KR850005454A - 환상 폴리펩타이드의 제조방법 - Google Patents

환상 폴리펩타이드의 제조방법 Download PDF

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Publication number
KR850005454A
KR850005454A KR1019840007236A KR840007236A KR850005454A KR 850005454 A KR850005454 A KR 850005454A KR 1019840007236 A KR1019840007236 A KR 1019840007236A KR 840007236 A KR840007236 A KR 840007236A KR 850005454 A KR850005454 A KR 850005454A
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KR
South Korea
Prior art keywords
polypeptide
amino acids
cyclic polypeptide
culture filtrate
formula
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KR1019840007236A
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English (en)
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페르테시(외 2) 라스쯔로
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하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔 게젤샤프트
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Application filed by 하인리히 벡커, 베른하르트 벡크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡크
Publication of KR850005454A publication Critical patent/KR850005454A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

환상 폴리펩타이드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 폴리펩타이드 생성균주인 스트렙토 마이세테스(Streptomycetes)를 발효 배지중에서 액침 배양한 후, 균사체 또는 배양여액으로부터 폴리팹타이드를 분리하여 경제시킴을 특징으로 하여, α-아밀라제 불활성 화제인 텐다미스태드(Tendamistat, HOE467)와 스트렙토마이세스 비올라세오루버(Streptomyces violaceoruber) ATCC31209의 배양여액으로 부터 분리되는 α-아밀라제 억제제를 제외한 10내지 2000개의 아미노산으로 구성된 일반식(Ⅰ)의 환상 폴리펩타이드를 제조하는 방법.
    상기식에서, Z는 Gln,Asn 또는 Met이며 ; S는 Ser 또는 Thr이고; Y는 Phe,Tyr 또는 Asn이며; As는 다른 천연 아미노산 또는 펩타이드쇄에 의해 추가로 치환될 수 있는, 5내지 25개의 천연 아미노산으로 구성된 폴리펩타이드쇄이다.
  2. 제1항에 있어서, Z가 Gln이고, S가 Ser이고, 또는 Tyr이고 , As가 2개의 펩타이드쇄로 치환된, 아미노산 12개로 구성된 폴리펩타이드쇄인 일반식(Ⅰ)의 환상 폴리펩타이드를 제조하는 방법.
  3. 제1항에 있어서, 다음 구조식(Ia) 의 환상 폴리펩타이드를 제조하는 방법.
  4. 제1항에 있어서, 스트렙토마이세스 오레오파시엔스(Streptomyces aureofaciens)DSM 2790을 배양한후 , 배양여액으로부터 폴리펩터이드 AI-3688를 분리하여 정제하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007236A 1984-01-21 1984-11-09 환상 폴리펩타이드의 제조방법 KR850005454A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3402021.7 1984-01-21
DE3402021 1984-01-21

Publications (1)

Publication Number Publication Date
KR850005454A true KR850005454A (ko) 1985-08-26

Family

ID=6225535

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007236A KR850005454A (ko) 1984-01-21 1984-11-09 환상 폴리펩타이드의 제조방법

Country Status (17)

Country Link
US (1) US4623714A (ko)
EP (1) EP0151246B1 (ko)
JP (1) JPS60152500A (ko)
KR (1) KR850005454A (ko)
AT (1) ATE56728T1 (ko)
AU (1) AU580973B2 (ko)
CA (1) CA1230841A (ko)
DE (1) DE3483260D1 (ko)
DK (1) DK520784A (ko)
ES (1) ES539678A0 (ko)
FI (1) FI844289L (ko)
GR (1) GR80840B (ko)
HU (1) HU192495B (ko)
IL (1) IL73472A0 (ko)
NO (1) NO844422L (ko)
PT (1) PT79840B (ko)
ZA (1) ZA848651B (ko)

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DE3508384A1 (de) * 1985-03-08 1986-11-06 Boehringer Mannheim Gmbh, 6800 Mannheim Hemmung humaner speichel- und pankreasamylase durch monoklonale antikoerper
CA2128044C (en) * 1993-08-05 2007-02-20 Klaus-Dieter Bremer Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
MX2007005137A (es) * 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
US20130072519A1 (en) 2010-05-21 2013-03-21 Edward Lee Conn 2-phenyl benzoylamides
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2680874A2 (en) 2011-03-04 2014-01-08 Pfizer Inc Edn3-like peptides and uses thereof
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
DK3186242T3 (da) 2014-08-29 2021-12-20 Tes Pharma S R L Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3526199B1 (en) 2016-10-14 2022-04-13 Tes Pharma S.r.l. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

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* Cited by examiner, † Cited by third party
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DE2701890C2 (de) * 1977-01-19 1983-08-04 Hoechst Ag, 6230 Frankfurt Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung
DE2716050A1 (de) * 1977-04-09 1978-10-19 Hoechst Ag Alpha-amylase-inhibitor aus einem streptomyceten und verfahren zu seiner gewinnung
ES505959A0 (es) * 1980-10-09 1982-09-01 Hoechst Ag Procedimiento para la preparacion de un inactivador de alfa-amilasa

Also Published As

Publication number Publication date
PT79840B (en) 1986-11-14
EP0151246A2 (de) 1985-08-14
GR80840B (en) 1985-02-26
ZA848651B (en) 1985-06-26
AU3519084A (en) 1985-07-25
EP0151246B1 (de) 1990-09-19
FI844289A0 (fi) 1984-11-01
FI844289L (fi) 1985-07-22
JPS60152500A (ja) 1985-08-10
PT79840A (en) 1985-02-01
ATE56728T1 (de) 1990-10-15
ES8602112A1 (es) 1985-11-16
CA1230841A (en) 1987-12-29
NO844422L (no) 1985-07-22
ES539678A0 (es) 1985-11-16
DE3483260D1 (de) 1990-10-25
DK520784A (da) 1985-07-22
HUT37657A (en) 1986-01-23
IL73472A0 (en) 1985-02-28
HU192495B (en) 1987-06-29
AU580973B2 (en) 1989-02-09
DK520784D0 (da) 1984-11-01
EP0151246A3 (en) 1987-05-27
US4623714A (en) 1986-11-18

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