KR830004259A - Method for preparing α-aryl-1H-imidazole-1-ethanol - Google Patents

Method for preparing α-aryl-1H-imidazole-1-ethanol Download PDF

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Publication number
KR830004259A
KR830004259A KR1019800004332A KR800004332A KR830004259A KR 830004259 A KR830004259 A KR 830004259A KR 1019800004332 A KR1019800004332 A KR 1019800004332A KR 800004332 A KR800004332 A KR 800004332A KR 830004259 A KR830004259 A KR 830004259A
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KR
South Korea
Prior art keywords
carbon atoms
alkyl
compound
formula
hydrogen
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Application number
KR1019800004332A
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Korean (ko)
Inventor
케네트 스펜서 호머
Original Assignee
진 크레머, 한스-루돌프 하우스
산도즈 리미티드
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Application filed by 진 크레머, 한스-루돌프 하우스, 산도즈 리미티드 filed Critical 진 크레머, 한스-루돌프 하우스
Publication of KR830004259A publication Critical patent/KR830004259A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Abstract

내용 없음No content

Description

α-아릴-1H-이미다졸-1-에탄올의 제조방법Method for preparing α-aryl-1H-imidazole-1-ethanol

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

다음 일반식 Ⅱ화합물과 다음 일반식 Ⅲ화합물을 불활성 유기용매중에서 반응시키거나, 다음 일반식 Ⅰb 화합물의 CH3그룹을 산화시켜 다음 일반식 Ⅰa 화합물을 수득하거나, 다음 일반식 Ⅳ의 알콜로 일반식 Ⅰa 화합물을 에스테르화하여 다음 일반식 Ⅰc 화합물을 수득하는 것을 특징으로하여 다음 일반식 Ⅰ화합물을 제조하는 방법.The following Formula II compound and the following Formula III compound are reacted in an inert organic solvent, or the CH 3 group of the following Formula Ib compound is oxidized to obtain the following Formula Ia compound, or the alcohol of Formula IV A process for preparing the following compound of formula (I), characterized by esterifying the compound (1a) to yield the following compound of formula (Ic). 상기에서From above R0는 탄소수 2 내지 6의 알킬, 탄소수 3 내지 6의 시클로알킬, 시클로알킬이 탄소수 3 내지 6이고 알킬이 탄소수 1 내지 3인 시클로알킬알킬인데, 상기의 시클로알킬 및 시클로알킬알킬은 환상에 탄소수 1 내지 3의 알킬그룹 하나 또는 둘로 임의 치환되며,R 0 is alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms and cycloalkylalkyl having 1 to 3 alkyl atoms, wherein the cycloalkyl and cycloalkylalkyl have cyclic carbon atoms Optionally substituted with one or two alkyl groups of 1 to 3, R은 수소, 원자번호 9 내지 35의 할로겐, 탄소수 1 내지 4의 알킬, 탄소수 1 내지 4의 알콕시, 탄소수 1 내지 4의 알킬티오 또는 니트로이며,R is hydrogen, halogen of atomic number 9 to 35, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio or nitro of 1 to 4 carbon atoms, R'는 수소, 원자번호 9 내지 35의 할로겐, 탄소수 1 내지 4의 알킬, 탄소수 1 내지 4의 알콕시, 탄소수 1 내지 4의 알킬티오 또는 니트로, A환 3-위치의 -CF3, -CN, -COOR", A환 4위치의 일반식의 임의 치환된 페닐그룹 또는 일반식의 임의 치환된 페녹시그룹이며 R"는 수소 또는 탄소수 1 내지 4의 알킬이거나 R 및 R'는 함께 페닐환 A의 탄소원자상에 치환된 탄소수 1 또는 2의 알킬렌디옥시를 나타내고,R 'is hydrogen, halogen of atomic number 9 to 35, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio or nitro of 1 to 4 carbon atoms, -CF 3 , -CN in the 3 -position of A ring, -COOR ", general formula of A position 4 position Optionally substituted phenyl group or a general formula of Is an optionally substituted phenoxy group of R " is hydrogen or alkyl of 1 to 4 carbon atoms or R and R 'together represent an alkylenedioxy of 1 or 2 carbon atoms substituted on a carbon atom of phenyl ring A, Y0및 Y는 각각 수소, 원자번호 9 내지 35의 할로겐, 탄소수 1 내지 4의 알킬 또는 탄소수 1 내지 4의 알콕시이며, 단 R0가 n-부틸이면Y 0 and Y are each hydrogen, halogen of atomic number 9 to 35, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, provided that R 0 is n-butyl a) 최소한 R 및 R'중 하나는수소가 아니며a) at least one of R and R 'is not hydrogen; b) R 또는 R'는 할로가 아니어야 하며b) R or R 'must not be halo X는 알칼리금속이고X is an alkali metal AlK는 C1-C4알킬이며 일반식 Ⅳ의 AlK는 C1-C4알킬이거나 그의 반응성의 관능성 유도체이다.AlK is C 1 -C 4 alkyl and AlK in Formula IV is C 1 -C 4 alkyl or a reactive functional derivative thereof. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019800004332A 1979-11-13 1980-11-12 Method for preparing α-aryl-1H-imidazole-1-ethanol KR830004259A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9380079A 1979-11-13 1979-11-13
US93800 1998-06-09

Publications (1)

Publication Number Publication Date
KR830004259A true KR830004259A (en) 1983-07-09

Family

ID=22240802

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800004332A KR830004259A (en) 1979-11-13 1980-11-12 Method for preparing α-aryl-1H-imidazole-1-ethanol

Country Status (4)

Country Link
JP (1) JPS5686167A (en)
KR (1) KR830004259A (en)
BE (1) BE886127A (en)
ZA (1) ZA807053B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2946956A1 (en) * 1979-11-21 1981-06-19 Bayer Ag, 5090 Leverkusen HYDROXYBUTYL-IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
CN1008735B (en) * 1984-11-02 1990-07-11 拜尔公司 Pyrrole ylmethyl-cyclopropyl-carbinol derivatives with replacement is a composition of active components
JP2539261B2 (en) * 1987-12-09 1996-10-02 エスエス製薬株式会社 Imidazole derivative
JP2006347882A (en) * 2003-09-02 2006-12-28 Ss Pharmaceut Co Ltd Benzyl alcohol derivative or salt thereof
AR100743A1 (en) * 2014-06-06 2016-10-26 Basf Se COMPOUNDS OF [1,2,4] SUBSTITUTED TRIAZOL

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Publication number Publication date
ZA807053B (en) 1982-06-30
JPS5686167A (en) 1981-07-13
BE886127A (en) 1981-05-13

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