KR850005454A - 환상 폴리펩타이드의 제조방법 - Google Patents
환상 폴리펩타이드의 제조방법 Download PDFInfo
- Publication number
- KR850005454A KR850005454A KR1019840007236A KR840007236A KR850005454A KR 850005454 A KR850005454 A KR 850005454A KR 1019840007236 A KR1019840007236 A KR 1019840007236A KR 840007236 A KR840007236 A KR 840007236A KR 850005454 A KR850005454 A KR 850005454A
- Authority
- KR
- South Korea
- Prior art keywords
- polypeptide
- amino acids
- cyclic polypeptide
- culture filtrate
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 폴리펩타이드 생성균주인 스트렙토 마이세테스(Streptomycetes)를 발효 배지중에서 액침 배양한 후, 균사체 또는 배양여액으로부터 폴리팹타이드를 분리하여 경제시킴을 특징으로 하여, α-아밀라제 불활성 화제인 텐다미스태드(Tendamistat, HOE467)와 스트렙토마이세스 비올라세오루버(Streptomyces violaceoruber) ATCC31209의 배양여액으로 부터 분리되는 α-아밀라제 억제제를 제외한 10내지 2000개의 아미노산으로 구성된 일반식(Ⅰ)의 환상 폴리펩타이드를 제조하는 방법.상기식에서, Z는 Gln,Asn 또는 Met이며 ; S는 Ser 또는 Thr이고; Y는 Phe,Tyr 또는 Asn이며; As는 다른 천연 아미노산 또는 펩타이드쇄에 의해 추가로 치환될 수 있는, 5내지 25개의 천연 아미노산으로 구성된 폴리펩타이드쇄이다.
- 제1항에 있어서, Z가 Gln이고, S가 Ser이고, 또는 Tyr이고 , As가 2개의 펩타이드쇄로 치환된, 아미노산 12개로 구성된 폴리펩타이드쇄인 일반식(Ⅰ)의 환상 폴리펩타이드를 제조하는 방법.
- 제1항에 있어서, 다음 구조식(Ia) 의 환상 폴리펩타이드를 제조하는 방법.
- 제1항에 있어서, 스트렙토마이세스 오레오파시엔스(Streptomyces aureofaciens)DSM 2790을 배양한후 , 배양여액으로부터 폴리펩터이드 AI-3688를 분리하여 정제하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3402021.7 | 1984-01-21 | ||
DE3402021 | 1984-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR850005454A true KR850005454A (ko) | 1985-08-26 |
Family
ID=6225535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840007236A KR850005454A (ko) | 1984-01-21 | 1984-11-09 | 환상 폴리펩타이드의 제조방법 |
Country Status (17)
Country | Link |
---|---|
US (1) | US4623714A (ko) |
EP (1) | EP0151246B1 (ko) |
JP (1) | JPS60152500A (ko) |
KR (1) | KR850005454A (ko) |
AT (1) | ATE56728T1 (ko) |
AU (1) | AU580973B2 (ko) |
CA (1) | CA1230841A (ko) |
DE (1) | DE3483260D1 (ko) |
DK (1) | DK520784A (ko) |
ES (1) | ES539678A0 (ko) |
FI (1) | FI844289L (ko) |
GR (1) | GR80840B (ko) |
HU (1) | HU192495B (ko) |
IL (1) | IL73472A0 (ko) |
NO (1) | NO844422L (ko) |
PT (1) | PT79840B (ko) |
ZA (1) | ZA848651B (ko) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3508384A1 (de) * | 1985-03-08 | 1986-11-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Hemmung humaner speichel- und pankreasamylase durch monoklonale antikoerper |
CA2128044C (en) * | 1993-08-05 | 2007-02-20 | Klaus-Dieter Bremer | Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor |
WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
MX2007005137A (es) * | 2004-11-23 | 2007-06-22 | Warner Lambert Co | Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia. |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
US20130072519A1 (en) | 2010-05-21 | 2013-03-21 | Edward Lee Conn | 2-phenyl benzoylamides |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2680874A2 (en) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-like peptides and uses thereof |
US20150050371A1 (en) | 2012-03-09 | 2015-02-19 | Biotropics Malaysia Berhad | Extract Formulations of Rhodamnia Cinerea And Uses Thereof |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
DK3186242T3 (da) | 2014-08-29 | 2021-12-20 | Tes Pharma S R L | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
EP3526199B1 (en) | 2016-10-14 | 2022-04-13 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
CN113574055B (zh) | 2019-01-18 | 2024-07-23 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2701890C2 (de) * | 1977-01-19 | 1983-08-04 | Hoechst Ag, 6230 Frankfurt | Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung |
DE2716050A1 (de) * | 1977-04-09 | 1978-10-19 | Hoechst Ag | Alpha-amylase-inhibitor aus einem streptomyceten und verfahren zu seiner gewinnung |
ES505959A0 (es) * | 1980-10-09 | 1982-09-01 | Hoechst Ag | Procedimiento para la preparacion de un inactivador de alfa-amilasa |
-
1984
- 1984-11-01 DK DK520784A patent/DK520784A/da not_active Application Discontinuation
- 1984-11-01 FI FI844289A patent/FI844289L/fi not_active Application Discontinuation
- 1984-11-05 GR GR80840A patent/GR80840B/el unknown
- 1984-11-06 US US06/668,839 patent/US4623714A/en not_active Expired - Fee Related
- 1984-11-06 NO NO844422A patent/NO844422L/no unknown
- 1984-11-06 ZA ZA848651A patent/ZA848651B/xx unknown
- 1984-11-06 HU HU844121A patent/HU192495B/hu not_active IP Right Cessation
- 1984-11-06 CA CA000467147A patent/CA1230841A/en not_active Expired
- 1984-11-07 AU AU35190/84A patent/AU580973B2/en not_active Ceased
- 1984-11-09 IL IL73472A patent/IL73472A0/xx unknown
- 1984-11-09 KR KR1019840007236A patent/KR850005454A/ko not_active Application Discontinuation
- 1984-11-20 JP JP59243562A patent/JPS60152500A/ja active Pending
- 1984-11-22 EP EP84114064A patent/EP0151246B1/de not_active Expired - Lifetime
- 1984-11-22 AT AT84114064T patent/ATE56728T1/de not_active IP Right Cessation
- 1984-11-22 DE DE8484114064T patent/DE3483260D1/de not_active Expired - Fee Related
-
1985
- 1985-01-18 PT PT79840A patent/PT79840B/pt unknown
- 1985-01-18 ES ES539678A patent/ES539678A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
PT79840B (en) | 1986-11-14 |
EP0151246A2 (de) | 1985-08-14 |
GR80840B (en) | 1985-02-26 |
ZA848651B (en) | 1985-06-26 |
AU3519084A (en) | 1985-07-25 |
EP0151246B1 (de) | 1990-09-19 |
FI844289A0 (fi) | 1984-11-01 |
FI844289L (fi) | 1985-07-22 |
JPS60152500A (ja) | 1985-08-10 |
PT79840A (en) | 1985-02-01 |
ATE56728T1 (de) | 1990-10-15 |
ES8602112A1 (es) | 1985-11-16 |
CA1230841A (en) | 1987-12-29 |
NO844422L (no) | 1985-07-22 |
ES539678A0 (es) | 1985-11-16 |
DE3483260D1 (de) | 1990-10-25 |
DK520784A (da) | 1985-07-22 |
HUT37657A (en) | 1986-01-23 |
IL73472A0 (en) | 1985-02-28 |
HU192495B (en) | 1987-06-29 |
AU580973B2 (en) | 1989-02-09 |
DK520784D0 (da) | 1984-11-01 |
EP0151246A3 (en) | 1987-05-27 |
US4623714A (en) | 1986-11-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR850005454A (ko) | 환상 폴리펩타이드의 제조방법 | |
Elfvin et al. | Paramyosin in invertebrate muscles. I. Identification and localization. | |
YU45871B (sh) | Polipeptid sa humanim imunointerferonskim (ifn-gama) svojstvima | |
ATE80660T1 (de) | Verfahren zur herstellung eines polypeptides. | |
ATE97448T1 (de) | Verfahren zur isolierung von ca 125-antigen. | |
DE3685487D1 (de) | Enzyme fuer den abbau von lignin. | |
KR840005483A (ko) | A47934 항생물질의 제조방법 | |
Meyer et al. | Molecular vehicle properties of the broad host range plasmid RK2 | |
KR900702009A (ko) | 인체 a형 모노아민 옥시다제를 코오딩 하는 dna | |
Thomas et al. | NEW TAXONOMIC CRITERIA IN THE CLASSIFICATION OF CHLOROCOCCUM SPECIES. III. ISOZYME ANALYSIS 1, 2 | |
KR870002253A (ko) | 펩타이드 항생제 | |
DE58903638D1 (de) | Verbessertes fischzuchtverfahren. | |
ATE72458T1 (de) | Zugeordnete ribosomen und ihre verwendung zur herstellung von proteinen aus zellkulturen. | |
KR890008166A (ko) | 융합 단백질의 선택적 분해 방법 | |
SE8103778L (sv) | Oxytocinanaloger och sett for framstellning derav | |
KR850000468A (ko) | 사이클릭 펩타이드의 제조방법 | |
Mizuta et al. | Subunit composition of two distinct types of collagen in the muscle of the squid Todarodes pacificus | |
KR910011898A (ko) | 데스(64,65)-프로인슐린의 제조방법 | |
DE3681212D1 (de) | Verfahren zur scheidung und isolierung von nosiheptid. | |
MURATA et al. | A synthetic medium for production of alpha toxin by Clostridium perfringens | |
KR900006517A (ko) | 항생제 pb-6042류 | |
KR840007437A (ko) | 항생제 a 51568 인자 a 및 b의 제조방법 | |
EA199800918A1 (ru) | Происходящие от хозяина сигналы для индуцирования экспрессии гена изопреноида и их применение | |
ATE99323T1 (de) | Verfahren zur wiedergewinnung eines gereinigten epi-proteins aus einer loesung, insbesondere einer gaerungsloesung. | |
ATE201903T1 (de) | Peptide-familie, genannt xenoxine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |