006-01-17 2007-07-26 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of janus kinases
CN101678022A (zh) 2006-12-21 2010-03-24 弗特克斯药品有限公司 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物
ES2604667T3 (es) 2009-06-17 2017-03-08 Vertex Pharmaceuticals Incorporated Inhibidores de la replicación de virus de influenza
KR20140014110A (ko) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI61030C (fi) * 1976-02-19 1982-05-10 Sanofi Sa Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent
US4474971A (en) * 1982-09-29 1984-10-02 Sandoz, Inc. (Tetrahydropyran-2-yl)-aldehydes
WO1984002131A1 (en) * 1982-11-22 1984-06-07 Sandoz Ag Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
GR81711B (ko) * 1983-01-24 1984-12-12 Sandoz Ag
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
JPS61502467A (ja) * 1984-06-22 1986-10-30 サンド・アクチエンゲゼルシヤフト メバロノラクトンのピラゾ−ル同族体およびその誘導体、それらの製造方法ならびに用途
US4677211A (en) * 1984-06-29 1987-06-30 Sandoz Pharmaceuticals Corp. Preparation of lactones
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs

Also Published As

Publication number Publication date
JPH01500834A (ja) 1989-03-23
HU200769B (en) 1990-08-28
FI882160A (fi) 1988-05-09
FI882160A0 (fi) 1988-05-09
NZ221717A (en) 1990-08-28
PL267646A1 (en) 1988-07-21
DK254488A (da) 1988-06-24
WO1988001997A2 (en) 1988-03-24
IL83821A0 (en) 1988-02-29
AU606621B2 (en) 1991-02-14
WO1988001997A3 (en) 1988-04-07
PT85662B (pt) 1990-06-29
AU8022187A (en) 1988-04-07
PT85662A (en) 1987-10-01
DK254488D0 (da) 1988-05-09
HUT46914A (en) 1988-12-28
EP0265640A2 (en) 1988-05-04
EP0265640A3 (en) 1988-05-18

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Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid