KR840004761A - N-글리코실화 카복스아미드 유도체의 제조방법 - Google Patents
N-글리코실화 카복스아미드 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840004761A KR840004761A KR1019830001562A KR830001562A KR840004761A KR 840004761 A KR840004761 A KR 840004761A KR 1019830001562 A KR1019830001562 A KR 1019830001562A KR 830001562 A KR830001562 A KR 830001562A KR 840004761 A KR840004761 A KR 840004761A
- Authority
- KR
- South Korea
- Prior art keywords
- general formula
- group
- preparing
- following general
- glycosylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 글리코시드를 하기 일반식(Ⅱ)의 아민과 반응시켜 하기 일반식(Ⅲ)의 아민을 제조한 다음, 하기 일반식(Ⅳ)의 아실화제와 그 자체 공지의 방법으로 아실화시킴을 특징으로 하여 하기 일반식(Ⅰ)의 N-글리코실화 카복스아미드 유도체를 제조하는 방법.상기식들에 있어서, Z는 아노머 탄소원자에 결합된 글리코실기를 나타내고; R1은 수소 또는 임의로 치환된 직쇄 또는 측쇄의 포화 또는 단일 또는 다중으로 불포화된 탄소수 1내지 30의 알킬기로서, O,N 또는 S로 차단될 수도 있으며; R2는 수소 또는 O로 차단되거나, 산소-함유기 또는 할로겐으로 치환될 수 있는 직쇄 또는 측쇄의 포화 또는 단일 또는 다중으로 불포화된 알킬 또는 아르알킬기를 나타내며; X는 아실화 반응에 있어서의 일반적인 이탈기를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823213650 DE3213650A1 (de) | 1982-04-14 | 1982-04-14 | N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr |
DE3213650.1 | 1982-04-14 | ||
DEP3213650.1 | 1982-04-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840004761A true KR840004761A (ko) | 1984-10-24 |
KR920000312B1 KR920000312B1 (ko) | 1992-01-11 |
Family
ID=6160842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830001562A KR920000312B1 (ko) | 1982-04-14 | 1983-04-14 | N-글리코실화 카복스아미드 유도체의 제조방법 |
Country Status (19)
Country | Link |
---|---|
US (1) | US4683222A (ko) |
EP (1) | EP0091645B1 (ko) |
JP (1) | JPS58188891A (ko) |
KR (1) | KR920000312B1 (ko) |
AT (1) | ATE25525T1 (ko) |
AU (1) | AU561016B2 (ko) |
CA (1) | CA1230594A (ko) |
DE (2) | DE3213650A1 (ko) |
DK (1) | DK162883A (ko) |
ES (1) | ES521422A0 (ko) |
FI (1) | FI75172C (ko) |
GR (1) | GR78512B (ko) |
HU (1) | HU194262B (ko) |
IE (1) | IE55112B1 (ko) |
IL (1) | IL68350A (ko) |
NO (1) | NO157145C (ko) |
PH (1) | PH25527A (ko) |
PT (1) | PT76502B (ko) |
ZA (1) | ZA832580B (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3213650A1 (de) * | 1982-04-14 | 1983-10-27 | Bayer Ag, 5090 Leverkusen | N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr |
DE3339694A1 (de) * | 1983-11-03 | 1985-05-15 | Bayer Ag, 5090 Leverkusen | Verwendung n-glycosilierter carbonsaeureamid-derivate als wachstumsfoerderer in der tierernaehrung |
DE3403495A1 (de) * | 1983-11-23 | 1985-05-30 | Bayer Ag, 5090 Leverkusen | Phosphorylierte glycosylamide, -harnstoffe, -carbamate und -thiocarbamate, verfahren zu ihrer herstellung sowie ihre verwendung |
DE3344257A1 (de) * | 1983-12-07 | 1985-06-13 | Bayer Ag, 5090 Leverkusen | Substituierte o-acyl-glycosylamide, verfahren zu iherer herstellung sowie ihre verwendung |
DE3346623A1 (de) * | 1983-12-14 | 1985-07-04 | Bayer Ag, 5090 Leverkusen | N-glycosylierte harnstoffe, carbamate und thiocarbamate, verfahren zu ihrer herstellung sowie ihre verwendung |
DE3347522A1 (de) * | 1983-12-30 | 1985-07-11 | Troponwerke GmbH & Co KG, 5000 Köln | N-glycosylierte carbonsaeureamid-derivate als mittel bei der bekaempfung von erkrankungen des rheumatischen formenkreises |
DE3410238A1 (de) * | 1984-03-21 | 1985-10-03 | Bayer Ag, 5090 Leverkusen | Glycolipid-aehnliche substanzen in liposomenform |
DE3508025A1 (de) * | 1985-03-07 | 1986-09-11 | Bayer Ag, 5090 Leverkusen | Substituierte o-sulfonyl-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE3521994A1 (de) * | 1985-06-20 | 1987-01-02 | Bayer Ag | N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3604681A1 (de) * | 1986-02-14 | 1987-08-20 | Bayer Ag | Neue n-glycosylamidderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE3812681A1 (de) * | 1988-04-16 | 1989-11-02 | Bayer Ag | Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US5476924A (en) * | 1989-01-27 | 1995-12-19 | Duke University | Protecting group for acetals and methods of using the same in the activation of saccharides |
FR2676739B1 (fr) * | 1991-05-22 | 1996-10-11 | Stepan Europe | N-alkyl, n-acetylosylamines, leur procede de preparation et leurs utilisations notamment en tant qu'agents tensioactifs ou agents de solubilisation pour l'isolement de proteines membranaires. |
US5362480A (en) * | 1991-12-31 | 1994-11-08 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions containing amino sugars as antiplaque agents |
US5455232A (en) * | 1992-02-04 | 1995-10-03 | Piljac; Goran | Pharmaceutical preparation based on rhamnolipid |
FR2709061B1 (fr) * | 1993-08-17 | 1996-07-19 | Ladislas Robert | Utilisation d'oligosaccharides dans la prévention et le traitement du vieillissement des tissus. |
AU7613694A (en) * | 1993-08-30 | 1995-03-22 | Bayer Aktiengesellschaft | Glycosyl amides of 6-amino-6-deoxy sugars |
DE4329094A1 (de) * | 1993-08-30 | 1995-03-02 | Bayer Ag | (Glycosylamid)-uronsäure-derivate |
US5905071A (en) * | 1993-08-30 | 1999-05-18 | Bayer Aktiengesellschaft | Glycosylamides of 2-aminoacylamino-2-deoxy sugars |
AU4371996A (en) * | 1994-12-16 | 1996-07-03 | Alcon Laboratories, Inc. | Ophthalmic formulations of substituted glycosides |
US6290971B1 (en) * | 1995-06-15 | 2001-09-18 | Aventis Pasteur Limited | Adjuvant compositions comprising a mineral salt and another immunostimulating compound |
US5872111A (en) * | 1997-05-19 | 1999-02-16 | Lever Brothers Company, Division Of Conopco, Inc. | Compositions comprising glycosylamide surfactants |
US6670330B1 (en) | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
JP3664401B2 (ja) * | 2003-01-22 | 2005-06-29 | 独立行政法人科学技術振興機構 | N−グリコシド型糖脂質及びこれから成る中空繊維状有機ナノチューブ |
US20050008699A1 (en) * | 2003-07-11 | 2005-01-13 | Fred Wehling | Effervescent glucosamine composition |
JP5538725B2 (ja) | 2006-01-26 | 2014-07-02 | ゾエティス・ピー・エルエルシー | 新規糖脂質アジュバント組成物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2808402A (en) * | 1954-08-19 | 1957-10-01 | Rohm & Haas | Method for preparing nu-sorbitylcarbamates |
DE1261861B (de) * | 1963-08-22 | 1968-02-29 | Dehydag Gmbh | Verfahren zur Herstellung von Glycaminabkoemmlingen |
FR2187324B1 (ko) * | 1972-06-14 | 1975-06-20 | Rech Pharmaceut Sc | |
US4228274A (en) * | 1976-09-28 | 1980-10-14 | Merck & Co., Inc. | 1-Substituted glycopyranosides |
JPS5649396A (en) * | 1979-09-28 | 1981-05-02 | Dai Ichi Seiyaku Co Ltd | Novel muramyldipeptide derivative |
DE3213650A1 (de) * | 1982-04-14 | 1983-10-27 | Bayer Ag, 5090 Leverkusen | N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr |
-
1982
- 1982-04-14 DE DE19823213650 patent/DE3213650A1/de not_active Withdrawn
-
1983
- 1983-03-21 AU AU12615/83A patent/AU561016B2/en not_active Ceased
- 1983-03-29 NO NO831163A patent/NO157145C/no unknown
- 1983-04-05 PT PT76502A patent/PT76502B/pt unknown
- 1983-04-06 DE DE8383103325T patent/DE3369851D1/de not_active Expired
- 1983-04-06 AT AT83103325T patent/ATE25525T1/de not_active IP Right Cessation
- 1983-04-06 EP EP83103325A patent/EP0091645B1/de not_active Expired
- 1983-04-08 JP JP58061065A patent/JPS58188891A/ja active Granted
- 1983-04-11 IL IL68350A patent/IL68350A/xx unknown
- 1983-04-12 CA CA000425694A patent/CA1230594A/en not_active Expired
- 1983-04-12 GR GR71057A patent/GR78512B/el unknown
- 1983-04-12 FI FI831230A patent/FI75172C/fi not_active IP Right Cessation
- 1983-04-12 PH PH28763A patent/PH25527A/en unknown
- 1983-04-13 ZA ZA832580A patent/ZA832580B/xx unknown
- 1983-04-13 ES ES521422A patent/ES521422A0/es active Granted
- 1983-04-13 IE IE840/83A patent/IE55112B1/en unknown
- 1983-04-13 DK DK162883A patent/DK162883A/da not_active Application Discontinuation
- 1983-04-14 KR KR1019830001562A patent/KR920000312B1/ko active IP Right Grant
- 1983-04-14 HU HU831306A patent/HU194262B/hu not_active IP Right Cessation
-
1985
- 1985-04-19 US US06/725,060 patent/US4683222A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL68350A (en) | 1988-09-30 |
NO157145B (no) | 1987-10-19 |
AU1261583A (en) | 1983-10-20 |
DE3213650A1 (de) | 1983-10-27 |
IL68350A0 (en) | 1983-07-31 |
CA1230594A (en) | 1987-12-22 |
AU561016B2 (en) | 1987-04-30 |
FI75172C (fi) | 1988-05-09 |
FI831230L (fi) | 1983-10-15 |
FI75172B (fi) | 1988-01-29 |
DK162883D0 (da) | 1983-04-13 |
EP0091645B1 (de) | 1987-02-25 |
PT76502B (en) | 1985-12-10 |
IE830840L (en) | 1983-10-14 |
ES8402313A1 (es) | 1984-01-16 |
JPS58188891A (ja) | 1983-11-04 |
ZA832580B (en) | 1984-01-25 |
EP0091645A1 (de) | 1983-10-19 |
NO831163L (no) | 1983-10-17 |
DK162883A (da) | 1983-10-15 |
US4683222A (en) | 1987-07-28 |
HU194262B (en) | 1988-01-28 |
ATE25525T1 (de) | 1987-03-15 |
NO157145C (no) | 1988-01-27 |
IE55112B1 (en) | 1990-06-06 |
JPH0140036B2 (ko) | 1989-08-24 |
PH25527A (en) | 1991-07-24 |
PT76502A (en) | 1983-05-01 |
GR78512B (ko) | 1984-09-27 |
ES521422A0 (es) | 1984-01-16 |
DE3369851D1 (en) | 1987-04-02 |
KR920000312B1 (ko) | 1992-01-11 |
FI831230A0 (fi) | 1983-04-12 |
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