KR880003881A - 이소프렌 유도체 - Google Patents
이소프렌 유도체 Download PDFInfo
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- KR880003881A KR880003881A KR870009954A KR870009954A KR880003881A KR 880003881 A KR880003881 A KR 880003881A KR 870009954 A KR870009954 A KR 870009954A KR 870009954 A KR870009954 A KR 870009954A KR 880003881 A KR880003881 A KR 880003881A
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- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical class CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 25
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 18
- -1 dimethylene group Chemical group 0.000 claims 11
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 7
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- RSJJPKLCCFJFEZ-UHFFFAOYSA-N 10-hydroxy-3,7,11-trimethyldodeca-2,6,11-trienoic acid Chemical compound CC(=C)C(O)CCC(C)=CCCC(C)=CC(O)=O RSJJPKLCCFJFEZ-UHFFFAOYSA-N 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 208000007107 Stomach Ulcer Diseases 0.000 claims 3
- 150000007513 acids Chemical class 0.000 claims 3
- 208000000718 duodenal ulcer Diseases 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 201000005917 gastric ulcer Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 claims 2
- KZQSYXJLFUPUHO-BIVKKUJPSA-N (2e,6e)-3,7,11-trimethyl-10-oxododeca-2,6,11-trienal Chemical compound CC(=C)C(=O)CC\C(C)=C\CC\C(C)=C\C=O KZQSYXJLFUPUHO-BIVKKUJPSA-N 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006017 1-propenyl group Chemical group 0.000 claims 1
- 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000006020 2-methyl-1-propenyl group Chemical group 0.000 claims 1
- 239000007818 Grignard reagent Substances 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- LZFFIZVDAUVCBH-UHFFFAOYSA-N dodeca-7,9,11-trien-2-one Chemical compound CC(=O)CCCCC=CC=CC=C LZFFIZVDAUVCBH-UHFFFAOYSA-N 0.000 claims 1
- 125000003700 epoxy group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 150000004795 grignard reagents Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003138 primary alcohols Chemical class 0.000 claims 1
- 238000007142 ring opening reaction Methods 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
-
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C11/00—Aliphatic unsaturated hydrocarbons
- C07C11/12—Alkadienes
- C07C11/173—Alkadienes with five carbon atoms
- C07C11/18—Isoprene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
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Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 일반식(Ⅰ)의 화합물 일반식(Ⅰ)의 산성화합물과 염기와의 약제학적으로 유용한 염.상기 식에서, R1은 하기 일반식 (a), (b), (c) 또는 (d)의 잔기이고,[상기 식에서 R5는 (C2-C8)-알킬(단, 이소프로필은 제외), (C3-C8)-사이클로알킬, (C2-C8)-알케닐, (C2-C8)-알키닐, 트리-(C1-C8)-알킬-실릴에티닐이거나 R1이 일반식 (a)의 잔기인 경우에는, 또한 하기 일반식(K)의 잔기이고,(여기서, R15는 (C1-C8)-알킬, (C2-C8)-알카노일, (C1-C8)-알콕시카보닐-(C1-C8)-알킬, 하이드록시-(C2-C8)-알킬, (C2-C8)-알카노일옥시-(C2-C8)-알킬 또는 (C2-C8)-알카노일아미노-(C2-C8)-알킬이거나, (C2-C8)-알콕시카보닐에 의해 이치환된 (C2-C8)-알킬이도, n은 0,1 또는 2이며, R16, R17및 R18은 각각 수소 또는 총 탄소원자가 6개 이하인 (C1-C8)-알킬, (C1-C6)-알콕시-(C1-C8)-알킬 또는 (C1-C8)-알콕시카보닐 그룹에 의해 임의로 지환된 디-또는 트리메틸렌 구릅울 나타내며, R8은 수소 또는 (C1-C8)--알킬이고, R9는 수소 또는 (C2-C8)-알카노일이다] R2및 R3중의 하나는 (C1-C8)-알킬이고 다른 하나는 수소 또는 (C1-C8)-알킬이며, R8은 일반식 (e), (f), (g), (h), (i) 또는 (j)의 잔기이고,[상기 식에서, R8는 수소 또는 (C1-Cx)-알킬이다) R10은 (C1-C8)-알킬이고, R11은 수소, (C1-C8)-알킬, (C2-C8)-알카노일 또는 하기 일반식 (Ⅰ) 또는 (m)의 잔기이며,(여기서, R19는 수소 또는 (C1-C5)-알킬이다) R12는 수소, (C1-C8)-알킬, (C2-C8)-알케닐 또는 (C2-C8)-알키닐이고, R13및 R14는 각각 수소 또는 (C1-C8)-알킬이거나 질소원자와 함께 1-피롤리디닐, 피페리디노 또는 모르폴리노를 나타낸다] 점선은 각각 E-또는 Z-배위를 갖는 임의의 추가의 C-C결합을 나타내며, 일반식(c) 및 (h)의 잔기에 존재하는 이중결합은 E-또는 Z-배위를 가지고, 단, 상기 화합물에서 10-하이드록시-3, 7, 11-트리메틸-2, 6, 11-도데카트리에노산 및 3, 7, 11-트리메틸-2, 6, 11-도데카트리엔-1, 10-디옥은 제외한다.
- 제1항에 있어서, R1이 일반식 (a), (b), (c) 또는 (d)의 잔기이고, R2및 R3은 각각 (C1-C8)-알킬이며, R4는 일반식 (f), (g), (h), (i) 또는 (j)의 잔기이고, R5는 (C2-C8)-알케닐, (C2-C8)-알키닐 또는 트리-(C1-C8)-알킬-실릴-에티닐이며, R6및 R1은 각각 (C1-C8)-알킬이거나 함께 디메틸렌그룹을 나타내고, R8은 수소 또는 (C1-C8)-알킬이며, R9는 수소이고, R11는 수소 또는 (C2-C8)-알카노일이며, R12, R13및 R14는 각각 수소이고, 2개의 점선을 비공액화된 추가의 C-C결합을 나타내는 화합물.
- 제2항에 있어서, R2및 R3이 각각 메틸이고, R5는 비닐, 1-메틸비닐, 1-프로페닐, 2-메틸-1-프로페닐, 에티닐, 1-프로피닐 또는 트리메틸실릴에티닐이여, R6및 R7은 각각 메틸 또는 에틸이거나 함께 디메틸렌 그룹을 나타내고, R8은 수소 또는 메틸이며, R11은 수소 또는 아세틸인 화합물.
- 제1항에 있어서, (모두-E)-12-하이드록시-6, 10-디메틸-6, 10-도데카디엔-1-인-3-온; (모두-E)-12-하이드록시-6, 10-디메틸-1, 6, 10-도데카트리엔-1-3-온; (모두-E)-13-하이드록시-7, 11-디메틸-7, 11-트리데카리엔-2-인-4-온; (코두-E)-13-하이도록시-7, 11-디메틸-2, 7, 11-트리데카트리엔-4-온; 및 (모두-E)-10, 10-디에톡시-3, 7-디메틸-2, 6-도데카디엔-11-인-올인 화합물.
- 제1항에 있어서, (모두-E)-12-하이드록시-2, 6, 10-트리메틸-1, 6, 10-도데카트리엔-3-온, (모두-E)-10옥소-3, 7, 11-트리메틸-2, 6, 11-도데카트리엔알, (6Z, 10Z)-12-하이드록시-2, 6, 10-트리메틸-1, 6, 10-도데카트리엔-3-온, (모두-E)03, 7-디메틸-9-[2-(1-메틸비닐)-1, 3-디옥솔란-2-일]-2, 6-노나디엔-1-올-, (E, E)-3, 7, 11-트리데카트리엔-4-온, (6E, 10E)-12-하이드록시-2, 6, 10-트리메틸 -1, 6, 10-도데카트리엔-3-온인 화합물.
- 제1항에 있어서, (모두-E)-10-옥소-3, 7, 11-트리메틸-2, 6, 11-도데카트리에노산; ㅋ(모두-E)-10, 10-디메톡시-3, 7, 11-트리메틸-2, 6, 11-도데카트리엔-1-올; (모두-E)-10-하이도록시-3, 7, 11-트리메틸-2, 6, 11-도데마트리엔알; (모두-E)-12-하이드록시-6, 10-디메틸-1-(트리메틸실릴)-6, 10-도데카디엔-1-인-3-온; (2E, 6E)--3, 7, 11-트리메틸-10-옥소-2, 6, 11-도데카트리엔알(E/Z)-옥심; (6E, 10E)-12-하이드록시-6, 10-디메틸-6, 10-도데카트리엔-1-인-3-온(E/Z)-0-메틸옥심; 및 (2E, 6E, 11(E/Z)-3, 7-디메틸-2, 6, 11-트리데카트리엔-1, 10-디올인 화합물.
- 치료학적 활성 물질로서, 특히 위궤양 및/또는 십이지장궤양을 억제하거나 예방하는 데 사용하기 위한, 10-하이드록시-3, 7, 11-트리메틸-2, 6, 10-도데카트리에노산 및 3, 7, 11-트리메틸-2, 6, 10-도데카트리엔-1, 10--디올과 제1항 내지 제6항중 어느 한 항에 따른 화합물.
- a) 하나 이상의 보호그룹을 함유하는 일반식(Ⅱ)의 화합물로부터 보호그룹(들)을 제거하거나; b) 일반식(Ⅲ)의 화합물에서 에폭사이드 환을 개환시키거나; c) 일반식(Ⅳ)의 카복실산으로 에스테르를 상응하는 1급 알콜로 환원시키거나; d) 일반식(Ⅴ)의 카복실산 에스테르를 상응하는 카복실산으로 가수분해하거나; e) R1이 하기에서 정의하는 일반식(b), (c) 또는 (d)의 잔기이거나 일반식(ai)의 잔기이고, 분가가 C-원자에 결합된 하나 이상의 하이드록시 그룹을 함유하는 일반식(Ⅰ)화합물을, (C1-C8)-알킬 그룹, (C2-C8)-알케닐 그룹 또는 (C2-C8)-알키닐 그룹을 제공하는 그리나드 시약으로 처리하거나; g) R1이 하기에서 정의하는 일반식(b), (c) 또는 (d)의 잔기이거나 일반식(ai)의 잔기이고 분자가 하나 이상의 옥소 그룹을 함유하는 일반식(Ⅰ)의 화합물을 일반식(Ⅶ)의 화합물과 반응시키거나; i) R1이 일반식(ki)의 잔기인 일반식(Ⅰ)의 화합물에서 머캅토 그룹을 설피닐 또는 설포닐 그룹으로 산화시키거나, 또는 설피닐 그룹을 설포닐 그룹으로 산화시키거나; j) R1이 하기에서 정의하는 일반식(a), (b) 또는 (d)의 잔기이거나 일반식 (ci)의 잔기이고 R4는 하기에 정의하는 일반식(e), (f), (g), (i) 또는 (j)의 잔기이거나 일반식(hi)의 잔기이며, 분자가 하나 이상의 하이드록시 그룹을 함유하는 일반식(Ⅰ)의 화합물에서 하이드록시 그룹(들)을, (C2-C8)-알카노일 잔기를 제공하는 시약으로 아실화하거나; 경우에 따라 생성된 일반식(Ⅰ)의 산성 화합물을 염기와 반응시켜 약제학적으로 유용한 염으로 전환시킴을 특징으로 하여 제1항 내지 제6항중 어느 한항에 따른 일반식(Ⅰ)의 화합물 및 일반식(Ⅰ)의 산성 화합물과 염기와의 약제학적으로 유용한 염을 제조하는 방법.상기 식에서, R1은 하기 일반식(a), (b), (c) 또는 (d)의 잔기이고,[상기 식에서, R5는 (C2-C8)-알킬(단, 이소프로필은 제외), (C3-C8)-사이클로알킬, (C2-C8)-알케닐, (C2-C89-알키닐, 트리-(C1-C8)-알킬-실릴에티닐이거나, R1이 일반식 (a)의 잔기인 경우에는 또한 일반식(k)의 잔기이고,(여기서, R15는 (C1-C8)-알킬, (C2-C8)-알카노일, (C1-C8)-알콕시카보닐-(C1-C8-알카노일옥시-(C2-C8)-알킬 또는 (C2-C8)-알카노일아미노-(C2-C8)-알킬이거나, (C2-C8)-알카노일아미노 및 (C1-C8)-알카노일아미노 및 (C1-C8)-알콕시카보닐에 의해 이치환되거나 (C2-C8)-알카노일옥시 및 (C1-C8)-알콕시카보닐에 의해 이치환된 (C2-C8)-알킬이고, n은 0, 1 또는 2이며, R16, R17및 R18은 각각 수소, 또는 총 탄소원자가 6개 이하인 (C1-C6)--알킬이다) R6및 R7은 각각 (C1-C8)-알킬이거나, R6및 R7이 함께 1 또는 2개의 (C1-C8)-알킬, (C1-C8)-알콕시-(C1-C8)-알킬 또는 (C1-C8)-알톡시카보닐그룹에 의해 임의로 치환된 디-또는 트리메틸렌 그룹을 나타내며, R8은 수소 또는 (C1-C8)-알킬이고, R9는 수소 또는 (C2-C8)-알킬이며, R4는 하기 일반식 (e), (f), (g), (h), (i) 또는 (j)의 잔기이고,[상기 식에서, R8은 수소 또는 (C1-C8)-알킬이며, R10은 (C1-C8)-알킬이고, R11은 수소, (C1-C8)-알킬, (C2-C8)-알카노일 또는 하기 일반식(Ⅰ) 또는 (m)의 잔기이며,R19 - CH = CH - CH2 - , R19 - C- C - CH2 -(Ⅰ) (m)(여기서, R19는 수소 또는 (C1-C5)-알킬이다) R12는 수소, (C1-C8)-알킬, (C2-C8)-알케닐 또는 (C2-C8)-알키닐이고, R13및 R14는 각각 수소 또는 (C1-C8)-알킬이거나 질소원자와 함께 1-피톨리디닐, 피페리디노 또는 모르폴리노를 나타낸다] 점선은 각각 E-또는 Z-배위를 갖는 임의의 추가의 C-C결합을 나타내며, 일반식 (c) 및 (h)의 잔기에 존재하는 이중 결합은 E-또는 Z-배위를 갖고, R5은 상기에서 정의한 일반식 (a), (b) 또는 (c)의 잔기이거나 일반식 (di)의 잔기이고,(여기서, R9i는 (C2-C8)-알카노일 또는 보호그룹이고, R5는 상기에서 정의한 바와 같다) R4i는 상기에서 정의한 일반식 (g), (h), (i) 또는 (j)의 잔기이거나 일반식 (ei) 또는 (fi)의 잔기이며,(여기서, R1ii는 수소, (C1-C8)-알킬, (C2-C8)-알카노일, 상기에서 정의한 일반식(Ⅰ) 또는 (m)의 그룹 또는 보호그룹이고, R2ii는 수소 또는 보호그룹이며, R10은 상기에서 정의한 일반식 (f), (g), (i) 또는 (j)의 잔기이고, R1ii는 상기에서 정의한 일반식(b)의 잔기이거나 일반식 (doo)의 잔기이며,(여기서, R5는 상기에서 정의한 바와 같다) R21은 (C1-C8)-알킬이고, R1ii는 상기에서 정의한 일반식(b) 또는 (c)의 잔기이거나 상기한 일반식(dii)의 잔기 또는 일반식 (ai)의 잔기이며,(여기서, R51(C2-C8)-알킬(단, 이소프로필은 제외), (C3-C8)-사이클로알킬, (C2-C8)-알케닐, (C2-C8)-알키닐 또는 트리-(C1-C8)-알킬-실릴-에티닐이다) R5ii는 (C2-C8)-알크-1-에닐이고, n1는 0 또는 1이며, R85(C1-C8)-알킬이고, 단, 일반식(Ⅰ)의 화합물에서 10-하이도록시-3, 7, 11-트리메틸-2, 6, 11-도데카트리에노산 및 3, 7, 11-트리메틸-2, 6, 10-도데카트리엔-1, 10-디올은 제회된다.
- 제1항 내지 제6항 중 어느 한 항에 따른 화합물 또는 10-하이드록시-3, 7, 11-트리메틸-2, 6, 11-도데카트리에노산 또는 3, 7, 11-트리메틸-2, 6, 11-도데카트리엔-1, 10-디올과 치료학적으로 불활성인 부형제를 함유하는, 특히 위궤양 및/또는 십이지장궤양을 치료하거나 예방하기 위한 약제.
- 위궤양 및/또는 십이지장궤양을 치료하거나 예방하기 위한 약제를 제조하기 위한 10-하이드록시-3, 7, 11-트리메틸-2, 6, 11-도데카트리에노산 및 3, 7, 11-트리메틸-2, 6, 11-도데카트리엔-1, 10-디올 및 제1항 내지 제6항중 어느 한 항에 따른 화합물의 용도.
- 제 8항에서 청구한 방법 또는 이와 명백히 화학적으로 동등한 방법으로 제조된 제1항 내지 제6항 중 어느 한 항에 청구한 화합물.
- 특히 실시예와 관련하여 본 명세서에 기술된 바와 같은 발명.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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CH364986 | 1986-09-10 | ||
CH3649/86-6 | 1986-09-10 |
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KR880003881A true KR880003881A (ko) | 1988-05-30 |
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KR870009954A KR880003881A (ko) | 1986-09-10 | 1987-09-09 | 이소프렌 유도체 |
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US (1) | US4827004A (ko) |
EP (1) | EP0260551A3 (ko) |
JP (1) | JPS6377828A (ko) |
KR (1) | KR880003881A (ko) |
CN (1) | CN87106285A (ko) |
AU (1) | AU7796687A (ko) |
DK (1) | DK435087A (ko) |
FI (1) | FI873926A (ko) |
HU (1) | HUT45228A (ko) |
IE (1) | IE872413L (ko) |
IL (1) | IL83778A0 (ko) |
MC (1) | MC1848A1 (ko) |
NO (1) | NO873768L (ko) |
PT (1) | PT85667A (ko) |
ZA (1) | ZA876595B (ko) |
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FR2621038B1 (fr) * | 1987-09-28 | 1989-12-29 | Rhone Poulenc Sante | Derives d'alcadienes, leurs preparations, les medicaments les contenant et produits intermediaires |
DE3921280A1 (de) * | 1989-06-29 | 1991-01-03 | Hoechst Ag | Verfahren zur herstellung von derivaten des 1,3-dioxolans und des 1,3-dioxans |
GB2328155B (en) * | 1996-04-12 | 2000-08-02 | Peptide Technology Pty Limited | Methods of treating immunopathologies using polyunsaturated fattyacids |
CA2333903A1 (en) * | 1998-06-01 | 1999-12-09 | Anthony J. Verbiscar | Topical transdermal treatments |
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US3453317A (en) * | 1962-07-11 | 1969-07-01 | Hoffmann La Roche | Unsaturated carbonyl compounds and processes |
CH579013A5 (ko) * | 1971-09-02 | 1976-08-31 | Basf Ag | |
GB1420886A (en) * | 1973-01-31 | 1976-01-14 | Teikoku Chem Ind Co Ltd | Preparation of polyene compounds and intermediates for the use therein |
JPS504021A (ko) * | 1973-05-17 | 1975-01-16 | ||
DE2532851C2 (de) * | 1975-07-23 | 1984-03-15 | Basf Ag, 6700 Ludwigshafen | 12-Alkoxy-3,7,11-trimethyldodecatetraene |
US4192953A (en) * | 1975-11-18 | 1980-03-11 | Sankyo Company Limited | Polyprenyl derivatives |
US4243683A (en) * | 1977-10-05 | 1981-01-06 | May & Baker Limited | Tertiary alcohols |
JPS56113718A (en) * | 1980-01-12 | 1981-09-07 | Agency Of Ind Science & Technol | Bifunctional terpenoid, its preparation, and ulcer preventive agent comprising it |
JPS5854796B2 (ja) * | 1980-05-19 | 1983-12-06 | 工業技術院長 | ポリプレニルカルボン酸誘導体およびその製造法 |
JPS5772933A (en) * | 1980-10-23 | 1982-05-07 | Agency Of Ind Science & Technol | Polyprenylketone derivative and its preparatio |
-
1987
- 1987-08-20 DK DK435087A patent/DK435087A/da not_active Application Discontinuation
- 1987-08-24 US US07/088,315 patent/US4827004A/en not_active Expired - Fee Related
- 1987-09-03 ZA ZA876595A patent/ZA876595B/xx unknown
- 1987-09-04 EP EP87112977A patent/EP0260551A3/de not_active Withdrawn
- 1987-09-04 AU AU77966/87A patent/AU7796687A/en not_active Abandoned
- 1987-09-04 IL IL83778A patent/IL83778A0/xx unknown
- 1987-09-08 MC MC871909A patent/MC1848A1/xx unknown
- 1987-09-09 IE IE872413A patent/IE872413L/xx unknown
- 1987-09-09 NO NO873768A patent/NO873768L/no unknown
- 1987-09-09 CN CN198787106285A patent/CN87106285A/zh active Pending
- 1987-09-09 KR KR870009954A patent/KR880003881A/ko not_active Application Discontinuation
- 1987-09-09 PT PT85667A patent/PT85667A/pt unknown
- 1987-09-09 HU HU874006A patent/HUT45228A/hu unknown
- 1987-09-10 JP JP62225414A patent/JPS6377828A/ja active Pending
- 1987-09-10 FI FI873926A patent/FI873926A/fi not_active Application Discontinuation
Also Published As
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EP0260551A3 (de) | 1989-12-27 |
NO873768D0 (no) | 1987-09-09 |
FI873926A (fi) | 1988-03-11 |
AU7796687A (en) | 1988-03-17 |
CN87106285A (zh) | 1988-04-20 |
DK435087A (da) | 1988-03-11 |
ZA876595B (en) | 1988-03-14 |
NO873768L (no) | 1988-03-11 |
DK435087D0 (da) | 1987-08-20 |
HUT45228A (en) | 1988-06-28 |
PT85667A (en) | 1987-10-01 |
US4827004A (en) | 1989-05-02 |
FI873926A0 (fi) | 1987-09-10 |
JPS6377828A (ja) | 1988-04-08 |
EP0260551A2 (de) | 1988-03-23 |
MC1848A1 (fr) | 1988-09-30 |
IE872413L (en) | 1988-03-10 |
IL83778A0 (en) | 1988-02-29 |
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