KR20230082337A - MPC and protease-based contact lens cleaning solution and manufacturing method thereof - Google Patents
MPC and protease-based contact lens cleaning solution and manufacturing method thereof Download PDFInfo
- Publication number
- KR20230082337A KR20230082337A KR1020210170158A KR20210170158A KR20230082337A KR 20230082337 A KR20230082337 A KR 20230082337A KR 1020210170158 A KR1020210170158 A KR 1020210170158A KR 20210170158 A KR20210170158 A KR 20210170158A KR 20230082337 A KR20230082337 A KR 20230082337A
- Authority
- KR
- South Korea
- Prior art keywords
- mpc
- protease
- cypress
- solution
- extract
- Prior art date
Links
- 239000004365 Protease Substances 0.000 title claims abstract description 74
- 108091005804 Peptidases Proteins 0.000 title claims abstract description 62
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title claims abstract description 62
- 238000004140 cleaning Methods 0.000 title claims abstract description 37
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 34
- 239000008213 purified water Substances 0.000 claims abstract description 28
- 239000011780 sodium chloride Substances 0.000 claims abstract description 17
- 241000894006 Bacteria Species 0.000 claims abstract description 14
- CXKOMPKKJHARHG-UHFFFAOYSA-O CC=CC(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical compound CC=CC(=O)OCCP(=O)=C(O)C[N+](C)(C)C CXKOMPKKJHARHG-UHFFFAOYSA-O 0.000 claims abstract description 4
- 241000218691 Cupressaceae Species 0.000 claims description 76
- 239000000243 solution Substances 0.000 claims description 73
- 235000019419 proteases Nutrition 0.000 claims description 58
- 241000208843 Arctium Species 0.000 claims description 41
- 235000003130 Arctium lappa Nutrition 0.000 claims description 41
- 235000008078 Arctium minus Nutrition 0.000 claims description 41
- 239000007864 aqueous solution Substances 0.000 claims description 38
- 238000002156 mixing Methods 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 20
- 239000003242 anti bacterial agent Substances 0.000 claims description 19
- 238000000605 extraction Methods 0.000 claims description 18
- 239000011259 mixed solution Substances 0.000 claims description 17
- 239000000654 additive Substances 0.000 claims description 12
- 230000000996 additive effect Effects 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 10
- 239000003431 cross linking reagent Substances 0.000 claims description 9
- 239000012046 mixed solvent Substances 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 239000004599 antimicrobial Substances 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 5
- ZHQQRIUYLMXDPP-SSDOTTSWSA-N Actinidine Natural products C1=NC=C(C)C2=C1[C@H](C)CC2 ZHQQRIUYLMXDPP-SSDOTTSWSA-N 0.000 claims description 4
- 108010004032 Bromelains Proteins 0.000 claims description 4
- 108090000270 Ficain Proteins 0.000 claims description 4
- 108090000526 Papain Proteins 0.000 claims description 4
- 108090000350 actinidain Proteins 0.000 claims description 4
- 235000019835 bromelain Nutrition 0.000 claims description 4
- 235000019836 ficin Nutrition 0.000 claims description 4
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 claims description 4
- 235000019834 papain Nutrition 0.000 claims description 4
- 229940055729 papain Drugs 0.000 claims description 4
- 240000007695 Nandina domestica Species 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 11
- 102000004169 proteins and genes Human genes 0.000 abstract description 11
- 108090000623 proteins and genes Proteins 0.000 abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 8
- 238000005728 strengthening Methods 0.000 abstract description 2
- 238000009736 wetting Methods 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 30
- 238000012360 testing method Methods 0.000 description 24
- 239000003921 oil Substances 0.000 description 21
- 230000008859 change Effects 0.000 description 19
- 239000000126 substance Substances 0.000 description 14
- 241000191967 Staphylococcus aureus Species 0.000 description 8
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 241000228245 Aspergillus niger Species 0.000 description 6
- 241000222122 Candida albicans Species 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229940095731 candida albicans Drugs 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000000645 desinfectant Substances 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 230000035899 viability Effects 0.000 description 5
- 241000224422 Acanthamoeba Species 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 241000224489 Amoeba Species 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- 229960001631 carbomer Drugs 0.000 description 4
- 239000000882 contact lens solution Substances 0.000 description 4
- 239000007951 isotonicity adjuster Substances 0.000 description 4
- 239000005445 natural material Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- -1 methylacryloyloxyethyl phosphoryl Chemical group 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 2
- NJNWCIAPVGRBHO-UHFFFAOYSA-N 2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical group OCC[N+](C)(C)C#P=O NJNWCIAPVGRBHO-UHFFFAOYSA-N 0.000 description 2
- 235000003320 Adansonia digitata Nutrition 0.000 description 2
- 244000056971 Adansonia gregorii Species 0.000 description 2
- 235000003319 Adansonia gregorii Nutrition 0.000 description 2
- 201000005702 Pertussis Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 206010023332 keratitis Diseases 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229950004354 phosphorylcholine Drugs 0.000 description 2
- 229920005650 polypropylene glycol diacrylate Polymers 0.000 description 2
- 150000003141 primary amines Chemical class 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 241000224423 Acanthamoeba castellanii Species 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000002111 Eye Abnormalities Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000010639 cypress oil Substances 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- XQYSTRMEVGHJAW-UHFFFAOYSA-L disodium;1-tridecoxytridecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCCOCCCCCCCCCCCCC XQYSTRMEVGHJAW-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 229940072106 hydroxystearate Drugs 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000671 polyethylene glycol diacrylate Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/364—Organic compounds containing phosphorus containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
본 발명은 MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법에 관한 것으로 더욱 상세하게는 정제수, 프로테아제, 메틸아크릴로일옥시에틸 포스포릴콜린(MPC) 및 염화나트륨을 포함하며, 단백질 제거와 습윤효과를 강화시켜 렌즈측 착용감을 현저히 개선하고, 감염세균에 대해 항균효과를 지닌 MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법에 관한 것이다.The present invention relates to a contact lens cleaning solution based on MPC and protease and a method for manufacturing the same, and more specifically, to a cleaning solution containing purified water, protease, methylacryloyloxyethyl phosphorylcholine (MPC) and sodium chloride, and to remove proteins and have a wetting effect. It relates to a contact lens cleaning solution based on MPC and protease that significantly improves the wearing comfort of the lens side by strengthening and has an antibacterial effect against infectious bacteria and a manufacturing method thereof.
Description
본 발명은 MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법에 관한 것으로 더욱 상세하게는 콘택트렌즈 세정액에 프로테아제가 포함됨으로써, 단백질 제거와 습윤효과를 강화시켜 콘택트렌즈 착용감을 현저히 개선할 수 있는 MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법에 관한 것이다.The present invention relates to a contact lens cleaning solution based on MPC and protease and a method for manufacturing the same, and more particularly, by including protease in the contact lens cleaning solution, MPC and It relates to a protease-based contact lens cleaning solution and a manufacturing method thereof.
콘택트렌즈는 눈의 전면인 각막에 장착하여 시력교정, 눈의치료 및 미용등의 목적을 위해 사용하는 렌즈로서, 안경을 대체하여 많이 사용되고 있다. 그러나 이러한 콘택트렌즈는 장시간 착용할 경우 단백질 침착물과 이물질에 의해 렌즈의 표면에 각종 미생물이 부착 및 증식이 촉진되어 세균감염으로 인한 각막염의 원인이 된다.Contact lenses are lenses mounted on the cornea, which is the front of the eye, and used for purposes such as vision correction, eye treatment and beauty, and are widely used as replacements for eyeglasses. However, when these contact lenses are worn for a long time, protein deposits and foreign substances promote the attachment and proliferation of various microorganisms on the surface of the lens, causing keratitis due to bacterial infection.
각막염은 주요원인이 콘택트렌즈에 기생하는 박테리아로서 그람 양성세균인 포도상규균과 그람 음성세균으로서 현재 가장 많이 보고된 녹농균으로 알려져 있다. 이때문에 그람 양성세균과 그럼 음성세균들로 인해 발생되는 각종 안질환을 예방하기 위한 것으로서, 단백질을 제거하고 이물질이 렌즈표면에 부착되는 것을 방지하는 여러 기술들이 제안되었다.The main cause of keratitis is bacteria parasitic on contact lenses, and Staphylococcus aureus, which is a gram-positive bacterium, and gram-negative bacteria, are known to be the most frequently reported Pseudomonas aeruginosa. For this reason, in order to prevent various eye diseases caused by Gram-positive bacteria and then negative bacteria, various techniques for removing proteins and preventing foreign matter from being attached to the lens surface have been proposed.
제안된 선행기술은 콘택트 렌즈용 케어 제제 및 패키징 용액(한국등록특허공보 제10-1797275호)으로 상기 선행기술은 특정한 포스포릴콜린 유사기 함유 단량체 단위와, 특정한 (메트)아크릴아미드 유도체 단위와, 특정한 소수성기 함유 단량체 단위를 특정 비율로 갖는, 중량 평균 분자량 5000 ∼ 2000000 의 중합체를 0.01 ∼ 2 중량/용적％ 함유하는 용액으로 이루어지는 콘택트렌즈용 케어 제제 및 패키징 용액으로 표면 윤활성과 아메바 부착 억제효과를 부여할 수 있는 장점이 있다.The proposed prior art is a contact lens care formulation and packaging solution (Korean Patent Registration No. 10-1797275), which includes a specific phosphorylcholine analog group-containing monomer unit, a specific (meth)acrylamide derivative unit, A contact lens care formulation and packaging solution comprising a solution containing 0.01 to 2% by weight/volume of a polymer having a weight average molecular weight of 5000 to 2000000 having a specific hydrophobic group-containing monomeric unit in a specific ratio and imparting surface lubricity and amoeba adhesion inhibitory effect There are advantages to doing so.
그러나 상기 선행기술은 일 실시예로 제조하여 종래의 콘택트렌즈 세정용액 제조방법에 따라 제조된 세정용액들과 비교하면 표면 윤활성과 아메바 부착억제 효과가 다소 미흡한 점이 있으며, 이에 따라 콘택트렌즈의 착용감이 우수하지 못하는 단점이 있다.However, the prior art is prepared in one embodiment and compared to the cleaning solutions prepared according to the conventional contact lens cleaning solution manufacturing method, the surface lubricity and the effect of inhibiting amoeba adhesion are somewhat insufficient, and thus the wearing comfort of the contact lens is excellent There are downsides to not being able to.
본 발명은 상기한 문제점을 해결하기 위해 안출된 것으로 콘택트렌즈 세정액에 MPC와 프로테아제가 포함됨으로써, 단백질 제거와 습윤효과를 강화시켜 렌즈착용감을 현저히 개선할 수 있는 MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법에 관한 것이다.The present invention has been made to solve the above problems, and by including MPC and protease in the contact lens cleaning solution, MPC and protease-based contact lens cleaning solution and its It's about manufacturing methods.
상기의 목적을 달성하기 위한 본 발명의 일 실시예에 따른 프로테아제 기반의 콘택트렌즈 세정액은 정제수, 프로테아제, 메틸아크릴로일옥시에틸 포스포릴콜린(MPC) 및 염화나트륨을 포함한다.A protease-based contact lens cleaning solution according to an embodiment of the present invention for achieving the above object includes purified water, protease, methylacryloyloxyethyl phosphorylcholine (MPC) and sodium chloride.
상기 프로테아제는 파파인(papain), 피신(ficin), 브로멜라인(bromelain), 및 액티니딘(actinidin)으로 이루어진 군으로부터 선택된다.The protease is selected from the group consisting of papain, ficin, bromelain, and actinidin.
상 기 MPC는 용매에 MPC가 혼합된 MPC수용액을 제조한 후, 상기 MPC수용액을 상기 정제수에 혼합하여 첨가하되, 상기 MPC수용액은 계면활성제가 용해된 편백추출오일상의 용액과 MPC 및 수용성가교제가 용해된 정제수가 혼합되며, 상기 MPC수용액은 세균의 증식을 방지하는 천연항균제를 더 포함하며, 상기 천연항균제는 상기 편백추출오일의 제조과정에서 생성된 편백추출수에 우엉을 침지 및 가열하여 우엉추출물을 추출함으로써 제조된다.The MPC is added by preparing an MPC aqueous solution in which MPC is mixed in a solvent, and then mixing the MPC aqueous solution with the purified water. Purified water is mixed, and the MPC aqueous solution further includes a natural antibacterial agent that prevents the growth of bacteria. prepared by extraction.
상기 천연항균제는 상기 편백추출오일의 제조과정에서 생성된 편백추출수에 남천(Nandina domestica Thunb)을 더해 침지 및 가열하여 남천추출물을 추출함으로써 제조된다.The natural antibacterial agent is prepared by adding Nandina domestica Thunb to the cypress extract produced in the manufacturing process of the cypress extract oil, immersing and heating to extract the cypress extract.
한편, 본 발명의 일 실시예에 따른 프로테아제 기반의 콘텍트렌즈 세정액 제조방법은 편백나무에서 편백추출수와 편백추출오일을 추출하는 편백나무 추출물 추출단계, 상기 편백나무 추출물 추출단계후, MPC수용액을 제조하는 MPC수용액 제조단계, 상기 MPC수용액 제조단계에서 제조된 MPC 수용액에 프로테아제를 첨가하는 프로테아제 첨가단계, 상기 프로테아제 첨가단계에서 프로테아제가 첨가된 MPC수용액에 염화나트륨 및 정제수를 혼합하여 혼합용액을 제조하는 혼합용액 제조단계, 상기 혼합용액제조단계에서 제조된 혼합용액에 첨가제를 첨가하는 첨가제 첨가단계 및 상기 첨가제 첨가단계에서 첨가된 혼합용액을 여과하는 여과단계를 포함하며, 상기 편백나무 추출물 추출단계는 상기 편백나무에 용매를 가하여 가열하고, 상기 가열에 의해 발생되는 수증기를 냉각하여 각각 편백추출수와 편백추출오일로 분리한다.On the other hand, in the method for manufacturing a protease-based contact lens cleaning solution according to an embodiment of the present invention, after the cypress tree extract extraction step of extracting the cypress tree extract and the cypress tree extract oil from the cypress tree, the cypress tree extract is extracted, and then an MPC aqueous solution is prepared. MPC aqueous solution preparation step, protease addition step of adding protease to the MPC aqueous solution prepared in the MPC aqueous solution preparation step, mixed solution of preparing a mixed solution by mixing sodium chloride and purified water with the MPC aqueous solution to which the protease was added in the protease addition step. It includes a manufacturing step, an additive adding step of adding an additive to the mixed solution prepared in the mixed solution preparing step, and a filtration step of filtering the mixed solution added in the additive adding step, and the cypress extract extraction step is the cypress tree extract. A solvent is added to and heated, and the water vapor generated by the heating is cooled to separate cypress extract water and cypress extract oil, respectively.
상기 MPC수용액 제조단계는 상기 편백나무 추출물 추출단계에서 추출된 편백추출오일에 계면활성제를 용해시켜 편백추출오일상의 용액을 제조하는 편백추출오일상 용액 제조단계, 상기 MPC와 수용성 가교제를 정제수에 용해시켜 MPC용액을 제조하는 MPC용액 제조단계 및 상기 MPC수용액을 제조하기 위해 편백추출오일상 용액과 MPC용액을 혼합하는 혼합단계를 포함한다.The MPC aqueous solution preparation step is the step of preparing a cypress extract oil phase solution by dissolving a surfactant in the cypress extract oil extracted in the cypress tree extract extraction step to prepare a cypress extract oil phase solution, dissolving the MPC and a water-soluble crosslinking agent in purified water It includes an MPC solution preparation step of preparing an MPC solution and a mixing step of mixing the cypress extract oil phase solution and the MPC solution to prepare the MPC aqueous solution.
상기 MPC용액 제조단계는 상기 편백나무 추출물 추출단계에서 추출된 편백추출수에 혼합용매를 가하고 우엉을 침지 및 가열하여 우엉추출물을 추출함으로서 제조된 천연항균제를 혼합하는 천연항균제 혼합단계를 더 포함한다.The MPC solution preparation step further includes a natural antibacterial agent mixing step of mixing a natural antimicrobial agent prepared by adding a mixed solvent to the cypress extract water extracted in the cypress tree extract extraction step and extracting the burdock extract by immersing and heating the burdock root.
상기 천연항균제 혼합단계에서는 상기 우엉이 침지된 편백추출수에 남천을 더해 침지 및 가열함으로서 남천추출물을 추출한다.In the step of mixing the natural antimicrobial agent, the Namcheon extract is extracted by adding Namcheon to the cypress extract in which the burdock is immersed, followed by immersion and heating.
본 발명에 따른 MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법은 다음과 같은 효과가 있다.The MPC and protease-based contact lens cleaning liquid and method for manufacturing the same according to the present invention have the following effects.
(1) 콘택트렌즈 세정액에 MPC와 프로테아제가 포함됨으로써, 단백질 제거와 습윤효과를 강화시켜 렌즈의 착용감을 현저히 개선할 수 있는 효과가 있다.(1) By including MPC and protease in the contact lens cleaning solution, there is an effect of significantly improving the wearing comfort of the lens by strengthening the protein removal and wetting effect.
(2) 콘택트렌즈 세정액에 천연물질인 편백나무 추출물, 우엉 추출물 및 남천 추출물을 포함함으로서, 유기체(박테리아)에 대해 항균효과가 있다.(2) By including natural substances such as cypress tree extract, burdock extract and namcheon extract in the contact lens cleaning solution, it has an antibacterial effect against organisms (bacteria).
도 1은 본 발명의 바람직한 일 실시예에 따른 프로테아제 기반의 콘택트렌즈 세정액 제조방법을 도시한 블럭도이다.
도 2는 본 발명의 바람직한 일 실시예에 따른 MPC와 프로테아제 기반의 콘택트렌즈 세정액 제조방법에서 MPC용액 제조단계를 도시한 블럭도이다.
도 3은 본 발명의 바람직한 일 실시예에 따른 MPC와 프로테아제 기반의 콘택트렌즈 세정액 제조방법에서 천연항균제 혼합단계를 도시한 블럭도이다.1 is a block diagram showing a method for producing a protease-based contact lens cleaning solution according to a preferred embodiment of the present invention.
2 is a block diagram showing the step of preparing an MPC solution in the method for manufacturing a contact lens cleaning solution based on MPC and protease according to a preferred embodiment of the present invention.
3 is a block diagram showing a natural antibacterial agent mixing step in the method for preparing a contact lens cleaning solution based on MPC and protease according to a preferred embodiment of the present invention.
이하, 첨부한 도면을 참조하여 본 발명의 실시예에 따른 "MPC와 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법"에 대해 상세히 설명한다. 본 발명은 다양한 변경을 가할 수 있고 여러 가지 형태를 가질 수 있는 바, 특정 실시 예들을 도면에 예시하고 본문에 상세하게 설명하고자 한다. 그러나 이는 본 발명을 특정한 개시 형태에 대해 한정하려는 것이 아니며, 본 발명의 사상 및 기술 범위에 포함되는 모든 변경, 균등물 내지 대체물을 포함하는 것으로 이해되어야 한다. 각 도면을 설명하면서 유사한 참조부호를 유사한 구성요소에 대해 사용하였다. 첨부된 도면에 있어서, 구조물들의 치수는 본 발명의 명확성을 기하기 위하여 실제보다 확대하여 도시한 것이다. Hereinafter, "contact lens cleaning solution based on MPC and protease and manufacturing method thereof" according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. Since the present invention can have various changes and various forms, specific embodiments will be illustrated in the drawings and described in detail in the text. However, this is not intended to limit the present invention to a specific form disclosed, and should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention. Like reference numerals have been used for like elements throughout the description of each figure. In the accompanying drawings, the dimensions of the structures are shown enlarged than actual for clarity of the present invention.
제1, 제2 등의 용어는 다양한 구성요소들을 설명하는데 사용될 수 있지만, 상기 구성요소들은 상기 용어들에 의해 한정되어서는 안 된다. 상기 용어들은 하나의 구성요소를 다른 구성요소로부터 구별하는 목적으로만 사용된다. 예를 들어, 본 발명의 권리 범위를 벗어나지 않으면서 제1 구성요소는 제2 구성요소로 명명될 수 있고, 유사하게 제2 구성요소도 제1 구성요소로 명명될 수 있다.Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. These terms are only used for the purpose of distinguishing one component from another. For example, a first element may be termed a second element, and similarly, a second element may be termed a first element, without departing from the scope of the present invention.
본 출원에서 사용한 용어는 단지 특정한 실시 예를 설명하기 위해 사용된 것으로, 본 발명을 한정하려는 의도가 아니다. 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다. 본 출원에서, "포함하다" 또는 "가지다" 등의 용어는 명세서 상에 기재된 특징, 숫자, 단계, 동작, 구성요소, 부분품 또는 이들을 조합한 것이 존재함을 지정하려는 것이지, 하나 또는 그 이상의 다른 특징들이나 숫자, 단계, 동작, 구성요소, 부분품 또는 이들을 조합한 것들의 존재 또는 부가 가능성을 미리 배제하지 않는 것으로 이해되어야 한다.Terms used in this application are only used to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, terms such as "comprise" or "have" are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that it does not preclude the possibility of the presence or addition of numbers, steps, operations, components, parts, or combinations thereof.
다르게 정의되지 않는 한, 기술적이거나 과학적인 용어를 포함해서 여기서 사용되는 모든 용어들은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 일반적으로 이해되는 것과 동일한 의미를 가지고 있다. 일반적으로 사용되는 사전에 정의되어 있는 것과 같은 용어들은 관련 기술의 문맥 상 가지는 의미와 일치하는 의미를 가지는 것으로 해석되어야 하며, 본 출원에서 명백하게 정의하지 않는 한, 이상적이거나 과도하게 형식적인 의미로 해석되지 않는다.Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the present application, they should not be interpreted in an ideal or excessively formal meaning. don't
본 발명의 일 실시예에 따른 프로테아제 기반의 콘택트렌즈 세정액은 정제수, 프로테아제, 메틸아크릴로일옥시에틸 포스포릴콜린(Methacryloyl phosphoryl choline, MPC) 및 염화나트륨을 포함한다.The protease-based contact lens cleaning solution according to an embodiment of the present invention includes purified water, protease, methylacryloyloxyethyl phosphoryl choline (MPC) and sodium chloride.
상기 프로테아제는 콘택트렌즈 표면의 단백질을 제거하는 것으로서, 카보머(carbomer)에 가교된 프로테아제를 포함하되, 상기 프로테아제의 1차 아민이 상기 카보머의 카복실기에 가교되고, 상기 프로테아제의 상기 아민이 아민 반응성 가교제에 의해 추가로 가교된다. The protease removes proteins on the surface of the contact lens, and includes a protease cross-linked to a carbomer, wherein the primary amine of the protease is cross-linked to a carboxyl group of the carbomer, and the amine of the protease is amine-reactive. It is further cross-linked by a cross-linking agent.
상기 프로테아제는 상기 프로테아제가 파파인(papain), 피신(ficin), 브로멜라인(bromelain), 및 액티니딘(actinidin)으로 이루어진 군으로부터 선택된다.The protease is selected from the group consisting of papain, ficin, bromelain, and actinidin.
상기 프로테아제는 상태 변화나 화학 변화를 방지하기 위하여 안정화제를 더 포함할 수 있다. 상기 안정화제는 바오밥오일, 아스코르빈산등이 적용될 수 있다.The protease may further include a stabilizer to prevent state change or chemical change. As the stabilizer, baobab oil, ascorbic acid, and the like may be applied.
상기 정제수는 본 발명의 부피의 대부분을 차지하는 용제로서 최종 제품에서의 멸균이나 항균 상태 유지에 효과적인 멸균 정제수를 사용하는 것이 바람직하다.The purified water is a solvent that occupies most of the volume of the present invention, and it is preferable to use sterilized purified water effective for maintaining a sterilization or antibacterial state in the final product.
상기 MPC는 메틸아크릴로일옥시에틸 포스포릴콜린(Methacryloyl phosphoryl choline)로서, 메타크릴레이트기(Methacrylate)와 포스포릴콜린기(Phosphorylcholine)가 결합된 물질로서, 인체세포막과 동일구조식을 가지며 신체 신체적합성, 친수성을 가지는 물질이다.The MPC is methylacryloyloxyethyl phosphoryl choline, a substance in which a methacrylate group and a phosphorylcholine group are combined, and has the same structural formula as human cell membranes and is physically synthesized , which is a hydrophilic substance.
본 발명에서는 콘택트렌즈의 표면의 단백질 제거제 또는 습윤제로서, 상기 프로테아제와 함께 콘택트렌즈의 표면의 단백질을 제거하며, 아메바의 부착을 억제하여 표면 윤활성을 제공한다.In the present invention, as a protein removal agent or wetting agent on the surface of contact lenses, it removes proteins on the surface of contact lenses together with the protease, and provides surface lubricity by suppressing the attachment of amoeba.
상기 MPC는 상기 정제수 100 중량부에 대하여 0.7 내지 1.2 중량부가 혼합되는 것이 바람직하다. 상기 0.7 이하로 혼합될 경우 단백질 제거 및 아메바 부착 억제력이 감소하여 착용감이 저하될 수 있고, 상기 1.2 이상으로 혼합될 경우 하기에서 설명한 MPC수용액의 점도가 높아질 우려가 있다.The MPC is preferably mixed in an amount of 0.7 to 1.2 parts by weight based on 100 parts by weight of the purified water. When mixed to 0.7 or less, protein removal and amoeba attachment inhibition may be reduced, resulting in a decrease in wearing comfort, and when mixed to 1.2 or more, the viscosity of the MPC aqueous solution described below may increase.
상기 MPC는 용매에 MPC가 혼합된 수용액을 제조한 후 상기 MPC수용액을 상기 정제수에 혼합하여 첨가하며, 이때 상기 MPC수용액은 계면활성제가 용해된 편백추출오일상의 용액과, MPC 및 수용성가교제가 용해된 정제수가 혼합된다. The MPC is added by preparing an aqueous solution in which MPC is mixed in a solvent, and then mixing and adding the MPC aqueous solution to the purified water. Purified water is mixed.
따라서, MPC수용액내에서 수용성가교제와 MPC에 의해 구형의 MPC 하이드로겔 입자가 분산 형성되어 종래의 기술로서 단순히 MPC를 첨가하는 것과 단백질 제거, 아베마 부착억제 및 수분감이 증대되어 윤활성이 향상된다.Therefore, spherical MPC hydrogel particles are dispersed and formed by the water-soluble crosslinking agent and MPC in the MPC aqueous solution, and the lubricity is improved by simply adding MPC as a conventional technique, protein removal, inhibition of Abema adhesion, and increased moisture.
상기 MPC수용액은 세균의 증식을 방지하는 천연항균제를 더 포함한다. 상기 천연항균제는 상기 편백추출오일의 제조과정에서 생성된 편백추출수에 우엉을 침지 및 가열하여 우엉추출물을 추출함으로서 제조된다. The MPC aqueous solution further contains a natural antibacterial agent that prevents the growth of bacteria. The natural antibacterial agent is prepared by extracting the burdock extract by immersing and heating the burdock in the cypress extract water generated in the manufacturing process of the cypress extract oil.
상기 편백추출수는 항생내성 균주의 생장을 억제시킬 수 있으며, 우엉추출물은 박테리아로서 그람 양성세균인 포도상규균을 억제하고, pH의 산성조건에서도 항세균 활성이 유지되는 천연물질로서 각각 종래의 화학성 화합물로서 독성을 지니며 인체의 안전을 장담할 수 없었던 항균제들을 대체한다. The cypress extract can inhibit the growth of antibiotic-resistant strains, and the burdock extract is a natural substance that inhibits Staphylococcus aureus, a gram-positive bacterium as a bacterium, and maintains antibacterial activity even under acidic conditions of pH. As a compound, it is toxic and replaces antibacterial agents that could not guarantee the safety of the human body.
또한, 상기 천연항균제는 우엉이 침지된 편백추출수에 남천(Nandina domestica Thunb)을 더해 침지 및 가열함으로서 남천추출물을 추출할 수 있다.In addition, the natural antibacterial agent can be extracted by adding Nandina domestica Thunb to the cypress extract in which burdock is immersed, followed by immersion and heating.
상기 남천은 남천죽엽이라고 하며, 백일해, 혈뇨, 타박상을 치료효과를 나타낸다. 겨울철에는 푸른색 잎은 빨간색으로 변하고 봄에 되며 다시 푸른색으로 변한다. 남천의 열매는 장과로 둥글고 50~100cm 정도로 10월 달에 익으며홍색으로 바뀐다. 남천 열매는 민간에서 남천실(南天實) 또는 남천(南天), 남천죽자(南天竹子)이라고 하며 약재로서 사용되며, 명목, 지해, 청간의 효능을 가지고 있고, 진해약으로 염폐, 해수, 일본에서 만성 기침, 매독, 자궁출혈, 천식, 백일해등의 치료에 사용되는 것으로 알려져 있으며, 본 발명의 일 실시예에서는 항알레르기 활성을 갖으므로 알레르기균을 억제할 수 있다.The Namcheon is called Namcheon bamboo leaf, and has a therapeutic effect on whooping cough, hematuria, and bruises. In winter, the green leaves turn red, and in spring they turn blue again. The fruit of Namcheon is a round berry, 50 to 100 cm in size, ripens in October and turns red. The fruit of Namcheon is called Namcheonsil, Namcheon, or Namcheonjukja in the private sector and is used as a medicine. It is known to be used in the treatment of chronic cough, syphilis, uterine bleeding, asthma, whooping cough, etc., and in one embodiment of the present invention, it has anti-allergic activity, so it can suppress allergic bacteria.
상기 염화나트륨(Sodium chloride)은 화학식 NaCl, 분자량 5544의 소금으로서, 등장화제, 부형제, 안정화제, 완충제, 용제, 점도조절제 및 pH조절제등 여러 기능을 한다. 본 발명에서는 실질적으로 삼투압을 눈물 및 혈청의 삼투압과 같게하는 등장화제로서 역할을 한다.The sodium chloride (Sodium chloride) is a salt with a chemical formula of NaCl and a molecular weight of 5544, and functions as an isotonic agent, an excipient, a stabilizer, a buffer, a solvent, a viscosity control agent, and a pH control agent. In the present invention, it serves as an isotonic agent that substantially equalizes the osmotic pressure to that of tears and serum.
상기 염화나트륨은 상기 정제수 100중량부에 대하여 0.7 내지 1 중량부가 혼합되는 것이 바람직하다. 상기 염화나트륨이 0.7 내지 1중량부의 범위를 벗어날 경우 눈물 및 혈청의 삼투압과 다르게 나타나기 때문에 등장화제로서 역할을 할 수 없다.The sodium chloride is preferably mixed in an amount of 0.7 to 1 part by weight based on 100 parts by weight of the purified water. If the sodium chloride is out of the range of 0.7 to 1 part by weight, it cannot serve as an isotonic agent because it appears different from the osmotic pressure of tears and serum.
한편, 생체적합성 MPC 고분자 기반의 콘택트렌즈 다기능 용액 제조방법은 편백나무 추출물 추출단계(S100), MPC수용액 제조단계(S200), 프로테아제 첨가단계(S300), 혼합용액 제조단계(S400), 첨가제 첨가단계(S500) 및 여과단계(S600)를 포함한다.On the other hand, the biocompatible MPC polymer-based contact lens multifunctional solution manufacturing method includes cypress extract extraction step (S100), MPC aqueous solution preparation step (S200), protease addition step (S300), mixed solution preparation step (S400), additive addition step (S500) and a filtration step (S600).
상기 편백나무 추출물 추출단계(S100)에서는 편백나무와 편백오일을 추출하는 것으로서, 상기 편백나무에 용매를 가하여 가열하고, 상기 가열에 의해 발생되는 수증기를 냉각하여 각각 편백추출수와 편백추출오일로 분리한다.In the cypress tree extract extraction step (S100), cypress tree and cypress oil are extracted, and a solvent is added to the cypress tree, heated, and the water vapor generated by the heating is cooled to separate into cypress tree extract and cypress tree extract oil, respectively do.
상기 MPC수용액 제조단계(S200)에서는 상기 편백나무 추출물 추출단계(S100)후 MPC 수용액을 제조하는 것으로 편백추출오일상 용액 제조단계(S210), MPC용액 제조단계(S220), 혼합단계(S230) 및 살균제 첨가단계(S240)를 포함한다.In the MPC aqueous solution preparation step (S200), an MPC aqueous solution is prepared after the cypress extract extraction step (S100), and the cypress extract oil phase solution preparation step (S210), MPC solution preparation step (S220), mixing step (S230), and A disinfectant addition step (S240) is included.
상기 편백추출오일상 용액 제조단계(S210)에서는 편백추출오일에 계면활성제를 용해시켜 편백추출오일상의 용액을 제조한다. 상기 계면활성제는 세틸 PEG/PPG-10/1 디메치콘(Cetyl PEG/PPG-10/1 dimethicone (ABIL EM-90)), 소르비탄 세스퀴올레이트(Sorbitan sesquioleate (ARLACEL 83)), 폴리에틸렌 글리콜 디폴리하이드록시 스테아레이트(Polyethylene glycol dipolyhydroxy stearate (ARLACEL P135))등을 사용할 수 있다.In the cypress extract oil phase solution preparation step (S210), a cypress extract oil phase solution is prepared by dissolving a surfactant in the cypress extract oil. The surfactant is Cetyl PEG/PPG-10/1 dimethicone (ABIL EM-90), sorbitan sesquioleate (ARLACEL 83), polyethylene glycol dipoly Hydroxy stearate (Polyethylene glycol dipolyhydroxy stearate (ARLACEL P135)) and the like can be used.
상기 MPC용액 제조단계(S220)에서는 MPC와 수용성 가교제를 정제수에 용해시켜 MPC용액을 제조한다. 본 발명에서는 상기 MPC와 수용성 가교제는 1:9의 중량비율로 혼합되는 것이 바람직하다.In the MPC solution preparation step (S220), an MPC solution is prepared by dissolving MPC and a water-soluble crosslinking agent in purified water. In the present invention, the MPC and the water-soluble crosslinking agent are preferably mixed in a weight ratio of 1:9.
상기 수용성 가교제는 폴리프로필렌 글리콜 디아크릴레이트(Polypropylene glycol diacrylate, PPG-DA) 또는 폴리에틸렌 글리콜 디아크릴레이트(Polyethylene glycol diacrylate, PEG-DA)가 바람직하다.The water-soluble crosslinking agent is preferably polypropylene glycol diacrylate (PPG-DA) or polyethylene glycol diacrylate (PEG-DA).
또한 상기 MPC용액 제조단계(S220)는 천연항균제 혼합단계(S221)를 더 포함한다. 상기 천연항균제 혼합단계(221)는 상기 편백나무 추출물 추출단계(S100)에서 추출된 편백추출수에 혼합용매를 가하고 우엉 또는 우엉과 남천을 침지 및 가열하여 우엉추출물을 추출함으로서 제조된 천연항균제를 상기 MPC용액에 혼합한다.In addition, the MPC solution preparation step (S220) further includes a natural antimicrobial agent mixing step (S221). The natural antibacterial agent mixing step 221 is a natural antibacterial agent prepared by adding a mixed solvent to the cypress extract water extracted in the cypress tree extract extraction step (S100) and extracting the burdock extract by immersing and heating burdock or burdock and burdock root. Mix with MPC solution.
상기 천연항균제 혼합단계(S221)는 우엉 세척 및 절단단계(S222), 우엉 건조단계(S223), 우엉 덖음단계(S224), 침지단계(S225), 염기 첨가단계(S226), 혼합용매 첨가단계(S227), 가열단계(S228) 및 MPC용액 혼합단계(S229)를 포함한다.The natural antimicrobial agent mixing step (S221) is a burdock washing and cutting step (S222), a burdock drying step (S223), a burdock roasting step (S224), a soaking step (S225), a base addition step (S226), a mixed solvent addition step ( S227), heating step (S228) and MPC solution mixing step (S229).
상기 우엉 세척 및 절단단계(S222)에서는 우엉의 잎과 줄기를 1:3의 중량비로 혼합한 후, 세척하여 0.1mm ~ 20.0mm 범위 내의 크기로 절단한다. 상기 우엉 건조단계(S223)에서는 70 ~ 80℃의 범위 내의 온도를 가진 열풍으로 건조한다.In the burdock washing and cutting step (S222), the leaves and stems of burdock are mixed in a weight ratio of 1:3, washed, and then cut to a size within the range of 0.1 mm to 20.0 mm. In the step of drying the burdock (S223), it is dried with hot air having a temperature in the range of 70 to 80 ° C.
상기 우엉 덖음단계(S224)에서는 상기 건조된 우엉을 진공상태에서 20 ~ 30분동안 연기가 나도록 덖음한다. 상기 침지단계(S225)에서는 상기 편백나무 추출단계에서 추출된 편백추출수에 덖음된 우엉을 침지시킨다. 이때, 상기 편백추출수에 남천을 더해 침지시킬 수 있다. 상기 남천은 여러 부위를 침지시킬 수 있으나, 바람직하게는 남천의 잎, 줄기 및 열매중 선택된 어느 하나의 부위를 침지시킨다.In the burdock roasting step (S224), the dried burdock is steamed for 20 to 30 minutes in a vacuum state. In the immersion step (S225), the soaked burdock is immersed in the cypress extract water extracted in the cypress tree extraction step. At this time, it can be immersed by adding Namcheon to the cypress extract. The Namcheon can be immersed in several parts, but preferably any one selected from the leaves, stems and fruits of the Namcheon is immersed.
상기 염기 첨가단계(S226)에서는 상기 편백추출수의 100 중량부에 대하여 염기 0.1 내지 10 중량부를 첨가한다. 상기 염기는 수산화나트륨(NaOH) 또는 수산화칼륨(KOH)일 수 있다.In the base addition step (S226), 0.1 to 10 parts by weight of a base is added based on 100 parts by weight of the cypress extract. The base may be sodium hydroxide (NaOH) or potassium hydroxide (KOH).
상기 염기는 우엉에서 항균물질인 플라보노이드의 추출 수율을 증가시키는 것으로서, 상기 범위 미만이면 추출 수율이 증가되는 정도가 미미하며, 상기 범위를 초과하며, 항균에 유효한 물질이 가수분해되어 바람직하지 않다.The base increases the extraction yield of flavonoids, which are antibacterial substances, from burdock. If it is less than the above range, the degree of increase in the extraction yield is insignificant, and if it exceeds the above range, antibacterial substances are hydrolyzed, which is not preferable.
상기 혼합용매 첨가단계(S227)에서는 우엉 또는 우엉과 남천이 침지된 편백나무 추출수에 혼합용매를 첨가한다. 상기 혼합용매는 정제수, 탄소수, 및 C1 내지 C4의 저급 알코올, 다가 알코올 또는 이들을 혼합한 것이다.In the mixed solvent addition step (S227), a mixed solvent is added to the cypress extract water in which burdock or burdock and Namcheon are immersed. The mixed solvent is purified water, carbon number, and C1 to C4 lower alcohol, polyhydric alcohol, or a mixture thereof.
상기 가열단계(S228)에서는 혼합용매 첨가단계(S227)에서 우엉 또는 우엉과 남천이 침지된 편백나무 추출수를 가열하며, 100 ~ 150℃ 범위 내의 온도로 가열하여 최종적으로 천연항균제가 제조된다.In the heating step (S228), the cypress extract water in which the burdock or burdock root and namcheon are immersed in the mixed solvent addition step (S227) is heated, and heated to a temperature within the range of 100 to 150 ° C., so that a natural antibacterial agent is finally prepared.
상기 MPC용액 혼합단계(S229)에서는 상기 가열단계(S228)에서 가열하여 제조된 천연항균제를 상기 MPC용액에 혼합한다.In the MPC solution mixing step (S229), the natural antibacterial agent prepared by heating in the heating step (S228) is mixed with the MPC solution.
상기 혼합단계(S230)에서는 상기 편백추출오일상 용액과 상기 MPC용액을 혼합하여 MPC수용액을 제조하며, 이때, 상기 편백추출오일상 용액과 상기 MPC용액은 중량기준 1:1 ~ 8:3으로 혼합하는 것이 바람직하다.In the mixing step (S230), the cypress extract oil phase solution and the MPC solution are mixed to prepare an MPC aqueous solution. At this time, the cypress extract oil phase solution and the MPC solution are mixed in a weight ratio of 1:1 to 8:3. It is desirable to do
상기 살균제 첨가단계(S240)에서는 상기 MPC수용액에 미생물, 박테리아 및 유기물들을 살균하는 살균제를 첨가한다. 상기 살균제는 이산화규소, 이산화티탄 및 나노은중 선택된 어느 하나이다.In the disinfectant adding step (S240), a disinfectant for sterilizing microorganisms, bacteria and organic matter is added to the MPC aqueous solution. The disinfectant is any one selected from silicon dioxide, titanium dioxide and nanosilver.
상기 프로테아제 첨가단계(S300)는 콘택트렌즈 표면의 단백질을 제거하는 프로테아제를 첨가한다. 이때, 상기 프로테아제는 콘택트렌즈 표면의 단백질을 제거하는 것으로서, 카보머(carbomer)에 가교된 프로테아제를 포함하되, 상기 프로테아제의 1차 아민이 상기 카보머의 카복실기에 가교되고, 상기 프로테아제의 상기 아민이 아민 반응성 가교제에 의해 추가로 가교된다.In the step of adding protease (S300), protease is added to remove proteins on the surface of the contact lens. At this time, the protease is to remove the protein on the surface of the contact lens, and includes a protease cross-linked to carbomer, wherein the primary amine of the protease is cross-linked to the carboxyl group of the carbomer, and the amine of the protease is Further crosslinked by an amine reactive crosslinker.
상기 프로테아제는 상기 프로테아제가 파파인(papain), 피신(ficin), 브로멜라인(bromelain), 및 액티니딘(actinidin)으로 이루어진 군으로부터 선택된다.The protease is selected from the group consisting of papain, ficin, bromelain, and actinidin.
상기 프로테아제는 상태 변화나 화학 변화를 방지하기 위하여 안정화제를 더 포함할 수 있다. 상기 안정화제는 바오밥오일, 아스코르빈산등이 적용되는 것이 바람직하다.The protease may further include a stabilizer to prevent state change or chemical change. The stabilizer is preferably baobab oil, ascorbic acid, etc. are applied.
상기 혼합용액 제조단계(S400)에서는 상기 MPC 수용액, 염화나트륨 및 정제수를 혼합하여 혼합용액을 제조하는 것으로서, 부피의 다수를 차지하는 정제수 100 중량부에 대해 염화나트륨 0.7 내지 1중량부를 첨가하고, MPC가 0.7 내지 1.2중량이 되도록 상기 MPC 수용액을 소량 첨가하여 혼합용액을 제조한다.In the mixed solution preparation step (S400), a mixed solution is prepared by mixing the MPC aqueous solution, sodium chloride, and purified water, and 0.7 to 1 part by weight of sodium chloride is added to 100 parts by weight of purified water occupying the majority of the volume, and MPC is 0.7 to 1 part by weight. A mixed solution is prepared by adding a small amount of the MPC aqueous solution to a weight of 1.2.
상기 첨가제 첨가단계(S500)에서는 상기 혼합용액에 첨가제를 첨가한다. 상기 첨가제는 등장화제, 부형제, 안정화제, 완충제, 용제, 점도조절제 및 pH조절제중 사용자의 필요에 따라 선택하여 첨가할 수 있다. 상기 여과단계(S600)에서는 혼합용액내에 존재하는 이물질을 여과하며, 최종적으로 생체적합성 MPC 고분자 기반의 콘택트렌즈 다기능 용액이 제조된다.In the additive adding step (S500), an additive is added to the mixed solution. The additive may be selected from among isotonic agents, excipients, stabilizers, buffers, solvents, viscosity control agents and pH control agents and added according to the user's needs. In the filtration step (S600), foreign substances present in the mixed solution are filtered, and finally, a multifunctional contact lens solution based on biocompatible MPC polymer is prepared.
실시예 1: MPC와 프로테아제 기반의 콘택트렌즈 세정액Example 1: Contact lens cleaning solution based on MPC and protease
실시예 1은 정제수에 프로테아제와 메틸아크릴로일옥시에틸 포스포릴콜린(MPC)와 염화나트륨을 혼합시킨다. 이후, 상기 MPC가 용매에 혼합되어 MPC수용액이 제조되고, 상기 MPC수용액은 정제수에 혼합시킨다.Example 1 mixes protease, methylacryloyloxyethyl phosphorylcholine (MPC) and sodium chloride in purified water. Thereafter, the MPC is mixed with a solvent to prepare an MPC aqueous solution, and the MPC aqueous solution is mixed with purified water.
또한, 상기 MPC수용액은 계면활성제가 용해된 편백추출오일상의 용액과 MPC 및 수용성가교제가 용해된 정제수가 혼합된다.In addition, the MPC aqueous solution is a mixture of a solution of cypress extract oil in which a surfactant is dissolved and purified water in which MPC and a water-soluble crosslinking agent are dissolved.
실시예 2: 천연항균제가 포함된 프로테아제 기반의 콘택트렌즈 세정액Example 2: Contact lens cleaning solution based on protease containing natural antibacterial agent
실시예 2는 상기 실시예 1의 MPC수용액에 세균의 증식을 방지하는 천연항균제가 포함된다. 이때, 상기 천연항균제는 상기 편백추출오일의 제조과정에서 생성된 편백추출수에 우엉과 남천을 침지 및 가열하여 우엉추출물과 남천추출물이 추출함으로써 제조된다. In Example 2, the MPC aqueous solution of Example 1 contains a natural antibacterial agent that prevents the growth of bacteria. At this time, the natural antibacterial agent is prepared by immersing and heating burdock and southern spring in the cypress extract water generated in the production of the cypress extract oil, and extracting the burdock extract and the southern spring extract.
비교예 1: 종래의 콘택트렌즈 다기능 용액 Comparative Example 1: Conventional contact lens multifunctional solution
비교예 1은 A사의 제품으로서 정제수에 염화나트륨, 염산 폴리아미노프로필비구아니드(PHMB), 히알루론산 및 첨가제가 혼합된 콘택트렌즈 다기능 용액을 제조했다.Comparative Example 1 was a product of Company A, and a multifunctional contact lens solution was prepared by mixing sodium chloride, polyaminopropylbiguanide hydrochloride (PHMB), hyaluronic acid, and additives in purified water.
비교예 2: 종래의 콘택트렌즈 다기능 용액 Comparative Example 2: Conventional contact lens multifunctional solution
비교예 2는 B사의 제품으로서 정제수에 염화나트륨, 염산 폴리아미노프로필비구아니드(PHMB) 및 글루콘산클로르헥시딘액이 혼합된 콘택트렌즈 다기능 용액을 제조했다.Comparative Example 2 was a product of company B, and a multifunctional contact lens solution was prepared by mixing sodium chloride, polyaminopropylbiguanide hydrochloride (PHMB), and chlorhexidine gluconate in purified water.
비교예 3:종래의 콘택트렌즈 다기능 용액 Comparative Example 3: Conventional contact lens multifunctional solution
비교예 3은 C사의 제품으로서 정제수에 염화나트륨, 염산 폴리아미노프로필비구아니드(PHMB) 및 트리데실에테르황산나트륨이 혼합된 콘택트렌즈 다기능 용액을 제조했다.In Comparative Example 3, a product of C company prepared a multifunctional contact lens solution in which sodium chloride, polyaminopropylbiguanide hydrochloride (PHMB), and tridecyl ether sodium sulfate were mixed in purified water.
시험예 1: 눈점막 자극시험Test Example 1: Eye mucosa irritation test
시험예 1은 상기 실시예 1 및 2와 비교예 1 내지 3의 안전성을 확인하기 위하여 식품의약품안전청고시중 의약품 등의 독성시험 기준을 준수하여 국소독성 시험항의 안점막자극시험을 실시하였다.In Test Example 1, in order to confirm the safety of Examples 1 and 2 and Comparative Examples 1 to 3, an eye irritation test was performed for a topical toxicity test item in compliance with the toxicity test standards for pharmaceuticals announced by the Food and Drug Administration.
시험예 1은 시험 전에 육안 및 검안경으로 안구를 검사하여 안구 이상이 없는 토끼(New zealand White 22±05 ㎏) 9마리를 1군으로 하여 시험물질을 우측 안구에 100 ㎕씩 점안하였고 좌측 안구는 비교를 위하여 시험물질을 점안하지 않았다.In Test Example 1, 9 rabbits (New zealand White 22 ± 05 kg) without eye abnormalities were examined with the naked eye and ophthalmoscope before the test, and 100 μl of the test substance was instilled into the right eye, and the left eye was compared. For this purpose, the test substance was not instilled.
점안 후에는 시험물질의 누출 방지를 위해 상하 안검을 잡아 약 1초간 폐안시켰으며, 토끼 9마리 중 6마리는 그대로 두었고 나머지 3마리는 점안한지 20 ~ 30초가 경과한 후 생리식염액 20 ㎖로 1분 동안 세안해 주었다.(6마리는 세안하지 않음)After instillation, the eyes were closed for about 1 second by holding the upper and lower eyelids to prevent leakage of the test substance, and 6 out of 9 rabbits were left as they were, and the remaining 3 rabbits were instilled with 20 ml of physiological saline after 20 to 30 seconds. I washed my face for 10 minutes. (6 did not wash my face)
이후에는 시험물질을 점안하지 않은 좌측 안구를 대조로 하여 점안 시작 후 1시간, 1, 2, 3, 4, 5일 후에 육안 관찰, 손전등 조사관찰 및 검안경 관찰에 의해 우측 안구를 관찰 하였다. 시험 결과는 하기 표 1에 나타내었다.Then, the right eye was observed by visual observation, flashlight irradiation observation, and ophthalmoscope observation 1 hour, 1, 2, 3, 4, and 5 days after the start of instillation using the left eye without instillation of the test substance as a control. The test results are shown in Table 1 below.
실시예 1 및 2와 비교예 1 내지 3은 점안 후 1시간, 1, 2, 3, 4, 5일째에 관찰한 결과 비세안군과 세안군 모두 결막의 발적 및 부종등의 자극이 첫날에만 미세하게 자극이 있는 것으로 확인되었으나, 사실상 무자극(Non-irritant)으로서 매우 안전한 것으로 확인되었다. 그러나 비교예 1 내지 3은 일부 자극이 실시예보다 더 높은 수치로 나타나 자극이 더 발생하는 것으로 나타났다. 따라서 실시예 1 및 2가 더 우수한 것임을 알 수 있다.Examples 1 and 2 and Comparative Examples 1 to 3 were observed at 1 hour, 1, 2, 3, 4, and 5 days after instillation. As a result, irritation such as redness and edema of the conjunctiva was slightly stimulated only on the first day in both the non-face wash group and the face wash group. It was confirmed to be irritating, but it was confirmed to be very safe as a non-irritant in fact. However, in Comparative Examples 1 to 3, some stimulation appeared to have a higher value than that of Examples, indicating that more stimulation occurred. Therefore, it can be seen that Examples 1 and 2 are superior.
시험예 2: 제품 특성비교Test Example 2: Comparison of Product Characteristics
시험예 2는 콘택트 렌즈 사용시 외관변화, Dia, 함수율, pH, 인장강도 및 세정효과등과 같은 기능적 특성을 측정 및 비교하였다. 하기 표 2는 실시예 1 및 2와 비교예 1 내지 3을 비교하여 나타난 결과이다.Test Example 2 measured and compared functional properties such as appearance change, Dia, moisture content, pH, tensile strength and cleaning effect when using contact lenses. Table 2 below shows the results of comparing Examples 1 and 2 and Comparative Examples 1 to 3.
본 발명에 따른 실시예 1 및 2는 비구아나이드를 포함하는 종래의 비교예 1 내지 3과 대비하여도 콘택트렌즈의 특성에 변화를 초래하지 않으며, 특히, 육안으로 보이는 세정효과도 종래의 비교예들보다 더 우수한 것으로 나타나 사용에 적합한 것임을 확인할 수 있다.Examples 1 and 2 according to the present invention do not cause a change in the characteristics of contact lenses even when compared with conventional comparative examples 1 to 3 containing biguanide, and in particular, the cleaning effect visible to the naked eye is also compared to conventional comparative examples. It can be seen that it is more excellent than that and is suitable for use.
시험예 3: 가시아메바에 대한 항균활성 비교 Test Example 3 : Comparison of antibacterial activity against Acanthamoeba
시험예 3은 프로테아제 기반이 콘택트렌즈 세정용액의 가시아메바에 대한 항균활성을 확인하기 위하여 항균 시험을 실시하였다. 그 결과는 하기의 표 3에 나타냈다.In Test Example 3, an antibacterial test was conducted to confirm the antibacterial activity of the protease-based contact lens cleaning solution against Acanthamoeba. The results are shown in Table 3 below.
1) 실험균주: Acanthamoeba castellanii(ATCC No 30011)1) Test strain: Acanthamoeba castellanii (ATCC No 30011)
2) 시험 균주의 농도: 105, 107, 108 2) Concentration of test strain: 10 5 , 10 7 , 10 8
3) 시험기간: 1 day3) Test period: 1 day
4) 배지: 혈액 한천 플레이트4) Medium: blood agar plate
상기 표 3에 나타난 것과 같이 실시예 1 및 2은 가시아메바에 대하여 높은 항균활성을 확보하고 있음을 알 수 있다. 이러한 결과는 염산 폴리아미노프로필비구아니드(PHMB)를 대체하여 프로테아제, MPC 및 천연물질을 사용하더라도 안전성을 확보하면서 가시아메바를 효과적으로 억제하는 것을 입증하는 것이라 할 수 있다.As shown in Table 3, it can be seen that Examples 1 and 2 have high antibacterial activity against Acanthamoeba. These results can be said to prove that it effectively inhibits Acanthamoeba while securing safety even when protease, MPC and natural substances are used instead of polyaminopropylbiguanide hydrochloride (PHMB).
특히, 실시예 2의 경우에는 다른 비교예들과 비교하여도 현저하게 우수한 효과를 나타내므로 현재 시중에서 판매중인 제품이나 종래의 기술들보다 더 나은 효과를 가지고 있음을 입증하고 있다.In particular, in the case of Example 2, it shows a remarkably superior effect compared to other comparative examples, so it is proved that it has a better effect than products currently on the market or conventional technologies.
시험예 4: 항미생물 활성Test Example 4: Antimicrobial activity
시험예 4는 상기 실시예 1 및 2와 비교예 1 내지 3에 대한 항미생물 활성 시험을 실시하였으며, 각각의 실시예와 비교예의 샘플에 유기체를 접종하여 기간 경과에 따른 항미생물 활성을 시험하였다. 시험결과는 하기 표 4 내지 8에 나타내었다.In Test Example 4, an antimicrobial activity test was performed on Examples 1 and 2 and Comparative Examples 1 to 3, and the antimicrobial activity was tested over a period of time by inoculating organisms into samples of each Example and Comparative Example. The test results are shown in Tables 4 to 8 below.
사용 유기체: Escherichia coli(에셔리키아 콜리), Staphylococcus aureus (스타필로코커스 아우레우스, 황색포도상규균), Pseudomonas aeruginosa(슈도모나스 아에루기노사, Candida Albicans(칸디다 알비칸스), Aspergillus niger(아스페르길루스 니게르)Organisms Used: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida Albicans, Aspergillus niger Gilus Niger)
상기 표에 나타난 바와 같이 실시예 1 및 2는 비교예 1 내지 3보다 우수한 항미생물 활성을 나타낸 것임을 확인할 수 있다. 이러한 결과는 염산 폴리아미노프로필비구아니드(PHMB)를 대체하여 프로테아제, MPC 및 천연물질을 사용하더라도 안전성을 확보하면서 항미생물 활성이 우수한 것을 입증하는 것이라 할 수 있다.As shown in the table above, it can be confirmed that Examples 1 and 2 exhibited better antimicrobial activity than Comparative Examples 1 to 3. These results can be said to prove that antimicrobial activity is excellent while securing safety even when protease, MPC and natural substances are used instead of polyaminopropylbiguanide hydrochloride (PHMB).
시험예 5: 저장 안정성 시험(우엉추출물과 남천추출물 함유여부)Test Example 5: Storage stability test (whether burdock extract and namcheon extract are contained)
시험예 5는 실시예 1 및 2와 비교예 1 내지 3을 HDPE 재질의 병에 넣고 밀봉시킨 후 온도 40℃ 상대습도 75%의 항온항습기에 보관하면서 8주 동안 불순물의 생성정도를 비교하였다. 이때 불순물의 함량 측정은 각 세정용액에 메탄올 0.0375mol/L 1-데칸설폰산나트륨용액·과염소산 (600 : 400 : 1) 혼합액에 넣고 초음파 처리를 통해 충분히 녹인 후 0.45㎛ 멤브레인 필터로 여과하여 액제 크로마토그래프법에 따라 측정하였다. 그 불순물의 함량은 하기의 표 9에 나타내었다.In Test Example 5, Examples 1 and 2 and Comparative Examples 1 to 3 were placed in a bottle made of HDPE, sealed, and stored in a thermo-hygrostat at a temperature of 40° C. and a relative humidity of 75%, while comparing the degree of generation of impurities for 8 weeks. At this time, the content of impurities was measured by adding 0.0375 mol/L of methanol 1-decanesulfonate sodium solution and perchloric acid (600:400:1) mixture to each cleaning solution, thoroughly dissolving it through ultrasonic treatment, and filtering with a 0.45㎛ membrane filter to perform liquid chromatography. It was measured according to the graph method. The content of the impurities is shown in Table 9 below.
실시예 1 및 2는 8주간 경시변화 이후의 불순물의 함량은 0.16 중량% 이하였으며, 저장 안정성이 개선된 콘택트렌즈 세정용액임을 확인할 수 있었다. 그러나 비교예 1 내지 3의 경우에는 8주간 경시변화 이후의 불순물의 함량이 실시예보다 낮은 저장 안정성을 나타내었다. In Examples 1 and 2, the content of impurities after 8 weeks of aging was 0.16% by weight or less, and it was confirmed that the contact lens cleaning solution had improved storage stability. However, in the case of Comparative Examples 1 to 3, the content of impurities after 8 weeks of aging showed lower storage stability than that of Examples.
특히, 실시예 2는 편백추출오일의 제조과정에서 생성된 편백추출수에 우엉과 남천을 침지 및 가열하여 우엉추출물과 남천추출물이 포함된 것으로서, 저장 안정성 시험에서 더 나은 효과를 나타낸 것이다. 특히, 실시예 2는 우엉추출물에 함유된 클로로겐산에 의해 pH변화와 화학적 변화에 따른 안정성을 유지시키는 장점이 있음을 알 수 있다.In particular, in Example 2, the burdock extract and the Namcheon extract were included by immersing and heating the burdock and Namcheon in the cypress extract produced during the manufacturing process of the Cypress extract oil, and showed a better effect in the storage stability test. In particular, it can be seen that Example 2 has the advantage of maintaining stability according to pH change and chemical change by the chlorogenic acid contained in the burdock extract.
제시된 실시예들에 대한 설명은 임의의 본 발명의 기술분야에서 통상의 지식을 가진 자가 본 발명을 이용하거나 또는 실시할 수 있도록 제공된다. 이러한 실시예들에 대한 다양한 변형들은 본 발명의 기술 분야에서 통상의 지식을 가진자에게 명백할 것이며, 여기에 정의된 일반적인 원리들은 본 발명의 범위를 벗어남이 없이 다른 실시예들에 적용될 수 있다. 그리하여, 본 발명은 여기에 제시된 실시예들로 한정되는 것이 아니라, 여기에 제시된 원리들 및 신규한 특징들과 일관되는 최광의 범위에서 해석되어야 할 것이다.The description of the presented embodiments is provided to enable any person skilled in the art to use or practice the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments without departing from the scope of the present invention. Thus, the present invention is not to be limited to the embodiments presented herein, but is to be interpreted in the widest scope consistent with the principles and novel features presented herein.
S100: 편백나무 추출물 추출단계
S200: MPC수용액 제조단계
S210: 편백추출오일상 용액 제조단계
S220: MPC용액 제조단계
S221: 천연항균제 혼합단계
S222: 우엉 세척 및 절단단계
S223: 우엉 건조단계
S224: 우엉 덖음단계
S225: 침지단계
S226: 염기 첨가단계
S227: 혼합용매 첨가단계
S228: 가열단계
S229: MPC용액 혼합단계
S230: 혼합단계
S240: 살균제 첨가단계
S300: 프로테아제 첨가단계
S400: 혼합용액 제조단계
S500: 첨가제 첨가단계
S600: 여과단계S100: Cypress extract extraction step
S200: MPC aqueous solution manufacturing step
S210: Cypress extract oil phase solution preparation step
S220: MPC solution manufacturing step
S221: Natural antibacterial agent mixing step
S222: Burdock washing and cutting step
S223: Burdock drying step
S224: Burdock roasting step
S225: immersion step
S226: base addition step
S227: mixed solvent addition step
S228: heating step
S229: MPC solution mixing step
S230: mixing step
S240: disinfectant addition step
S300: protease addition step
S400: Mixed solution manufacturing step
S500: additive addition step
S600: filtration step
Claims (8)
MPC와 프로테아제 기반의 콘택트렌즈 세정액.
Characterized in that it contains purified water, protease, methylacryloyloxyethyl phosphorylcholine (MPC) and sodium chloride
Contact lens cleaning solution based on MPC and protease.
상기 프로테아제가 파파인(papain), 피신(ficin), 브로멜라인(bromelain), 및 액티니딘(actinidin)으로 이루어진 군으로부터 선택되는 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액.
According to claim 1,
Characterized in that the protease is selected from the group consisting of papain, ficin, bromelain, and actinidin
Contact lens cleaning solution based on MPC and protease.
상기 MPC는 용매에 MPC가 혼합된 MPC수용액을 제조한 후, 상기 MPC수용액을 상기 정제수에 혼합하여 첨가하되,
상기 MPC수용액은 계면활성제가 용해된 편백추출오일상의 용액과 MPC 및 수용성가교제가 용해된 정제수가 혼합되며,
상기 MPC수용액은 세균의 증식을 방지하는 천연항균제를 더 포함하며,
상기 천연항균제는 상기 편백추출오일의 제조과정에서 생성된 편백추출수에 우엉을 침지 및 가열하여 우엉추출물을 추출함으로써 제조된 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액.
According to claim 1,
The MPC is added by preparing an MPC aqueous solution in which MPC is mixed in a solvent, and then mixing the MPC aqueous solution with the purified water,
The MPC aqueous solution is a mixture of a solution of cypress extract oil in which a surfactant is dissolved and purified water in which MPC and a water-soluble crosslinking agent are dissolved,
The MPC aqueous solution further includes a natural antibacterial agent that prevents the growth of bacteria,
The natural antibacterial agent is characterized in that it is prepared by extracting the burdock extract by immersing and heating the burdock in the cypress extract produced in the manufacturing process of the cypress extract oil.
Contact lens cleaning solution based on MPC and protease.
상기 천연항균제는 상기 편백추출오일의 제조과정에서 생성된 편백추출수에 남천(Nandina domestica Thunb)을 더해 침지 및 가열하여 남천추출물을 추출함으로써 제조된 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액.
According to claim 3,
The natural antibacterial agent is characterized in that it is prepared by adding Nandina domestica Thunb to the cypress extract produced in the manufacturing process of the cypress extract oil, immersing and heating to extract the cypress extract.
Contact lens cleaning solution based on MPC and protease.
상기 편백나무 추출물 추출단계후, MPC수용액을 제조하는 MPC수용액 제조단계;
상기 MPC수용액 제조단계에서 제조된 MPC 수용액에 프로테아제를 첨가하는 프로테아제 첨가단계;
상기 프로테아제 첨가단계에서 프로테아제가 첨가된 MPC수용액에 염화나트륨 및 정제수를 혼합하여 혼합용액을 제조하는 혼합용액 제조단계;
상기 혼합용액제조단계에서 제조된 혼합용액에 첨가제를 첨가하는 첨가제 첨가단계; 및
상기 첨가제 첨가단계에서 첨가된 혼합용액을 여과하는 여과단계를 포함하며,
상기 편백나무 추출물 추출단계는 상기 편백나무에 용매를 가하여 가열하고, 상기 가열에 의해 발생되는 수증기를 냉각하여 각각 편백추출수와 편백추출오일로 분리하는 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액 제조방법.
A cypress tree extract extraction step of extracting cypress extract water and cypress extract oil from cypress trees;
After the cypress tree extract extraction step, MPC aqueous solution preparation step of preparing an MPC aqueous solution;
A protease addition step of adding a protease to the MPC aqueous solution prepared in the MPC aqueous solution preparation step;
A mixed solution preparation step of preparing a mixed solution by mixing sodium chloride and purified water with the MPC aqueous solution to which the protease was added in the protease addition step;
an additive adding step of adding an additive to the mixed solution prepared in the mixed solution preparing step; and
And a filtration step of filtering the mixed solution added in the additive addition step,
The cypress tree extract extraction step is characterized in that a solvent is added to the cypress tree, heated, and the water vapor generated by the heating is cooled to separate the cypress extract and the cypress extract oil, respectively.
Manufacturing method of contact lens cleaning solution based on MPC and protease.
상기 MPC수용액 제조단계는
상기 편백나무 추출물 추출단계에서 추출된 편백추출오일에 계면활성제를 용해시켜 편백추출오일상의 용액을 제조하는 편백추출오일상 용액 제조단계;
상기 MPC와 수용성 가교제를 정제수에 용해시켜 MPC용액을 제조하는 MPC용액 제조단계; 및
상기 MPC수용액을 제조하기 위해 편백추출오일상 용액과 MPC용액을 혼합하는 혼합단계를 포함하는 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액 제조방법.
According to claim 5,
The step of preparing the MPC aqueous solution
A cypress extract oil phase solution preparation step of preparing a cypress extract oil phase solution by dissolving a surfactant in the cypress extract oil extracted in the cypress extract extraction step;
An MPC solution preparation step of preparing an MPC solution by dissolving the MPC and the water-soluble crosslinking agent in purified water; and
Characterized in that it comprises a mixing step of mixing the cypress extract oil phase solution and the MPC solution to prepare the MPC aqueous solution
Manufacturing method of contact lens cleaning solution based on MPC and protease.
상기 MPC용액 제조단계는 상기 편백나무 추출물 추출단계에서 추출된 편백추출수에 혼합용매를 가하고 우엉을 침지 및 가열하여 우엉추출물을 추출함으로서 제조된 천연항균제를 혼합하는 천연항균제 혼합단계를 더 포함하는 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액 제조방법.
According to claim 6,
The MPC solution preparation step further comprises a natural antimicrobial agent mixing step of mixing a natural antimicrobial agent prepared by adding a mixed solvent to the cypress extract water extracted in the cypress tree extract extraction step and extracting the burdock extract by immersing and heating the burdock. characterized
Manufacturing method of contact lens cleaning solution based on MPC and protease.
상기 천연항균제 혼합단계에서는 상기 우엉이 침지된 편백추출수에 남천을 더해 침지 및 가열함으로서 남천추출물을 추출하는 것을 것을 특징으로 하는
MPC와 프로테아제 기반의 콘택트렌즈 세정액 제조방법.According to claim 7,
In the natural antimicrobial agent mixing step, the burdock is added to the cypress extract in which the burdock is immersed, and the southern stream extract is extracted by immersion and heating.
Manufacturing method of contact lens cleaning solution based on MPC and protease.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210170158A KR20230082337A (en) | 2021-12-01 | 2021-12-01 | MPC and protease-based contact lens cleaning solution and manufacturing method thereof |
| PCT/KR2021/018034 WO2023101046A1 (en) | 2021-12-01 | 2021-12-01 | Contact lens solution based on mpc and protease, and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210170158A KR20230082337A (en) | 2021-12-01 | 2021-12-01 | MPC and protease-based contact lens cleaning solution and manufacturing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230082337A true KR20230082337A (en) | 2023-06-08 |
Family
ID=86612408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020210170158A KR20230082337A (en) | 2021-12-01 | 2021-12-01 | MPC and protease-based contact lens cleaning solution and manufacturing method thereof |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR20230082337A (en) |
| WO (1) | WO2023101046A1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101797275B1 (en) | 2012-03-02 | 2017-11-13 | 니치유 가부시키가이샤 | Contact lens care preparation and packaging solution |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4316739B2 (en) * | 1998-08-31 | 2009-08-19 | 日油株式会社 | Treatment solution for contact lenses |
| JP4162316B2 (en) * | 1999-02-22 | 2008-10-08 | 日油株式会社 | Treatment solution for contact lenses |
| KR20140104174A (en) * | 2013-02-20 | 2014-08-28 | (주)엔보이비젼 | Composition for preventing protein adsorption and application thereof |
| KR102163884B1 (en) * | 2013-10-31 | 2020-10-12 | (주)아모레퍼시픽 | Spherical hydrogel particles using MPC and water-soluble crosslinking agent |
| KR101618012B1 (en) * | 2015-08-31 | 2016-05-04 | 전라남도 | Composition for preventing or improving dry eye syndrome comprising Chamaecyparis obtuse extracts |
| ES2939641T3 (en) * | 2016-02-17 | 2023-04-25 | Seed Co Ltd | Anti-Acanthamoeba solvent for contact lenses |
-
2021
- 2021-12-01 KR KR1020210170158A patent/KR20230082337A/en not_active Application Discontinuation
- 2021-12-01 WO PCT/KR2021/018034 patent/WO2023101046A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101797275B1 (en) | 2012-03-02 | 2017-11-13 | 니치유 가부시키가이샤 | Contact lens care preparation and packaging solution |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023101046A1 (en) | 2023-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5380303A (en) | Method for using an antimicrobial agent for ophthalmic formulations | |
| EP2155271B1 (en) | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions | |
| EP2377543A2 (en) | Ophthalmic, pharmaceutical and other healthcare preparations with naturally ocurring plant compounds, extracts and derivatives | |
| JP2009114206A (en) | Medicinal composition having antimicrobial activity | |
| CN111407774B (en) | Ophthalmic composition and preparation method thereof | |
| TW201136621A (en) | Multipurpose lens care solution with benefits to corneal epithelial barrier function | |
| US20110230424A1 (en) | Ophthalmic solutions, including contact lens care and eye drops comprising carnosine, preferably in combination with dexpanthenol and/or hyaluronic acid | |
| CN106236706A (en) | A kind of levofloxacin hydrochloride slow release eye drop | |
| KR100878053B1 (en) | Antibacterial contact lens compring naringin and process for preparing the same | |
| JPH0368503A (en) | Liquid medicine for contact lens | |
| KR102479119B1 (en) | Contact lens multifunctional solution based on biocompatible MPC polymer and its manufacturing method | |
| KR20100092843A (en) | contact lens preservative | |
| CN108697820B (en) | Solvent for anti-acanthamoeba contact lens | |
| KR20230082337A (en) | MPC and protease-based contact lens cleaning solution and manufacturing method thereof | |
| KR20230082338A (en) | Contact lens multifunctional solution based on biocompatible MPC polymer and its manufacturing method | |
| JPH08503701A (en) | Ophthalmic solutions and methods of use | |
| KR101605145B1 (en) | Contact lenses solution for removing microorganism and acanthamoebae | |
| HU209538B (en) | Set and cleaning composition for treating contactlenses | |
| CN108310442B (en) | Ophthalmic composition | |
| DE2436905A1 (en) | MEANS AND METHODS FOR TREATMENT OF CONTACT LENSES | |
| KR102469315B1 (en) | Hand sanitizer based on biocompatible MPC polymer and its manufacturing method | |
| EP1522321B1 (en) | Method for disinfecting and/or cleaning contact lenses, using a liquid aqueous composition comprising at least one constituent of the aloe vera plant | |
| KR102637031B1 (en) | Composition of contact lens cleaner | |
| CN116139067B (en) | Method for forming gel by zinc hyaluronate and eye drop gel containing zinc hyaluronate and preparation thereof | |
| KR100804105B1 (en) | Moisture Artificial Tear Including Antimicrobial Mineral |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |