KR870004703A - 비-스테로이드성 소염제의 국소투여에 의한 수술후 유착증발생 억제방법 - Google Patents
비-스테로이드성 소염제의 국소투여에 의한 수술후 유착증발생 억제방법 Download PDFInfo
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- KR870004703A KR870004703A KR860010031A KR860010031A KR870004703A KR 870004703 A KR870004703 A KR 870004703A KR 860010031 A KR860010031 A KR 860010031A KR 860010031 A KR860010031 A KR 860010031A KR 870004703 A KR870004703 A KR 870004703A
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- South Korea
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- active ingredient
- composition
- ester
- pharmaceutically acceptable
- acceptable salt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (27)
- 활성성분으로서 비-스테로이드성 소염제를 함유하는 무균 조성물 유효량을, 수술후의 유착증 발생을 억제하기에 충분한 기간동안 수술외 상부위에 국소투여함을 특징으로하여 포유동물에 있어서의 수술후의 유착증발생을 억제하는 방법.
- 제1항에 있어서, 활성성분이 이부프로펜 또는 이의 약학적으로 허용되는 염 또는 에스테르인 방법.
- 제1항에 있어서, 활성성분이 수프로펜 또는 이의 약학적으로 허용되는 염 또는 에스테르인 방법.
- 제1항에 있어서, 활성성분이 톨메틴 또는 이의 약학적으로 허용되는 염 또는 에스테르인 방법.
- 제1항에 있어서, 활성성분이 언급된 기간에 걸쳐 유효량으로 언급된 활성성분을 방출하는 방출-조절담체중에 함유되는 방법.
- 제5항에 있어서, 담체가 인지질인 방법.
- 제6항에 있어서, 인지질이 인지질 베시클(vesicle)인 방법.
- 제7항에 있어서, 인지질 베시클이 멀티라멜라(multilamellar)베시클인 방법.
- 제8항에 있어서, 베시클이 약 1 내지 약 10마이크론의 크기를 갖는 방법.
- 제8항에 있어서, 베시클이 지방산 잔기가 단일 지방산으로부터 유도되는 포스페이티딜 콜린으로 이루어진 방법.
- 제8항에 있어서, 베시클이 포스페이티딜 콜린과 콜레스테롤 과의 혼합물로 이루어진 방법.
- 제5항에 있어서, 담체가 흡수성 중합체인 방법.
- 제12항에 있어서, 흡수성 중합체가 락트산, 글리콜산, 이들의 환식 이량체 에스테르 또는 p-디옥사논의 호모폴리머 또는 공중합체인 방법.
- 제13항에 있어서, 중합체가 마이크로캡슐 형태인 방법.
- 제1항에 있어서, 언급된 기간이 약 1 내지 7일인 방법.
- 제14항에 있어서, 마이크론캡슐이, 수술외상 부위에 점착하기 위한 마이크론캡슐의 능력을 증강시키기에 충분한 양으로 렉시틴을 함유하는 방법.
- 제1항에 있어서, 활성성분이, 계면활성제를 함유하는 수성조성물중에 함유되는 방법.
- 제17항에 있어서, 수성 조성물이 에톡실화된 솔비탄 모노-올레이트의 수용액으로 이루어진 방법.
- 제1항에 있어서, 조성물이 단일용량으로 투여되며, 조성물중의 활성성분의 농도가 약 0.025 내지 5mg/ml인 방법.
- 제1항에 있어서, 조성물이 언급된 기간에 걸쳐 연속적으로 투여되며, 조성물중의 활성성분의 농도가 약 0.01 내지 10mg/ml인 방법.
- 계면활성제 및 비-스테로이드성 소염제를 함유하는 무균 수성 조성물.
- 제21항에 있어서, 약제가 이부프로펜, 수프로펜, 톨메틴 또는 이들의 약학적으로 허용되는 염 또는 에스테르인 무균 조성물.
- 비-스테로이드성 소염제를 함유하는 인지질 베시클로 이루어진 무균 조성물.
- 제23항에 있어서, 약제가 이부프로펜, 톨메틴, 수프로펜, 또는 이들의 약학적으로 허용되는 염 또는 에스테르인 방법.
- 비-스테로이드성 소염제를 함유하는 흡수성 중합체 마이크로캡슐로 이루어진 무균 조성물.
- 제25항에 있어서, 중합체가 락티드, 글리콜리드 또는 p-디옥사논의 호로폴리머 또는 공중합체인 조성물.
- 제26항에 있어서, 약제가 이부프로펜, 수프로펜, 톨메틴 또는 이들의 약학적으로 허용되는 염 또는 에스테르인 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80254585A | 1985-11-27 | 1985-11-27 | |
US802,545 | 1985-11-27 | ||
US802545 | 1985-11-27 | ||
US90012286A | 1986-08-25 | 1986-08-25 | |
US900122 | 1986-08-25 | ||
US900,122 | 1986-08-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870004703A true KR870004703A (ko) | 1987-06-01 |
KR940006321B1 KR940006321B1 (ko) | 1994-07-16 |
Family
ID=27122463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860010031A KR940006321B1 (ko) | 1985-11-27 | 1986-11-27 | 수출후의 유착증 발생을 억제하기 위한 국소투여용 비-스테로이드성 소염제 함유 담체의 제조방법 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0225162B1 (ko) |
JP (1) | JPH0798755B2 (ko) |
KR (1) | KR940006321B1 (ko) |
AU (1) | AU587299B2 (ko) |
DE (1) | DE3683606D1 (ko) |
GR (1) | GR3003915T3 (ko) |
YU (1) | YU46032B (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4877619A (en) * | 1986-08-25 | 1989-10-31 | Vestar, Inc. | Liposomal vesicles for intraperitoneal administration of therapeutic agents |
GB8701392D0 (en) * | 1987-01-22 | 1987-02-25 | Boots Co Plc | Therapeutic agents |
WO1991012026A1 (en) * | 1990-02-14 | 1991-08-22 | Macnaught Pty Limited | Means of reducing surgical adhesions |
WO1992009268A1 (en) * | 1990-12-03 | 1992-06-11 | Vestar, Inc. | Prevention of synovial adhesions |
US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
GR1003359B (el) * | 1998-12-24 | 2000-04-10 | �.�. ����������� �.�.�.�. | Λιποσωμιακο νιφλουμικο οξυ - νεο διαδερμικο αντιφλεγμονωδες φαρμακο [κεφαλη ψαροτουφεκου |
JP2003519651A (ja) * | 2000-01-14 | 2003-06-24 | ブラウン ユニバーシティ リサーチ ファウンデーション | 微紛化凍結乾燥粒子 |
US7029700B2 (en) | 2000-01-14 | 2006-04-18 | Brown University Research Foundation | Micronized freeze-dried particles |
JP4768440B2 (ja) * | 2003-03-06 | 2011-09-07 | セルミド リミテッド | 開腹手術後の癒着の予防剤 |
US9066912B2 (en) * | 2003-11-17 | 2015-06-30 | Ethicon, Inc. | Drug-enhanced adhesion prevention |
US20050106230A1 (en) * | 2003-11-17 | 2005-05-19 | Young Janel E. | Drug-enhanced adhesion prevention |
DE102008005172A1 (de) * | 2008-01-19 | 2009-07-23 | Mike Ehrlich | Pharmazeutische Zusammensetzung zur Verhinderung von post-operativen Adhäsionen |
ES2330295B1 (es) | 2008-06-06 | 2010-09-23 | Laboratorios Alcala Farma, Sl | Formulacion topica de ibuprofeno. |
US10561627B2 (en) | 2014-12-31 | 2020-02-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films |
US11007161B1 (en) | 2014-12-31 | 2021-05-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermatic surfactant films |
US10596117B1 (en) | 2014-12-31 | 2020-03-24 | Eric Morrison | Lipoleosomes as carriers for aromatic amide anesthetic compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3755558A (en) * | 1971-02-23 | 1973-08-28 | Du Pont | Polylactide drug mixtures for topical application atelet aggregation |
GB1523965A (en) * | 1976-03-19 | 1978-09-06 | Ici Ltd | Pharmaceutical compositions containing steroids |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4346108A (en) * | 1981-06-22 | 1982-08-24 | The Upjohn Manufacturing Company M | Method for preventing adhesion formation |
US4530840A (en) * | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
-
1986
- 1986-11-26 JP JP61279915A patent/JPH0798755B2/ja not_active Expired - Lifetime
- 1986-11-26 AU AU65709/86A patent/AU587299B2/en not_active Expired
- 1986-11-26 EP EP86309202A patent/EP0225162B1/en not_active Expired - Lifetime
- 1986-11-26 DE DE8686309202T patent/DE3683606D1/de not_active Expired - Lifetime
- 1986-11-27 KR KR1019860010031A patent/KR940006321B1/ko not_active IP Right Cessation
- 1986-11-27 YU YU202886A patent/YU46032B/sh unknown
-
1992
- 1992-02-27 GR GR920400332T patent/GR3003915T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3683606D1 (de) | 1992-03-05 |
EP0225162A3 (en) | 1987-11-19 |
AU587299B2 (en) | 1989-08-10 |
AU6570986A (en) | 1987-06-04 |
EP0225162A2 (en) | 1987-06-10 |
EP0225162B1 (en) | 1992-01-22 |
JPH0798755B2 (ja) | 1995-10-25 |
YU202886A (en) | 1988-06-30 |
GR3003915T3 (ko) | 1993-03-16 |
KR940006321B1 (ko) | 1994-07-16 |
YU46032B (sh) | 1992-12-21 |
JPS62155223A (ja) | 1987-07-10 |
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