KR840004750A - 피라졸로피리딘 화합물의 제조방법 - Google Patents

피라졸로피리딘 화합물의 제조방법 Download PDF

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KR840004750A
KR840004750A KR1019830002044A KR830002044A KR840004750A KR 840004750 A KR840004750 A KR 840004750A KR 1019830002044 A KR1019830002044 A KR 1019830002044A KR 830002044 A KR830002044 A KR 830002044A KR 840004750 A KR840004750 A KR 840004750A
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South Korea
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group
alkyl group
hydrogen
substituted
aryl
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KR1019830002044A
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English (en)
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마이클 베어 토마스 (외 2)
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원본미기재
임페리알 케미칼 인더스트리스 어메리카즈 아이 엔시.
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Priority claimed from GB838301676A external-priority patent/GB8301676D0/en
Priority claimed from GB838310260A external-priority patent/GB8310260D0/en
Application filed by 원본미기재, 임페리알 케미칼 인더스트리스 어메리카즈 아이 엔시. filed Critical 원본미기재
Publication of KR840004750A publication Critical patent/KR840004750A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C07C53/21—Acids containing three or more carbon atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

피라졸로피리딘 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. a) D가 산소이고, n이 1인 경우, 일반식(Ⅷ)의 화합물을 25―130℃에서 일반식 H2NR4의 아민과 함께 반응시켜 고리화시키고,
    식중, X는 염소 또는 브롬이고, R과 R11은 각각 같거나 다른 알킬기임.
    b) D가 산소인 경우, 일반식(ⅩⅦ)의 화합물을 일반식 H2NR4의 아민과 함께 반응시키고,
    c) R4가 수소인 경우, 일반식(ⅩⅤ)의 화합물을 150―250℃에서 내부 고리화시키고:
    d) D가 NR6인 경우, D가 산소인 일반식(Ⅰ)의 화합물을 일반식 H2NR4의 아민과 함께 반응시키고,
    e) D가 NR6이고 R6는 수소가 아닌 경우, D가 NH인 일반식(Ⅰ)의 화합물을 강염기 존재하에서 일반식 R6―LG(여기서 LG는 이탈기임)와 함께 바응시키고, f) R4가 알카노일, 아로일, 아랄알카노일 또는 (치환아릴) 알카노일기인 경우, R4가 수소인 화합물(Ⅰ)을 적당한 아실할라이드 또는 산무수물과 함께 아실화 시키고, g) D가 산소이고, n이 2인 경우, 일반식(ⅩⅥ)의 화합물을 일반식 H2NR4의 아민과 함께 반응하여 고리화시키고,
    식중, R15는 알킬이고, R16은 ―CR7R8OH이 h) D는 산소, R4는 수소가 아니고, R7과 R8중 최소한 하나는 수소가 아닌 경우, R4가 수소인 일반식(Ⅰ)의 화합물을 250―300℃에서 가수소가 아닌 일반식 H2NR4의 아민과 함께 반응시키고, i) R4가 수소가 아닌 경우, R4가 수소인 일반식(Ⅰ)의 화합물을 강염기 존재하에서 R4는 수소가 아니고 LG인 이탈기인 일반식 R4―LG의 화합물과 함께 반응시켜서, 다음 일반식(Ⅰ)의 피리졸로피리딘 화합물을 제조하는 방법.
    식중, R1은 알킬기, 치환알킬기, 사이클로알킬기, 사이클로알킬알킬가, 알케닐닐기, 알키닐기, 아릴기, 치환아릴기, 아일알킬기 또는 (치환아릴)알킬기, R3는 수소 또는 알킬기, R4는 수소, 알킬기, 수산기치환알킬기, 옥소치환알킬기, 아미노에 의해 치환된 옥소―치환알킬기, 알케닐기, 알키닐기, 아릴기, 치환아릴기, 아릴알킬기, (치환아릴)알킬기, 아릴(옥소―치환)알킬기 또는)치환아릴)옥소―치환 알킬기, D는 산소 또는 NR6, R6는 수소, 알킬기, 치환알킬기, 사이클로알킬기, 사이클로알킬, 알킬기, 알케닐기, 알키닐기, 아릴기, 치환아릴기, 아릴알킬기, (치환아릴)알킬기 또는 아릴(옥소-치환) 알킬기;n은 1 또는2; R7은 수소, 알킬기, 아릴기, 치환아릴기, 아릴알킬기 또는 (치환 아릴)알킬기;이며, R8은 수소, 알킬기, 아릴기, 치환아릴기, 아릴알킬기 또는 (치환 아릴)알킬기이다.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002044A 1982-05-12 1983-05-12 피라졸로피리딘 화합물의 제조방법 KR840004750A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8213700 1982-05-12
GB8213700 1982-05-12
GB8301676 1983-01-21
GB838301676A GB8301676D0 (en) 1983-01-21 1983-01-21 Nitrogen containing heterocycles
GB8310260 1983-04-15
GB838310260A GB8310260D0 (en) 1982-04-30 1983-04-15 Preparation of selected epoxides

Publications (1)

Publication Number Publication Date
KR840004750A true KR840004750A (ko) 1984-10-24

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KR1019830002044A KR840004750A (ko) 1982-05-12 1983-05-12 피라졸로피리딘 화합물의 제조방법

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US (2) US4511568A (ko)
EP (1) EP0094175B1 (ko)
KR (1) KR840004750A (ko)
AU (1) AU1425983A (ko)
DD (1) DD210456A5 (ko)
DE (1) DE3367217D1 (ko)
DK (1) DK211783A (ko)
ES (1) ES8502116A1 (ko)
FI (1) FI831646L (ko)
GB (1) GB8310266D0 (ko)
GR (1) GR78856B (ko)
IL (1) IL68571A0 (ko)
IN (1) IN159825B (ko)
NO (1) NO831678L (ko)
NZ (1) NZ204203A (ko)
PT (1) PT76678B (ko)
ZW (1) ZW10983A1 (ko)

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GB8329531D0 (en) * 1983-11-04 1983-12-07 Ici America Inc Pyrazolopyridine cycloalkanones
DE3520390A1 (de) * 1984-07-07 1986-02-06 Bayer Ag, 5090 Leverkusen Imidazo-pyrrolo-pyridin-derivate
GB8421116D0 (en) * 1984-08-20 1984-09-26 Ici America Inc Alkynyl derivatives
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
DE19944332A1 (de) * 1999-09-16 2001-03-22 Dresden Arzneimittel Antikonvulsiv und anxiolytisch wirkende 4-Amino-1-aryl-1,5-dihydro-pyrrol-2-one und Verfahren zu deren Herstellung
US20030220646A1 (en) * 2002-05-23 2003-11-27 Thelen Sarah L. Method and apparatus for reducing femoral fractures
US7465795B2 (en) * 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
AU2006327300A1 (en) * 2005-12-20 2007-06-28 Astrazeneca Ab Substituted Cinnoline derivatives as GABAa-receptor modulators and method for their synthesis
TW200911760A (en) * 2007-06-19 2009-03-16 Astrazeneca Ab Compounds and uses thereof

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FR1514010A (fr) * 1966-03-14 1968-02-16 American Home Prod Procédé de préparation de benzonaphtyridines
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3850940A (en) * 1972-11-24 1974-11-26 Squibb & Sons Inc Intermediate pyrazolopyridine carbonitriles
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US4038281A (en) * 1975-10-16 1977-07-26 E. R. Squibb & Sons, Inc. Certain 2,7-dihydro-4H-pyrazolo[3,4-b]pyridine-5-ketones
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AU1425983A (en) 1983-11-17
EP0094175A1 (en) 1983-11-16
ZW10983A1 (en) 1984-12-05
FI831646A0 (fi) 1983-05-11
GB8310266D0 (en) 1983-05-18
GR78856B (ko) 1984-10-02
DD210456A5 (de) 1984-06-13
PT76678B (en) 1986-01-14
NO831678L (no) 1983-11-14
IN159825B (ko) 1987-06-06
NZ204203A (en) 1986-01-24
PT76678A (en) 1983-06-01
US4645838A (en) 1987-02-24
ES522325A0 (es) 1984-12-16
EP0094175B1 (en) 1986-10-29
ES8502116A1 (es) 1984-12-16
US4511568A (en) 1985-04-16
DE3367217D1 (en) 1986-12-04
FI831646L (fi) 1983-11-13
DK211783A (da) 1983-11-13
DK211783D0 (da) 1983-05-11
IL68571A0 (en) 1983-09-30

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