KR830007570A - 아자비시클로-옥탄-카복실산의 제조방법 - Google Patents

아자비시클로-옥탄-카복실산의 제조방법 Download PDF

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Publication number
KR830007570A
KR830007570A KR1019810004015A KR810004015A KR830007570A KR 830007570 A KR830007570 A KR 830007570A KR 1019810004015 A KR1019810004015 A KR 1019810004015A KR 810004015 A KR810004015 A KR 810004015A KR 830007570 A KR830007570 A KR 830007570A
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KR
South Korea
Prior art keywords
group
carboxylic acid
compound
structural formula
lower alkoxy
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KR1019810004015A
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English (en)
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KR860001877B1 (ko
Inventor
빈셀트 미셀
리봉 게오르그
라우비 미셀
Original Assignee
잭퀴스 미테
사이언스 유니온 에르 씨에 쏘시에떼 후란카이세 데 레차체 메디카레
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Publication of KR830007570A publication Critical patent/KR830007570A/ko
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Publication of KR860001877B1 publication Critical patent/KR860001877B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

아자비시클로-옥탄-카복실산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음의 구조식(Ⅱ)와 같은 아자비시클로옥탄-카복실산이나그의 에스테르 구조식(Ⅲ)과 같은 치환된 카복실산으로 작용시켜서 구조식(Ⅳ)의 산을 얻고 이를 사포닌화 및 가수소분해와 같은 통상의 보호 공정으로 처리하여 R1이 H인 구조식(Ⅰ)의 화합물로 전환시키고 이를 구조식(V)의 화합물과 환원알킬화 반응시켜서 X가 NH이고 R1이인 구조식(I)의 화합물을 얻는 것을 특징으로 하는 아자비 시클로-옥탄-카복실산의 제조방법.
    윗 구조식에서, A는 비닐렌이나 디메틸렌기, q는 0이나 1, R은 아미노그룹을 가질 수 있는 저급알킬기, X는 -S-나 -NH-, 그리고 R1은 수소, 또는기를 나타내며 여기에서 R2는 하이드록실이나 저급알콕시그룹, R3는 수소, 직쇄나 측쇄 알킬기, 시클로알킬알킬기, 또는 페닐 알킬기(이들은 각기 총탄소수가 8이상이다), 혹은-(CH2)P-기를 나타내는데 여기에서 R4는 H, 저급알킬기, 또는(C3-C6)-시클로 알킬기이고 R5는 H, (C3-C6)-시클로알킬기나 (저급알콕시)카보닐기이며 P는 1이나 2이다.
    그리고 R'는 하이드록시기나 저급알콕시기, R"는 알킬이나 보호된 아미노알킬기, X'는 SH나 NH2그룹으서 각기 아세틸, 벤질 옥시카보닐, 또는 3차 부톡시 카보닐과 같은 통상의 아실기로 보호된 그룹이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810004015A 1980-10-21 1981-10-21 아자비시클로-옥탄-카복실산의 제조방법 KR860001877B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8022438A FR2492381A1 (fr) 1980-10-21 1980-10-21 Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR80.22438 1980-10-21

Publications (2)

Publication Number Publication Date
KR830007570A true KR830007570A (ko) 1983-10-21
KR860001877B1 KR860001877B1 (ko) 1986-10-24

Family

ID=9247120

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004015A KR860001877B1 (ko) 1980-10-21 1981-10-21 아자비시클로-옥탄-카복실산의 제조방법

Country Status (29)

Country Link
US (1) US4397857A (ko)
EP (1) EP0051020B1 (ko)
JP (2) JPS5798281A (ko)
KR (1) KR860001877B1 (ko)
AR (1) AR228621A1 (ko)
AT (1) ATE8892T1 (ko)
AU (1) AU540609B2 (ko)
CA (1) CA1183140A (ko)
DD (1) DD201891A5 (ko)
DE (1) DE3165428D1 (ko)
DK (1) DK162444C (ko)
EG (1) EG15419A (ko)
ES (1) ES8301927A1 (ko)
FI (1) FI73678C (ko)
FR (2) FR2492381A1 (ko)
GR (1) GR75389B (ko)
HU (1) HU185058B (ko)
IE (1) IE51823B1 (ko)
IL (1) IL64075A0 (ko)
MA (1) MA19307A1 (ko)
MX (1) MX155032A (ko)
NO (1) NO155098C (ko)
NZ (1) NZ198701A (ko)
OA (1) OA06930A (ko)
PH (1) PH17338A (ko)
PT (1) PT73857B (ko)
SU (1) SU1138022A3 (ko)
YU (1) YU42587B (ko)
ZA (1) ZA817251B (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE20469T1 (de) * 1980-10-23 1986-07-15 Schering Corp Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
IE54551B1 (en) * 1982-01-22 1989-11-22 Ici Plc Amide derivatives
DE3227055A1 (de) * 1982-07-20 1984-01-26 Hoechst Ag, 6230 Frankfurt Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
DE3246757A1 (de) * 1982-12-17 1984-06-20 Hoechst Ag, 6230 Frankfurt Neue 2-azabicyclo(2.2.1)heptan-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(2.2.1)heptan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
DE3707911C1 (de) * 1987-03-12 1988-03-31 Texaco Ag Bicyclische Aminkatalysatoren
FR2619813B1 (fr) * 1987-08-28 1991-05-03 Adir Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2635684A1 (fr) * 1988-08-24 1990-03-02 Adir Utilisation de derives de l'acide aza - 2 bicyclooctane (2.2.2) carboxylique - 3 pour l'obtention de medicaments destines au traitement des maladies consecutives a l'alteration de la paroi vasculaire ainsi qu'aux troubles de la microcirculation
JPH0426348U (ko) * 1990-06-25 1992-03-02
TW197945B (ko) * 1990-11-27 1993-01-11 Hoechst Ag
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
IL152719A0 (en) * 2000-06-28 2003-06-24 Bristol Myers Squibb Co Selective androgen receptor modulators and methods for their identification
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE94175C (ko) *
GB1095105A (en) * 1965-04-12 1967-12-13 Scherico Ltd Novel n-(phenyl-sulfonyl)-isoquinuclidine-carboxamides
US3740408A (en) * 1967-09-11 1973-06-19 Upjohn Co Oxygenated 3-aza bicyclo(3,3,1)nonanes
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids

Also Published As

Publication number Publication date
DD201891A5 (de) 1983-08-17
MX155032A (es) 1988-01-21
US4397857A (en) 1983-08-09
DK460181A (da) 1982-04-22
IL64075A0 (en) 1982-01-31
NO155098C (no) 1987-02-11
ATE8892T1 (de) 1984-08-15
AR228621A1 (es) 1983-03-30
FR2525604A2 (fr) 1983-10-28
AU7662481A (en) 1982-04-29
HU185058B (en) 1984-11-28
DK162444B (da) 1991-10-28
FI813279L (fi) 1982-04-22
JPS6146453B2 (ko) 1986-10-14
FR2525604B2 (fr) 1985-06-07
NO155098B (no) 1986-11-03
NO813541L (no) 1982-04-22
PH17338A (en) 1984-08-01
JPS61126025A (ja) 1986-06-13
KR860001877B1 (ko) 1986-10-24
EP0051020A1 (fr) 1982-05-05
YU245481A (en) 1984-04-30
PT73857B (fr) 1983-01-25
EP0051020B1 (fr) 1984-08-08
JPS6112911B2 (ko) 1986-04-10
DE3165428D1 (en) 1984-09-13
GR75389B (ko) 1984-07-13
EG15419A (en) 1986-03-31
PT73857A (fr) 1981-11-01
ES506222A0 (es) 1983-01-01
IE812460L (en) 1982-04-21
FI73678C (fi) 1987-11-09
CA1183140A (fr) 1985-02-26
IE51823B1 (en) 1987-04-01
FR2492381B1 (ko) 1983-08-12
SU1138022A3 (ru) 1985-01-30
AU540609B2 (en) 1984-11-29
FI73678B (fi) 1987-07-31
OA06930A (fr) 1983-05-31
ZA817251B (en) 1982-09-29
DK162444C (da) 1992-03-23
JPS5798281A (en) 1982-06-18
YU42587B (en) 1988-10-31
MA19307A1 (fr) 1982-07-01
ES8301927A1 (es) 1983-01-01
NZ198701A (en) 1984-07-06
FR2492381A1 (fr) 1982-04-23

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