KR880013909A - 고혈압 치료 화합물에 대한 테트라졸 중간체 - Google Patents

고혈압 치료 화합물에 대한 테트라졸 중간체 Download PDF

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KR880013909A
KR880013909A KR1019880006012A KR880006012A KR880013909A KR 880013909 A KR880013909 A KR 880013909A KR 1019880006012 A KR1019880006012 A KR 1019880006012A KR 880006012 A KR880006012 A KR 880006012A KR 880013909 A KR880013909 A KR 880013909A
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carbon atoms
alkyl
phenyl
tetrazole
benzyl
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KR1019880006012A
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KR960009571B1 (ko
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에드워드 알드리히 폴
조나스 비타우타스 던시아 죤
어니스트 피어스 마이클
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제임스 제이.플린
이.아이.듀퐁 드 네모아 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)

Abstract

내용 없음

Description

고혈압 치료 화합물에 대한 테트라졸 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(Ⅰ)의 데트라졸.
    상기식에서, X1은 H, Sn(R)3, -C(페닐)3, P-니트로 벤질 또는 β-프로피오니트릴이고 : X2는 H, Cl, Br, I, O-토실, OH, O-메실 또는
    R은 탄소수 1 내지 6의 알킬, 페닐 또는 사이클로헥실이고 : R1은 탄소수 3 내지 10의 알킬, 탄소수 3 내지 10의 알키닐이거나, 탄소수 1 내지 4의 알콕시, 할로겐, 탄소수 탄소수 1 내지 4의 알킬, 니트로 및 아미노중에서 선택된 두개 이하의 그룹으로 치환된 벤질이며 : R2는 지방족 부분의 탄소수가 2내지 4인 페닐알케닐 ;-(CH2)m-이미다조일-1-일 ; CO2CH3및 탄소수 1 내지 4의 알킬중에서 선택된 하나 또는 두개의 그룹으로 임의 치환된 -(CH2)m-1, 3-트리아졸릴 ; (CH2)m-테트라졸릴, -(CH2)nOR4, -(CH2)nNHSO2R8, -(CH2)mF 또는이고 ; R3은 H, F, Cl, Br, I, NO2, CF3또는 CN이며 ; R4는 H, 탄소수 1 내지 6의 알킬, 탄소수 3 내지 6의 사이클로알킬, 페닐 또는 벤질이고 ; R5는 탄소수 1 내지 8의 알킬 또는 퍼플루오로알킬, 탄소수 3 내지 6의 사이클로알킬, 페닐 또는 벤질이며 ; R6은 H, 탄소수 1 내지 5의 알킬, OR1또는 NR10R11이고 ; R7은 H, 탄소수 1 내지 6의 알킬, 탄소수 3 내지 6의 사이클로알킬, 페닐, 벤질, 탄소수 1 내지 4의 아실 또는 펜아실이며 ;R8은 탄소수 1 내지 6의 알킬 또는 탄소수 1 내지 6의 퍼플루오로알킬, 1-아다만틸, 1-나프틸, 1-(1-나프틸)에틸 또는 (CH2)PC6H5이고 ; R9은 H, 탄소수 1 내지 6의 알킬, 탄소수 3 내지 6의 사이클로알킬 또는 페닐이며 ; R10및 R11은 각기 H, 탄소수 1 내지 4의 알킬, 페닐, 벤질이거나, 둘이 함께 일반식의 환을 형성하고 ; Q는 NR12, O 또는 CH2이며 ; R12는 H, 탄소수 1 내지 4의 알킬 또는 페닐이고 ; m은 1 내지 5이며 : n은 1 내지 10이고 : s는 0 내지 5이며 ; p는 0 내지 3이고 : t는 0 또는 1이며 : 단 X1이 H일 경우 X2는 일반식의 그룹이 될 수 없다.
  2. 제1항에 있어서, X1이, H, Sn(R)3또는 -C(페닐)3이고, R이 탄소수 1 내지 6의 알킬 또는 페닐인 테트라졸.
  3. 제1항에 있어서, X2가 H, Br, Cl 또는
    R1, R2이 제1항에서 정의한 바와 같은 테트라졸.
  4. 제3항에 있어서, R1이 탄소수 3 내지 7의 알킬, 알케닐 또는 알키닐이고 : R2가 -(CH2)mOR4,, -(CH2)mNHSO2R8, -CH2 또는이며 ; R3이 H, Cl, Br 또는 I이고 ; R4가 H 또는 탄소수 1 내지 4의 알킬이며 ; R5가 H 또는 탄소수 1 내지 4의 알킬이고 ; R6가 H 또는 탄소수 1 내지 5의 알킬, OR9또는 NR10R11이며 ; R7가 H, 또는 탄소수 1 내지 4의 알킬 또는 탄소수 1 내지 4의 아실이고 ; R8이 CF3, 탄소수 1 내지 6의 알킬 또는 페닐이며 ; m이 1 내지 5인 테트라졸.
  5. 제1항에 있어서, X1이, H, Sn(R)3또는 -C(페닐)3이고, R이 탄소수 1 내지 6의 알킬 도는 페닐이며 ; X2가 H, Br, Cl 또는이고 ; R1이 탄소수 3 내지 7의 알킬, 알케닐 또는 알키닐이며 : R2가 -(CH2)mOR4,, -(CH2)nNHSO2R8, -CH2 또는이고 ; R3이 H, Cl, Br 또는 I이며 ; R4가 H 또는 탄소수 1 내지 4의 알킬이고 ; R5가 H 또는 탄소수 1 내지 4의 알킬이며 ; R6이 H, 탄소수 1 내지 5의 알킬, 0R9또는 NR10R11이고 ; R7가 H, 또는 탄소수 1 내지 4의 알킬 또는 탄소수 1 내지 4의 아실이며 ; R8이 CF3, 탄소수 1 내지 6의 알킬 또는 페닐이고 ; m이 1 내지 5이며 ; 단, X1이 H일 경우, X2는 일반식의 그룹이 아닌 테트라졸.
  6. 제5항에 있어서, X2가 H, Br, 또는이고 ; R1이 탄소수 3 내지 7의 알킬이며 ; R2가 -(CH2)mOR4이고 ; R3이가 Cl이며 ; R4가 H 또는 탄소수 1 내지 4의 알킬이고 ; m이 1 내지 5인 테트라졸.
  7. 제6항에 있어서, X2가 H인 테트라졸.
  8. 제6항에 있어서, X2가 Br인 테트라졸.
  9. 제6항에 있어서, X2가이고, R1, R2및 R3이 제6항에서 정의한 바와 같은 테트라졸.
  10. 제9항에 있어서, R1이 n-부틸이고, R2가 -CH2OH이며, R3이 Cl인 테트라졸.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880006012A 1987-05-22 1988-05-21 혈압강하제 화합물을 제조하기 위한 테트라졸 중간체 KR960009571B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/053,198 US4820843A (en) 1987-05-22 1987-05-22 Tetrazole intermediates to antihypertensive compounds
US053,198 1987-05-22

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KR880013909A true KR880013909A (ko) 1988-12-22
KR960009571B1 KR960009571B1 (ko) 1996-07-20

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US (1) US4820843A (ko)
EP (1) EP0291969B1 (ko)
JP (1) JPH0774207B2 (ko)
KR (1) KR960009571B1 (ko)
AT (1) ATE101603T1 (ko)
AU (1) AU603525B2 (ko)
CA (1) CA1340325C (ko)
DE (1) DE3887772T2 (ko)
DK (1) DK274788A (ko)
ES (1) ES2061552T3 (ko)
FI (1) FI93831C (ko)
HU (1) HU198698B (ko)
IE (1) IE63204B1 (ko)
IL (1) IL86456A (ko)
MY (1) MY101284A (ko)
NO (1) NO178189C (ko)
NZ (1) NZ224741A (ko)
PT (1) PT87552B (ko)
RU (1) RU2091376C1 (ko)
ZA (1) ZA883528B (ko)

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DK274788D0 (da) 1988-05-19
NO178189C (no) 1996-02-07
IE63204B1 (en) 1995-04-05
IL86456A0 (en) 1988-11-15
AU603525B2 (en) 1990-11-15
US4820843A (en) 1989-04-11
FI882390A (fi) 1988-11-23
HUT47550A (en) 1989-03-28
DE3887772D1 (de) 1994-03-24
MY101284A (en) 1991-08-17
NZ224741A (en) 1990-12-21
ATE101603T1 (de) 1994-03-15
IE881515L (en) 1988-11-22
HU198698B (en) 1989-11-28
ZA883528B (en) 1990-01-31
RU2091376C1 (ru) 1997-09-27
IL86456A (en) 1992-12-01
FI882390A0 (fi) 1988-05-20
NO882241D0 (no) 1988-05-20
DK274788A (da) 1988-11-23
PT87552B (pt) 1992-09-30
FI93831B (fi) 1995-02-28
CA1340325C (en) 1999-01-19
AU1650388A (en) 1988-11-24
KR960009571B1 (ko) 1996-07-20
EP0291969A3 (en) 1990-10-31
EP0291969B1 (en) 1994-02-16
FI93831C (fi) 1995-06-12
NO178189B (no) 1995-10-30
NO882241L (no) 1988-11-23
EP0291969A2 (en) 1988-11-23
JPH0774207B2 (ja) 1995-08-09
JPH01117876A (ja) 1989-05-10
PT87552A (pt) 1989-05-31
DE3887772T2 (de) 1994-06-23
ES2061552T3 (es) 1994-12-16

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