KR850001160A - 폴리하이드록시 벤조산 유도체의 제조방법 - Google Patents

폴리하이드록시 벤조산 유도체의 제조방법 Download PDF

Info

Publication number
KR850001160A
KR850001160A KR1019840002882A KR840002882A KR850001160A KR 850001160 A KR850001160 A KR 850001160A KR 1019840002882 A KR1019840002882 A KR 1019840002882A KR 840002882 A KR840002882 A KR 840002882A KR 850001160 A KR850001160 A KR 850001160A
Authority
KR
South Korea
Prior art keywords
formula
noh
compound
benzoic acid
acid derivative
Prior art date
Application number
KR1019840002882A
Other languages
English (en)
Other versions
KR920004187B1 (ko
Inventor
반리에 바쏠로뮤 (외 2)
Original Assignee
반리에 바쏠로뮤 (외 2)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 반리에 바쏠로뮤 (외 2) filed Critical 반리에 바쏠로뮤 (외 2)
Publication of KR850001160A publication Critical patent/KR850001160A/ko
Application granted granted Critical
Publication of KR920004187B1 publication Critical patent/KR920004187B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
  • Laminated Bodies (AREA)

Abstract

내용 없음

Description

폴리하이드록시 벤조산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. R'가 NOH이고 R이 NH2인 일반식(I)의 화합물을 제조하기 위해서, 일반식(II)의 니트릴을 하이드록실아민 수용액과 반응시키거나; R이 O-C1-3알킬이고 R'가 NH인 일반식(I)의 화합물을 제조하기 위해서, 일반식(II)의 니트릴을 저급 알칸올(C1-3알킬 OH)과 반응시키고 산을 가하거나; R이 NHOH이고 R'가 NOH인 일반식(I)의 화합물을 제조하기 위해서, 상응하는 일반식(IV)의 만델아미드옥심, 페닐아세트 아미드옥심 또는 벤즈아미드옥심을 하이드록실아민 염산염과 반응시킴을 특징으로 하여, 일반식(I)의 화합물 및 이의 약학적으로 허용되는 산부가염을 제조하는 방법.
    상기 일반식에서
    n은 2내지 5이고 m은 0 또는 1이고 R'은 NOH 또는 NH이고 R은 R'이 NOH일 경우 NH2또는 NHOH 이고, R'이 NH일 경우 NH2또는 O-C1-3알킬이며 R"은 H 또는 OH이고 단, 일반식(II)에서 m은 0 또는 1이고 R"는 H이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002882A 1983-05-23 1984-05-23 폴리하이드록시 벤조산 유도체의 제조방법 KR920004187B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US497,370 1983-05-23
US06/497,370 US4623659A (en) 1983-05-23 1983-05-23 Polyhydroxybenzoic acid derivatives
US497370 1995-06-30

Publications (2)

Publication Number Publication Date
KR850001160A true KR850001160A (ko) 1985-03-16
KR920004187B1 KR920004187B1 (ko) 1992-05-30

Family

ID=23976584

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002882A KR920004187B1 (ko) 1983-05-23 1984-05-23 폴리하이드록시 벤조산 유도체의 제조방법

Country Status (13)

Country Link
US (1) US4623659A (ko)
EP (1) EP0144396B1 (ko)
JP (2) JPS60501409A (ko)
KR (1) KR920004187B1 (ko)
AT (1) ATE59553T1 (ko)
AU (1) AU589111B2 (ko)
CA (1) CA1339221C (ko)
DE (1) DE3483822D1 (ko)
DK (1) DK13785A (ko)
FI (1) FI843681A (ko)
IT (1) IT1209548B (ko)
NO (1) NO843739L (ko)
WO (1) WO1984004676A1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2740133A (en) * 1951-03-01 1956-04-03 Seng Co Detachable footboard for a bed
US5183828A (en) * 1983-05-23 1993-02-02 Riet Bartholomeus Van T Polyhydroxybenzoic acid derivatives
US4942253A (en) * 1983-05-23 1990-07-17 Riet Bartholomeus Van T Polyhydroxybenzoic acid derivatives
EP0610444B1 (en) * 1991-10-31 2003-01-29 ELFORD, Howard L. Use of a polyhydroxybenzamide or a derivative thereof in the manufacture of a medicament for treating viral infectious diseases
US5350770A (en) * 1992-07-28 1994-09-27 Elford Howard L Therapeutic process for the treatment of septic shock
US6028111A (en) * 1996-03-08 2000-02-22 Oxigene, Inc. Compositions and use of benzamides and nicotinamides as anti-inflammatory agents
US6713517B1 (en) 1996-03-08 2004-03-30 Oxigene, Inc. Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use
WO1998041202A1 (en) * 1997-03-20 1998-09-24 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Hydroxybenzoate metabolites and hydroxybenzoate analogues as protectors against oxidative stress and chemotherapeutic drug cytotoxicity, cardiotoxicity and extravasation tissue injury
US6924308B1 (en) * 1997-07-30 2005-08-02 Howard L. Elford Therapeutic process for inhibiting NF-κB
US6516479B1 (en) * 2000-06-02 2003-02-11 Burke Mobility Products, Inc. Foldable rehabilitation bed for accommodating an obese person
CA2520228A1 (en) * 2003-03-26 2004-10-07 Bayer Cropscience Gmbh Use of aromatic compounds as safeners
US8029815B2 (en) * 2004-04-28 2011-10-04 Elford Howard L Methods for treating or preventing restenosis and other vascular proliferative disorders
EP2030615A3 (en) 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB358279A (en) * 1930-10-07 1931-10-08 Ig Farbenindustrie Ag Process for inhibiting the development of micro organisms
US2849480A (en) 1956-10-05 1958-08-26 Kreuchunas Algird Process for the preparation of 2, 3, 6-trihydroxybenzoic acid and derivatives
US3629443A (en) 1967-11-29 1971-12-21 Orsymonde Therapeutic composition containing a mandelamidine derivative
GB1243186A (en) * 1967-11-29 1971-08-18 Orsymonde Improvements in or relating to mandelamidine derivatives
US4263322A (en) * 1979-03-01 1981-04-21 Riet Bartholomeus Van T Hydroxy benzohydroxamic acids and benzamides
US4236322A (en) 1979-03-15 1980-12-02 Hastings Allen M Apparatus for and method of drying items by open air and solar energy

Also Published As

Publication number Publication date
NO843739L (no) 1984-12-06
AU589111B2 (en) 1989-10-05
JPH0578299A (ja) 1993-03-30
FI843681A (fi) 1984-11-24
KR920004187B1 (ko) 1992-05-30
JPH051780B2 (ko) 1993-01-11
DK13785D0 (da) 1985-01-11
EP0144396A1 (en) 1985-06-19
US4623659A (en) 1986-11-18
EP0144396A4 (en) 1986-08-21
IT8421068A0 (it) 1984-05-23
CA1339221C (en) 1997-08-05
EP0144396B1 (en) 1991-01-02
ATE59553T1 (de) 1991-01-15
DE3483822D1 (de) 1991-02-07
JPS60501409A (ja) 1985-08-29
FI843681A0 (fi) 1984-09-20
WO1984004676A1 (en) 1984-12-06
DK13785A (da) 1985-01-11
IT1209548B (it) 1989-08-30
AU3013084A (en) 1984-12-18

Similar Documents

Publication Publication Date Title
KR850001160A (ko) 폴리하이드록시 벤조산 유도체의 제조방법
KR870001142A (ko) 페닐 에테르의 제법
IE790652L (en) Imidazole derivatives
IE40511B1 (en) N-(1-(-phenylalkyl)-piperidyl-j)-(-(-pyridyl)-carbonic acid amides
KR860003249A (ko) 피록시캄 1수화물의 제조 방법
GB1277239A (en) Cycloalkane-carboxylic acid derivatives
KR920007995A (ko) 벤즈아미드 유도체
KR870003994A (ko) 도파민-β-하이드록시라제 억제제
KR830008971A (ko) 페닐알카노산의 제조방법
GB1195180A (en) Use of Alkyl 2-Benzimidazole-Carbamate Salts a Fungicides
KR830009011A (ko) 신규 구아니디노시 클로헥산카복실산 유도체 및 그의 제법
KR920002594A (ko) 5-이소티아졸아민 유도체
GB2135997B (en) N-(m-trifluoromethylphenyl)-n'-propargylpiperazine
KR900012884A (ko) (+)1-[(3,4,5-트리메톡시)-벤질옥시메틸]-1-페닐-N,N-디메틸-n-프로필아민, 그의 제조방법 및 치료학적 용도
GB1505633A (en) 3,5-bis(acylamino)benzamides
KR840008149A (ko) 치환된 푸루푸라논 유도체의 제조방법
KR850001185A (ko) 프로판-2-올 유도체의 제조방법
GB1126994A (en) Guanidine derivatives and processes for preparing the same
KR850001181A (ko) 아미노-n-(1h-테트라졸-5-일) 벤즈아미드의 카바메이트 및 옥살아미드의 제조방법
KR830009074A (ko) 염기-치환된 안트라닐 산의 제조방법
JPS52106837A (en) Substituted benzoic acid amides and their preparation
ES454901A1 (es) Un procedimiento de preparacion de acidos carboxilicos deri-vados del indano.
KR850001182A (ko) 2-(포르밀아미노)-n-(1h-테트라졸-5-일)벤즈아미드의 제조방법
GB1313585A (en) Fungicidally and fungistatically active thiocarbonates
JPS55111447A (en) Novel 3-amino-4-homoisotwistane derivative

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030423

Year of fee payment: 12

EXPY Expiration of term