KR840000533A - 화합물의 제조방법 - Google Patents

화합물의 제조방법

Info

Publication number
KR840000533A
KR840000533A KR1019820002896A KR820002869A KR840000533A KR 840000533 A KR840000533 A KR 840000533A KR 1019820002896 A KR1019820002896 A KR 1019820002896A KR 820002869 A KR820002869 A KR 820002869A KR 840000533 A KR840000533 A KR 840000533A
Authority
KR
South Korea
Prior art keywords
pyridyl
oxo
methyl
compound
dimethyl
Prior art date
Application number
KR1019820002896A
Other languages
English (en)
Other versions
KR880001475B1 (ko
Inventor
시드니 쌕 조오지
Original Assignee
디. 엠. 워터즈
스미스 크라인 앤드 프렌춰 라보라트리즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 디. 엠. 워터즈, 스미스 크라인 앤드 프렌춰 라보라트리즈 리미티드 filed Critical 디. 엠. 워터즈
Publication of KR840000533A publication Critical patent/KR840000533A/ko
Application granted granted Critical
Publication of KR880001475B1 publication Critical patent/KR880001475B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Treating Waste Gases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 구조식 (2)
    (식중 R1은 할로겐이나 니트로기이고 ; R2는 C1-4알킬기이고 ; R3은 C1-3알킬렌 그룹이고 ; R4는 3-피리딜, N-옥소-3-피리딜, 6-메틸-3-피리딜, N-옥소-6-메틸-3-피리딜, 6-하이드록시메틸-3-피리딜, 4,6-디메틸-3-피리딜, N-옥소-4,6-디메틸-3-피리딜, 6-하이드록시메틸-4-메틸-3-피리딜, 5,6-디메틸-3-피리딜, N-옥소-5,6-디메틸-3-피리딜, 6-하이드록시메틸-5-메틸-3-피리딜, 4-피리딜이나 N-옥소-4-피리딜)으로 표시되는 신규화합물 및 이의 제약상으로 허용되는 염을 제조함에 있어,
    구조식 (3)
    (여기서 R1, R2및 R3은 위에서 정의한 것 같음)
    으로 표시되는 화합물이나 이의 염을 구조식 (4)
    (여기서 R4는 위에서 정의한 것과 같고, R5은 아민과 대치시킬 수 있는 그룹임)
    을 반응시키고, 생성된 구조식 (2)의 화합물 중 R4가 N-옥소-6-메틸-3-피리딜, N-옥소-4,6-디메틸-3-피리딜 또는 N-옥소-5,6-디메틸-3-피리딜인 화합물을 상응하는 6-하이드록시메틸-3-피리딜, 6-하이드록시메틸-4-메틸-3-피리딜 또는 6-하이드록시메틸-5-메틸-3-피리딜인 화합물로 전환시키고, 임의로 이들 화합물을 제약적으로 허용되는 염으로 제조하는 것을 특징으로 하기 구조식 (2)의 화합물 및 이의 제약상으로 허용되는 염의 제조방법.
  2. 제 1 항에 있어서, R1이 취소인 구조식 (2)의 화합물 및 이의 제약상으로 허용되는 염의 제조방법.
  3. 제 1 항이나 2항에 있어서, R2가 메틸인 구조식 (2) 및 이의 제약상으로 허용되는 염의 제조방법.
  4. 제 1,2 또는 3항에 있어서 R4가 피리드-3-일, 6-메틸피리드-3-일, 6-하이드록시메틸피리드-3-일 또는 5,6-디메틸피리드-3-일인 구조식 (2)의 화합물 및 이의 제약상으로 허용되는 염의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202869A 1981-06-27 1982-06-26 피리미돈 유도체의 제조방법 KR880001475B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8119906 1981-06-27
GB8119906 1981-06-27

Publications (2)

Publication Number Publication Date
KR840000533A true KR840000533A (ko) 1984-02-25
KR880001475B1 KR880001475B1 (ko) 1988-08-13

Family

ID=10522859

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202869A KR880001475B1 (ko) 1981-06-27 1982-06-26 피리미돈 유도체의 제조방법

Country Status (27)

Country Link
US (4) US4444772A (ko)
EP (2) EP0068833B1 (ko)
JP (4) JPS588079A (ko)
KR (1) KR880001475B1 (ko)
AT (2) ATE21900T1 (ko)
AU (2) AU551066B2 (ko)
BG (1) BG38163A3 (ko)
CS (1) CS241036B2 (ko)
DD (1) DD202291A5 (ko)
DE (2) DE3273782D1 (ko)
DK (2) DK287082A (ko)
ES (1) ES513469A0 (ko)
FI (1) FI822281L (ko)
GR (2) GR74925B (ko)
HU (1) HU190396B (ko)
IE (1) IE53348B1 (ko)
IL (1) IL66125A (ko)
JO (1) JO1185B1 (ko)
NO (1) NO822120L (ko)
NZ (1) NZ201077A (ko)
PH (1) PH19680A (ko)
PL (3) PL138524B1 (ko)
PT (1) PT75074B (ko)
SU (1) SU1232145A3 (ko)
YU (1) YU138982A (ko)
ZA (2) ZA824537B (ko)
ZW (1) ZW13082A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100498005B1 (ko) * 2002-07-26 2005-07-01 주식회사 소하드 기능성 액상비료 및 그 제조방법

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (ko) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
DE3376422D1 (en) * 1982-03-25 1988-06-01 Smith Kline French Lab Process for preparing 3,5-disubstituted 2-pyridylalkyl amines
GR78463B (ko) * 1982-03-25 1984-09-27 Smith Kline French Lab
PT77287B (en) * 1982-10-01 1986-02-04 Smith Kline French Lab Compound
GB8319874D0 (en) * 1983-07-23 1983-08-24 Smith Kline French Lab Compounds
CA1286297C (en) * 1985-06-13 1991-07-16 George S. Sach Pyridine derivatives
GB8601816D0 (en) * 1986-01-25 1986-02-26 Smith Kline French Lab Pyridine derivatives
GB8610867D0 (en) * 1986-05-02 1986-06-11 Smith Kline French Lab 3-hydroxypyridines
JP2679977B2 (ja) * 1986-09-19 1997-11-19 株式会社日立製作所 半導体集積回路
EP0364584A4 (en) * 1988-04-27 1990-12-05 Kievsky Nauchno-Issledovatelsky Institut Farmakologii I Toxikologii Antidote for organic phosphorus compound poisoning
US5216170A (en) * 1989-01-26 1993-06-01 Bayer Aktiengesellschaft (2-aminopropyl) pyridines useful as intermediates
WO2004058828A1 (en) * 2002-12-20 2004-07-15 Exxonmobil Chemical Patents Inc. Polymerization processes
US7443103B2 (en) * 2005-06-24 2008-10-28 General Electric Company High pressure lamp with lamp flicker suppression and lamp voltage control
KR20110050616A (ko) * 2008-07-10 2011-05-16 노파르티스 아게 Ｂａｃｅ 억제제로서 유용한 아미노벤질 치환을 갖는 시클릭 술폰

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN146736B (ko) * 1975-10-02 1979-08-25 Smith Kline French Lab
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
US4216318A (en) * 1975-12-29 1980-08-05 Smith Kline & French Laboratories Limited Heterocyclic alkyl 4-pyrimidones
US4227000A (en) * 1978-04-11 1980-10-07 Smith Kline & French Laboratories Limited Intermediates in the process for making histamine antagonists
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
US4255428A (en) * 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
EP0017680B1 (en) * 1979-04-11 1982-04-21 Smith Kline & French Laboratories Limited Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100498005B1 (ko) * 2002-07-26 2005-07-01 주식회사 소하드 기능성 액상비료 및 그 제조방법

Also Published As

Publication number Publication date
EP0068834A3 (en) 1983-04-06
DK286982A (da) 1982-12-28
ZW13082A1 (en) 1982-09-29
PT75074A (en) 1982-07-01
KR880001475B1 (ko) 1988-08-13
JPS6328424B2 (ko) 1988-06-08
US4535163A (en) 1985-08-13
ATE22891T1 (de) 1986-11-15
ES8305755A1 (es) 1983-05-01
PL138524B1 (en) 1986-09-30
JPH0244812B2 (ko) 1990-10-05
PL137627B1 (en) 1986-07-31
EP0068833A3 (en) 1983-03-30
ATE21900T1 (de) 1986-09-15
AU8535282A (en) 1983-01-06
US4486434A (en) 1984-12-04
US4444772A (en) 1984-04-24
JPS588079A (ja) 1983-01-18
YU138982A (en) 1985-03-20
GR74926B (ko) 1984-07-12
JPS61233670A (ja) 1986-10-17
IL66125A0 (en) 1982-09-30
IE53348B1 (en) 1988-10-26
IE821533L (en) 1982-12-27
PL240628A1 (en) 1983-10-10
EP0068833A2 (en) 1983-01-05
EP0068834B1 (en) 1986-09-03
DK287082A (da) 1982-12-28
PL237110A1 (en) 1983-06-20
FI822281L (fi) 1982-12-28
BG38163A3 (en) 1985-10-15
DD202291A5 (de) 1983-09-07
GR74925B (ko) 1984-07-12
PH19680A (en) 1986-06-13
DE3273019D1 (en) 1986-10-09
NZ201077A (en) 1985-09-13
JPH0345073B2 (ko) 1991-07-09
PL137600B1 (en) 1986-07-31
EP0068834A2 (en) 1983-01-05
JPS588080A (ja) 1983-01-18
JO1185B1 (en) 1983-11-30
AU8535182A (en) 1983-01-06
ZA824580B (en) 1983-05-25
JPS61233616A (ja) 1986-10-17
IL66125A (en) 1986-01-31
CS480082A2 (en) 1985-06-13
US4584381A (en) 1986-04-22
ES513469A0 (es) 1983-05-01
NO822120L (no) 1982-12-28
ZA824537B (en) 1983-05-25
CS241036B2 (en) 1986-03-13
FI822281A0 (fi) 1982-06-24
SU1232145A3 (ru) 1986-05-15
PT75074B (en) 1986-02-26
EP0068833B1 (en) 1986-10-15
AU551066B2 (en) 1986-04-17
DE3273782D1 (en) 1986-11-20
HU190396B (en) 1986-08-28

Similar Documents

Publication Publication Date Title
KR840000533A (ko) 화합물의 제조방법
KR850006404A (ko) 니트로 메틸렌 유도체의 제조방법
KR830005201A (ko) 2-r_3rn-3-r_1rn-5-py-6-q-피리딘 또는 그의 산부가염의 제조방법
KR840007406A (ko) 중추 신경계에 활성을 나타내는 복소환 화합물의 제조방법
ES8308326A1 (es) Procedimiento para la preparacion de amidobenzamidas.
EP0089765A3 (en) Pyridine derivatives
KR850001194A (ko) 화합물
KR840003630A (ko) 피리미돈 유도체
DK157854C (da) Analogifremgangsmaade til fremstilling af alfa-aryl-alfa-(2-pyridyl)-alkansyrederivater
KR920019752A (ko) 2-클로로피리딘의 제조방법
KR910011839A (ko) 이미다졸리딘 유도체, 그의 제조 방법 및 이를 함유하는 살충제
KR840006993A (ko) 피리딘 유도체
KR830005188A (ko) 혈당강하성 구아닐 아미딘의 제조방법
KR870002089A (ko) 아미디노 아졸의 제조방법
KR830007625A (ko) N-히드록시-1-r₁-1,2-디하이드로-2-옥소-5-py-6-r-니코틴이미드아마이드 또는 그의 산부가염의 제조방법
KR830003426A (ko) 테트라하이드로퀴놀린 유도체의 제조방법
KR830009040A (ko) 1-(2h)-이소퀴놀론 화합물 및 그 산부가염의 제조방법
SE8101592L (sv) Pyrazolopyridinoner och pyridinylnikotinater och forfarande for framstellning derav