KR830001220A - Method for preparing 4- (2'-pyridylamino) phenyl acetic acid derivative - Google Patents

Method for preparing 4- (2'-pyridylamino) phenyl acetic acid derivative Download PDF

Info

Publication number
KR830001220A
KR830001220A KR1019790004158A KR790004158A KR830001220A KR 830001220 A KR830001220 A KR 830001220A KR 1019790004158 A KR1019790004158 A KR 1019790004158A KR 790004158 A KR790004158 A KR 790004158A KR 830001220 A KR830001220 A KR 830001220A
Authority
KR
South Korea
Prior art keywords
hydrogen
halogen
methyl
carbon atoms
compound
Prior art date
Application number
KR1019790004158A
Other languages
Korean (ko)
Other versions
KR830002276B1 (en
Inventor
히도시 우노
야스다게 나가이
가쓰히고 히노
히데오 나가무라
Original Assignee
미야다게 도구지로오
다이닛뽕 세이야구 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미야다게 도구지로오, 다이닛뽕 세이야구 가부시기 가이샤 filed Critical 미야다게 도구지로오
Priority to KR1019790004158A priority Critical patent/KR830002276B1/en
Publication of KR830001220A publication Critical patent/KR830001220A/en
Application granted granted Critical
Publication of KR830002276B1 publication Critical patent/KR830002276B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

4-(2'-피리딜아미노) 페닐 아세트산 유도체의 제조방법Method for preparing 4- (2'-pyridylamino) phenyl acetic acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

쥐의 관절염에 대한 시험 화합물의 예방효과를 표시하는 그래프.Graph showing the protective effect of test compounds on arthritis in rats.

Claims (6)

일반식 : General formula: 의 화합물을 일반식 : Compound of general formula: 의 화합물과 반응시켜서 일반식 : React with compounds of general formula: 의 화합물을 얻고, 상기의 화합물을 임의로 가수분해하고, 또 더 나아가서 임의로 탈카르복시반응을 시키며, 또 임의로 그 생성 화합물을 약제로 사용 가능한 염으로 전환시키는 일반식:A compound of formula (I), wherein the compound is optionally hydrolyzed, and further optionally, a decarboxylation reaction is carried out, and optionally the resulting compound is converted into a salt usable as a medicament: 인 화합물 또는 약제로 사용 가능한 염의 제조방법.Process for preparing a salt which can be used as a phosphorus compound or a medicament. 여기서, R1은 수소, 할로겐, 1 내지 3 탄소원자를 가진 저급 알킬, 또는 니트로이고, R2는 수소, 할로겐, 또는 1 내지 3 탄소원자를 가진 저급 알킬, R3은 수소, 할로겐, 또는 1 내지 3 탄소원자를 가진 저급 알킬, R4는 수소 또는 1 내지 3 탄소원자를 가진 저급 알킬, R5는 수소 또는 2 내지 3 탄소원자를 갖고, 그리고 R1또는 R2가 4-할로겐이 아닌 경우에는 1 또는 2 히드록시기로 치환된 -CH2CH2OR6, X는 할로겐이고, Z는, 또는 탈카르복시반응을 수반시키는 임의의 가수분해에 의하여로 전환시킬 수 있는 것이다.Wherein R 1 is hydrogen, halogen, lower alkyl having 1 to 3 carbon atoms, or nitro, R 2 is hydrogen, halogen, or lower alkyl having 1 to 3 carbon atoms, R 3 is hydrogen, halogen, or 1-3 Lower alkyl having carbon atoms, R 4 is hydrogen or lower alkyl having 1 to 3 carbon atoms, R 5 has hydrogen or 2 to 3 carbon atoms, and 1 or 2 hydroxy groups when R 1 or R 2 is not 4-halogen; Substituted with -CH 2 CH 2 OR 6 , X is halogen, Z is Or by any hydrolysis involving a decarboxylation reaction Can be converted to. R1이 수소, 할로겐, 또는 니트로이고, 그리고 R2가 수소 또는 할로겐인 청구범위 제1항에 의거한 방법.The process according to claim 1, wherein R 1 is hydrogen, halogen, or nitro, and R 2 is hydrogen or halogen. R1및 R2가 공히 수소이고, R3이 수소, 3-할로겐, 또는 2,3-메틸, R4가 메틸, 그리고 R5가 수소 또는 2-(2-히드록시에톡시) 에틸인 청구범위 제1항에 의거한 방법.R 1 and R 2 are both hydrogen and R 3 is hydrogen, 3-halogen, or 2,3-methyl, R 4 is methyl, and R 5 is hydrogen or 2- (2-hydroxyethoxy) ethyl Scope Method according to claim 1. R1, R2, R3그리고 R5가 다같이 수소이고, R4가 메틸인 청구범위 제1항에 의거한 방법.The process according to claim 1 , wherein R 1 , R 2 , R 3 and R 5 are all hydrogen and R 4 is methyl. R1, R2및 R5가 다같이 수소이고, R3이 3-염소, R4가 메틸인 청구범위 제1항에 의거한 방법.The process according to claim 1 , wherein R 1 , R 2 and R 5 are together hydrogen, R 3 is 3-chlorine and R 4 is methyl. R1, R2및 R5가 다같이 수소이고, 그리고 R3이 3-메틸, 그리고 R4가 메틸인 청구범위제1항에 의거한 방법.The process according to claim 1 , wherein R 1 , R 2 and R 5 are together hydrogen and R 3 is 3-methyl and R 4 is methyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019790004158A 1979-11-27 1979-11-27 Method for preparing 4- (2'-pyridyl amino) phenyl acetic acid derivative KR830002276B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019790004158A KR830002276B1 (en) 1979-11-27 1979-11-27 Method for preparing 4- (2'-pyridyl amino) phenyl acetic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019790004158A KR830002276B1 (en) 1979-11-27 1979-11-27 Method for preparing 4- (2'-pyridyl amino) phenyl acetic acid derivative

Publications (2)

Publication Number Publication Date
KR830001220A true KR830001220A (en) 1983-04-29
KR830002276B1 KR830002276B1 (en) 1983-10-21

Family

ID=19213672

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019790004158A KR830002276B1 (en) 1979-11-27 1979-11-27 Method for preparing 4- (2'-pyridyl amino) phenyl acetic acid derivative

Country Status (1)

Country Link
KR (1) KR830002276B1 (en)

Also Published As

Publication number Publication date
KR830002276B1 (en) 1983-10-21

Similar Documents

Publication Publication Date Title
KR860001104A (en) Method for producing tetrahydrophthalimide
ES473074A1 (en) Thienothiazine derivatives, their preparation and compositions containing them.
KR850000406A (en) Method for preparing 4-chloro-2-phenylimidazole-5-acetic acid derivative
ES2000910A6 (en) Preparation of substituted and disubstituted pyridine-2,3-dicarboxylate esters.
KR840001952A (en) N- (4- (3-aminopropyl) aminobutyl) -2- (ω) -guanidino-fatty acid-amido) -2-substituted-ethanamide salts thereof and process for preparing them
KR870002056A (en) Process for preparing substituted propargyloxyacetonitrile derivatives
KR830007631A (en) 2-pyridinecarboxamide derivatives and preparation method thereof
KR840004746A (en) Method for preparing 2-oxo-1-azetidinesulfonic acid derivative
KR830001220A (en) Method for preparing 4- (2'-pyridylamino) phenyl acetic acid derivative
ES463783A1 (en) Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
KR880007490A (en) Substituted aminopropionamides, methods of preparation thereof, medicaments containing the same, uses thereof and intermediates produced during the preparation thereof
ATE8257T1 (en) PROCESS FOR THE PREPARATION OF 4-QUINOLINONES.
KR860008983A (en) Method for preparing 4-benzoyl-1-alkyl (alkenyl) pyrazole
KR870004038A (en) Method for preparing herbicide compound
KR830001900A (en) Phenylmorphane and its intermediates and preparation methods
ES432789A1 (en) Procedure for the preparation of benzytamines. (Machine-translation by Google Translate, not legally binding)
KR840001165A (en) Process for preparing cydnon imine derivative
KR840002821A (en) Method for preparing N- (2,3-epoxypropylene) -N-aralkylsulfonamide derivative
ES378203A1 (en) 2-(imidazolid inylidence-(2)-amino)-5-nitro-thiazoles and salts thereof
KR840003632A (en) Method for preparing furyloxazolyl acetic acid derivative
KR830003487A (en) Method for preparing benzodiazepines derivatives
KR840002848A (en) Method for preparing organophosphate
KR900006295A (en) Halogeno-4-methylpyrazoles and preparation method thereof
ES469524A1 (en) A procedure for the preparation of certain sters of the acid4 - ((dipropilamino) -sulfonil) -benzoic. (Machine-translation by Google Translate, not legally binding)
KR830001265A (en) New thiadiazole compounds and preparation method thereof

Legal Events

Date Code Title Description
E701 Decision to grant or registration of patent right