KR830004328A - Method for producing platinum (IV) -diamine-complex - Google Patents

Method for producing platinum (IV) -diamine-complex Download PDF

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KR830004328A
KR830004328A KR1019800005027A KR800005027A KR830004328A KR 830004328 A KR830004328 A KR 830004328A KR 1019800005027 A KR1019800005027 A KR 1019800005027A KR 800005027 A KR800005027 A KR 800005027A KR 830004328 A KR830004328 A KR 830004328A
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platinum
diamine complex
formula
prepared
accompanying drawings
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KR1019800005027A
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KR840000746B1 (en
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잔 불렌 에릭
버어빅 프랜코이스
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윌리암 알렉산더 드 공, 죠한스 종커
네델란드스 쎈트럴 오거니새티 부어 토게파스트 나투어웨텐샤펠리즈크 온더젝
죠한스 종커
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System

Abstract

내용 없음No content

Description

백금(Ⅳ)-디아민-복합체의 제조방법Method for producing platinum (IV) -diamine-complex

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

첨부도면은 본 발명에 관련된 여러 화합물의 구조식임.The accompanying drawings are structural formulas of various compounds related to the present invention.

Claims (26)

R1과 R2가 독자적으로 수소원자 또는 치환되거나 치환되지 않은 알킬, 시클로알킬, 아릴 또는 아르알킬기이며 반면, R1과 R2는 함께 치환되거나 치환되지 않은 시클로알킬기이며, R3와 R4는 수소원자 또는 치환되거나 또는 치환되지 않은 알킬, 아릴, 아르알킬기이며 X와 Y는 독자적으로 음이온기인 하기구조식의 백금(Ⅳ)-디 아민복합체.R 1 and R 2 are independently a hydrogen atom or a substituted or unsubstituted alkyl, cycloalkyl, aryl or aralkyl group, while R 1 and R 2 together are a substituted or unsubstituted cycloalkyl group, and R 3 and R 4 are A platinum (IV) -diamine complex of the following structural formula wherein a hydrogen atom or a substituted or unsubstituted alkyl, aryl, aralkyl group and X and Y are independently anionic groups. R1,R2,X와 Y가 청구범위 1에서와 같고 R1또는 R2가 탄소원자 1개이상을 함유하는 첨부도면중 구조식 6의 백금(Ⅳ)-디아민 복합체.Platinum (IV) -diamine complex of formula 6 in the accompanying drawings, wherein R 1 , R 2 , X and Y are the same as in claim 1 and R 1 or R 2 contains at least one carbon atom. 첨부도면중 구조식 7의 시스-디클로로-트랜스-디하이드록시-1,1-비스(아미노메틸) 시클로헥산 백금(Ⅳ).Cis-dichloro-trans-dihydroxy-1,1-bis (aminomethyl) cyclohexane platinum (IV) of formula 7 in the accompanying drawings. 첨부도면중 구조식 8의 시스-테트라클로로-1,1-비스(아미노메틸) 시클로헥산 백금(Ⅳ)Cis-tetrachloro-1,1-bis (aminomethyl) cyclohexane platinum (IV) of Structural Formula 8 in the accompanying drawings. 첨부도면중 구조식 9의 시스-테트라클로로-2,2-디에틸-1,3-디아미노프로판 백금(Ⅳ)Cis-tetrachloro-2,2-diethyl-1,3-diaminopropane platinum (IV) of formula 9 in the accompanying drawings. 첨부도면중 구조식 10의 시스-테트라클로로-1,1-비스(아미노메틸) 시클로부탄 백금(Ⅳ)Cis-tetrachloro-1,1-bis (aminomethyl) cyclobutane platinum (IV) of Structural Formula 10 in the accompanying drawings. 첨부도면중 구조식 11의 시스-디클로로-트랜스-디하이드록시-2,2-디에틸-1,3-디아미노프로판 백금(Ⅳ)Cis-dichloro-trans-dihydroxy-2,2-diethyl-1,3-diaminopropane platinum (IV) of formula 11 in the accompanying drawings. 첨부도면중 구조식 12의 시스-테트라클로로-1,1-비스(아미노메틸) 시클로펜탄 백금(Ⅳ)Cis-tetrachloro-1,1-bis (aminomethyl) cyclopentane platinum (IV) of Structural Formula 12 in the accompanying drawings. 첨부도면중 구조식 13의 시스-디클로로-트랜스-디하이드록시-1,1-비스(아미노메틸) 시클로펜탄 백금(Ⅳ)Cis-dichloro-trans-dihydroxy-1,1-bis (aminomethyl) cyclopentane platinum (IV) of formula 13 in the accompanying drawings. R1, R2, X와 Y가 청구범위 1 또는 2에서 규정한 것과 같은 구조식 5의 화합물을, 백금(Ⅳ) 디아민 복합체로서, 투여하기에 적당한 형태를 만드는 것을 특징으로 하는 활성 화합물로서 백금(Ⅳ) 디아민 복합체를 이용하여 암치료를 위한 의약품의 제조방법.Platinum (A) as an active compound, wherein R 1 , R 2 , X and Y form a form suitable for administration of the compound of formula 5 as defined in claims 1 or 2 as a platinum (IV) diamine complex. Ⅳ) A method for preparing a medicament for cancer treatment using the diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 7을 갖는 청구범위 3에 의한 화합물이 이용되는 것을 특징으로 하는 청구범위 10에 의한 방법.A method according to claim 10, characterized in that a compound according to claim 3 having the formula 7 is used as the platinum (IV) diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 8을 갖는 청구범위 4에 의한 화합물이 이용되는 것을 특징으로 하는 청구범위 10에 의한 방법.A method according to claim 10, characterized in that a compound according to claim 4 having the formula 8 is used as the platinum (IV) diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 9을 갖는 청구범위 5에 의한 화합물이 이용되는 것을 특징으로 하는 청구범위 10에 의한 방법.The method according to claim 10, wherein the compound according to claim 5 having the structural formula 9 is used as the platinum (IV) diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 10을 갖는 청구범위 6에 의한 화합물이 이용되는 것을 특징으로하는 청구범위 10에 의한 방법.A method according to claim 10, characterized in that a compound according to claim 6 having the formula 10 is used as the platinum (IV) diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 11을 갖는 청구범위 7에 의한 화합물이 이용된것을 특징으로하는 청구범위 10에 의한 방법.A method according to claim 10, characterized in that a compound according to claim 7 having structure 11 is used as platinum (IV) diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 12을 갖는 청구범위 8에 의한 화합물이 이용되는 것을 특징으로하는 청구범위 10에 의한 방법.A method according to claim 10, wherein a compound according to claim 8 having structure 12 is used as platinum (IV) diamine complex. 백금(Ⅳ) 디아민 복합체로서 구조식 13을 갖는 청구범위 9에 의한 화합물이 이용되는 것을 특징으로 하는 청구범위 10에 의한 방법.The method according to claim 10, wherein a compound according to claim 9 having the formula 13 is used as the platinum (IV) diamine complex. 청구범위 10-17에 따른 공정을 이용하여 얻어진 성형된 의약품.Molded pharmaceuticals obtained using the process according to claims 10-17. R1, R2, X와 Y가 청구범위 1 또는 2에 규정한 것과 같은 구조식 5를 갖는 백금(Ⅳ) 디아민 복합체가 공지된 방법으로 제조되는 것을 특징으로 하는 청구범위 10-17에 따른 공정에 사용되는 백금(Ⅳ)-디아민 복합체의 제조방법.A process according to claim 10-17, wherein a platinum (IV) diamine complex having the structure 5, wherein R 1 , R 2 , X and Y, as defined in claims 1 or 2, is prepared by a known method. Method for producing the platinum (IV) -diamine complex used. 구조식 7을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.Process according to claim 19, characterized in that a platinum (IV) diamine complex having the structure 7 is prepared. 구조식 8을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.The method according to claim 19, wherein a platinum (IV) diamine complex having the structure (8) is prepared. 구조식 9을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.Process according to claim 19, characterized in that a platinum (IV) diamine complex having the structure 9 is prepared. 구조식 10을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.The method according to claim 19, wherein a platinum (IV) diamine complex having the structure 10 is prepared. 구조식 11을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.The method according to claim 19, wherein a platinum (IV) diamine complex having the structure 11 is prepared. 구조식 12을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.The method according to claim 19, wherein a platinum (IV) diamine complex having the structure 12 is prepared. 구조식 13을 갖는 백금(Ⅳ) 디아민 복합체가 제조되는 것을 특징으로하는 청구범위 19에 의한 방법.Process according to claim 19, characterized in that a platinum (IV) diamine complex having structure 13 is prepared. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019800005027A 1980-12-30 1980-12-30 The preparation for platinum(tv)diamine complexes KR840000746B1 (en)

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