KR830007698A - 암모니오메틸 화합물의 제조방법 - Google Patents

암모니오메틸 화합물의 제조방법 Download PDF

Info

Publication number: KR830007698A
Authority: KR; South Korea
Prior art keywords: formula; group; lower alkyl; compound; amino
Prior art date: 1980-09-12

Application number

KR1019810003417A

Other languages

English (en)

Korean (ko)

Inventor

뮬러 비이트

센데스 이반

Original Assignee

아놀드 자일러, 에론스트 알레르

시바-가이기 에이지

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-12

Filing date

1981-09-11

Publication date

1983-11-04

1981-09-11 Application filed by 아놀드 자일러, 에론스트 알레르, 시바-가이기 에이지 filed Critical 아놀드 자일러, 에론스트 알레르

1983-11-04 Publication of KR830007698A publication Critical patent/KR830007698A/ko

Links

-1 ammoniomethyl compound Chemical class 0.000 title claims 70
238000000034 method Methods 0.000 title claims 5
150000001875 compounds Chemical class 0.000 claims 26
125000000217 alkyl group Chemical group 0.000 claims 17
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
229910052739 hydrogen Inorganic materials 0.000 claims 12
239000001257 hydrogen Substances 0.000 claims 12
150000003839 salts Chemical class 0.000 claims 11
125000004356 hydroxy functional group Chemical group O* 0.000 claims 10
150000002431 hydrogen Chemical class 0.000 claims 8
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 7
125000000524 functional group Chemical group 0.000 claims 7
238000004519 manufacturing process Methods 0.000 claims 7
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
125000000753 cycloalkyl group Chemical group 0.000 claims 5
229910052736 halogen Inorganic materials 0.000 claims 5
150000002367 halogens Chemical class 0.000 claims 5
125000003342 alkenyl group Chemical group 0.000 claims 4
125000003545 alkoxy group Chemical group 0.000 claims 4
125000003282 alkyl amino group Chemical group 0.000 claims 4
125000004414 alkyl thio group Chemical group 0.000 claims 4
125000001589 carboacyl group Chemical group 0.000 claims 4
229910052799 carbon Inorganic materials 0.000 claims 4
150000001721 carbon Chemical group 0.000 claims 4
125000004093 cyano group Chemical group *C#N 0.000 claims 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical group C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 claims 3
YGTAZGSLCXNBQL-UHFFFAOYSA-N 1,2,4-thiadiazole Chemical group C=1N=CSN=1 YGTAZGSLCXNBQL-UHFFFAOYSA-N 0.000 claims 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
125000005115 alkyl carbamoyl group Chemical group 0.000 claims 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 3
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
239000003440 toxic substance Substances 0.000 claims 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
238000006243 chemical reaction Methods 0.000 claims 2
239000003795 chemical substances by application Substances 0.000 claims 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
231100000167 toxic agent Toxicity 0.000 claims 2
125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
230000010933 acylation Effects 0.000 claims 1
238000005917 acylation reaction Methods 0.000 claims 1
125000004423 acyloxy group Chemical group 0.000 claims 1
125000003158 alcohol group Chemical group 0.000 claims 1
125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
150000001408 amides Chemical class 0.000 claims 1
229910021529 ammonia Inorganic materials 0.000 claims 1
150000001735 carboxylic acids Chemical class 0.000 claims 1
125000004966 cyanoalkyl group Chemical group 0.000 claims 1
239000011521 glass Substances 0.000 claims 1
150000004678 hydrides Chemical class 0.000 claims 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
150000002443 hydroxylamines Chemical class 0.000 claims 1
TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims 1
150000002540 isothiocyanates Chemical class 0.000 claims 1
239000002184 metal Substances 0.000 claims 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
231100000252 nontoxic Toxicity 0.000 claims 1
230000003000 nontoxic effect Effects 0.000 claims 1
238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
230000001681 protective effect Effects 0.000 claims 1
125000001302 tertiary amino group Chemical group 0.000 claims 1
231100000331 toxic Toxicity 0.000 claims 1
230000002588 toxic effect Effects 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

KR1019810003417A 1980-09-12 1981-09-11 암모니오메틸 화합물의 제조방법 KR830007698A (ko)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH688180		1980-09-12
CH6881/80-5?		1980-09-12

Publications (1)

Publication Number	Publication Date
KR830007698A true KR830007698A (ko)	1983-11-04

Family

ID=4316521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019810003417A KR830007698A (ko)	1980-09-12	1981-09-11	암모니오메틸 화합물의 제조방법

Country Status (3)

Country	Link
JP (1)	JPS5781493A (ja)
KR (1)	KR830007698A (ja)
ZA (1)	ZA816321B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0062321B1 (en) *	1981-04-03	1989-03-01	Fujisawa Pharmaceutical Co., Ltd.	New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
JPS5841887A (ja) *	1981-08-19	1983-03-11	Fujisawa Pharmaceut Co Ltd	新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤
JPS5859992A (ja) *	1981-09-14	1983-04-09	Fujisawa Pharmaceut Co Ltd	新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤
JPS60226884A (ja) *	1984-04-25	1985-11-12	Dai Ichi Seiyaku Co Ltd	セフアロスポリン誘導体
CA1293719C (en) *	1986-09-22	1991-12-31	Takao Takaya	Cephem compounds and processes for preparation thereof
US5210080A (en) *	1987-09-07	1993-05-11	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU183006B (en) *	1978-12-29	1984-04-28	Fujisawa Pharmaceutical Co	Process for producing 7-substituted-3-cepheme- and cephame-4-carboxylic acid derivatives

1981
- 1981-09-11 ZA ZA816321A patent/ZA816321B/xx unknown
- 1981-09-11 KR KR1019810003417A patent/KR830007698A/ko unknown
- 1981-09-12 JP JP56143192A patent/JPS5781493A/ja active Pending

Also Published As

Publication number	Publication date
ZA816321B (en)	1982-09-29
JPS5781493A (en)	1982-05-21

Publication	Publication Date	Title
KR830007698A (ko)	1983-11-04	암모니오메틸 화합물의 제조방법
KR840007012A (ko)	1984-12-04	-7카르복시메톡시페닐아세트 아미도 -3-세펨 유도체의 제조방법 및 이를 함유한 항박테리아 제제
ES8305371A1 (es)	1983-04-01	Procedimiento de preparacion de derivados de la familia de las cefalosporinas.
ES8300774A1 (es)	1982-11-01	Un procedimiento para preparar nuevos compuestos de cefem
PT87945A (pt)	1989-06-30	Processo para a preparacao de novos derivados de cefalosporina
ES8207548A1 (es)	1982-09-16	Un procedimiento para preparar nuevos compuestos de cefem
ES483839A1 (es)	1980-09-01	Un procedimiento para preparar compuestos de acido 3-cefem- -4-carboxilico disustituido en las posiciones 3 y 7
GB950521A (en)	1964-02-26	Pyrimidinyl-guanazoles
IL62946A (en)	1985-03-31	Process for the preparation of 1-carbamoyl-3-(3,5-dichlorophenyl)-hydantoin and the compound 1-chlorocarbonyl-3-(3,5-dichlorophenyl)-hydantoin as an intermediate in this process
ES8602712A1 (es)	1985-12-01	Un procedimiento para preparar un derivado de rodanina
Okazaki et al.	1987	A new synthesis of 1, 3-thiazine derivatives having a dithiolane ring and their reductive cleavage with sodium cyanoborohydride
US4289775A (en)	1981-09-15	Penicillins
ES447615A1 (es)	1977-10-01	Un procedimiento para obtener compuesto de cefalosporina.
US3682944A (en)	1972-08-08	Certain 3-methylene diaxyphenyl-rhodanines
GB1211694A (en)	1970-11-11	Derivatives of 7-aminocephalosporanic acid
KR840004115A (ko)	1984-10-06	세푸록심 유도체의 제조방법
HUT45016A (en)	1988-05-30	Herbicides containing as active substance derivatives of piridil-phenil-ether and process for production of these derivatives
ES2002912A6 (es)	1988-10-01	Procedimiento para la produccion de antibioticos de cefalosporina
GB899199A (en)	1962-06-20	Production of ª--substituted alkyl penicillins and salts thereof
KR830006305A (ko)	1983-09-20	신규락탐의 제조방법
GB1368716A (en)	1974-10-02	Cephalosporin compounds
JPS54106495A (en)	1979-08-21	Cephem derivative
JPS56161395A (en)	1981-12-11	7-substituted ureido-3-cephem-4-carboxylic acid derivative, its preparation and preventing agent and remedy for microbism containing the same as active constituent
JPS55133385A (en)	1980-10-17	Novel cephem compound, its preparation, and remedy and preventive against microbism
ES480165A1 (es)	1980-04-01	Un procedimiento para preparar compuestos de cefem.