KR840001547A - 항염증작용, 살균작용 및 항균작용을 갖는 화합물의 제조방법 - Google Patents
항염증작용, 살균작용 및 항균작용을 갖는 화합물의 제조방법 Download PDFInfo
- Publication number
- KR840001547A KR840001547A KR1019820004408A KR820004408A KR840001547A KR 840001547 A KR840001547 A KR 840001547A KR 1019820004408 A KR1019820004408 A KR 1019820004408A KR 820004408 A KR820004408 A KR 820004408A KR 840001547 A KR840001547 A KR 840001547A
- Authority
- KR
- South Korea
- Prior art keywords
- action
- solvent
- preparing compound
- inflammatory
- bactericidal
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- 150000001875 compounds Chemical class 0.000 title claims 2
- 230000000844 anti-bacterial effect Effects 0.000 title 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 239000002904 solvent Substances 0.000 claims 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 2
- VIBOGIYPPWLDTI-UHFFFAOYSA-N 2-naphthylacetic acid Chemical compound C1=CC=CC2=CC(CC(=O)O)=CC=C21 VIBOGIYPPWLDTI-UHFFFAOYSA-N 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
- C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- N, N″-비스(4-클로로페닐)-3, 12-디이미노-2, 4, 11, 13-테트라아자-테트라데칸-디이미도아미드와 (+)-6-메톡시-α-메틸-2-나프탈렌아세트산을 1 : 2몰 비율로 약 10-100℃의 온도에서 용매와의 현탁액으로 반응시킨 다음 수득되는 용액을 냉각시켜 용액으로부터 하기 구조식(Ⅰ)의 화합물을 분리시킴을 특징으로 하여 구조식(Ⅰ)의 N, N″-비스(4-클로로페닐)-3, 12-디이미노-2, 4, 11, 13-테트라아자-테트라데칸-디이미도아미드와 (+)-6-메톡시-α-메틸-2-나프탈렌아세테이트를 제조하는 방법.
- 제1항에 있어서, 용매가 C1-C4알코올로 조성되는 방법.
- 제1항 또는 제2항에 있어서,용매가 소량의 물을 함유하는 방법.
- 제1항 내지 제3항중 어느 하나의 항에 있어서 반응 온도가 용매의 비점인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT25298/81A IT1168068B (it) | 1981-11-26 | 1981-11-26 | Composto ad attvita' antiinfiammatoria, disinfettante e antibatterica, procedimento per la sua preparazione e relative composizioni farmaceutiche |
IT25298A/81 | 1981-11-26 | ||
ITN25298A/81 | 1981-11-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840001547A true KR840001547A (ko) | 1984-05-07 |
KR860001000B1 KR860001000B1 (ko) | 1986-07-26 |
Family
ID=11216264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8204408A KR860001000B1 (ko) | 1981-11-26 | 1982-09-29 | N,N"-비스(4-클로로페닐)-3,12-디이미노-2,4,11,13-테트라아자-테트라데칸-디이미도아미드의 (+)-6-메톡시-α-메틸-2-나프탈렌아세테이트화합물의 제조방법 |
Country Status (16)
Country | Link |
---|---|
US (1) | US4496589A (ko) |
JP (1) | JPS5899458A (ko) |
KR (1) | KR860001000B1 (ko) |
BE (1) | BE894521A (ko) |
CH (1) | CH651823A5 (ko) |
DE (1) | DE3236191C2 (ko) |
ES (1) | ES8308828A1 (ko) |
FR (1) | FR2516919A1 (ko) |
GB (1) | GB2110209B (ko) |
GR (1) | GR77659B (ko) |
IN (1) | IN155615B (ko) |
IT (1) | IT1168068B (ko) |
LU (1) | LU84396A1 (ko) |
NL (1) | NL8203824A (ko) |
PT (1) | PT75630B (ko) |
ZA (1) | ZA827182B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60178801A (ja) * | 1984-02-24 | 1985-09-12 | Dainippon Ink & Chem Inc | グアニジン系農園芸用殺菌剤 |
US4843099A (en) * | 1987-07-20 | 1989-06-27 | Colgate-Palmolive Company | Device and composition for treatment of the gums |
FR2791890B1 (fr) * | 1999-04-12 | 2004-12-10 | Gilbert Lab | Solution de chlorhexidine alcoolique coloree et sa methode de fabrication |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2684924A (en) * | 1951-02-05 | 1954-07-27 | Ici Ltd | Nu-chlorophenyldiguanidino compounds |
BE612529A (ko) * | 1961-01-13 | |||
US3468898A (en) * | 1966-05-26 | 1969-09-23 | Sterling Drug Inc | Bridged bis-biguanides and bis-guanidines |
US4009197A (en) * | 1967-01-13 | 1977-02-22 | Syntex Corporation | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof |
US4207241A (en) * | 1967-01-13 | 1980-06-10 | Syntex Corporation | 2-Naphthyl acetic acid derivatives and compositions and methods thereof |
US3980699A (en) * | 1971-11-04 | 1976-09-14 | Syntex Corporation | 2-Naphthyl acetic acid derivatives |
US4022834A (en) * | 1972-03-16 | 1977-05-10 | A/S Farmaceutisk Industri | Antibacterially active hexamethylene-bis-biguanides |
US4198392A (en) * | 1975-06-23 | 1980-04-15 | The Procter & Gamble Company | Oral compositions containing bis-biguanides with reduced staining tendencies |
EP0011279B1 (en) * | 1978-11-14 | 1982-05-05 | Sagami Chemical Research Center | Process for the preparation of aromatically substituted acetic acids |
-
1981
- 1981-11-26 IT IT25298/81A patent/IT1168068B/it active
-
1982
- 1982-09-09 CH CH5355/82A patent/CH651823A5/it not_active IP Right Cessation
- 1982-09-28 IN IN1125/CAL/82A patent/IN155615B/en unknown
- 1982-09-28 GR GR69385A patent/GR77659B/el unknown
- 1982-09-29 JP JP57172467A patent/JPS5899458A/ja active Pending
- 1982-09-29 ES ES516060A patent/ES8308828A1/es not_active Expired
- 1982-09-29 KR KR8204408A patent/KR860001000B1/ko active
- 1982-09-29 LU LU84396A patent/LU84396A1/fr unknown
- 1982-09-29 PT PT75630A patent/PT75630B/pt unknown
- 1982-09-29 BE BE2/59848A patent/BE894521A/nl not_active IP Right Cessation
- 1982-09-29 FR FR8216416A patent/FR2516919A1/fr active Granted
- 1982-09-30 DE DE3236191A patent/DE3236191C2/de not_active Expired
- 1982-09-30 GB GB08227889A patent/GB2110209B/en not_active Expired
- 1982-09-30 ZA ZA827182A patent/ZA827182B/xx unknown
- 1982-09-30 NL NL8203824A patent/NL8203824A/nl not_active Application Discontinuation
- 1982-11-04 US US06/439,067 patent/US4496589A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT75630A (en) | 1982-10-01 |
IT8125298A0 (it) | 1981-11-26 |
JPS5899458A (ja) | 1983-06-13 |
IN155615B (ko) | 1985-02-16 |
US4496589A (en) | 1985-01-29 |
ZA827182B (en) | 1983-08-31 |
ES516060A0 (es) | 1983-10-01 |
FR2516919A1 (fr) | 1983-05-27 |
IT1168068B (it) | 1987-05-20 |
LU84396A1 (fr) | 1983-06-07 |
BE894521A (nl) | 1983-01-17 |
ES8308828A1 (es) | 1983-10-01 |
GB2110209B (en) | 1985-04-17 |
GB2110209A (en) | 1983-06-15 |
PT75630B (en) | 1986-03-11 |
DE3236191C2 (de) | 1986-06-05 |
NL8203824A (nl) | 1983-06-16 |
GR77659B (ko) | 1984-09-25 |
KR860001000B1 (ko) | 1986-07-26 |
FR2516919B1 (ko) | 1984-08-24 |
DE3236191A1 (de) | 1983-07-07 |
CH651823A5 (it) | 1985-10-15 |
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