KR840001547A - 항염증작용, 살균작용 및 항균작용을 갖는 화합물의 제조방법 - Google Patents

항염증작용, 살균작용 및 항균작용을 갖는 화합물의 제조방법 Download PDF

Info

Publication number
KR840001547A
KR840001547A KR1019820004408A KR820004408A KR840001547A KR 840001547 A KR840001547 A KR 840001547A KR 1019820004408 A KR1019820004408 A KR 1019820004408A KR 820004408 A KR820004408 A KR 820004408A KR 840001547 A KR840001547 A KR 840001547A
Authority
KR
South Korea
Prior art keywords
action
solvent
preparing compound
inflammatory
bactericidal
Prior art date
Application number
KR1019820004408A
Other languages
English (en)
Other versions
KR860001000B1 (ko
Inventor
드 빈센티스 레오나르도
Original Assignee
아메데오 데 빈센티스
오소니아 파마슈티시 에스. 알에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아메데오 데 빈센티스, 오소니아 파마슈티시 에스. 알에이 filed Critical 아메데오 데 빈센티스
Publication of KR840001547A publication Critical patent/KR840001547A/ko
Application granted granted Critical
Publication of KR860001000B1 publication Critical patent/KR860001000B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

항염증작용, 살균작용 및 항균작용을 갖는 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. N, N″-비스(4-클로로페닐)-3, 12-디이미노-2, 4, 11, 13-테트라아자-테트라데칸-디이미도아미드와 (+)-6-메톡시-α-메틸-2-나프탈렌아세트산을 1 : 2몰 비율로 약 10-100℃의 온도에서 용매와의 현탁액으로 반응시킨 다음 수득되는 용액을 냉각시켜 용액으로부터 하기 구조식(Ⅰ)의 화합물을 분리시킴을 특징으로 하여 구조식(Ⅰ)의 N, N″-비스(4-클로로페닐)-3, 12-디이미노-2, 4, 11, 13-테트라아자-테트라데칸-디이미도아미드와 (+)-6-메톡시-α-메틸-2-나프탈렌아세테이트를 제조하는 방법.
  2. 제1항에 있어서, 용매가 C1-C4알코올로 조성되는 방법.
  3. 제1항 또는 제2항에 있어서,용매가 소량의 물을 함유하는 방법.
  4. 제1항 내지 제3항중 어느 하나의 항에 있어서 반응 온도가 용매의 비점인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8204408A 1981-11-26 1982-09-29 N,N"-비스(4-클로로페닐)-3,12-디이미노-2,4,11,13-테트라아자-테트라데칸-디이미도아미드의 (+)-6-메톡시-α-메틸-2-나프탈렌아세테이트화합물의 제조방법 KR860001000B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT25298/81A IT1168068B (it) 1981-11-26 1981-11-26 Composto ad attvita' antiinfiammatoria, disinfettante e antibatterica, procedimento per la sua preparazione e relative composizioni farmaceutiche
IT25298A/81 1981-11-26
ITN25298A/81 1981-11-26

Publications (2)

Publication Number Publication Date
KR840001547A true KR840001547A (ko) 1984-05-07
KR860001000B1 KR860001000B1 (ko) 1986-07-26

Family

ID=11216264

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204408A KR860001000B1 (ko) 1981-11-26 1982-09-29 N,N"-비스(4-클로로페닐)-3,12-디이미노-2,4,11,13-테트라아자-테트라데칸-디이미도아미드의 (+)-6-메톡시-α-메틸-2-나프탈렌아세테이트화합물의 제조방법

Country Status (16)

Country Link
US (1) US4496589A (ko)
JP (1) JPS5899458A (ko)
KR (1) KR860001000B1 (ko)
BE (1) BE894521A (ko)
CH (1) CH651823A5 (ko)
DE (1) DE3236191C2 (ko)
ES (1) ES8308828A1 (ko)
FR (1) FR2516919A1 (ko)
GB (1) GB2110209B (ko)
GR (1) GR77659B (ko)
IN (1) IN155615B (ko)
IT (1) IT1168068B (ko)
LU (1) LU84396A1 (ko)
NL (1) NL8203824A (ko)
PT (1) PT75630B (ko)
ZA (1) ZA827182B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178801A (ja) * 1984-02-24 1985-09-12 Dainippon Ink & Chem Inc グアニジン系農園芸用殺菌剤
US4843099A (en) * 1987-07-20 1989-06-27 Colgate-Palmolive Company Device and composition for treatment of the gums
FR2791890B1 (fr) * 1999-04-12 2004-12-10 Gilbert Lab Solution de chlorhexidine alcoolique coloree et sa methode de fabrication

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2684924A (en) * 1951-02-05 1954-07-27 Ici Ltd Nu-chlorophenyldiguanidino compounds
BE612529A (ko) * 1961-01-13
US3468898A (en) * 1966-05-26 1969-09-23 Sterling Drug Inc Bridged bis-biguanides and bis-guanidines
US4009197A (en) * 1967-01-13 1977-02-22 Syntex Corporation 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof
US4207241A (en) * 1967-01-13 1980-06-10 Syntex Corporation 2-Naphthyl acetic acid derivatives and compositions and methods thereof
US3980699A (en) * 1971-11-04 1976-09-14 Syntex Corporation 2-Naphthyl acetic acid derivatives
US4022834A (en) * 1972-03-16 1977-05-10 A/S Farmaceutisk Industri Antibacterially active hexamethylene-bis-biguanides
US4198392A (en) * 1975-06-23 1980-04-15 The Procter & Gamble Company Oral compositions containing bis-biguanides with reduced staining tendencies
EP0011279B1 (en) * 1978-11-14 1982-05-05 Sagami Chemical Research Center Process for the preparation of aromatically substituted acetic acids

Also Published As

Publication number Publication date
PT75630A (en) 1982-10-01
IT8125298A0 (it) 1981-11-26
JPS5899458A (ja) 1983-06-13
IN155615B (ko) 1985-02-16
US4496589A (en) 1985-01-29
ZA827182B (en) 1983-08-31
ES516060A0 (es) 1983-10-01
FR2516919A1 (fr) 1983-05-27
IT1168068B (it) 1987-05-20
LU84396A1 (fr) 1983-06-07
BE894521A (nl) 1983-01-17
ES8308828A1 (es) 1983-10-01
GB2110209B (en) 1985-04-17
GB2110209A (en) 1983-06-15
PT75630B (en) 1986-03-11
DE3236191C2 (de) 1986-06-05
NL8203824A (nl) 1983-06-16
GR77659B (ko) 1984-09-25
KR860001000B1 (ko) 1986-07-26
FR2516919B1 (ko) 1984-08-24
DE3236191A1 (de) 1983-07-07
CH651823A5 (it) 1985-10-15

Similar Documents

Publication Publication Date Title
KR840001145A (ko) 피리다진의 아미노 화합물의 제조방법
KR840004756A (ko) 항 정신질환제의 제조방법
KR850006415A (ko) 항균제의 제조방법
KR850008678A (ko) 2-아미노-3-에톡시카보닐아미노-6-cP-플루오로-벤질아미노)-피리딘 글루코노이트의 제조방법
KR840001124A (ko) 2-[2' -하이드록시-3' -(1,1-디메칠프로필아미노)-프로폭시]-β-페닐프로피오페논 및 이의 염을 제조하는 방법
KR860008143A (ko) 4,5,6,7- 테트라히드로 2h- 인다졸 유도체의 제조방법
KR840001547A (ko) 항염증작용, 살균작용 및 항균작용을 갖는 화합물의 제조방법
KR830006311A (ko) 7-β-[α-syn-메톡시이미노-α-(2-아미노티아졸-4-일)-아세트아미도]-3-[(1,2,3-티아졸-5-일티오)메틸]-3-세펨-4-카르복시산 및 C₁-C6 알킬 유도체 제조방법
KR880009937A (ko) 치환된 3-알킬퀴놀린-8-카르복실산의 제조방법
KR830006286A (ko) 빈카민 사카리내이트의 제조방법
KR850004481A (ko) 4, 5-디하이드로-6-[2-[4-(1h-이미다졸-1-일)페닐]-에테닐]-3(2h)-피리다지논류의 제법
KR830001948A (ko) 페니실린 설폭사이드의 제조방법
KR910007945A (ko) 알킬 메틸-3-카브알콕시에틸포스피네이트의 제조방법
GB1305025A (ko)
KR830005175A (ko) 치환된 트리아릴티아졸 화합물의 제조방법
KR850006428A (ko) 에리드로마이신 아세트산염의 제조방법
ATE11281T1 (de) Verfahren zur herstellung von polyfunktionalen organischen verbindungen mit wenigstens einer tert. butylaether- oder -estergruppe.
KR860002471A (ko) 피라졸 제초제의 제조방법
KR920007967A (ko) 케탈의 연속 제조방법
KR830005094A (ko) 2-(4-이소부틸페닐)-프로피온산 유도체의 제조
KR840002367A (ko) 3-메틸-3-(4-아세틸아미노펜옥시)-2,4-디옥사벤조-사이클로헥사논-1-의 제조방법
KR850005413A (ko) 아미노니트로피리딘의 제조방법
KR830001261A (ko) 안트라퀴논 유도체의 제조방법
KR830005250A (ko) 빈크리스틴의 제조방법
KR850006393A (ko) 퀴놀린 카르복실산의 피페라지닐 유도체의 제조방법