KR880004814A - 이포스파미드 동결건조물 및 이의 제조방법 - Google Patents
이포스파미드 동결건조물 및 이의 제조방법 Download PDFInfo
- Publication number
- KR880004814A KR880004814A KR870012077A KR870012077A KR880004814A KR 880004814 A KR880004814 A KR 880004814A KR 870012077 A KR870012077 A KR 870012077A KR 870012077 A KR870012077 A KR 870012077A KR 880004814 A KR880004814 A KR 880004814A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- phosphamide
- ifosfamide
- hexitol
- parts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Control Of El Displays (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Amplifiers (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 이포스파미드(Ifosfamide), 이포스파미드 1중량부를 기준으로 하여 0.1 내지 17중량부의 헥시톨 및 임의로 다른 통상의 약제학적 보조물질을 함유하는 동결건조제제.
- 제1항에 있어서, 헥시톨이 만니톨임을 특징으로 하는 동결건조제제.
- 이포스파미드 1내지 13중량%, 이스파미드 1중량부를 기준으로 하여 헥시톨 0.1내지 17중량부 및, 임의로 이포스파미드 1중량부를 기준으로 하여 다른 약제학적 보조물질 0내지 16.9중량부를 함유하는 이포스파미드 수성 또는 수성-에탄올성 용액을 -70° 내지 0℃에서 동결시키고 ; 동결상태에서 이와 같이 수득한 생성물로부터 물을 제거함을 특징으로 하여, 이포스파미드 동결건조물을 제조하는 방법.
- 제3항에 있어서, 초기에 비-흡수성 결합수를 -30 내지 40℃의 온도 및 10-3내지 10mbar의 압력에서 먼저 제거하고 ; 이어서 흡수성 결합수를 0내지 40℃의 온도 및 10-4내지 10-1mbar의 압력에서 제거함을 특징으로 하는 방법.
- 제3 또는 4항에 있어서, 핵시톨이 만니톨임을 특징으로 하는 방법.
- 제3 내지 5항중 어느 한 항에 따라 수득한 이포스파미드 동결건조물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3637089 | 1986-10-31 | ||
DEP3637089.4 | 1986-10-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880004814A true KR880004814A (ko) | 1988-06-27 |
KR900003491B1 KR900003491B1 (ko) | 1990-05-21 |
Family
ID=6312873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870012077A KR900003491B1 (ko) | 1986-10-31 | 1987-10-30 | 이포스파미드 동결건조물 및 이의 제조방법 |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0265812B1 (ko) |
JP (1) | JPS63159319A (ko) |
KR (1) | KR900003491B1 (ko) |
AT (1) | ATE55250T1 (ko) |
AU (1) | AU598602B2 (ko) |
CA (1) | CA1314231C (ko) |
DD (1) | DD262582A5 (ko) |
DE (1) | DE3764235D1 (ko) |
DK (1) | DK169308B1 (ko) |
EG (1) | EG18333A (ko) |
ES (1) | ES2017982B3 (ko) |
FI (1) | FI87140C (ko) |
GE (1) | GEP19971025B (ko) |
GR (1) | GR3000708T3 (ko) |
HU (1) | HU197987B (ko) |
IL (1) | IL84312A (ko) |
IN (1) | IN168119B (ko) |
LV (1) | LV10051B (ko) |
MX (1) | MX8958A (ko) |
NO (1) | NO873860L (ko) |
PT (1) | PT86032B (ko) |
RU (1) | RU1836079C (ko) |
UA (1) | UA11075A (ko) |
YU (1) | YU197387A (ko) |
ZA (1) | ZA878183B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE58900183D1 (de) * | 1988-03-19 | 1991-08-29 | Asta Pharma Ag | Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung. |
US5227373A (en) * | 1991-10-23 | 1993-07-13 | Bristol-Myers Squibb Co. | Lyophilized ifosfamide compositions |
WO1995007083A1 (en) * | 1993-09-10 | 1995-03-16 | F.H. Faulding & Co. Limited | Ifosfamide lyophilisate composition |
DE19529057B4 (de) * | 1995-08-08 | 2007-12-13 | Baxter Healthcare S.A. | Ifosfamid-Lyophilisat-Zubereitungen |
JP2002505282A (ja) * | 1998-03-03 | 2002-02-19 | 塩野義製薬株式会社 | ホスホリパーゼ阻害剤の[[3−(2−アミノ−1,2−ジオキソエチル)−2−エチル−1−フェニルメチル)−1h−インドール−4−イル]オキシ]酢酸ナトリウムを含む薬学的組成物 |
NZ538584A (en) * | 2002-09-05 | 2007-05-31 | Bharat Serums & Vaccines Ltd | Stable liquid composition of oxazaphosphorine, mesna and etherified beta-cyclodextrin |
MXPA05005919A (es) * | 2002-12-02 | 2005-09-21 | Bharat Serums & Vaccines Ltd | Composiciones de ifosfamida para la administracion parenteral, y un proceso para su preparacion. |
US8436190B2 (en) * | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
JP5619419B2 (ja) * | 2006-09-29 | 2014-11-05 | インファ ソシエテ アノニム | 薬学的組成物用調剤システム及び静脈内投与用キット |
WO2016087001A1 (en) * | 2014-12-04 | 2016-06-09 | Huawei Technologies Co., Ltd. | Load allocation in a data communication network |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732340A (en) * | 1966-07-11 | 1973-05-08 | Asta Werke Ag Chem Fab | N',o-propylene phosphoric acid ester diamides |
DE2750207A1 (de) * | 1977-05-09 | 1978-11-16 | Walton J Smith | Gefriergetrocknete zusammensetzungen, insbesondere gefriergetrocknete pharmazeutische praeparate und verfahren zu deren herstellung |
EP0083439B1 (de) * | 1981-12-31 | 1989-07-26 | ASTA Pharma AG | 4-Sulfido-oxazaphosphorine und deren Verwendung bei der Krebsbekämpfung und zur Immunsuppression |
US4537883A (en) * | 1982-11-12 | 1985-08-27 | Mead Johnson & Company | Lyophilized cyclophosphamide |
-
1987
- 1987-09-15 NO NO873860A patent/NO873860L/no unknown
- 1987-10-20 AT AT87115322T patent/ATE55250T1/de not_active IP Right Cessation
- 1987-10-20 DE DE8787115322T patent/DE3764235D1/de not_active Expired - Lifetime
- 1987-10-20 ES ES87115322T patent/ES2017982B3/es not_active Expired - Lifetime
- 1987-10-20 EP EP87115322A patent/EP0265812B1/de not_active Expired - Lifetime
- 1987-10-23 MX MX895887A patent/MX8958A/es unknown
- 1987-10-26 IN IN837/CAL/87A patent/IN168119B/en unknown
- 1987-10-27 FI FI874727A patent/FI87140C/fi not_active IP Right Cessation
- 1987-10-28 EG EG61687A patent/EG18333A/xx active
- 1987-10-29 RU SU874203570A patent/RU1836079C/ru active
- 1987-10-29 IL IL84312A patent/IL84312A/xx not_active IP Right Cessation
- 1987-10-29 PT PT86032A patent/PT86032B/pt unknown
- 1987-10-29 JP JP62272002A patent/JPS63159319A/ja active Granted
- 1987-10-29 UA UA4203570A patent/UA11075A/uk unknown
- 1987-10-30 DK DK569687A patent/DK169308B1/da not_active IP Right Cessation
- 1987-10-30 CA CA000550706A patent/CA1314231C/en not_active Expired - Lifetime
- 1987-10-30 AU AU80529/87A patent/AU598602B2/en not_active Ceased
- 1987-10-30 DD DD87308471A patent/DD262582A5/de not_active IP Right Cessation
- 1987-10-30 ZA ZA878183A patent/ZA878183B/xx unknown
- 1987-10-30 YU YU01973/87A patent/YU197387A/xx unknown
- 1987-10-30 KR KR1019870012077A patent/KR900003491B1/ko not_active IP Right Cessation
- 1987-10-30 HU HU874900A patent/HU197987B/hu unknown
-
1990
- 1990-08-09 GR GR90400533T patent/GR3000708T3/el unknown
-
1992
- 1992-10-27 LV LVP-92-174A patent/LV10051B/lv unknown
-
1993
- 1993-07-07 GE GEAP1993972A patent/GEP19971025B/en unknown
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Legal Events
Date | Code | Title | Description |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20070517 Year of fee payment: 18 |
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EXPY | Expiration of term |