KR840005134A - 트리아졸 항진균제의 제조방법 - Google Patents

트리아졸 항진균제의 제조방법 Download PDF

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KR840005134A
KR840005134A KR1019830002555A KR830002555A KR840005134A KR 840005134 A KR840005134 A KR 840005134A KR 1019830002555 A KR1019830002555 A KR 1019830002555A KR 830002555 A KR830002555 A KR 830002555A KR 840005134 A KR840005134 A KR 840005134A
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South Korea
Prior art keywords
het
chloro
compound
pyridyl
formula
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KR1019830002555A
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KR870000358B1 (ko
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쿠퍼 켈빈 (외 1)
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윌리암 죤 윌슨
화이자 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

트리아졸 항진균제의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 다음 일반식(II)의 화합물을 염기 존재하 반응 불활성 유기용매중에서 트리아졸과 반응시킴을 특징으로하여 다음 일반식(I)의 화합물을 제조하는 방법.
    상기식에서,
    Het는 방향족 헤테로 사이클릭 그룹이다.
  2. 제1항에 있어서, 탄산 칼륨 존재시, N,N-디메틸포름아미드중에 용해된 반응물과 함께 수행할 경우의방법.
  3. 제1항 또는 2항에 있어서, Het가 임의로 폐닐 또는 헤테로사이클릭환에 융합될 수 있으며 헤테로 사이클릭 또는 융합된 환에서 플루오로, 클로로, 브로모, 요도, C1-C4알킬, C1-C4알콕시 및 CF3에서 선택한 3개까지의 치환제로 임의로 치환될 수 있는, N, S 또는 0에서 선택한 하나 또는 2개의 헤테로원자를 함유한 5 또는 6원 방향족 헤테로 사이클릭환 시스템인 방법.
  4. 제3항에 있아서, Het가 티에닐, 특히 5-브로모-2-티에닐 또는 피리딜, 특히 5-클로로-2-피리딜인 방법.
  5. 제4항에 있어서, Het가 5-클로로-2-피리딜 그룹인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002555A 1982-06-12 1983-06-08 트리아졸 항진균제의 제조방법 KR870000358B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8217114 1982-06-12
GB8217114 1982-06-12
GB8,217,114 1982-06-12

Publications (2)

Publication Number Publication Date
KR840005134A true KR840005134A (ko) 1984-11-03
KR870000358B1 KR870000358B1 (ko) 1987-03-05

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ID=10531001

Family Applications (1)

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KR1019830002555A KR870000358B1 (ko) 1982-06-12 1983-06-08 트리아졸 항진균제의 제조방법

Country Status (16)

Country Link
US (1) US4510148A (ko)
EP (1) EP0097014B1 (ko)
JP (1) JPS5962587A (ko)
KR (1) KR870000358B1 (ko)
AT (1) ATE24909T1 (ko)
AU (1) AU542450B2 (ko)
CA (1) CA1238909A (ko)
DE (1) DE3369137D1 (ko)
DK (1) DK160825C (ko)
ES (1) ES8407488A1 (ko)
FI (1) FI74465C (ko)
GR (1) GR77534B (ko)
IE (1) IE55233B1 (ko)
IL (1) IL68945A (ko)
PH (1) PH21493A (ko)
PT (1) PT76846B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305377D0 (en) * 1983-02-25 1983-03-30 Pfizer Ltd Antifungal agents
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
US4992454A (en) * 1983-03-16 1991-02-12 Pfizer Inc. Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
GB8313235D0 (en) * 1983-05-13 1983-06-22 Pfizer Ltd Antifungal agents
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
US5068333A (en) * 1990-03-07 1991-11-26 Pfizer Inc. 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
US6291463B1 (en) 1998-06-30 2001-09-18 Neurogen Corporation 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands
EP1089990A1 (en) * 1998-06-30 2001-04-11 Neurogen Corporation 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands
MX2015014365A (es) * 2013-04-12 2015-12-07 Bayer Cropscience Ag Derivados de triazol novedosos.
JP2017513848A (ja) * 2014-04-15 2017-06-01 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としての金属酵素阻害剤化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658813A (en) * 1970-01-13 1972-04-25 Janssen Pharmaceutica Nv 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles
DE2738725A1 (de) * 1977-08-27 1979-03-08 Basf Ag Azolylalkohole
DE2926280A1 (de) * 1979-06-29 1981-01-08 Basf Ag Fungizide alpha -triazolylglykolderivate, ihre herstellung und verwendung
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
EP0046337A3 (en) * 1980-08-20 1982-09-15 Imperial Chemical Industries Plc Triazole compounds, a process for preparing them, their use as plant and pharmaceutical fungicides and as plant growth regulators and compositions containing them
JPS5758671A (en) * 1980-09-25 1982-04-08 Ishihara Sangyo Kaisha Ltd Phenoxyalkylazole type compound and agricultural and gardening fungicide comprising it
GB2099818A (en) * 1981-06-06 1982-12-15 Pfizer Ltd Triazoles
DE3262386D1 (en) * 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them

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KR870000358B1 (ko) 1987-03-05
PT76846A (en) 1983-07-01
JPS5962587A (ja) 1984-04-10
EP0097014A2 (en) 1983-12-28
AU1570283A (en) 1983-12-15
JPS6330308B2 (ko) 1988-06-17
DK266083D0 (da) 1983-06-10
FI832101L (fi) 1983-12-13
DK160825B (da) 1991-04-22
IE831371L (en) 1983-12-12
AU542450B2 (en) 1985-02-21
PT76846B (en) 1986-04-09
FI832101A0 (fi) 1983-06-10
PH21493A (en) 1987-11-10
DE3369137D1 (en) 1987-02-19
EP0097014B1 (en) 1987-01-14
DK266083A (da) 1983-12-13
IL68945A0 (en) 1983-10-31
DK160825C (da) 1991-10-14
ES523146A0 (es) 1984-10-01
IL68945A (en) 1986-09-30
ATE24909T1 (de) 1987-01-15
US4510148A (en) 1985-04-09
CA1238909A (en) 1988-07-05
IE55233B1 (en) 1990-07-04
FI74465C (fi) 1988-02-08
GR77534B (ko) 1984-09-24
ES8407488A1 (es) 1984-10-01
FI74465B (fi) 1987-10-30
EP0097014A3 (en) 1984-07-25

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