ES463783A1 - Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them - Google Patents

Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them

Info

Publication number
ES463783A1
ES463783A1 ES463783A ES463783A ES463783A1 ES 463783 A1 ES463783 A1 ES 463783A1 ES 463783 A ES463783 A ES 463783A ES 463783 A ES463783 A ES 463783A ES 463783 A1 ES463783 A1 ES 463783A1
Authority
ES
Spain
Prior art keywords
octahydro
formula
pyrindines
cis
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES463783A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES463783A1 publication Critical patent/ES463783A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Abstract

A process for the preparation of 2-substituted cis-4A-aryl-octahydro-1H-octahydro-1H-2-pyrindines of general formula: ** (Formula 01) ** where R1 is C1-C8 alkyl or CH2R3; where R3 is C2-C7 alkenyl or tetrahydrofuryl; R2 is hydrogen, hydroxy or C1-C3 alkoxy; and its non-toxic and pharmaceutically acceptable acid addition salts; whose procedure is characterized by reacting a compound of the general formula: ** (Formula 02) ** where R2 is as defined above and R''1 is hydrogen, with an alkylating agent and optionally deesterify when R2 is C1-C3 alkoxy to obtain a compound of formula (I) where R2 is hydroxy. (Machine-translation by Google Translate, not legally binding)
ES463783A 1976-11-02 1977-11-02 Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them Expired ES463783A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
ES463783A1 true ES463783A1 (en) 1979-07-16

Family

ID=24965981

Family Applications (3)

Application Number Title Priority Date Filing Date
ES463783A Expired ES463783A1 (en) 1976-11-02 1977-11-02 Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
ES463784A Expired ES463784A1 (en) 1976-11-02 1977-11-02 Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
ES472276A Expired ES472276A1 (en) 1976-11-02 1978-08-01 Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES463784A Expired ES463784A1 (en) 1976-11-02 1977-11-02 Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
ES472276A Expired ES472276A1 (en) 1976-11-02 1978-08-01 Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them

Country Status (26)

Country Link
JP (1) JPS5356669A (en)
AR (1) AR223454A1 (en)
AT (1) ATA782177A (en)
AU (1) AU513679B2 (en)
BE (1) BE860314A (en)
CA (1) CA1100136A (en)
CS (1) CS211380B2 (en)
DD (1) DD133795A5 (en)
DE (1) DE2748466A1 (en)
DK (1) DK485277A (en)
ES (3) ES463783A1 (en)
FR (1) FR2369267A1 (en)
GB (1) GB1590155A (en)
GR (1) GR70053B (en)
HU (1) HU176231B (en)
IE (1) IE45901B1 (en)
IL (1) IL53236A0 (en)
NL (1) NL7712053A (en)
NZ (1) NZ185539A (en)
PH (1) PH12590A (en)
PL (3) PL108466B1 (en)
PT (1) PT67194B (en)
RO (3) RO72900A (en)
SE (3) SE7712218L (en)
SU (3) SU812174A3 (en)
ZA (1) ZA776497B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT68934A (en) * 1977-12-27 1979-01-01 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
EP2595989B1 (en) 2010-05-06 2016-07-13 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
US8916565B2 (en) 2011-02-02 2014-12-23 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
EP2675812B1 (en) 2011-02-18 2017-08-30 Vertex Pharmaceuticals Incorporated Chroman - spirocyclic piperidine amides as modulators of ion channels
AU2012229187B2 (en) 2011-03-14 2016-11-10 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
AR223454A1 (en) 1981-08-31
CS211380B2 (en) 1982-02-26
IL53236A0 (en) 1977-12-30
SU913941A3 (en) 1982-03-15
SU845777A3 (en) 1981-07-07
ES463784A1 (en) 1978-06-16
RO78300A (en) 1982-04-12
NZ185539A (en) 1979-12-11
BE860314A (en) 1978-04-28
SU812174A3 (en) 1981-03-07
PT67194B (en) 1979-03-23
HU176231B (en) 1981-01-28
PL108466B1 (en) 1980-04-30
GB1590155A (en) 1981-05-28
DD133795A5 (en) 1979-01-24
ATA782177A (en) 1981-10-15
NL7712053A (en) 1978-05-05
DK485277A (en) 1978-05-03
SE8103107L (en) 1981-05-18
FR2369267A1 (en) 1978-05-26
ES472276A1 (en) 1979-10-01
PL109690B1 (en) 1980-06-30
CA1100136A (en) 1981-04-28
JPS5356669A (en) 1978-05-23
IE45901B1 (en) 1982-12-29
SE7712218L (en) 1978-05-02
DE2748466A1 (en) 1978-05-03
RO72900A (en) 1981-11-04
PT67194A (en) 1977-11-01
AU513679B2 (en) 1980-12-18
GR70053B (en) 1982-07-26
RO77935A (en) 1981-12-25
IE45901L (en) 1978-05-02
FR2369267B1 (en) 1980-05-16
AU3023577A (en) 1979-05-10
SE8103106L (en) 1981-05-18
PL108610B1 (en) 1980-04-30
PH12590A (en) 1979-06-27
PL201885A1 (en) 1978-12-04
ZA776497B (en) 1979-06-27

Similar Documents

Publication Publication Date Title
JPS5513278A (en) Benzomorphane compound and medical compound containing it
ES394370A1 (en) Pharmacologically active 3-piperazinyl-carbonyloxy-2-pyridyl-isoindolin-1-ones
ES413639A1 (en) Dopamine derivatives
ES8802039A1 (en) 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions.
ES463783A1 (en) Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
ES457993A1 (en) Isothiazolo-pyridines
ES8106289A1 (en) Derivatives of alpha-phenyl-2-pyrrolidine methanol and their salts, process for their preparation, use as medicines and compositions containing them.
ES476385A1 (en) Novel pyrindines and their preparation, formulations and use.
DK373783D0 (en) THIENO-THIAZOL DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE
ES421067A1 (en) Procedure for the preparation of new 2-phenylamine-substitute imidazolines. (Machine-translation by Google Translate, not legally binding)
ES418827A1 (en) 2-aminoindane derivatives
ES466127A1 (en) 4"-deoxyvincristine and related compounds
ES8601910A1 (en) New amidine derivatives of 2-substituted 4-phenilimidazole.
ES8401957A1 (en) Preparation of thiophene compounds
ES446132A1 (en) A procedure for the preparation of new derivatives of 2-alkyl (bottom) -2 or 3-cefem-4-carboxylic acid. (Machine-translation by Google Translate, not legally binding)
GB2001062A (en) Preparation of Pyridinecarboxylic acid piperazides
ES8403891A1 (en) Furyloxazolylacetic acid derivatives, process for preparing same and pharmaceutical compositions containing same.
ES471872A1 (en) Tetrahydro-s-triazine thiones, process for their preparation and acaricidal compositions containing them.
ES401342A1 (en) Pyridine derivatives
ES413742A1 (en) Derivatives of alpha-halo-alpha-benzyl propionic acid
ES476405A1 (en) Methylthiofluorothioxanthene derivative, its preparation and compositions containing it.
ES472572A1 (en) F3-phenoxy-n-substituted morphinan derivatives their manufacture and pharmaceutical preparations containing them
ES444483A1 (en) A procedure for the preparation of new derivatives of acid2,3-alquilen (lower) penam-3-carboxylic. (Machine-translation by Google Translate, not legally binding)
ES398368A1 (en) A procedure for the preparation of new derivatives of 1,2,3,4-tetrahidroisoquinoleina. (Machine-translation by Google Translate, not legally binding)
ES405106A1 (en) Substituted pyrrolidines