KR880013909A - 고혈압 치료 화합물에 대한 테트라졸 중간체 - Google Patents
고혈압 치료 화합물에 대한 테트라졸 중간체 Download PDFInfo
- Publication number
- KR880013909A KR880013909A KR1019880006012A KR880006012A KR880013909A KR 880013909 A KR880013909 A KR 880013909A KR 1019880006012 A KR1019880006012 A KR 1019880006012A KR 880006012 A KR880006012 A KR 880006012A KR 880013909 A KR880013909 A KR 880013909A
- Authority
- KR
- South Korea
- Prior art keywords
- carbon atoms
- alkyl
- phenyl
- tetrazole
- benzyl
- Prior art date
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- 150000003536 tetrazoles Chemical class 0.000 title claims abstract 11
- 150000001875 compounds Chemical class 0.000 title claims 6
- 239000000543 intermediate Substances 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 36
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- -1 3-triazolyl Chemical group 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 229910004013 NO 2 Inorganic materials 0.000 claims 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 claims 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2284—Compounds with one or more Sn-N linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 일반식(Ⅰ)의 데트라졸.상기식에서, X1은 H, Sn(R)3, -C(페닐)3, P-니트로 벤질 또는 β-프로피오니트릴이고 : X2는 H, Cl, Br, I, O-토실, OH, O-메실 또는R은 탄소수 1 내지 6의 알킬, 페닐 또는 사이클로헥실이고 : R1은 탄소수 3 내지 10의 알킬, 탄소수 3 내지 10의 알키닐이거나, 탄소수 1 내지 4의 알콕시, 할로겐, 탄소수 탄소수 1 내지 4의 알킬, 니트로 및 아미노중에서 선택된 두개 이하의 그룹으로 치환된 벤질이며 : R2는 지방족 부분의 탄소수가 2내지 4인 페닐알케닐 ;-(CH2)m-이미다조일-1-일 ; CO2CH3및 탄소수 1 내지 4의 알킬중에서 선택된 하나 또는 두개의 그룹으로 임의 치환된 -(CH2)m-1, 3-트리아졸릴 ; (CH2)m-테트라졸릴, -(CH2)nOR4, -(CH2)nNHSO2R8, -(CH2)mF 또는이고 ; R3은 H, F, Cl, Br, I, NO2, CF3또는 CN이며 ; R4는 H, 탄소수 1 내지 6의 알킬, 탄소수 3 내지 6의 사이클로알킬, 페닐 또는 벤질이고 ; R5는 탄소수 1 내지 8의 알킬 또는 퍼플루오로알킬, 탄소수 3 내지 6의 사이클로알킬, 페닐 또는 벤질이며 ; R6은 H, 탄소수 1 내지 5의 알킬, OR1또는 NR10R11이고 ; R7은 H, 탄소수 1 내지 6의 알킬, 탄소수 3 내지 6의 사이클로알킬, 페닐, 벤질, 탄소수 1 내지 4의 아실 또는 펜아실이며 ;R8은 탄소수 1 내지 6의 알킬 또는 탄소수 1 내지 6의 퍼플루오로알킬, 1-아다만틸, 1-나프틸, 1-(1-나프틸)에틸 또는 (CH2)PC6H5이고 ; R9은 H, 탄소수 1 내지 6의 알킬, 탄소수 3 내지 6의 사이클로알킬 또는 페닐이며 ; R10및 R11은 각기 H, 탄소수 1 내지 4의 알킬, 페닐, 벤질이거나, 둘이 함께 일반식의 환을 형성하고 ; Q는 NR12, O 또는 CH2이며 ; R12는 H, 탄소수 1 내지 4의 알킬 또는 페닐이고 ; m은 1 내지 5이며 : n은 1 내지 10이고 : s는 0 내지 5이며 ; p는 0 내지 3이고 : t는 0 또는 1이며 : 단 X1이 H일 경우 X2는 일반식의 그룹이 될 수 없다.
- 제1항에 있어서, X1이, H, Sn(R)3또는 -C(페닐)3이고, R이 탄소수 1 내지 6의 알킬 또는 페닐인 테트라졸.
- 제1항에 있어서, X2가 H, Br, Cl 또는R1, R2이 제1항에서 정의한 바와 같은 테트라졸.
- 제3항에 있어서, R1이 탄소수 3 내지 7의 알킬, 알케닐 또는 알키닐이고 : R2가 -(CH2)mOR4,, -(CH2)mNHSO2R8, -CH2 또는이며 ; R3이 H, Cl, Br 또는 I이고 ; R4가 H 또는 탄소수 1 내지 4의 알킬이며 ; R5가 H 또는 탄소수 1 내지 4의 알킬이고 ; R6가 H 또는 탄소수 1 내지 5의 알킬, OR9또는 NR10R11이며 ; R7가 H, 또는 탄소수 1 내지 4의 알킬 또는 탄소수 1 내지 4의 아실이고 ; R8이 CF3, 탄소수 1 내지 6의 알킬 또는 페닐이며 ; m이 1 내지 5인 테트라졸.
- 제1항에 있어서, X1이, H, Sn(R)3또는 -C(페닐)3이고, R이 탄소수 1 내지 6의 알킬 도는 페닐이며 ; X2가 H, Br, Cl 또는이고 ; R1이 탄소수 3 내지 7의 알킬, 알케닐 또는 알키닐이며 : R2가 -(CH2)mOR4,, -(CH2)nNHSO2R8, -CH2 또는이고 ; R3이 H, Cl, Br 또는 I이며 ; R4가 H 또는 탄소수 1 내지 4의 알킬이고 ; R5가 H 또는 탄소수 1 내지 4의 알킬이며 ; R6이 H, 탄소수 1 내지 5의 알킬, 0R9또는 NR10R11이고 ; R7가 H, 또는 탄소수 1 내지 4의 알킬 또는 탄소수 1 내지 4의 아실이며 ; R8이 CF3, 탄소수 1 내지 6의 알킬 또는 페닐이고 ; m이 1 내지 5이며 ; 단, X1이 H일 경우, X2는 일반식의 그룹이 아닌 테트라졸.
- 제5항에 있어서, X2가 H, Br, 또는이고 ; R1이 탄소수 3 내지 7의 알킬이며 ; R2가 -(CH2)mOR4이고 ; R3이가 Cl이며 ; R4가 H 또는 탄소수 1 내지 4의 알킬이고 ; m이 1 내지 5인 테트라졸.
- 제6항에 있어서, X2가 H인 테트라졸.
- 제6항에 있어서, X2가 Br인 테트라졸.
- 제6항에 있어서, X2가이고, R1, R2및 R3이 제6항에서 정의한 바와 같은 테트라졸.
- 제9항에 있어서, R1이 n-부틸이고, R2가 -CH2OH이며, R3이 Cl인 테트라졸.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/053,198 US4820843A (en) | 1987-05-22 | 1987-05-22 | Tetrazole intermediates to antihypertensive compounds |
US053,198 | 1987-05-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880013909A true KR880013909A (ko) | 1988-12-22 |
KR960009571B1 KR960009571B1 (ko) | 1996-07-20 |
Family
ID=21982564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880006012A KR960009571B1 (ko) | 1987-05-22 | 1988-05-21 | 혈압강하제 화합물을 제조하기 위한 테트라졸 중간체 |
Country Status (20)
Country | Link |
---|---|
US (1) | US4820843A (ko) |
EP (1) | EP0291969B1 (ko) |
JP (1) | JPH0774207B2 (ko) |
KR (1) | KR960009571B1 (ko) |
AT (1) | ATE101603T1 (ko) |
AU (1) | AU603525B2 (ko) |
CA (1) | CA1340325C (ko) |
DE (1) | DE3887772T2 (ko) |
DK (1) | DK274788A (ko) |
ES (1) | ES2061552T3 (ko) |
FI (1) | FI93831C (ko) |
HU (1) | HU198698B (ko) |
IE (1) | IE63204B1 (ko) |
IL (1) | IL86456A (ko) |
MY (1) | MY101284A (ko) |
NO (1) | NO178189C (ko) |
NZ (1) | NZ224741A (ko) |
PT (1) | PT87552B (ko) |
RU (1) | RU2091376C1 (ko) |
ZA (1) | ZA883528B (ko) |
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JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
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CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
-
1987
- 1987-05-22 US US07/053,198 patent/US4820843A/en not_active Expired - Lifetime
-
1988
- 1988-04-19 CA CA000564538A patent/CA1340325C/en not_active Expired - Lifetime
- 1988-05-18 ZA ZA883528A patent/ZA883528B/xx unknown
- 1988-05-19 DK DK274788A patent/DK274788A/da not_active Application Discontinuation
- 1988-05-19 AT AT88108005T patent/ATE101603T1/de not_active IP Right Cessation
- 1988-05-19 DE DE3887772T patent/DE3887772T2/de not_active Expired - Lifetime
- 1988-05-19 EP EP88108005A patent/EP0291969B1/en not_active Expired - Lifetime
- 1988-05-19 ES ES88108005T patent/ES2061552T3/es not_active Expired - Lifetime
- 1988-05-20 IL IL86456A patent/IL86456A/xx not_active IP Right Cessation
- 1988-05-20 PT PT87552A patent/PT87552B/pt not_active IP Right Cessation
- 1988-05-20 NO NO882241A patent/NO178189C/no not_active IP Right Cessation
- 1988-05-20 MY MYPI88000523A patent/MY101284A/en unknown
- 1988-05-20 JP JP63122216A patent/JPH0774207B2/ja not_active Expired - Lifetime
- 1988-05-20 AU AU16503/88A patent/AU603525B2/en not_active Expired
- 1988-05-20 HU HU882601A patent/HU198698B/hu unknown
- 1988-05-20 IE IE151588A patent/IE63204B1/en not_active IP Right Cessation
- 1988-05-20 FI FI882390A patent/FI93831C/fi not_active IP Right Cessation
- 1988-05-20 NZ NZ224741A patent/NZ224741A/en unknown
- 1988-05-21 KR KR1019880006012A patent/KR960009571B1/ko not_active IP Right Cessation
-
1992
- 1992-05-18 RU SU925011512A patent/RU2091376C1/ru active
Also Published As
Publication number | Publication date |
---|---|
DK274788D0 (da) | 1988-05-19 |
NO178189C (no) | 1996-02-07 |
IE63204B1 (en) | 1995-04-05 |
IL86456A0 (en) | 1988-11-15 |
AU603525B2 (en) | 1990-11-15 |
US4820843A (en) | 1989-04-11 |
FI882390A (fi) | 1988-11-23 |
HUT47550A (en) | 1989-03-28 |
DE3887772D1 (de) | 1994-03-24 |
MY101284A (en) | 1991-08-17 |
NZ224741A (en) | 1990-12-21 |
ATE101603T1 (de) | 1994-03-15 |
IE881515L (en) | 1988-11-22 |
HU198698B (en) | 1989-11-28 |
ZA883528B (en) | 1990-01-31 |
RU2091376C1 (ru) | 1997-09-27 |
IL86456A (en) | 1992-12-01 |
FI882390A0 (fi) | 1988-05-20 |
NO882241D0 (no) | 1988-05-20 |
DK274788A (da) | 1988-11-23 |
PT87552B (pt) | 1992-09-30 |
FI93831B (fi) | 1995-02-28 |
CA1340325C (en) | 1999-01-19 |
AU1650388A (en) | 1988-11-24 |
KR960009571B1 (ko) | 1996-07-20 |
EP0291969A3 (en) | 1990-10-31 |
EP0291969B1 (en) | 1994-02-16 |
FI93831C (fi) | 1995-06-12 |
NO178189B (no) | 1995-10-30 |
NO882241L (no) | 1988-11-23 |
EP0291969A2 (en) | 1988-11-23 |
JPH0774207B2 (ja) | 1995-08-09 |
JPH01117876A (ja) | 1989-05-10 |
PT87552A (pt) | 1989-05-31 |
DE3887772T2 (de) | 1994-06-23 |
ES2061552T3 (es) | 1994-12-16 |
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