KR830000679A - N-알킬화 아미노알콜의 제조방법 - Google Patents

N-알킬화 아미노알콜의 제조방법 Download PDF

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Publication number
KR830000679A
KR830000679A KR1019820001066A KR820001066A KR830000679A KR 830000679 A KR830000679 A KR 830000679A KR 1019820001066 A KR1019820001066 A KR 1019820001066A KR 820001066 A KR820001066 A KR 820001066A KR 830000679 A KR830000679 A KR 830000679A
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group
substituted
hydrogen
hydroxyl
preparing
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KR1019820001066A
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오스터마이어 푸란쯔
찌머만 마르쿠스
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아놀드 자일러 에른스트 알테르
시바 가이기 에이지
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Publication of KR830000679A publication Critical patent/KR830000679A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

내용 없음

Description

N-알킬화 아미노알콜의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(IV)의 화합물 또는 그의 염을 수소화시키고, 하이드록실 보호그룹을 제거시킴을 특징으로 하여 일반식(I)의 N-알킬화 아미노알콜 및 그의 염을 제조하는 방법.
    상기식중
    Ar은 치환되지 않거나 하이드록실로 치환된 방향족기이고,
    n은 0 또는 1이며,
    Alk는 탄소수 2 내지 5개의 알킬렌기이며,
    질소원자는 산소원자 또는 n이 0인 경우에는 페닐기와 적어도 2개의 탄소원자에 의해 서로 분리되어 있고,
    Ar1은 Ar기에서 정의된 바와 같거나 또는 하이드록실 기로 전환될 수 없는 그룹 1 내지 2개로 치환된 Ar기이고, x2, x3및 x4는 각각 수소이거나 수소로 치환될 수 있는 치환기이고 x5는 수소이거나, x2및 x3및/또는 x4및 x5가 함께 두개의 수소원자로 치환될 수 있는 2가(價)기이며, 단, 이때 x2, x3및 x4기중의 적어도 하나는 수소가 아니거나 적어도 Ar1이 히드록실기로 전환될 수 있는 그룹 1 내지 2개로 치환된 Ar기이거나 적어도 x2및 x3가 함께 또는 x4및 x5가 함께 두개의 수소원자로 치환될 수 있는 2가기이다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019820001066A 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법 KR830000679A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH613678 1978-06-05
CH6136/78-4? 1978-06-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR7901814A Division KR840000926B1 (ko) 1978-06-05 1979-06-04 N-알킬화된 아미노알콜의 제조방법

Publications (1)

Publication Number Publication Date
KR830000679A true KR830000679A (ko) 1983-04-18

Family

ID=4304840

Family Applications (4)

Application Number Title Priority Date Filing Date
KR7901814A KR840000926B1 (ko) 1978-06-05 1979-06-04 N-알킬화된 아미노알콜의 제조방법
KR1019820001067A KR830000680A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법
KR1019820001068A KR830000681A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법
KR1019820001066A KR830000679A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법

Family Applications Before (3)

Application Number Title Priority Date Filing Date
KR7901814A KR840000926B1 (ko) 1978-06-05 1979-06-04 N-알킬화된 아미노알콜의 제조방법
KR1019820001067A KR830000680A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법
KR1019820001068A KR830000681A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법

Country Status (26)

Country Link
US (1) US4460580A (ko)
EP (1) EP0005848B1 (ko)
JP (1) JPS54163543A (ko)
KR (4) KR840000926B1 (ko)
AR (3) AR229022A1 (ko)
AT (1) ATE511T1 (ko)
AU (1) AU522483B2 (ko)
CA (1) CA1124241A (ko)
CY (1) CY1256A (ko)
DD (1) DD144050A5 (ko)
DE (1) DE2961669D1 (ko)
DK (1) DK229879A (ko)
ES (1) ES481238A1 (ko)
FI (1) FI791727A (ko)
GB (1) GB2026474B (ko)
GR (1) GR74057B (ko)
HK (1) HK15585A (ko)
HU (1) HU182019B (ko)
IL (1) IL57471A (ko)
MY (1) MY8500690A (ko)
NO (1) NO149034C (ko)
NZ (1) NZ190632A (ko)
PL (5) PL116612B1 (ko)
PT (1) PT69723A (ko)
SG (1) SG45884G (ko)
ZA (1) ZA792748B (ko)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
CA1152517A (en) 1979-06-29 1983-08-23 Ian H. Coates Heterocyclic compounds, processes for their preparation and their use
DD157796A5 (de) * 1979-12-04 1982-12-08 Ciba Geigy Ag Verfahren zur herstellung neuer derivate des 2-amino-aethanols
JPS5726653A (en) * 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
DE3026534A1 (de) * 1980-07-12 1982-03-18 C.H. Boehringer Sohn, 6507 Ingelheim 3,1-benzoxazin-2-one, ihre herstellung und verwendung
GR74992B (ko) * 1980-08-13 1984-07-12 Ciba Geigy Ag
JPS57185243A (en) * 1981-05-08 1982-11-15 Ciba Geigy Ag Substituted 2-aminoethanol
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
FR2543139B1 (fr) * 1983-03-22 1985-08-16 Cerm Cent Europ Rech Mauvernay Derives de (1-alcoxy 2-amino) ethyl pyridine ou pyrazine, leur preparation et leur application en therapeutique
DE3621775A1 (de) * 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3608290A1 (de) * 1986-03-13 1987-09-24 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1287061C (en) * 1986-06-27 1991-07-30 Roche Holding Ltd. Pyridine ethanolamine derivatives
GB8714901D0 (en) * 1986-07-23 1987-07-29 Ici Plc Amide derivatives
DE3627663A1 (de) * 1986-08-14 1988-03-03 Bayer Ag Heteroarylethylamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
JPH0466934A (ja) * 1990-07-04 1992-03-03 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5232948A (en) * 1990-09-10 1993-08-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted monocyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
WO1993004373A1 (en) * 1991-08-23 1993-03-04 Nps Pharmaceuticals, Inc. Calcium receptor active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5208252A (en) * 1992-07-24 1993-05-04 Ortho Pharmaceutical Corporation Aminoethylthiophene derivatives
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
AU1533495A (en) * 1994-01-12 1995-08-01 Byk Nederland Bv Phenyl ethanol amine ethers and uses thereof as beta-adreno-receptor agonists
BRPI9509411B8 (pt) 1994-10-21 2021-07-06 Nps Pharma Inc composto modulador de receptor de íon inorgânico e composição farmacêutica
ES2201300T3 (es) * 1996-05-01 2004-03-16 Nps Pharmaceuticals, Inc. Compuestos activos frente a receptores de iones inorganicos.
KR100380520B1 (ko) * 2000-09-08 2003-04-23 한국화학연구원 피리딘을 포함한 β-아미노알코올 유도체
JP2005523565A (ja) * 2002-04-22 2005-08-04 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 発光スクリーン
US7538141B2 (en) * 2004-03-23 2009-05-26 Alan Daniel Brown Compounds for the treatment of diseases
JP2013522195A (ja) * 2010-03-08 2013-06-13 ザ ユニバーシティー オブ テネシー リサーチ ファウンデーション ベータアドレナリン受容体アゴニスト及びその使用
ITMI20122221A1 (it) * 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende
CN104008939B (zh) * 2014-06-19 2016-05-11 苏州普京真空技术有限公司 一种耐用电子枪灯丝
USD954933S1 (en) 2018-06-01 2022-06-14 Chiaro Technology Limited Breast pump accessory

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178400A (en) * 1966-12-13 1970-01-21 Delalande Sa Nitrogen Substituted Amines and their process of Preparation.
DE1543538A1 (de) * 1966-12-30 1976-02-05 Degussa Verfahren zur herstellung neuer heterocyclischer aminoalkohole
US4012444A (en) * 1969-07-08 1977-03-15 Allen & Hanburys Limited 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide and physiologically acceptable acid addition salts thereof
GB1301134A (en) * 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
GB1398738A (en) * 1972-12-05 1975-06-25 Pfizer Ltd Propanolamine derivatives
US4082772A (en) * 1975-04-18 1978-04-04 American Home Products Corporation Thiophene ethanolamines
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines

Also Published As

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FI791727A (fi) 1979-12-06
AU522483B2 (en) 1982-06-10
NO791841L (no) 1979-12-06
NO149034C (no) 1984-02-01
EP0005848A1 (de) 1979-12-12
GB2026474A (en) 1980-02-06
IL57471A (en) 1982-11-30
KR830000681A (ko) 1983-04-18
SG45884G (en) 1985-03-08
JPS54163543A (en) 1979-12-26
PL117155B1 (en) 1981-07-31
HK15585A (en) 1985-03-15
NO149034B (no) 1983-10-24
PL116612B1 (en) 1981-06-30
PL116529B1 (en) 1981-06-30
DD144050A5 (de) 1980-09-24
EP0005848B1 (de) 1981-12-30
ZA792748B (en) 1980-06-25
PL117158B1 (en) 1981-07-31
PL216090A1 (ko) 1980-03-24
ATE511T1 (de) 1982-01-15
KR830000680A (ko) 1983-04-18
KR840000926B1 (ko) 1984-06-29
MY8500690A (en) 1985-12-31
CA1124241A (en) 1982-05-25
PL116597B1 (en) 1981-06-30
AR229581A1 (es) 1983-09-30
DE2961669D1 (en) 1982-02-18
ES481238A1 (es) 1980-02-16
HU182019B (en) 1983-12-28
US4460580A (en) 1984-07-17
NZ190632A (en) 1984-07-06
DK229879A (da) 1979-12-06
GR74057B (ko) 1984-06-06
PT69723A (de) 1979-07-01
AU4773679A (en) 1979-12-13
AR229951A1 (es) 1984-01-31
CY1256A (en) 1984-11-23
AR229022A1 (es) 1983-05-31
GB2026474B (en) 1982-07-14

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