KR840002652A - Method for preparing a composition for long-acting nicardipine - Google Patents

Method for preparing a composition for long-acting nicardipine Download PDF

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Publication number
KR840002652A
KR840002652A KR1019820005782A KR820005782A KR840002652A KR 840002652 A KR840002652 A KR 840002652A KR 1019820005782 A KR1019820005782 A KR 1019820005782A KR 820005782 A KR820005782 A KR 820005782A KR 840002652 A KR840002652 A KR 840002652A
Authority
KR
South Korea
Prior art keywords
mixture
nicardipine
water
organic solvent
composition
Prior art date
Application number
KR1019820005782A
Other languages
Korean (ko)
Other versions
KR860001147B1 (en
Inventor
다까시 소노베 (외 6)
Original Assignee
모리오까 시게오
야마노우찌 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56208608A external-priority patent/JPS58116414A/en
Application filed by 모리오까 시게오, 야마노우찌 세이야꾸 가부시끼 가이샤 filed Critical 모리오까 시게오
Publication of KR840002652A publication Critical patent/KR840002652A/en
Application granted granted Critical
Publication of KR860001147B1 publication Critical patent/KR860001147B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Abstract

내용 없음.No content.

Description

지속성 니카르디핀 제제용 조성물의 제조방법Method for preparing a composition for long-acting nicardipine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

유기용매, 유기용매의 혼합물 또는 물과 유기용매와의 혼합물에 (a) 니카르디핀 또는 이의 염 그리고 (b) pH-의존성 첨가제 및/또는 수용성 중합체를 용해시키고 소과립핵을 상기 용액으로 분무코팅함을 특징으로 하는 구형 펠렛상 니카르디핀 지속성 제제용 조성물의 제조방법.(A) Nicardipine or its salt and (b) pH-dependent additives and / or water-soluble polymers are dissolved in an organic solvent, a mixture of organic solvents, or a mixture of water and an organic solvent and spray coating the microgranules with the solution. A process for producing a composition for the preparation of a spherical pellet-like nickel cardipine long-acting agent, characterized in that. 유기용매, 유기용매의 혼합물 또는 물과 유기용매와의 혼합물에 (a) 니카르디핀 또는 이의 염 그리고 (b) pH-의존성 첨가제 및/또는 수용성 중합체를 용해시키고, 소과립핵을 상기 용액으로 분무코팅한 다음 이의 생성물을 (c) 약제 침투물질의 유기용액으로 재차 분무코팅함을 특징으로 하는 구형 펠렛상 니카르디핀 지속성 제제용 조성물의 제조방법.(A) Nicardipine or its salt and (b) pH-dependent additives and / or water-soluble polymers are dissolved in an organic solvent, a mixture of organic solvents or a mixture of water and an organic solvent, and the small granule nuclei are sprayed into the solution. (C) spray coating the product thereof again with an organic solution of a drug penetrating substance, the method for producing a composition for the preparation of a spherical pellet-like nickel cardinine persistent formulation. 유기용매, 유기용매의 혼합물 또는 물과 유기용매와의 혼합물에 (a) 니카르디핀 또는 이의 염, (b) pH-의존성 첨가제 및/또는 수용성 중합체, 그리고 계면활성제를 용해시키고 소 과립핵을 상기 용액으로 분무코팅함을 특징으로 하는 구형 펠렛상 니카르디핀 지속성 제제용 조성물의 제조방법.(A) Nicardipine or a salt thereof, (b) pH-dependent additives and / or water-soluble polymers, and surfactants are dissolved in an organic solvent, a mixture of organic solvents, or a mixture of water and an organic solvent. A spherical pellet-like nicardipine sustained-agent formulation for producing a composition, which is characterized by spray coating with a solution. 유기용매, 유기용매의 혼합물 또는 물과 유기용매와의 혼합물에 (a) 니카르디핀 또는 이의 염, (b) pH-의존성 첨가제 및/또는 수용성 중합체, 그리고 계면활성제를 용해시키고, 소과립핵을 상기 용액으로 분무코팅한 다음 이의 생성물을 (c) 약제침투물질의 유기용액으로 재차 분무코팅함을 특징으로 하는 구형 펠렛상 니카르디핀 지속성 제제용 조성물의 제조방법.(A) Nicardipine or a salt thereof, (b) pH-dependent additives and / or water-soluble polymers, and surfactants are dissolved in an organic solvent, a mixture of organic solvents, or a mixture of water and an organic solvent. Spray coating of the solution and then the product thereof (c) Spraying the coating again with the organic solution of the drug penetrating material, characterized in that the preparation method for the composition of a spherical pellet-like nicardipine persistent formulation. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR8205782A 1981-12-23 1982-12-23 A process for producing composition forlong acting nicardipine preparation KR860001147B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP268608 1981-12-23
JP56208608A JPS58116414A (en) 1981-12-23 1981-12-23 Composition for pharmaceutical of prolonged release containing nicardipine and preparation thereof
JP208608 1981-12-23

Publications (2)

Publication Number Publication Date
KR840002652A true KR840002652A (en) 1984-07-16
KR860001147B1 KR860001147B1 (en) 1986-08-18

Family

ID=16559022

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205782A KR860001147B1 (en) 1981-12-23 1982-12-23 A process for producing composition forlong acting nicardipine preparation

Country Status (8)

Country Link
KR (1) KR860001147B1 (en)
AT (1) AT386743B (en)
CA (1) CA1200494A (en)
ES (1) ES518487A0 (en)
GR (1) GR77096B (en)
IT (1) IT1200966B (en)
MX (1) MX7567E (en)
PT (1) PT76023B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8414220D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Medicaments in unit dose form

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (en) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material

Also Published As

Publication number Publication date
CA1200494A (en) 1986-02-11
PT76023A (en) 1983-01-01
ES8402156A1 (en) 1984-02-01
ES518487A0 (en) 1984-02-01
ATA460682A (en) 1988-03-15
IT8268503A0 (en) 1982-12-22
AT386743B (en) 1988-10-10
PT76023B (en) 1986-02-12
GR77096B (en) 1984-09-06
MX7567E (en) 1989-10-27
IT1200966B (en) 1989-01-27
KR860001147B1 (en) 1986-08-18

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