KR840003632A - 푸릴옥사졸릴 아세트산 유도체의 제조방법 - Google Patents

푸릴옥사졸릴 아세트산 유도체의 제조방법 Download PDF

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Publication number
KR840003632A
KR840003632A KR1019830000770A KR830000770A KR840003632A KR 840003632 A KR840003632 A KR 840003632A KR 1019830000770 A KR1019830000770 A KR 1019830000770A KR 830000770 A KR830000770 A KR 830000770A KR 840003632 A KR840003632 A KR 840003632A
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carbon atoms
alkyl
phenyl
compound
formula
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KR1019830000770A
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KR900001423B1 (ko
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가즈오 마쓰모또 (외 1)
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마쓰바라 이찌로
다나베 세이야꾸 가부시끼 가이샤
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Publication of KR840003632A publication Critical patent/KR840003632A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

푸릴옥사졸릴 아세트산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 일반식(II)의 화합물을 탈수적인 폐환 반응을 시킴을 특징으로하여 일반식(I-a)의 화합물을 제조하는 방법.
  4. 상기식에서, R1은 탄소수 1 내지 6의 알킬, 탄소수 5 내지 6의 시클로알킬, 페닐 또는 치환된 페닐(여기에서 치환된 페닐은 탄소수 1 내지 2의 알킬, 탄소수 1 내지 2의 알콕시 및 할로겐 중에서 선택한 1 또는 2개의 라디칼로 치환된 페닐그룹이다)이고, R3는 탄소수 1 내지 12의 알킬이다.
  5. 일반식(I-a)의 화합물을 가수분해시키고 필요시 생성물을 약제학적으로 허용될 수 있는 그의 염으로 전환시킴을 특징으로 하여 일반식(I-b)의 화합물 또는 약제학적을 허용될 수 있는 그의 염을 제조하는 방법.
  8. 상기식에서, R1은 탄소수 1 내지 6의 알킬, 탄소수 5 내지 6의 시클로알킬, 페닐 또는 치환된 페닐(여기에서 치환된 페닐은 탄소수 1 내지 2의 알킬, 탄소수 1 내지 2의 알콕시 및 할로겐 중에서 선택한 1 또는 2개의 라디칼로 치환된 페닐그룹이다)이고 R3는 탄소수 1 내지 12의 알킬이다.
  9. 일반식(I-b)의 화합물을 에스테르화시킴을 특징으로 하여 일반식(I-c)의 화합물을 제조하는 방법.
  12. 상기식에서, R1은 탄소수 1 내지 6의 알킬, 탄소수 5 내지 6의 시클로알킬, 페닐 또는 치환된 페닐(여기에서 치환된 페닐은 탄소수 1 내지 2의 알킬, 탄소수 1 내지 2의 알콕시 및 할로겐 중에서 선택한 1 또는 2개의 라디칼로 치환된 페닐그룹이다)이고 R4는 탄소수 1 내지 12의 알킬이다.
  13. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830000770A 1982-02-26 1983-02-25 푸릴옥사졸릴아세트산 유도체의 제조방법 KR900001423B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP82-30921 1982-02-26
JP57030921A JPS58148882A (ja) 1982-02-26 1982-02-26 フリルオキサゾリル酢酸誘導体及びその製法

Publications (2)

Publication Number Publication Date
KR840003632A true KR840003632A (ko) 1984-09-15
KR900001423B1 KR900001423B1 (ko) 1990-03-09

Family

ID=12317149

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830000770A KR900001423B1 (ko) 1982-02-26 1983-02-25 푸릴옥사졸릴아세트산 유도체의 제조방법

Country Status (14)

Country Link
US (1) US4642313A (ko)
EP (1) EP0087782B1 (ko)
JP (1) JPS58148882A (ko)
KR (1) KR900001423B1 (ko)
AT (1) ATE19879T1 (ko)
BG (1) BG39977A3 (ko)
CA (1) CA1194483A (ko)
DE (1) DE3363575D1 (ko)
DK (1) DK82583A (ko)
ES (1) ES520136A0 (ko)
HK (1) HK87188A (ko)
HU (1) HU193648B (ko)
SG (1) SG10688G (ko)
SU (1) SU1169536A3 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59152382A (ja) * 1983-02-18 1984-08-31 Tanabe Seiyaku Co Ltd フリルオキサゾリル酢酸誘導体
CA2160440C (en) * 1994-10-13 1998-08-25 Louis G. Lange, Iii Method of manufacturing non-absorbable synthetic sulfated polysaccharides
US7071174B1 (en) 1994-10-13 2006-07-04 Cv Therapeutics, Inc. Method and composition for inhibiting cholesterol esterase
CN101519386A (zh) * 2001-04-16 2009-09-02 田边三菱制药株式会社 高传导率钙-活化k通道开启剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32084B1 (en) * 1967-06-07 1973-04-04 Wyeth John & Brother Ltd Thiazole derivatives
FI53314C (fi) * 1967-06-14 1978-04-10 Wyeth John & Brother Ltd Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-(fenyleller p-klorfenyl) oxazol-4-yl (aettiksyra -acetatsalt eller -acetamid)
GB1245087A (en) * 1967-10-26 1971-09-02 Wyeth John & Brother Ltd Heterocyclic compounds
US3578671A (en) * 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
FR2068418A1 (en) * 1969-10-27 1971-08-27 Innothera Lab Sa 2-substd-5-amino isoxazole derivs
AR208400A1 (es) * 1974-03-13 1976-12-27 Yoshitomi Pharmaceutical Un metodo para producir nuevos acidos 5-alcoxi-4-oxazolalcanoicos 2-substituidos y sus esteres
JPS51110039A (ja) * 1975-02-28 1976-09-29 Yoshitomi Pharmaceutical Ketsuchushishitsutaishakaizenzai
GB1542315A (en) * 1976-08-13 1979-03-14 Wyeth John & Brother Ltd Process for preparing oxazoles
JPS5677268A (en) * 1979-11-28 1981-06-25 Yoshitomi Pharmaceut Ind Ltd Oxazoleacetic acid derivative
JPS57188587A (en) * 1981-05-15 1982-11-19 Tanabe Seiyaku Co Ltd Thienyloxazolylacetic acid derivative and its preparation

Also Published As

Publication number Publication date
BG39977A3 (en) 1986-09-15
DE3363575D1 (en) 1986-06-26
SU1169536A3 (ru) 1985-07-23
HU193648B (en) 1987-11-30
DK82583D0 (da) 1983-02-23
CA1194483A (en) 1985-10-01
SG10688G (en) 1988-07-01
JPS635027B2 (ko) 1988-02-01
HK87188A (en) 1988-11-04
EP0087782B1 (en) 1986-05-21
JPS58148882A (ja) 1983-09-05
ES8403891A1 (es) 1984-04-01
EP0087782A1 (en) 1983-09-07
ATE19879T1 (de) 1986-06-15
KR900001423B1 (ko) 1990-03-09
US4642313A (en) 1987-02-10
DK82583A (da) 1983-08-27
ES520136A0 (es) 1984-04-01

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