KR850001147A - (±) 2-(6'-메톡시-2'-나프틸)-프로피온산의 광학적 분해방법 - Google Patents
(±) 2-(6'-메톡시-2'-나프틸)-프로피온산의 광학적 분해방법 Download PDFInfo
- Publication number
- KR850001147A KR850001147A KR1019840002333A KR840002333A KR850001147A KR 850001147 A KR850001147 A KR 850001147A KR 1019840002333 A KR1019840002333 A KR 1019840002333A KR 840002333 A KR840002333 A KR 840002333A KR 850001147 A KR850001147 A KR 850001147A
- Authority
- KR
- South Korea
- Prior art keywords
- chloroform
- naphthyl
- methoxy
- propionic acid
- solution
- Prior art date
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title claims 4
- 230000003287 optical effect Effects 0.000 title claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 5
- 239000012071 phase Substances 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 239000000706 filtrate Substances 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000012670 alkaline solution Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- (±) 2-(6'-메톡시-2'-나프틸)-프로피온산의 광학적 분해를 위한 방법에 있어서, (1) 0˚내지 58℃의 온도에서 산 1몰당 (S)-알파-페닐에틸아민 0.45내지 0.65몰을 산 1에 대하여 3±15%의 클로로포름속에 첨가하고, (2) 반응혼합물을 0℃까지 냉각시키고, (3) 이와같이 얻은 침전물을 여과시키고, (4) 여과물을 15˚내지 58℃의 온도에서 클로로포름속에 넣어 현탁시키고, (5) 반응혼합물을 냉각시키고, (6) 이와같이 얻은 침전물을 여과시키고, (7) 여과물을 클로로포름속에 넣어 다시 한번 현탁시켜서, 알칼리용액으로 처리하고, (8) 클로로포름위상을 수상으로부터 분리시키고, (9) 수상을 산으로 처리하여 (+) 2-(6'-메톡시-2'-나프틸)-프로피온산을 얻고, 통상적 방법으로 이를 회수하는 방법.
- 제1항에 있어서, (10) 전단계(3)의 클로로포름용액을 수용액/알칼리용액으로 처리하고, (11) 클로로포름위상을 수상으로부터 분리시키고, (12) 알려진 방법으로 수상을 가열하여 (±) 2-(6'-메톡시-2'-나프틸)-프로피온산을 얻고, 이를 재순환시키는 방법.
- 제1항에 있어서, (13) 다음 배치(batch)에 관한 단계(1)를 수행하기 위하여 전단계(6)의 클로로포름용액을 처리할 필요없이, 재순환시키는 방법.
- 제1항 및 제2항에 있어서, (14) 전단계들 (8) 및 (11)에서 얻은 (S)-알파-페닐에틸아민의 클로로포름용액을 원하는 농도까지 증발시킨 후 재순환시키는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22261/83A IT1164319B (it) | 1983-07-27 | 1983-07-27 | Procedimento per la risoluzione dell'acido (+-)2-(6'-metossi-2'-naftil)-propionico |
IT22261A/83 | 1983-07-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850001147A true KR850001147A (ko) | 1985-03-16 |
KR860001600B1 KR860001600B1 (ko) | 1986-10-13 |
Family
ID=11193807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840002333A KR860001600B1 (ko) | 1983-07-27 | 1984-05-01 | (±)2-(6'-메톡시-2'-나프틸)-프로피온산의 광학적 분할방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US4546201A (ko) |
EP (1) | EP0132854B1 (ko) |
JP (1) | JPS6042347A (ko) |
KR (1) | KR860001600B1 (ko) |
AT (1) | ATE28742T1 (ko) |
AU (1) | AU561778B2 (ko) |
CA (1) | CA1223888A (ko) |
DE (1) | DE3465186D1 (ko) |
DK (1) | DK53384A (ko) |
IT (1) | IT1164319B (ko) |
ZA (1) | ZA841530B (ko) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010038127A (ko) * | 1999-10-22 | 2001-05-15 | 김춘식 | 볏짚을 이용한 버섯재배용 배지와 그 배지의 제조방법 및 볏짚파쇄장치 |
KR100421565B1 (ko) * | 2002-01-08 | 2004-03-09 | 이병노 | 양송이 버섯 재배용 개량복토 및 그 제조방법 |
KR20220087311A (ko) * | 2020-12-17 | 2022-06-24 | 대한민국(농촌진흥청장) | 환기량 조절이 용이한 양송이버섯 배지 발효용 터널 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650897A (en) * | 1985-05-20 | 1987-03-17 | Warner-Lambert Co. | Organic synthesis |
NL9001703A (nl) * | 1990-07-27 | 1992-02-17 | Westspur Investment Ltd | Werkwijze voor de bereiding van s(+)-6-methoxy-alfa-methyl-2-naftaleen-azijnzuur. |
DE19624604A1 (de) * | 1996-06-20 | 1998-01-02 | Hoechst Ag | Verfahren zur Herstellung chiraler, nicht racemischer (4-Aryl-2,5-dioxoimidazolidin-1-yl)essigsäuren |
US5936118A (en) * | 1997-04-04 | 1999-08-10 | Albemarle Corporation | Process for chiral enrichment of optically active carboxylic acids or salts or esters thereof |
US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
TWI262791B (en) | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3686183A (en) * | 1969-03-24 | 1972-08-22 | Syntex Corp | Preparation of optical isomers of arylalkylacetic acids |
US3766264A (en) * | 1971-03-02 | 1973-10-16 | Pfizer | Process for resolving 2-(2beta-benzyloxymethyl-3alpha-hydroxy-4-cyclopentene-1alpha-yl)acetic acid |
US4209639A (en) * | 1975-09-22 | 1980-06-24 | American Cyanamid Company | 13-Thia-prostaglandins |
JPS54151912A (en) * | 1978-05-18 | 1979-11-29 | Santen Pharmaceutical Co Ltd | Manufacture of photoactive sulfur contained carboxylic acid |
IT1110479B (it) * | 1978-05-22 | 1985-12-23 | Montedison Spa | Processo per la preparazione dell acido 2-(6-metossi-2-naftil)-propionico |
JPS55135A (en) * | 1978-06-17 | 1980-01-05 | Matsushita Electric Works Ltd | Wool gathered cape |
IT1136598B (it) * | 1981-05-18 | 1986-09-03 | Blasinachim Spa | Risoluzione dell'acido dl 2-(6'-metossi-2'-naftil)-propionico |
-
1983
- 1983-07-27 IT IT22261/83A patent/IT1164319B/it active
-
1984
- 1984-02-07 DK DK53384A patent/DK53384A/da not_active Application Discontinuation
- 1984-02-10 AU AU24490/84A patent/AU561778B2/en not_active Ceased
- 1984-02-29 ZA ZA841530A patent/ZA841530B/xx unknown
- 1984-03-09 CA CA000449281A patent/CA1223888A/en not_active Expired
- 1984-03-12 JP JP59048034A patent/JPS6042347A/ja active Pending
- 1984-04-19 EP EP84200560A patent/EP0132854B1/en not_active Expired
- 1984-04-19 AT AT84200560T patent/ATE28742T1/de not_active IP Right Cessation
- 1984-04-19 DE DE8484200560T patent/DE3465186D1/de not_active Expired
- 1984-04-23 US US06/602,744 patent/US4546201A/en not_active Expired - Fee Related
- 1984-05-01 KR KR1019840002333A patent/KR860001600B1/ko active Pre-grant Review Request
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010038127A (ko) * | 1999-10-22 | 2001-05-15 | 김춘식 | 볏짚을 이용한 버섯재배용 배지와 그 배지의 제조방법 및 볏짚파쇄장치 |
KR100421565B1 (ko) * | 2002-01-08 | 2004-03-09 | 이병노 | 양송이 버섯 재배용 개량복토 및 그 제조방법 |
KR20220087311A (ko) * | 2020-12-17 | 2022-06-24 | 대한민국(농촌진흥청장) | 환기량 조절이 용이한 양송이버섯 배지 발효용 터널 |
Also Published As
Publication number | Publication date |
---|---|
IT1164319B (it) | 1987-04-08 |
CA1223888A (en) | 1987-07-07 |
KR860001600B1 (ko) | 1986-10-13 |
EP0132854B1 (en) | 1987-08-05 |
ATE28742T1 (de) | 1987-08-15 |
AU2449084A (en) | 1985-01-31 |
DE3465186D1 (en) | 1987-09-10 |
EP0132854A2 (en) | 1985-02-13 |
JPS6042347A (ja) | 1985-03-06 |
DK53384D0 (da) | 1984-02-07 |
IT8322261A0 (it) | 1983-07-27 |
AU561778B2 (en) | 1987-05-14 |
ZA841530B (en) | 1985-06-26 |
US4546201A (en) | 1985-10-08 |
EP0132854A3 (en) | 1985-05-02 |
DK53384A (da) | 1985-01-28 |
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Date | Code | Title | Description |
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G160 | Decision to publish patent application | ||
O035 | Opposition [patent]: request for opposition |
Free format text: OPPOSITION NUMBER: 001986001241; OPPOSITION DATE: 19861208 |