KR850008278A - 니카르디핀 염산염의 주사용 제제의 제조방법 - Google Patents

니카르디핀 염산염의 주사용 제제의 제조방법 Download PDF

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Publication number
KR850008278A
KR850008278A KR1019850003448A KR850003448A KR850008278A KR 850008278 A KR850008278 A KR 850008278A KR 1019850003448 A KR1019850003448 A KR 1019850003448A KR 850003448 A KR850003448 A KR 850003448A KR 850008278 A KR850008278 A KR 850008278A
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KR
South Korea
Prior art keywords
nicardipine hydrochloride
preparation
injectable preparations
polyhydric alcohol
nicardipine
Prior art date
Application number
KR1019850003448A
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English (en)
Other versions
KR910003555B1 (ko
Inventor
가따야스(외 3) 오가와
Original Assignee
모리오까 시게오
야마노우찌 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 모리오까 시게오, 야마노우찌 세이야꾸 가부시끼가이샤 filed Critical 모리오까 시게오
Publication of KR850008278A publication Critical patent/KR850008278A/ko
Application granted granted Critical
Publication of KR910003555B1 publication Critical patent/KR910003555B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

니카르디핀 염산염의 주사용 제제의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 니카드리핀 염산염과, 주사용 제제 총량에 대해 2내지 7W/V%의 다가 알콜을 물에 용해시키고, 용액의 pH를 2.5내지 5로 조정함을 특징으로 하는 니카르디핀 염산염의 주사용 제제를 제조하는 방법.
  2. 제1항에 있어서, 다가 알콜을 소르비틀, 만니틀, 크실리틀, 프로필렌 글리콜, 글리세롤 및 이노시틀로 이루어진 그룹중에서 선택하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003448A 1984-05-22 1985-05-20 니카르디핀 염산염의 주사용 제제의 제조방법 KR910003555B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP102991 1984-05-22
JP10299/84 1984-05-22
JP59102991A JPS60246313A (ja) 1984-05-22 1984-05-22 塩酸ニカルジピンの注射剤およびその製法

Publications (2)

Publication Number Publication Date
KR850008278A true KR850008278A (ko) 1985-12-16
KR910003555B1 KR910003555B1 (ko) 1991-06-05

Family

ID=14342164

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003448A KR910003555B1 (ko) 1984-05-22 1985-05-20 니카르디핀 염산염의 주사용 제제의 제조방법

Country Status (11)

Country Link
US (1) US4880823A (ko)
EP (1) EP0162705B1 (ko)
JP (1) JPS60246313A (ko)
KR (1) KR910003555B1 (ko)
AT (1) ATE63810T1 (ko)
CA (1) CA1240930A (ko)
DE (1) DE3582954D1 (ko)
ES (1) ES8700567A1 (ko)
GR (1) GR851230B (ko)
MX (1) MX9203588A (ko)
PT (1) PT80486B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8617482D0 (en) * 1986-07-17 1986-08-28 Geistlich Soehne Ag Pharmaceutical composition
US5210083A (en) * 1986-07-17 1993-05-11 Ed. Geistlich Sohne A.G. Fur Chemische Industrie Pharmaceutical compositions
JPH0696533B2 (ja) * 1987-01-14 1994-11-30 北陸製薬株式会社 キノロンカルボン酸の水性組成物
YU45837B (sh) * 1988-01-18 1992-07-20 LEK TOVARNA FARMACEVTSKIH IN KEMIČKIH IZDELKOV d.d. Postopek za pripravo novega inkluzijskega kompleksa nikardipina oz. njegovega hidroklorida z beta-ciklodekstrinom
GB2228412B (en) * 1989-02-28 1993-04-14 Syntex Inc Nicardipine pharmaceutical composition for parenteral administration
WO1998001138A1 (fr) * 1996-07-04 1998-01-15 Nippon Kayaku Kabushiki Kaisha Injections de succinate sodique de methylprednisolone
US20070112041A1 (en) * 2005-11-16 2007-05-17 Sun Pharmaceutical Industries Limited Nicardipine injection composition
JP2009534388A (ja) 2006-04-18 2009-09-24 イーケーアール セラピューティクス， インク． 予備混合即時使用製薬製剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720761A (en) * 1968-10-14 1973-03-13 W Hunter Injectable radio-pharmaceutical scanning agent and preparation
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3023495C2 (de) * 1980-06-24 1982-04-08 Kienzle Apparate Gmbh, 7730 Villingen-Schwenningen Diagrammauswertegerät für die Unfalldiagrammauswertung von Fahrtschreiber-Diagrammen
JPS57167967A (en) * 1981-04-08 1982-10-16 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt
DE3205504C2 (de) * 1982-02-16 1983-12-01 Dolorgiet Gmbh & Co Kg, 5300 Bonn Äußerlich anwendbares, Ibuprofen enthaltendes Arzneimittel
JPS58172312A (ja) * 1982-04-02 1983-10-11 Toa Eiyou Kagaku Kogyo Kk ニフエジピン外用剤
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
JPS597163A (ja) * 1982-07-02 1984-01-14 Yamanouchi Pharmaceut Co Ltd 抗動脈硬化剤
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
JPS6016917A (ja) * 1983-07-08 1985-01-28 Yamanouchi Pharmaceut Co Ltd 塩酸ニカルジピンまたはニフエジピンの軟膏剤

Also Published As

Publication number Publication date
ES543343A0 (es) 1986-10-16
MX9203588A (es) 1992-07-31
EP0162705A3 (en) 1987-01-28
ES8700567A1 (es) 1986-10-16
CA1240930A (en) 1988-08-23
GR851230B (ko) 1985-11-25
EP0162705B1 (en) 1991-05-29
PT80486B (en) 1986-12-12
JPS60246313A (ja) 1985-12-06
PT80486A (en) 1985-06-01
US4880823A (en) 1989-11-14
DE3582954D1 (de) 1991-07-04
KR910003555B1 (ko) 1991-06-05
EP0162705A2 (en) 1985-11-27
JPH0247964B2 (ko) 1990-10-23
ATE63810T1 (de) 1991-06-15

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