KR880001587A - [2-디메틸아미노에틸][2-[2-(메틸티오)페닐](페닐메틸)아미노]-2-옥소에틸]카바메이트 또는 요소, 그의 제법 및 치료에의 응용 - Google Patents
[2-디메틸아미노에틸][2-[2-(메틸티오)페닐](페닐메틸)아미노]-2-옥소에틸]카바메이트 또는 요소, 그의 제법 및 치료에의 응용 Download PDFInfo
- Publication number
- KR880001587A KR880001587A KR1019870007251A KR870007251A KR880001587A KR 880001587 A KR880001587 A KR 880001587A KR 1019870007251 A KR1019870007251 A KR 1019870007251A KR 870007251 A KR870007251 A KR 870007251A KR 880001587 A KR880001587 A KR 880001587A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- formula
- compound according
- halogen atoms
- optionally substituted
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 일반식 I 의 화합물 및 약리적으로 허용도는 그의 부가염상기식에서X는 수소 또는 할로겐원자 또는 메틸티오기를 나타내며 Y는 산소원자 또는 NH기를 나타내고 R1은 수소원자, 하나 또는 두개의 할로겐 원자 또는 트리플푸오로메틸기, 메틸기, 메톡시기, 시아노기, 니트로기, 메록사키트보닐기, 부착되는 벤젠고리의 두인접 탄소원자에 연결된 메틸렌디옥시기 또는 다르게는 부착되는 벤젠고리와 α-나프틸 또는 β-나프틸기를 형성하는 융합된 벤조기를 나타내며, R2는 할로겐원자 또는 메톡시기로 임의적으로 치환된 선형 또는 분기형 C1-C8알킬 또는 알케닐기, 또는 시클로프로필메틸기, 또는 다르게는 하나 또는 두개의 할로겐원자 또는 메틸기로 임의적으로 치환된 페닐기를 나타내며, R은 C1-C4알킬기의 나타내고, n은 1또는 2의 숫자를 나타내며 m은 2또는 3의 숫자를 나타낸다.
- 제1항에 있어서, m및 m은 각각 2를 나타내고, Y는 산소원자를 나타내는 것을 특징으로 하는 화합물
- 일반식Ⅱ(여기서 X는 제 1항에 정의한 바와 같다)와 2-메틸티오벤젠아민을 먼저 일반식Ⅲ(여기서 R1은 제 1항에 정의한 바와 같다)의 벤즈알데히드와 축합시키고 다음에 이로써 얻은 일반식Ⅳ의 아민을 수소화시키고, 다음에 이로써 얻은 일반식Ⅴ의 아민을 일반식Ⅳ(여기서 n은 제1항에 정의한 바와 같다.)의 산염과 반응시키고 다음에 이로써 얻은 일반식Ⅶ의 염화물을 일반식 ⅧH2N-(CH2 m-N(R)2(VⅢ)(여기서 R및 m은 제 1항에 정의한 바와 같다)의 디아민과 반응시키고 최종적으로 이로서 얻은 일반식Ⅸ의 화합물을 일반식 R2-O-CO-C1의 클로로포름산염과 반응시키거나 또는 일반식 R2NCO(여기서R2는 제1항에 정의한 바와 같다)의 이소시아네이트와 반응시키는 것을 특징으로 하는 제1항에 따르는 화합물의 제조방법.
- 제1항 또는 제2항에 따르는 화합물로 구성되는 것을 특징으로 하는 의약생성물.
- 제1항 또는 제2항에 따르는 화합물을 약리적으로 허용되는 부형제와 조합하여 포함하는 것을 특징으로 하는 제약조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8609887 | 1986-07-08 | ||
FR8609887A FR2601363B1 (fr) | 1986-07-08 | 1986-07-08 | (dimethylamino)-2 ethyl) ((((methylthio)-2 phenyl) (phenylmethyl)amino)-2 oxo-2 ethyl) carbamates ou urees, leur preparation et leur application en therapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880001587A true KR880001587A (ko) | 1988-04-25 |
Family
ID=9337176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870007251A KR880001587A (ko) | 1986-07-08 | 1987-07-07 | [2-디메틸아미노에틸][2-[2-(메틸티오)페닐](페닐메틸)아미노]-2-옥소에틸]카바메이트 또는 요소, 그의 제법 및 치료에의 응용 |
Country Status (19)
Country | Link |
---|---|
US (1) | US4840967A (ko) |
EP (1) | EP0252810B1 (ko) |
JP (1) | JPS6323856A (ko) |
KR (1) | KR880001587A (ko) |
AT (1) | ATE62669T1 (ko) |
AU (1) | AU595340B2 (ko) |
CA (1) | CA1277330C (ko) |
CS (1) | CS357891A3 (ko) |
DE (1) | DE3769384D1 (ko) |
DK (1) | DK349287A (ko) |
FI (1) | FI85583C (ko) |
FR (1) | FR2601363B1 (ko) |
GR (1) | GR3002081T3 (ko) |
HU (1) | HU196169B (ko) |
IL (1) | IL83092A (ko) |
NO (1) | NO164593C (ko) |
NZ (1) | NZ220987A (ko) |
PT (1) | PT85280B (ko) |
ZA (1) | ZA874945B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2641279B1 (fr) * | 1989-01-03 | 1991-02-22 | Synthelabo | Derives de n-(amino-2 ethyl) n-(((methylthio-2 phenyl) (phenylmethyl)amino)-2 oxo ethyl)amides et carbamates, leur preparation et leur application en therapeutique |
JPH02290464A (ja) * | 1989-04-28 | 1990-11-30 | Takagi Ind Co Ltd | 瞬間湯沸器 |
EP0903341A1 (en) * | 1997-07-22 | 1999-03-24 | Akzo Nobel N.V. | "Novel ortho-mercaptoaniline compounds" |
WO1999037604A2 (en) | 1998-01-21 | 1999-07-29 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
AU2002359922A1 (en) * | 2001-12-27 | 2003-07-15 | Taisho Pharmaceutical Co., Ltd. | Carboxylic acid derivative |
FR2885129B1 (fr) * | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
EP2091917A1 (en) * | 2006-12-11 | 2009-08-26 | Wyeth a Corporation of the State of Delaware | Ion channel modulators |
CN102105162B (zh) * | 2008-08-13 | 2014-05-07 | 温特研究公司 | Wnt5-α肽衍生物用于治疗黑色素瘤和胃癌的用途 |
WO2013006129A1 (en) | 2011-07-01 | 2013-01-10 | Wntresearch Ab | Treatment of prostate cancer and a method for determining the prognosis for prostate cancer patients |
AU2015299055C1 (en) * | 2014-08-06 | 2021-05-06 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
-
1986
- 1986-07-08 FR FR8609887A patent/FR2601363B1/fr not_active Expired
-
1987
- 1987-07-01 DE DE8787401523T patent/DE3769384D1/de not_active Expired - Fee Related
- 1987-07-01 EP EP87401523A patent/EP0252810B1/fr not_active Expired - Lifetime
- 1987-07-01 AT AT87401523T patent/ATE62669T1/de not_active IP Right Cessation
- 1987-07-06 IL IL83092A patent/IL83092A/xx unknown
- 1987-07-07 FI FI873009A patent/FI85583C/fi not_active IP Right Cessation
- 1987-07-07 NO NO872832A patent/NO164593C/no unknown
- 1987-07-07 US US07/070,580 patent/US4840967A/en not_active Expired - Fee Related
- 1987-07-07 NZ NZ220987A patent/NZ220987A/xx unknown
- 1987-07-07 DK DK349287A patent/DK349287A/da not_active Application Discontinuation
- 1987-07-07 HU HU873054A patent/HU196169B/hu unknown
- 1987-07-07 AU AU75294/87A patent/AU595340B2/en not_active Ceased
- 1987-07-07 KR KR1019870007251A patent/KR880001587A/ko not_active Application Discontinuation
- 1987-07-07 PT PT85280A patent/PT85280B/pt not_active IP Right Cessation
- 1987-07-07 ZA ZA874945A patent/ZA874945B/xx unknown
- 1987-07-07 CA CA000541475A patent/CA1277330C/en not_active Expired - Fee Related
- 1987-07-07 JP JP62169610A patent/JPS6323856A/ja active Pending
-
1991
- 1991-06-06 GR GR91400752T patent/GR3002081T3/el unknown
- 1991-11-25 CS CS913578A patent/CS357891A3/cs unknown
Also Published As
Publication number | Publication date |
---|---|
FI873009A0 (fi) | 1987-07-07 |
CS357891A3 (en) | 1992-12-16 |
IL83092A0 (en) | 1987-12-31 |
NZ220987A (en) | 1989-12-21 |
HU196169B (en) | 1988-10-28 |
PT85280B (pt) | 1990-03-30 |
GR3002081T3 (en) | 1992-12-30 |
DE3769384D1 (de) | 1991-05-23 |
EP0252810A3 (en) | 1988-09-07 |
ZA874945B (en) | 1988-02-24 |
FI873009A (fi) | 1988-01-09 |
FI85583B (fi) | 1992-01-31 |
DK349287D0 (da) | 1987-07-07 |
AU7529487A (en) | 1988-01-14 |
NO872832D0 (no) | 1987-07-07 |
IL83092A (en) | 1991-11-21 |
ATE62669T1 (de) | 1991-05-15 |
FR2601363B1 (fr) | 1988-10-21 |
EP0252810A2 (fr) | 1988-01-13 |
PT85280A (fr) | 1987-08-01 |
NO164593B (no) | 1990-07-16 |
CA1277330C (en) | 1990-12-04 |
NO872832L (no) | 1988-01-11 |
FR2601363A1 (fr) | 1988-01-15 |
EP0252810B1 (fr) | 1991-04-17 |
DK349287A (da) | 1988-01-09 |
AU595340B2 (en) | 1990-03-29 |
HUT44482A (en) | 1988-03-28 |
NO164593C (no) | 1990-10-24 |
JPS6323856A (ja) | 1988-02-01 |
FI85583C (fi) | 1992-05-11 |
US4840967A (en) | 1989-06-20 |
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