KR20210143444A - Vesicle comprising Glycolipids, and Cosmetic Composition comprising the vesicle as an active ingredient - Google Patents
Vesicle comprising Glycolipids, and Cosmetic Composition comprising the vesicle as an active ingredient Download PDFInfo
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Abstract
Description
본 발명은 글리코리피드를 함유한 베지클 및 이를 유효성분으로 포함하는 화장료 조성물으로서, 계면활성제로 글루코리피드를 사용하여 형성된 베지클을 화장품의 미용성분의 유효성분으로 함유함으로써, 분자량이 큰 화장품 미용성분을 적은 양으로도 생체 이용률을 높히고, 잘 녹지 않는 물질의 용해성을 높이며, 미용성분의 안정성을 높이는 글리코리피드를 함유한 베지클 및 이를 유효성분으로 포함하는 화장료 조성물에 관한 것이다.The present invention relates to a vesicle containing glycolipid and a cosmetic composition comprising the same as an active ingredient. By containing a vesicle formed using glucolipid as a surfactant as an active ingredient of a cosmetic ingredient, a cosmetic cosmetic ingredient having a large molecular weight It relates to a vesicle containing glycolipids, which increases bioavailability even in a small amount, increases solubility of insoluble substances, and improves the stability of cosmetic ingredients, and a cosmetic composition comprising the same as an active ingredient.
일반적으로 화장품 미용성분은 분자량이 매우 크기 때문에 피부에 흡수되기가 어렵다. 따라서, 이러한 화장품 미용성분이 피부에 침투될수 있도록 입자의 크기를 조절하는 것이 매우 중요하다. In general, cosmetic ingredients are difficult to absorb into the skin because of their very large molecular weight. Therefore, it is very important to control the size of the particles so that these cosmetic cosmetic ingredients can penetrate the skin.
통상 만들어지는 나노에멀젼은 나노리포좀이며, 리포좀은 지질이중막으로 형성되는 폐쇄된 소포이고, 그 소포 공간내에 수상의 미용성분을 포함한다. 리포좀으로는 SUV(small unilamellar Vesicle), LUV(Large unilamellar Vesicle), GUV(giant unilamellar Vesicle)와 같은 이중막 구조가 알려져 있고, 이러한 이중막이 5개이상 이루어지는 것을 멀티 라멜라 소포체(MLV, Multilamellar Vesicle)라고 한다.Nanoemulsions usually made are nanoliposomes, and liposomes are closed vesicles formed with a lipid bilayer, and contain aqueous cosmetic ingredients in the vesicle space. As liposomes, double membrane structures such as SUV (small unilamellar vesicle), LUV (large unilamellar vesicle), and GUV (giant unilamellar vesicle) are known. do.
이러한 일반적인 나노에멀젼이 폐쇄된 소포안에 액체의 유상성분을 포접할수있는데 이러한 나노에멀젼은 외부의 수상과 삼투 작용에 의해 포접된 유상성분이 파괴될 수 있다, 이를 방지하기 위하여 액체의 유상성분을 고체의 리피드로 만든 것이 SLN(soild Lipid Nanoparticle)인데 이러한 SLN은 외부와 삼투작용이 적어 유효성분이 잘 보전된다. 그러나, 유상성분을 고체 리피드로 하기 때문에 시간이 지나감에 따라 나노에멀젼이 굳는 현상이 생긴다, 이러한 단점을 보완하고자 오일을 5 ~ 10% 정도 첨가하여 나노에멀젼이 굳는 현상을 막는다(NLC).These general nanoemulsions can encapsulate the oily component of the liquid in the closed vesicle. In this nanoemulsion, the encapsulated oily component can be destroyed by the osmotic action with the external aqueous phase. Soiled Lipid Nanoparticles (SLN) are made from lipids, and these SLNs have less osmotic action with the outside, so the active ingredients are well preserved. However, since the oil phase component is a solid lipid, the nano-emulsion hardens over time.
또한, 기존의 리포좀은 리포좀 벽이 탄력적이지 못하기 때문에 유효성분을 피부깊숙이 침투시키지 못하므로 이러한 리포좀벽을 탄력적으로 만들어서 피부침투를 원활하게 만든것이 트랜스퍼좀(탄성리포좀/탄력리포좀/플렉시블리포좀)이라 불린다.In addition, because the existing liposome wall is not elastic, the active ingredient cannot penetrate deep into the skin. is called
니오좀(Niosome)은 비이온성 계면활성제로 구성된 이중막 수송체로 생분해성이며 극성 및 비극성 물질을 봉입할 수 있고 리포좀에 비하여 안정하여 리포좀의 대규모 생산 및 안정성과 관련된 문제를 극복하기 위한 대안으로 개발되고 있다. Niosome is a double-membrane transporter composed of nonionic surfactants, biodegradable, capable of encapsulating polar and non-polar substances, and is stable compared to liposomes, so it is developed as an alternative to overcome the problems related to the large-scale production and stability of liposomes. have.
니오좀과 리포좀은 구조적으로 유사하지만 니오좀은 전하가 없는 단일 사슬 계면활성제 및 콜레스테롤로부터 제조되는 반면 리포좀은 이중사슬 인지질으로부터 제조되기 때문에 리포좀과 니오좀 사이에 특성 차이가 존재한다. 이들 소포체의 안정화는 막(MEMBRANCES)을 유지시켜주는 콜레스테롤 성분에 의해 좌우된다. 비이온 계면활성제로 구성된 니오좀은 비이온 계면활성제 자체만으로는 지질과 같은 역할을 기대할수 없고 천연지질성분과 유사하도록 만들어야 하는데 주로 이용되는 것이 글리세린(GLYCERINE) 골격에 인산염(PHOSPHATE) 유도체를 접목시켜 양친매성 성질을 갖도록 만들어 사용한다. 니오좀은 극성 및 비극성 물질을 봉입할 수 있고, 삼투압적으로 활성이 있으며, 제조시 사용되는 계면활성제가 보관 및 취급에 특별한 조건이 필요하지 않다는 장점이 있다.Although niosomes and liposomes are structurally similar, there is a difference in properties between liposomes and niosomes because niosomes are prepared from uncharged single-chain surfactants and cholesterol whereas liposomes are prepared from double-chain phospholipids. The stabilization of these endoplasmic reticulum depends on the cholesterol component that maintains the membrane (MEMBRANCES). Niosomes composed of nonionic surfactants cannot be expected to play the same role as lipids by themselves, and should be made to be similar to natural lipid components. It is used to make it have masculine properties. Niosomes are advantageous in that they can encapsulate polar and non-polar substances, are osmotically active, and do not require special conditions for storage and handling of the surfactant used in the preparation.
NSV(NONIONIC SURFACTANT VESICLES)는 안정한 비이온 계면활성제(NONIONIC SURFACTANT)로 안정한 베지클을 이룬다. 비이온 계면활성제로는 Polyoxyethylene alkylether, Polyoxyethylene alkylester,Saccharose diester 등이 있다.NONIONIC SURFACTANT VESICLES (NSV) is a stable nonionic surfactant (NONIONIC SURFACTANT) that forms a stable vesicle. Nonionic surfactants include polyoxyethylene alkylether, polyoxyethylene alkylester, and saccharose diester.
또한, 피부의 구성 성분을 보면 인지질(Phospholipids), 콜레스테롤(Cholesterol), 콜레스테롤 설페이트(Cholesterol sulphate), 지방산(Free fatty acids), 글리코실 세라마이드(Glycosyl ceramides), 세라마이드(Ceramides)로 구성되어있다. 그중에서 세라마이드는 피부보습과 노화에 매우 밀접한 관계가 있다. 생체막은 지질 구성분으로서 포스포글리세리드 이외에 당지질을 가진다. 스테로이드는 진핵생물에 있는데 그 중 콜레스테롤은 동물의 세포막에 있고 콜레스테롤과 유사한 피테스테롤(phytosterol)은 식물에 있다. 지질 이분자층에서 극성 머리부분은 물과 접촉하고 있고 비극성 꼬리는 내부로 향한다. 이분자층 전체는 반데르발스(van der Waals) 상호 작용과 소수성 상호작용 같은 비공유 상호작용에 의한 결합으로 배열 된다. 이분자층의 표면은 극성이며 하전된 부분을 포함하고 있다. 이분자층의 비극성 탄화수소 내부는 포화되거나 포화되지 않은 지방산과 융합 고리계의 콜레스테롤로 구성된다. 이분자층의 내부층과 외부층 모두는 지질의 혼합물을 가지고 있지만 거대한 분자들은 외부층에 존재하는 경향이 있고 작은 분자들은 내부층에서 발견되는 경향이 있다. 이분자층 내부에 있는 탄화수소 배열은 질서 정연하여 단단하거나 또는 무질서하여 유동적인 상태로 존재할 수 있다.Also, looking at the components of the skin, it is composed of phospholipids, cholesterol, cholesterol sulphate, free fatty acids, glycosyl ceramides, and ceramides. Among them, ceramides are closely related to skin hydration and aging. The biological membrane has glycolipids in addition to phosphoglycerides as lipid components. Steroids are found in eukaryotes, including cholesterol in animal cell membranes and cholesterol-like phytosterol in plants. In the lipid bilayer, the polar head is in contact with water and the non-polar tail is inward. The entire bilayer is arranged in bonds by non-covalent interactions such as van der Waals interactions and hydrophobic interactions. The surface of the bilayer is polar and contains charged moieties. The inside of the non-polar hydrocarbon of the bimolecular layer is composed of saturated or unsaturated fatty acids and cholesterol in a fused ring system. Both the inner and outer layers of the bilayer contain a mixture of lipids, but large molecules tend to exist in the outer layer and small molecules tend to be found in the inner layer. The arrangement of hydrocarbons in the bilayer can be in an ordered and rigid state or disordered and in a fluid state.
글리코리피드(glycolipid)는 당(모노사카라이드)과 지방(지질)로 이루어진 당지질의 일종으로 세포벽과 세라마이드의 중요 성분을 형성한다. 글리코리피드는 세포벽을 코팅하고 피부에 수분을 잡아 두는 벽을 형성한다. 당지질(glycolipid )은 탄수화물이 글리코시드결합에 의해서 지질 알코올기에 연결되어 생기는 화합물이다. 종종 세라마이드는 당지질의 모체 화합물이 되며, 글리코시드결합은 세라마이드의 일차 알코올과 당사이에 형성된다. 결과적으로 생기는 화합물을 세레브로시드(cerebroside )라 부른다.Glycolipid is a type of glycolipid composed of sugar (monosaccharide) and fat (lipid), and forms an important component of cell walls and ceramides. Glycolipids coat the cell wall and form a wall that holds moisture in the skin. A glycolipid is a compound formed by linking a carbohydrate to a lipid alcohol group by a glycosidic bond. Often, ceramides are the parent compounds of glycolipids, and glycosidic bonds are formed between the primary alcohols and sugars of the ceramides. The resulting compound is called cerebroside.
본 발명에서는, 이와 같은 특성을 가진 글리코리피드를 이용하여 베지클을 형성하고 이를 유효성분으로 함유하는 화장료를 개발하게 된 것이다.In the present invention, a vesicle is formed using glycolipids having such characteristics and a cosmetic composition containing it as an active ingredient has been developed.
본 발명은 계면활성제로 글루코리피드를 사용하여 형성된 베지클을 화장료 조성물의 유효성분으로 함유함으로써, 분자량이 큰 화장품 미용활성성분을 적은 양으로도 생체 이용률을 높히고, 잘 녹지 않는 물질의 용해성을 높이며, 미용성분의 안정성을 높이는 글리코리피드를 함유한 베지클 및 이를 유효성분으로 포함하는 화장료 조성물을 제공하는 것이다.The present invention contains a vesicle formed using glucolipid as a surfactant as an active ingredient in a cosmetic composition, thereby increasing the bioavailability of a cosmetic cosmetic active ingredient having a large molecular weight in a small amount, and increasing the solubility of insoluble substances, It is to provide a vesicle containing glycolipid that increases the stability of cosmetic ingredients and a cosmetic composition comprising the same as an active ingredient.
상기 과제를 해결하기 위하여, 본 발명에 따른 글리코리피드를 함유한 베지클은, 계면활성제로 글루코리피드와, 보조계면활성제로 폴리글리세린-10 올레이트, 용매로 물, 폴리올, 오일 및 화장품 미용활성성분을 사용하고 고압 미세 유화기로 1000바에 연속 5회 통과시킨후 냉각 탈포하여 베지클을 형성한다.In order to solve the above problems, the vesicle containing glycolipid according to the present invention contains glucolipid as a surfactant, polyglycerin-10 oleate as an auxiliary surfactant, water, polyol, oil and cosmetic cosmetic active ingredient as a solvent. After using a high-pressure micro-emulsifier and passing it 5 times continuously at 1000 bar, cooling and defoaming to form a vesicle.
여기서, 글리코리피드 0.001-20%, 폴리글리세린-10 올레이트 0.1-5%, 폴리올 1-60%, 오일 0.1-50%, 화장품 미용활성성분 0.01-50% 및 나머지 물 함량이 바람직하다.Here, 0.001-20% of glycolipid, 0.1-5% of polyglycerin-10 oleate, 1-60% of polyol, 0.1-50% of oil, 0.01-50% of cosmetic active ingredient and the remaining water content are preferable.
상기 계면활성제의 총량이 0.001% 미만인 경우에는 베지클이 형성되지 않으며, 25%를 초과하는 경우에는 피부 자극성에 문제가 있을 수 있다.If the total amount of the surfactant is less than 0.001%, vesicles are not formed, and if it exceeds 25%, there may be a problem in skin irritation.
이때, 폴리올의 경우, 특별한 제한은 없다고 할 것이나, 그 중에서도, 글리세롤, 솔비톨, 자일리톨, 에리스톨, 과당, 유당, 만니톨, 포도당, 설탕, 말토스 및 말티톨로 이루어진 군에서 선택되는 1 종 이상의 물질이 바람직하다.At this time, in the case of polyol, it will be said that there is no particular limitation, but among them, at least one material selected from the group consisting of glycerol, sorbitol, xylitol, erythritol, fructose, lactose, mannitol, glucose, sugar, maltose and maltitol desirable.
또한, 오일의 경우, 특별한 제한은 없다고 할 것이나, 그 중에서도, 유지, 왁스, 탄화수소, 고급지방산 에스테르, 고급 알코올, 실리콘 및 에스테르오일 등으로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, in the case of oil, it will be said that there is no particular limitation, but among them, at least one material selected from the group consisting of oils and fats, waxes, hydrocarbons, higher fatty acid esters, higher alcohols, silicones, ester oils, and the like is preferable.
이 때, 유지로는, 특별한 제한은 없다고 할 것이나, 그 중에서도, 지방산과 트리글리세라이드가 주성분인것이 바람직하며, 더욱 바람직하게는, 마카다미아넛오일, 올리브오일, 호호바오일, 썬플라워오일, 아르간오일, 동백오일, 아보카도오일, 콩기름, 포도씨오일, 피마자오일, 미강오일 등으로 이루어진 군에서 선택되는 1 종 이상일 수 있다. At this time, it will be said that there is no particular limitation as to the fats and oils, but among them, fatty acids and triglycerides are preferred, and more preferably, macadamia nut oil, olive oil, jojoba oil, sunflower oil, argan oil, camellia It may be at least one selected from the group consisting of oil, avocado oil, soybean oil, grape seed oil, castor oil, rice bran oil, and the like.
또한, 왁스로는, 특별한 제한은 없다고 할 것이나, 그 중에서도, 고급 지방산과 고급 알코올의 에스테르가 바람직하며, 더욱 바람직하게는, 카나우바 왁스, 칸데릴리 왁스, 호호바유, 밀납, 라놀린 등으로 이루어진 군에서 선택되는 1 종 이상이 사용될 수 있다.In addition, it will be said that there is no particular limitation on the wax, but among them, an ester of a higher fatty acid and a higher alcohol is preferable, and more preferably, a group consisting of carnauba wax, candelili wax, jojoba oil, beeswax, lanolin, etc. One or more types selected from may be used.
또한, 탄화수소로는, 특별한 제한은 없다고 할 것이나, 그 중에서도, 유동파라핀, 파라핀, 바세린, 세레신, 마이크로 크리스탈 왁스, 스쿠알란 등으로 이루어진 군에서 선택되는 1 종 이상이 바람직하다.In addition, it will be said that there is no particular restriction|limiting as a hydrocarbon, Among them, 1 or more types selected from the group which consists of liquid paraffin, paraffin, vaseline, ceresin, microcrystal wax, squalane, etc. are preferable.
또한, 고급지방산에스테르(고급 지방산 ROOH, 이 때 R: 포화알킬기, 불포화알키닐기)로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 천연유지밀납 등에 에스테르류를 반응시켜 결합된 것인 라우린산, 미리스틴산, 팔미틴산, 스테아린산, 이소스테아린산 등으로 이루어진 군에서 선택되는 1 종 이상이 바람직하다. In addition, the higher fatty acid ester (higher fatty acid ROOH, at this time R: saturated alkyl group, unsaturated alkynyl group) is said to be not particularly limited, but among them, lauric acid, which is bound by reacting esters with natural oil and beeswax, in advance At least one selected from the group consisting of stinic acid, palmitic acid, stearic acid, isostearic acid, and the like is preferable.
또한, 고급알코올로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 세틸알코올, 스테아릴 알코올, 이소스테아릴 알코올, 2-옥틸도데실, 2-에틸헥산세틸, 사과산 디이소스테아릴 등으로 이루어진 군에서 선택되는 1 종 이상이 바람직하다.In addition, it will be said that the higher alcohol is not particularly limited, but among them, in the group consisting of cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecyl, 2-ethylhexanecetyl, and diisostearyl malate, 1 or more types selected are preferable.
또한, 실리콘으로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 디메치콘류, 사이클로메치콘류, 실리콘고분자류, 실리콘오일 등으로 이루어진 군에서 선택되는 1 종 이상이 바람직하다.In addition, it will be said that there is no particular limitation on the silicone, but among them, at least one selected from the group consisting of dimethicones, cyclomethicones, silicone polymers, silicone oil, and the like is preferable.
여기서, 에스테르오일은 세칠에칠헥사노에트,디글리세릴트리이소스테아레이트, 카프릭/카프릴릭 트리글리세라이드, 글리세릴트리2-에칠헥사노에트, 이소노닐이소노나노에이트, 에칠헥실이소노나노에이트, 에칠헥실 팔미테이트, 이소스테아릴 이소스테아레이트, 네오펜칠 글리콜 디카프레이트, 네오펜칠 글리콜 디에칠헥사노에이트, 옥틸도데실미리스테이트, 펜타에쓰릴리 테트라에칠헥사노에이트, 펜타에쓰릴리 테트라이소스테아레이트, 이소트리덴실 이소노나노에이트, 트리메칠로프로판 트리이소스테아레이트, 스쿠알란 등으로 이루어진 군에서 선택되는 1 종 이상이 바람직하다.Here, the ester oil is cetylethylhexanoate, diglyceryl triisostearate, capric/caprylic triglyceride, glyceryl tri2-ethylhexanoate, isononylisononanoate, ethylhexylisono Nanoate, ethylhexyl palmitate, isostearyl isostearate, neopentyl glycol dicaprate, neopentyl glycol diethylhexanoate, octyldodecylmyristate, pentaethryl tetraethylhexanoate, pentaethryl tetra At least one selected from the group consisting of isostearate, isotridensyl isononanoate, trimethylopropane triisostearate, squalane, and the like is preferable.
또한, 본 발명에서 사용될 수 있는 화장품 미용활성성분의 경우, 특별한 제한은 없다고 할 것이나, 그 중에서도, 보습제, 미백제, 주름개선제, 자외선 차단제, 육모제, 비타민과 그 유도체, 아미노산, 항염증제, 여드름 치료제, 살균제, 여성호르몬제, 프라센타, 알란토인, 각질박리용해제, 효모추출물, 콜라겐, 엘라스틴, DHA(도코사헥사엔산), EPA(에이코사펜타엔산), 향 및 천연물로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, in the case of cosmetic active ingredients that can be used in the present invention, it will be said that there is no particular limitation, but among them, moisturizing agents, whitening agents, wrinkle improving agents, sunscreen agents, hair growth agents, vitamins and derivatives thereof, amino acids, anti-inflammatory agents, acne treatment agents, bactericides , female hormones, placenta, allantoin, exfoliating agent, yeast extract, collagen, elastin, DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), fragrance and at least one selected from the group consisting of natural products material is preferred.
이 때, 보습제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 젖산나트륨, 하이드로프롤린, 2-피톨리포-5-카르본산나트륨, 히알루론산, 히알루론산나트륨, 세라마이드, 피토스테롤, 콜레스테롤, 씨토스테롤로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.At this time, it will be said that there is no particular limitation as a moisturizing agent, but among them, sodium lactate, hydroproline, 2-phytolipo-5-carbonate sodium, hyaluronic acid, sodium hyaluronate, ceramide, phytosterol, cholesterol, sitosterol At least one material selected from the group is preferred.
또한, 자외선 차단제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 벤조페논 유도체, 파라아미노안 식향산유도체, 메톡시계피산 유도체, 살리실산 유도체로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation on the sunscreen agent, but among them, at least one material selected from the group consisting of benzophenone derivatives, para-aminobenzoic acid derivatives, methoxycinnamic acid derivatives, and salicylic acid derivatives is preferable.
또한, 미백제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 알부틴과 알부틴 유도체, 코직산, 비사보놀, 나이아신아마이드, 비타민C와 비타민 C 유도체가 바람직하다. 이때 주름개선제로 다양한 천연물로부터 획득한 천연추출물과, 레티놀, 레티놀유도체. 아데노신, 리코러스추출물, 홍삼추출물, 인삼추출물( RG, RH관련) 등으로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation on the whitening agent, but among them, arbutin and arbutin derivatives, kojic acid, bisabonol, niacinamide, vitamin C and vitamin C derivatives are preferable. At this time, as a wrinkle improvement agent, natural extracts obtained from various natural products, retinol, and retinol derivatives. At least one substance selected from the group consisting of adenosine, lycopene extract, red ginseng extract, ginseng extract (RG, RH related), etc. is preferable.
또한, 육모제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 혈행촉진제 및/또는 국소자극제가 바람직하다. 상기 혈행촉진제로는 월견초 엑기스, 세파라틴, 비타민 E 및 그 유도체, 감마 오리자놀로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하고, 상기 국소자극제로는 고추 틴크, 생강 틴크, 칸타리스 틴크, 니코틴산 벤질에스테르로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation as a hair restorer, but among them, a blood circulation promoter and/or a local stimulant are preferable. As the blood circulation promoting agent, at least one substance selected from the group consisting of ginseng extract, ceparatine, vitamin E and its derivatives, and gamma oryzanol is preferable, and the local irritant is red pepper tincture, ginger tincture, cantalis tincture, and nicotinic acid. At least one material selected from the group consisting of benzyl esters is preferred.
또한, 비타민과 그 유도체로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 비타민 A 및 그 유도체, 비타민 B1, B2, B6, E 및 그 유도체, 비타민 D, H, K, 판토텐산 및 그 유도체, 비오틴, 판테놀로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation on vitamins and their derivatives, but among them, vitamin A and its derivatives, vitamins B1, B2, B6, E and its derivatives, vitamins D, H, K, pantothenic acid and its derivatives, biotin, At least one substance selected from the group consisting of panthenol is preferred.
또한, 아미노산으로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 시스틴, 시스테인, 메티오닌, 세린, 로이신, 트립토판, 아미노산 엑기스, EGF(상피세포 성장인자; Epidermal Growth Factor), IGF(인슐린유사 성장인자;Insulin-like growth factor), FGF(섬유아세포 성장인자; Fibroblast Growth Factor), 카파-펩타이드로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation on the amino acid, but among them, cystine, cysteine, methionine, serine, leucine, tryptophan, amino acid extract, EGF (Epidermal Growth Factor), IGF (Insulin-like growth factor; Insulin) -like growth factor), FGF (Fibroblast Growth Factor), one or more substances selected from the group consisting of kappa-peptide is preferable.
또한, 항염증제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 베타-글리틸리틴산, 글리틸리탄산 유도체, 아프렌, 아미노카프론산, 하이드로코티손, 베타글루칸, 리코러스로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that the anti-inflammatory agent is not particularly limited, but among them, at least one selected from the group consisting of beta-glitylittic acid, glitylitanic acid derivatives, aphrene, aminocaproic acid, hydrocortisone, beta-glucan, and lycorus. material is preferred.
또한, 여드름치료제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 에스트라디올, 에스트로, 에티닐에스트라리올, 트리크로산, 아젤린산으로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation as an acne treatment agent, but among them, one or more substances selected from the group consisting of estradiol, estro, ethynyl estrariol, tricroic acid, and azelinic acid are preferable.
또한, 살균제로는 특별한 제한은 없다고 할 것이나, 그 중에서도, 염화벤잘코늄, 염화벤젤토니올, 하로칼반으로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation on the disinfectant, but among them, at least one material selected from the group consisting of benzalkonium chloride, benzeltoniol chloride, and halocalban is preferable.
또한, 여성호르몬제로는 특별한 제한은 없다고 할 것이나, 그 중에서도 에스트로겐이 적합하며, 에스트로겐으로서는, 에스트라디올, 에티닐 에스트라디올, 식물성 에스트로겐인 이소플라본 등으로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation as a female hormone agent, but among them, estrogen is suitable, and as the estrogen, one or more substances selected from the group consisting of estradiol, ethinyl estradiol, isoflavones, which are phytoestrogens, etc. are preferable. .
또한, 각질박리용해제로는 특별한 제한은 없다고 할 것이나, 그 중에서도 유황, 살리실산, 아하, 바하, 레소로신 등으로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, it will be said that there is no particular limitation on the exfoliating agent, but among them, at least one substance selected from the group consisting of sulfur, salicylic acid, aha, bach, resorosin, and the like is preferable.
또한, 천연물로는 동식물, 해양동식물 또는 해조류의 추출엑기스 또는 그들로부터 추출된 성분이라면 특별한 제한은 없다고 할 것이나, 그 중에서도, 풍년화, 광대수염, 백화, 대왕, 감초, 알로에, 카모마일, 로즈힙, 히노키티올, 마로니에, 베타카로틴, 인삼추출물, 수세미, 오이, 김추출물, 미역추출물로 이루어진 군에서 선택되는 1종 이상의 물질이 바람직하다.In addition, as a natural product, it will be said that there is no particular limitation as long as it is an extract of animals, plants, marine animals, or seaweeds, or ingredients extracted from them. , horse chestnut, beta-carotene, ginseng extract, loofah, cucumber, laver extract, one or more substances selected from the group consisting of seaweed extract is preferable.
이들 성분을 용기에 도입한 후 80℃ 온도에서 용해시킨 다음, 호모 믹서를 이용하여 대략 5분 동안 혼합 후에 고압 미세 유화기로 1000bar에서 연속 5회 통과 시킨 후 냉각, 탈포시켜 리포좀을 수득한다. After introducing these components into the container, they are dissolved at a temperature of 80° C., and then mixed for about 5 minutes using a homo mixer, and then passed through a high-
이렇게 형성된 베지클을 스킨케어, 바디케어, 크림, 헤어케어, 에멀젼, 에센스 또는 메이크업화장품 등의 제형의 유효성분으로 포함함으로써, 분자량이 큰 화장품 미용성분을 적은 양으로도 생체 이용률을 높히고, 잘녹지 않는 물질을 용해성이 좋게 만들었으며, 미용활성성분이 불안정한 물질(빛, 열, 공기, 산소등)에 대한 안정성을 높혔다.By including the thus formed vesicle as an active ingredient in formulations such as skin care, body care, cream, hair care, emulsion, essence, or makeup cosmetics, the bioavailability of cosmetics with a large molecular weight is increased even with a small amount, and It made the substances that do not have good solubility, and the cosmetically active ingredients increased the stability of the unstable substances (light, heat, air, oxygen, etc.).
본 발명에 따른 글리코리피드 함유 베지클은, 베지클의 입자사이즈가 59.4nm로 레티놀의 경피흡수 촉진 실험 결과 피부에 매우 빠르게 침투되어 탁월한 효과를 나타내었으며, 베지클이 매우 잘 형성되어 있었고, 베지클 안정성이 뛰어나고 레티놀의 안정성도 뛰어난 효과가 있다.The glycolipid-containing vesicle according to the present invention had a particle size of 59.4 nm, and as a result of a test for promoting percutaneous absorption of retinol, it penetrated into the skin very quickly and showed an excellent effect, the vesicle was very well formed, and the vesicle It has excellent stability and excellent stability of retinol.
또한, 본 발명에 따라 형성된 베지클을 화장품의 유효성분으로 포함함으로써, 분자량이 큰 화장품 미용성분을 적은 양으로도 생체 이용률을 높히고, 잘녹지 않는 물질을 용해성이 좋게 만들었으며, 미용성분이 불안정한 물질(빛, 열, 공기, 산소등)에 대해 안정성이 높아지는 효과가 있다.In addition, by including the vesicle formed according to the present invention as an active ingredient in cosmetics, the bioavailability of cosmetic cosmetic ingredients having a large molecular weight is increased even in a small amount, and substances that are not easily soluble are made good in solubility, and cosmetic ingredients are unstable substances. It has the effect of increasing stability against (light, heat, air, oxygen, etc.).
도 1은 본 발명에 따른 글리코리피드 함유 베지클의 입자 분포를 나타낸 그래프.
도 2는 본 발명에 따른 글리코리피드 함유 베지클의 입자 사진도면.
도 3은 본 발명에 따른 글리코리피드 함유 베지클의 안정성 측정 제타포텐셜 그래프.
도 4는 본 발명에 따른 글리코리피드 함유 베지클의 장기 안정성 측정 그래프.
도 5의 (a),(b),(c)는 본 발명에 따른 레티놀 함유 글리코리피드 함유 베지클의 빛, 온도에 대한 안정성을 비교예와 비교한 도표.1 is a graph showing the particle distribution of glycolipid-containing vesicles according to the present invention.
Figure 2 is a particle photograph of a glycolipid-containing vesicle according to the present invention.
3 is a zeta potential graph for measuring stability of glycolipid-containing vesicles according to the present invention.
Figure 4 is a graph of long-term stability measurement of glycolipid-containing vesicles according to the present invention.
Figure 5 (a), (b), (c) is a table comparing the stability to light and temperature of the retinol-containing glycolipid-containing vesicles according to the present invention with those of Comparative Examples.
이하, 본 발명의 바람직한 실시예의 상세한 설명은 첨부된 도면들을 참조하여 설명할 것이다. 하기에서 본 발명을 설명함에 있어서, 관련된 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 것이다.DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, detailed description of preferred embodiments of the present invention will be described with reference to the accompanying drawings. In the following description of the present invention, if it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.
실시예 1 : 오일을 함유하는 투명한 베지클의 제조Example 1: Preparation of transparent vesicles containing oil
하기와 같은 조성물을 혼합교반하고 고압미세균질기를 1000bar 연속 5회 통과시킨후 냉각, 탈포함으로써 베지클을 제조하였다.A vesicle was prepared by mixing and stirring the following composition and passing it through a high-pressure micro homogenizer at 1000
실시예 2 : 오일을 함유하는 투명한 베지클의 제조Example 2: Preparation of transparent vesicles containing oil
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예3: 오일을 함유하는 베지클의 제조Example 3: Preparation of Vesicles Containing Oil
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 4 : 오일을 함유하는 베지클의 제조Example 4: Preparation of Vesicles Containing Oil
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 5 : 오일을 함유하는 투명한 베지클의 제조Example 5: Preparation of transparent vesicles containing oil
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 6 : 왁스를 함유하는 베지클의 제조Example 6: Preparation of Vesicles Containing Wax
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 7 : 탄화수소를 함유하는 베지클의 제조Example 7: Preparation of Vesicles Containing Hydrocarbons
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 8 : 고급 지방산을 함유하는 베지클의 제조Example 8: Preparation of Vesicles Containing Higher Fatty Acids
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 9 : 에스테르를 함유하는 베지클의 제조Example 9: Preparation of Vesicles Containing Ester
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 10 : 고급 알코올을 함유하는 베지클의 제조Example 10: Preparation of Vesicles Containing Higher Alcohols
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 11 : 실리콘을 함유하는 베지클의 제조Example 11: Preparation of Vesicles Containing Silicon
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 12 : 보습제를 함유하는 베지클의 제조Example 12: Preparation of Vesicles Containing Moisturizer
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 13 : 미백제를 함유하는 투명한 베지클의 제조Example 13: Preparation of transparent vesicles containing whitening agent
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 14 : 자외선 차단제를 함유하는 베지클의 제조Example 14: Preparation of Vesicles Containing Sunscreen
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 15 : 육모제를 함유하는 베지클의 제조Example 15: Preparation of vesicles containing hair restorer
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 16 : 비타민을 함유하는 베지클의 제조Example 16: Preparation of Vesicles Containing Vitamins
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 17 : 아미노산을 함유하는 베지클의 제조Example 17: Preparation of Vesicles Containing Amino Acids
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 18 : 항염증제를 함유하는 베지클의 제조Example 18: Preparation of Vesicles Containing Anti-Inflammatory Agents
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 19 : 여드름 치료제를 함유하는 베지클의 제조Example 19: Preparation of Vesicles Containing Acne Treatment
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
실시예 20 : 천연물을 함유하는 베지클의 제조Example 20: Preparation of Vesicles Containing Natural Products
하기와 같은 조성물을 사용한 것을 제외하고는, 실시예 1과 동일한 방법으로 베지클을 제조하였다.A vesicle was prepared in the same manner as in Example 1, except that the following composition was used.
비교예 1 : 비타민을 함유하는 일반적인 리포좀의 제조Comparative Example 1: Preparation of general liposomes containing vitamins
하기와 같은 조성물을 혼합교반하고 고압미세균질기를 1000bar 연속 5회 통과시킨후 냉각, 탈포함으로써 베지클을 제조하였다.A vesicle was prepared by mixing and stirring the following composition and passing it through a high-pressure micro homogenizer at 1000
실험 1. 글리코리피드 함유 베지클의 입자 분포
실시예1의 입자 분포를 Photal. ELS-Z를 이용해서 측정한 결과는 도 1에 나타냈다. 도 1에 도시된 바와 같이, 입자의 크기가 59.4nm 임을 알 수 있다.The particle distribution of Example 1 was described in Photal. The results measured using ELS-Z are shown in FIG. 1 . As shown in Figure 1, it can be seen that the particle size is 59.4 nm.
이는 통상의 리포좀의 입자 크기 87.3nm와 비교할때 현격하게 작은 크기이다.This is a remarkably small size compared to the particle size of a conventional liposome of 87.3 nm.
실험 2. 글리코리피드 함유 베지클의 입자 사진Experiment 2. Photo of particles of vesicles containing glycolipids
실시예1의 입자 크기는 너무 미세하여 일반적인 광학 현미경으로는 측정이 불가능하므로, 액체 질소를 이용하여 시료를 -176℃로 유지시켜 동결상태로 구조분석하는 동결 전자현미경(photo Graphing Freeze-Fracture Scanning Electron Microscopy)을 이용하여 찍은 입자 사진을 도 2에 나타냈다. Since the particle size of Example 1 is too fine to be measured with a general optical microscope, the sample is maintained at -176° C. using liquid nitrogen to analyze the structure in a frozen state (photo Graphing Freeze-Fracture Scanning Electron) A photograph of the particles taken using microscopy is shown in FIG. 2 .
도 2에 도시된 바와 같이, 베지클이 잘형성되어 있음을 알수있다.As shown in Fig. 2, it can be seen that the vesicles are well formed.
실험 3. 글리코리피드 함유 베지클의 경피 흡수촉진 효과Experiment 3. Percutaneous absorption promoting effect of vesicles containing glycolipids
인공피부인 태고사이언스의 네오덤을 Franz-type diffusion cell(Lab fine instruments, korea)에 장착하여 실험하였다. Franz-type diffusion cell의 Receptor용기(5㎖)에 50mM인산염 완충액(pH 7.4, 0.1M Nacl)을 넣어준후, diffusion cell을 32℃, 600rpm으로 혼합, 분산시켜 주었으며, 비교예1에서 레티놀을 함유한 일반 리포좀과 실시예16 베지클 50㎕를 donor용기에 넣어 주었다. 미리 예정한 시간에 따라 흡수 확산시켜 주었으며, 흡수 확산이 일어나는 피부의 0.64cm2가 되게 하였다. Neoderm of Taego Science, an artificial skin, was tested by mounting it in a Franz-type diffusion cell (Lab fine instruments, Korea). After putting 50 mM phosphate buffer (pH 7.4, 0.1 M Nacl) into the receptor container (5 ml) of the Franz-type diffusion cell, the diffusion cell was mixed and dispersed at 32 ° C., 600 rpm. General liposomes and 50 μl of Example 16 vesicles were put in a donor container. Absorption and diffusion were given according to a predetermined time, and 0.64 cm 2 of the skin where absorption and diffusion occurred was made.
유효성분의 흡수확산이 끝난후에는 건조된 kimwipes 또는 10㎖의 에탄올로 흡수되지 못하고 피부에 남아 있는 유화물을 씻어주고, 팁-타입균등기를 사용하여 유효성분이 흡수 확산되어 있는 피부를 갈아준후, 피부 내부로 흡수된 레티놀량을 4㎖의 디클로로메탄을 사용하여 추출하였다. 이후 추출액을 0.45㎛ 나일론 멤브레인 (nylon membrane)여과막으로 여과하고, 다음 조건으로 HPLC법으로 함량을 측정한 후에 그 결과를 [표 22]에 나타내었다.After the absorption and diffusion of the active ingredient is finished, wash the emulsion remaining on the skin that cannot be absorbed with dried kimwipes or 10 ml of ethanol, and use a tip-type equalizer to change the skin where the active ingredient is absorbed and diffused, then inside the skin The amount of retinol absorbed by the was extracted using 4 ml of dichloromethane. Then, the extract was filtered through a 0.45 μm nylon membrane filtration membrane, and the content was measured by HPLC under the following conditions, and the results are shown in [Table 22].
B) 이동상: 메탄올:헥산=2:1
C) 유속: 0.8㎖/min
D) 검출기:UV 275nmA) Column: C18 (4.6x 200 mm, 5 μm)
B) Mobile Phase: Methanol:Hexane=2:1
C) Flow rate: 0.8 ml/min
D) Detector: UV 275nm
[표 22]에 나타난 바와 같이, 본 발명에 따른 글리코리피드 함유 베지클의 경우, 경피흡수율이 46.86% 증가되었음을 알 수 있다.As shown in [Table 22], in the case of the glycolipid-containing vesicle according to the present invention, it can be seen that the transdermal absorption rate was increased by 46.86%.
실험 4. 글리코리피드 함유 베지클의 안정성 측정Experiment 4. Determination of stability of glycolipid-containing vesicles
베지클의 안정도 측정을 위해 제타포텐셜을 Photal, ELS-Z를 이용해서 측정한 결과는 도 3에 나타내었다.The results of measuring the zeta potential using Photal and ELS-Z for measuring the stability of the vesicle are shown in FIG. 3 .
도 3에 도시된 바와 같이, 입자의 전위가 -67.39mV로 안정함을 알수 있다As shown in Figure 3, it can be seen that the potential of the particle is stable at -67.39mV.
실험 5. 글리코리피드 함유 베지클의 장기 안정성 측정
베지클의 1년 동안의 안정도 측정을 위해 Turbiscan을 사용해서 40℃ 온도에서 4시간 동안 측정한 결과를 도 4에 나타내었다.Figure 4 shows the results of measuring the stability of the vesicles for 1 year at 40°C for 4 hours using Turbiscan.
도 4에 도시된 바와 같이, 베지클이 오랜시간 안정함을 알 수 있다.As shown in Figure 4, it can be seen that the vesicle is stable for a long time.
실험 6. 레티놀 함유 글리코리피드 함유 베지클의 안정성Experiment 6. Stability of retinol-containing glycolipid-containing vesicles
레티놀의 안정성을 보기위해 실시예16(크림B)과 비교예1(크림A)에 대해 빛, 온도에 대한 안정성을 HPLC로 분석한 결과를 도 5의 (a),(b),(c)에 나타내었다.To see the stability of retinol, Example 16 (Cream B) and Comparative Example 1 (Cream A) of Example 16 (Cream B) and Comparative Example 1 (Cream A) the results of analyzing the stability to light and temperature by HPLC in Figure 5 (a), (b), (c) shown in
도 5의 (a),(b),(c)에 도시된 바와 같이, 유효성분인 레티놀을 글리코리피드로 안정화한 것이 더 효과적임을 알 수 있다.As shown in (a), (b), (c) of Figure 5, it can be seen that the stabilization of the active ingredient retinol with glycolipids is more effective.
결과를 종합하면, 베지클의 입자사이즈가 59.4nm로 레티놀의 경피흡수 촉진 실험 결과 피부에 매우 빠르게 침투되어 탁월한 효과를 나타내었으며, 입자사진의 결과로 베지클이 매우 잘 형성되어 있었고, 제타포텐셜과 터비스캔 측정결과 베지클 안정성이 뛰어나고 레티놀의 안정성도 뛰어남을 확인했다. Taken together, the particle size of the vesicle was 59.4 nm, and as a result of the test for promoting the percutaneous absorption of retinol, it penetrated the skin very quickly and showed an excellent effect. As a result of the turbiscan measurement, it was confirmed that the vesicle stability was excellent and the stability of retinol was also excellent.
이하, 본 발명에 따라 제조된 베지클을 함유한 화장품 적용예는 다음과 같다.Hereinafter, cosmetic application examples containing vesicles prepared according to the present invention are as follows.
(1) 베지클을 함유한 스킨 제조(1) Preparation of skin containing vesicles
(2) 베지클을 함유한 로션 제조(2) Preparation of lotion containing vesicles
(3) 베지클을 함유한 바디 로션 제조(3) Preparation of body lotion containing vesicles
(4) 베지클을 함유한 크림 제조(4) Preparation of cream containing vesicles
(5) 베지클을 함유한 에센스 제조(5) Preparation of essence containing vesicles
Claims (27)
폴리글리세린-10 올레이트;
물;
폴리올;
오일; 및
미용활성성분;을 포함하여 구성되는 것을 특징으로 하는 글리코리피드를 함유한 베지클.
glucolipid;
polyglycerin-10 oleate;
water;
polyols;
oil; and
A vesicle containing glycolipids, characterized in that it comprises a cosmetic active ingredient.
상기 글리코리피드 0.001-20%, 폴리글리세린-10 올레이트 0.1-5%, 폴리올 1-60%, 오일 0.1-50%, 미용활성성분 0.01-50% 및 물 함량을 포함하여 구성되는 것을 특징으로 하는 글리코리피드를 함유한 베지클.
The method of claim 1,
0.001-20% of the glycolipid, 0.1-5% of polyglycerin-10 oleate, 1-60% of polyol, 0.1-50% of oil, 0.01-50% of cosmetic active ingredient and water content Vesicles containing glycolipids.
상기 폴리올은, 글리세롤, 솔비톨, 자일리톨, 에리스톨, 과당, 유당, 만니톨, 포도당, 설탕, 말토스 및 말티톨로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
The method of claim 1,
The polyol is vesicle containing glycolipid, characterized in that at least one selected from the group consisting of glycerol, sorbitol, xylitol, erythritol, fructose, lactose, mannitol, glucose, sugar, maltose and maltitol.
상기 오일은, 유지, 왁스, 탄화수소, 고급지방산 에스테르, 고급 알코올, 실리콘 및 에스테르오일로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
The method of claim 1,
The oil is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of oils and fats, waxes, hydrocarbons, higher fatty acid esters, higher alcohols, silicones and ester oils.
상기 유지는, 지방산과 트리글리세라이드가 주성분인 것을 특징으로 하며,
마카다미아넛오일, 올리브오일, 호호바오일, 썬플라워오일, 아르간오일, 동백오일, 아보카도오일, 콩기름, 포도씨오일, 피마자오일, 미강오일로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The fat is characterized in that fatty acids and triglycerides are the main components,
Macadamia nut oil, olive oil, jojoba oil, sunflower oil, argan oil, camellia oil, avocado oil, soybean oil, grape seed oil, castor oil, rice bran oil vesicle.
상기 왁스는, 고급 지방산과 고급 알코올의 에스테르이거나, 또는
카나우바 왁스, 칸데릴리 왁스, 호호바유, 밀납, 라놀린으로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The wax is an ester of a higher fatty acid and a higher alcohol, or
A vesicle containing glycolipids, characterized in that at least one selected from the group consisting of carnauba wax, candelilli wax, jojoba oil, beeswax, and lanolin.
상기 탄화수소는, 유동파라핀, 파라핀, 바세린, 세레신, 마이크로 크리스탈 왁스, 스쿠알란으로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The hydrocarbon is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of liquid paraffin, paraffin, vaseline, ceresin, microcrystal wax, and squalane.
상기 고급지방산 에스테르는, 라우린산, 미리스틴산, 팔미틴산, 스테아린산, 이소스테아린산으로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The higher fatty acid ester is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, and isostearic acid.
상기 고급알코올은, 세틸알코올, 스테아릴 알코올, 이소스테아릴 알코올, 2-옥틸도데실, 2-에틸헥산세틸, 사과산 디이소스테아릴로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The higher alcohol contains glycolipid, characterized in that at least one selected from the group consisting of cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecyl, 2-ethylhexanecetyl, and diisostearyl malate one vesicle.
상기 실리콘은, 디메치콘류, 사이클로메치콘류, 실리콘고분자류, 실리콘오일로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The silicone is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of dimethicones, cyclomethicones, silicone polymers, and silicone oil.
상기 에스테르오일은, 세칠에칠헥사노에트,디글리세릴트리이소스테아레이트, 카프릭/카프릴릭 트리글리세라이드, 글리세릴트리2-에칠헥사노에트,이소노닐이소노나노에이트, 에칠헥실이소노나노에이트, 에칠헥실 팔미테이트, 이소스테아릴 이소스테아레이트, 네오펜칠 글리콜 디카프레이트, 네오펜칠 글리콜 디에칠헥사노에이트, 옥틸도데실미리스테이트, 펜타에쓰릴리 테트라에칠헥사노에이트, 펜타에쓰릴리 테트라이소스테아레이트, 이소트리덴실 이소노나노에이트, 트리메칠로프로판 트리이소스테아레이트, 스쿠알란으로 이루어진 군에서 선택되는 1 종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
5. The method of claim 4,
The ester oil is cetylethyl hexanoate, diglyceryl triisostearate, capric/caprylic triglyceride, glyceryl tri2-ethylhexanoate, isononylisononanoate, ethylhexylisono Nanoate, ethylhexyl palmitate, isostearyl isostearate, neopentyl glycol dicaprate, neopentyl glycol diethylhexanoate, octyldodecylmyristate, pentaethryl tetraethylhexanoate, pentaethryl tetra A vesicle containing glycolipid, characterized in that at least one selected from the group consisting of isostearate, isotridensyl isononanoate, trimethylopropane triisostearate, and squalane.
상기 미용활성성분은, 보습제, 미백제, 주름개선제, 자외선 차단제, 육모제, 비타민과 그 유도체, 아미노산, 항염증제, 여드름 치료제, 살균제, 여성호르몬제, 프라센타, 알란토인, 각질박리용해제, 효모추출물, 콜라겐, 엘라스틴, DHA(도코사헥사엔산), EPA(에이코사펜타엔산), 향 및 천연물로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
The method of claim 1,
The cosmetically active ingredients include moisturizing agents, whitening agents, wrinkle improvement agents, sunscreen agents, hair growth agents, vitamins and derivatives, amino acids, anti-inflammatory agents, acne treatment agents, bactericides, female hormones, placenta, allantoin, keratin exfoliating agent, yeast extract, collagen, elastin , DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of fragrance and natural products.
상기 보습제는, 젖산나트륨, 하이드로프롤린, 2-피톨리포-5-카르본산나트륨, 히알루론산, 히알루론산나트륨, 세라마이드, 피토스테롤, 콜레스테롤, 씨토스테롤로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The moisturizing agent, sodium lactate, hydroproline, 2-phytolipo-5-carbonate sodium, hyaluronic acid, sodium hyaluronate, ceramide, phytosterol, cholesterol, glycos, characterized in that at least one selected from the group consisting of sitosterol Vesicles containing lipids.
상기 자외선 차단제는, 벤조페논 유도체, 파라아미노안 식향산유도체, 메톡시계피산 유도체, 살리실산 유도체로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The sunscreen is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of benzophenone derivatives, para-aminobenzoic acid derivatives, methoxycinnamic acid derivatives, and salicylic acid derivatives.
상기 미백제는, 알부틴과 알부틴 유도체, 코직산, 비사보놀, 나이아신아마이드, 비타민C와 비타민 C 유도체로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The whitening agent is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of arbutin and arbutin derivatives, kojic acid, bisabonol, niacinamide, and vitamin C and vitamin C derivatives.
상기 주름개선제는, 천연추출물, 레티놀, 레티놀유도체, 아데노신, 리코러스추출물, 홍삼추출물, 인삼추출물로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The wrinkle improving agent is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of natural extracts, retinol, retinol derivatives, adenosine, lycorus extract, red ginseng extract, and ginseng extract.
상기 육모제는, 혈행촉진제 또는 국소자극제이며,
상기 혈행촉진제는 월견초 엑기스, 세파라틴, 비타민 E 및 그 유도체, 감마 오리자놀로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하고,
상기 국소자극제는 고추 틴크, 생강 틴크, 칸타리스 틴크, 니코틴산 벤질에스테르로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The hair restorer is a blood circulation promoter or a local stimulant,
The blood circulation promoting agent is characterized in that at least one selected from the group consisting of wolgyeoncho extract, ceparatin, vitamin E and its derivatives, and gamma oryzanol,
The local irritant is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of red pepper tincture, ginger tincture, cantalis tincture, and nicotinic acid benzyl ester.
상기 비타민과 그 유도체는, 비타민 A 및 그 유도체, 비타민 B1, B2, B6, E 및 그 유도체, 비타민 D, H, K, 판토텐산 및 그 유도체, 비오틴, 판테놀로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The vitamin and its derivatives include at least one selected from the group consisting of vitamin A and its derivatives, vitamins B1, B2, B6, E and its derivatives, vitamins D, H, K, pantothenic acid and its derivatives, biotin, and panthenol. Vesicles containing glycolipids.
상기 아미노산은, 시스틴, 시스테인, 메티오닌, 세린,로이신, 트립토판, 아미노산 엑기스, EGF(상피세포 성장인자), IGF(인슐린유사 성장인자), FGF(섬유아세포 성장인자), 카파-펩타이드로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The amino acid is cystine, cysteine, methionine, serine, leucine, tryptophan, amino acid extract, EGF (epithelial growth factor), IGF (insulin-like growth factor), FGF (fibroblast growth factor), from the group consisting of kappa-peptide A vesicle containing glycolipid, characterized in that at least one selected type.
상기 항염증제는, 베타-글리틸리틴산, 글리틸리탄산 유도체, 아프렌, 아미노카프론산, 하이드로코티손, 베타글루칸, 리코러스로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The anti-inflammatory agent is beta-glycolipid, characterized in that at least one selected from the group consisting of glycyrrhizic acid, glitylitanic acid derivatives, afren, aminocaproic acid, hydrocortisone, beta-glucan, and lycorus vesicles containing glycolipids. .
상기 여드름치료제는, 에스트라디올, 에스트로, 에티닐에스트라리올, 트리크로산, 아젤린산으로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The acne treatment agent is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of estradiol, estro, ethinyl estrariol, tricroic acid, and azelinic acid.
상기 살균제는, 염화벤잘코늄, 염화벤젤토니올, 하로칼반으로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The bactericide is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of benzalkonium chloride, benzeltoniol chloride, and halocalban.
상기 여성호르몬제는 에스트로겐이 적합하며,
상기 에스트로겐은, 에스트라디올, 에티닐 에스트라디올, 식물성 에스트로겐인 이소플라본으로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
Estrogen is suitable for the female hormone agent,
The estrogen is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of estradiol, ethinyl estradiol, and isoflavones, which are phytoestrogens.
상기 각질박리용해제는, 유황, 살리실산, 아하, 바하, 레소로신으로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The keratin dissolving agent is a vesicle containing glycolipid, characterized in that at least one selected from the group consisting of sulfur, salicylic acid, aha, baja, and resorosin.
상기 천연물은 동식물, 해양동식물 또는 해조류의 추출엑기스 또는 그들로 부터 추출된 성분이며,
풍년화, 광대수염, 백화, 대왕, 감초, 알로에, 카모마일, 로즈힙, 히노키티올, 마로니에, 베타카로틴, 인삼추출물, 수세미, 오이, 김추출물, 미역추출물로 이루어진 군에서 선택되는 1종 이상인 것을 특징으로 하는 글리코리피드를 함유한 베지클.
13. The method of claim 12,
The natural product is an extract of animals and plants, marine animals and plants or seaweeds or a component extracted from them,
It is characterized in that at least one selected from the group consisting of fern, clown beard, white flower, giant, licorice, aloe, chamomile, rosehip, hinokitiol, horse chestnut, beta-carotene, ginseng extract, loofah, cucumber, laver extract, seaweed extract Vesicles containing glycolipids.
A cosmetic composition comprising the vesicle containing the glycolipid of any one of claims 1 to 25 as an active ingredient.
상기 글리코리피드를 함유한 베지클을 유효성분으로 포함하는 화장료 조성물은, 스킨케어, 바디케어, 크림, 헤어케어, 에멀젼, 에센스 또는 메이크업화장품 제형으로 제조되는 것을 특징으로 하는 화장료 조성물.27. The method of claim 26,
The cosmetic composition comprising the glycolipid-containing vesicle as an active ingredient is a cosmetic composition, characterized in that it is prepared in a skin care, body care, cream, hair care, emulsion, essence or makeup cosmetic formulation.
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| KR1020200060192A KR20210143444A (en) | 2020-05-20 | 2020-05-20 | Vesicle comprising Glycolipids, and Cosmetic Composition comprising the vesicle as an active ingredient |
| KR1020230064988A KR20230076808A (en) | 2020-05-20 | 2023-05-19 | Vesicle comprising Glycolipids, and Cosmetic Composition comprising the vesicle as an active ingredient |
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| KR1020230064988A KR20230076808A (en) | 2020-05-20 | 2023-05-19 | Vesicle comprising Glycolipids, and Cosmetic Composition comprising the vesicle as an active ingredient |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557913A (en) * | 2022-03-04 | 2022-05-31 | 广州妮趣化妆品有限公司 | High-content ceramide repairing and moisturizing cream and preparation method thereof |
| KR102500758B1 (en) * | 2022-09-23 | 2023-02-16 | 주식회사 디보트 | Method for preparing cosmetic composition containg liposomes containing five kinds of ceramides |
| CN114557913B (en) * | 2022-03-04 | 2024-06-07 | 广州妮趣化妆品有限公司 | High-content ceramide repair moisturizing cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101264902B1 (en) | 2006-03-07 | 2013-05-15 | 주식회사 엘지생활건강 | Cosmetic composition in the form of liquid crystal emulsion |
| KR20190033962A (en) | 2017-09-22 | 2019-04-01 | 주식회사 유나이티드엑티브 | Fermented emulsifier using microorganism and preparation thereof |
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2020
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101264902B1 (en) | 2006-03-07 | 2013-05-15 | 주식회사 엘지생활건강 | Cosmetic composition in the form of liquid crystal emulsion |
| KR20190033962A (en) | 2017-09-22 | 2019-04-01 | 주식회사 유나이티드엑티브 | Fermented emulsifier using microorganism and preparation thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557913A (en) * | 2022-03-04 | 2022-05-31 | 广州妮趣化妆品有限公司 | High-content ceramide repairing and moisturizing cream and preparation method thereof |
| CN114557913B (en) * | 2022-03-04 | 2024-06-07 | 广州妮趣化妆品有限公司 | High-content ceramide repair moisturizing cream and preparation method thereof |
| KR102500758B1 (en) * | 2022-09-23 | 2023-02-16 | 주식회사 디보트 | Method for preparing cosmetic composition containg liposomes containing five kinds of ceramides |
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