CN114557913A - High-content ceramide repairing and moisturizing cream and preparation method thereof - Google Patents
High-content ceramide repairing and moisturizing cream and preparation method thereof Download PDFInfo
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- CN114557913A CN114557913A CN202210209083.XA CN202210209083A CN114557913A CN 114557913 A CN114557913 A CN 114557913A CN 202210209083 A CN202210209083 A CN 202210209083A CN 114557913 A CN114557913 A CN 114557913A
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- ceramide
- weight
- emulsifier
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Links
- 229940106189 ceramide Drugs 0.000 title claims abstract description 54
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims abstract description 52
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 52
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 52
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000006071 cream Substances 0.000 title claims abstract description 18
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 229930186217 Glycolipid Natural products 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 32
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000002537 cosmetic Substances 0.000 claims abstract description 21
- 239000004519 grease Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 37
- 239000003921 oil Substances 0.000 claims description 33
- 239000003755 preservative agent Substances 0.000 claims description 23
- 230000002335 preservative effect Effects 0.000 claims description 23
- 239000002562 thickening agent Substances 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 14
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 229920005862 polyol Polymers 0.000 claims description 12
- 150000003077 polyols Chemical class 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- 239000004359 castor oil Substances 0.000 claims description 8
- 235000019438 castor oil Nutrition 0.000 claims description 8
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 8
- 150000002191 fatty alcohols Chemical class 0.000 claims description 8
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 8
- 229930182470 glycoside Natural products 0.000 claims description 8
- 150000002338 glycosides Chemical class 0.000 claims description 8
- 229940070765 laurate Drugs 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 229940105132 myristate Drugs 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- 229940100460 peg-100 stearate Drugs 0.000 claims description 8
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 8
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 8
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 7
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 7
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- 239000003002 pH adjusting agent Substances 0.000 claims description 7
- 229920000223 polyglycerol Polymers 0.000 claims description 7
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 7
- GCDXVKZXCQGDHC-BLCQCPAESA-N [30-oxo-30-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC GCDXVKZXCQGDHC-BLCQCPAESA-N 0.000 claims description 6
- 229940086668 ceramide eop Drugs 0.000 claims description 6
- 150000005846 sugar alcohols Polymers 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 4
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
- 229940114077 acrylic acid Drugs 0.000 claims description 4
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 4
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims description 4
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 4
- 229960004217 benzyl alcohol Drugs 0.000 claims description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 4
- 229960003993 chlorphenesin Drugs 0.000 claims description 4
- 229940080421 coco glucoside Drugs 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229920006037 cross link polymer Polymers 0.000 claims description 4
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims description 4
- 229930182478 glucoside Natural products 0.000 claims description 4
- 150000008131 glucosides Chemical class 0.000 claims description 4
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 4
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 4
- 229960002216 methylparaben Drugs 0.000 claims description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 4
- 229940049964 oleate Drugs 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 4
- 229960003415 propylparaben Drugs 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- 229960003885 sodium benzoate Drugs 0.000 claims description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 4
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 claims description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
- 229960000281 trometamol Drugs 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940094541 polyglycerin-10 Drugs 0.000 claims 7
- XYTHHAXRVHHXKO-JIUYZRCGSA-N 18-[(2r,3s,4r,5r)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxyoctadecanoic acid;ethanol Chemical compound CCO.COC1O[C@H](CO)[C@@H](OCCCCCCCCCCCCCCCCCC(O)=O)[C@H](O)[C@H]1O XYTHHAXRVHHXKO-JIUYZRCGSA-N 0.000 claims 1
- 229940099549 polyglycerin-3 Drugs 0.000 claims 1
- 238000004090 dissolution Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 5
- 230000008439 repair process Effects 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 19
- 238000012360 testing method Methods 0.000 description 16
- 239000000126 substance Substances 0.000 description 8
- 238000013112 stability test Methods 0.000 description 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 239000011449 brick Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 102100028314 Filaggrin Human genes 0.000 description 1
- 101710088660 Filaggrin Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- RBBHGNBWKGCPAF-XEKXCHJCSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC RBBHGNBWKGCPAF-XEKXCHJCSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and relates to a high-content ceramide repairing and moisturizing cream and a preparation method thereof. The invention provides a composition, which comprises the following components in parts by weight: 0.1-20 parts of ceramide, 1-30 parts of glycolipid and 10-40 parts of polar oil. The high-content ceramide repair moisturizing cream prepared from the composition has the synergistic effect of ceramide and glycolipid, the glycolipid not only promotes the dissolution of ceramide, reduces the addition amount of dissolved ceramide grease and the greasy feeling of the cream, but also has more remarkable repair moisturizing effect. The operation process is simple, and the large-scale production is convenient.
Description
Technical Field
The invention belongs to the field of cosmetics, and relates to a high-content ceramide repairing and moisturizing cream and a preparation method thereof.
Background
The skin, which is the largest organ covering the surface of the human body, is directly in contact with the external environment and is easily damaged by ultraviolet rays, microorganisms, physical and chemical stimuli, and the like. The skin is composed of three parts, namely epidermis, dermis and subcutaneous tissue, and the outermost structure of the epidermis, namely the stratum corneum, plays an important role in the barrier of the skin. Researchers visually analogize the cuticle to a brick wall structure: the horny layer cells are bricks of walls and are formed by mutual crosslinking of filaggrin, cytokeratin and the like to form an insoluble compact structure; while intercellular lipids are likened to the wall's lime. Intercellular lipids contain mainly 50% ceramide, 30% cholesterol and 20% free fatty acids. Studies have shown one of the major causes of impaired skin barrier in the absence of ceramide.
However, the ceramide, which is an oil-soluble substance with high melting point, is difficult to be directly added into cosmetics for use, particularly, the high-content ceramide needs a large amount of grease to be dissolved, the prepared paste is greasy, and meanwhile, the ceramide is easy to separate out to influence the stability of the whole formula.
The patent CN 111568829A discloses a high-content ceramide repair cream and a preparation method thereof, and the preparation process is special, has higher selection requirements on an operation process and an emulsifier, and is inconvenient for large-scale production. Meanwhile, the patent needs to compound the formulated efficacy composition, and has limitation on the selection of formula raw materials.
Disclosure of Invention
In some embodiments, the present invention provides a composition comprising the following components in parts by weight: 0.1-20 parts of ceramide, 1-30 parts of glycolipid and 10-40 parts of polar oil.
In some embodiments, the composition comprises the following components in parts by weight: 0.3-15 parts of ceramide, 3-30 parts of glycolipid and 12-37 parts of polar oil.
In some embodiments, the composition comprises the following components in parts by weight: 0.5-10 parts of ceramide, 5-25 parts of glycolipid and 14-37 parts of polar oil.
In some embodiments, the composition further comprises a polyol, an emulsifier, and a thickener.
In some embodiments, the composition further comprises 5 to 25 parts by weight of a polyol, 2 to 10 parts by weight of an emulsifier, and 0.1 to 5 parts by weight of a thickener.
In some embodiments, the composition further comprises 7 to 25 parts by weight of a polyol, 3 to 8 parts by weight of an emulsifier, and 0.3 to 4 parts by weight of a thickener.
In some embodiments, the composition further comprises 10 to 20 parts by weight of a polyol, 5 to 8 parts by weight of an emulsifier, and 0.3 to 3 parts by weight of a thickener.
In some embodiments, the composition further comprises a pH adjusting agent and a preservative.
In some embodiments, the composition further comprises 0 to 3 parts by weight of a pH adjusting agent and 0.01 to 1 part by weight of a preservative.
In some embodiments, the composition further comprises 0 to 2 parts by weight of a pH adjusting agent and 0.05 to 1 part by weight of a preservative.
In some embodiments, the composition further comprises 0-1 part by weight of a pH regulator and 0.1-1 part by weight of a preservative.
In some embodiments, the composition further comprises 10 to 80 parts by weight of water.
In some embodiments, the composition further comprises 10 to 70 parts by weight of water.
In some embodiments, the composition further comprises 10 to 60 parts by weight of water.
In some embodiments, the ceramide comprises at least one of ceramide EOP, ceramide NP, or ceramide AP.
In some embodiments, the polar oil comprises at least one of caprylic/capric triglyceride, cetyl ethylhexanoate, ethylhexyl palmitate, or C12-15 alcohol benzoate.
In some embodiments, the polyol comprises at least one of glycerol, diglycerol, butanediol, propylene glycol, dipropylene glycol, pentanediol, or hexanediol.
In some embodiments, the emulsifier comprises at least one of a PEG-based emulsifier, a polyglycerol-based emulsifier (, a higher fatty alcohol, or a glycoside-based emulsifier).
In some embodiments, the PEG-based emulsifier includes at least one of PEG-100 stearate, PEG-20 methylgluco sesquistearate, PEG-40 hydrogenated castor oil, PEG-4 polyglyceryl-2 stearate, PEG-60 hydrogenated castor oil, PEG-100 stearate, or PEG-40 stearate.
In some embodiments, the polyglycerol-based emulsifier comprises at least one of polyglycerol-3 methylglucdistearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-10 dioleate, polyglycerol-10 laurate, polyglycerol-10 isostearate, polyglycerol-10 oleate, polyglycerol-10 diisostearate, polyglycerol-6 laurate or polyglycerol-6 myristate.
In some embodiments, the higher fatty alcohol comprises at least one of ceteareth-12 or cetearyl alcohol.
In some embodiments, the glycoside emulsifier comprises at least one of cetearyl glucoside or coco glucoside.
In some embodiments, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid/C10-30 alkanol acrylate crosspolymer, ammonium acryloyldimethyl taurate/VP copolymer, or sodium polyacrylate.
In some embodiments, the pH adjusting agent comprises at least one of aminomethyl propanol, arginine, triethanolamine, potassium hydroxide, or tromethamine.
In some embodiments, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
In some embodiments, the present invention provides a cosmetic product comprising a composition as described in any of the above.
In some embodiments, the present invention provides a cosmetic comprising the following components in weight percent: 0.1-20% of ceramide, 1-30% of glycolipid, 10-40% of polar grease, 5-25% of polyalcohol, 2-10% of emulsifier, 0.1-5% of thickener, 0-3% of pH regulator, 0.01-1% of preservative and 100% of water.
In some embodiments, the cosmetic comprises the following components in weight percent: 0.3-15% of ceramide, 3-30% of glycolipid, 12-37% of polar grease, 7-25% of polyalcohol, 3-8% of emulsifier, 0.3-4% of thickener, 0-2% of pH regulator, 0.05-1% of preservative and 100% of water.
In some embodiments, the cosmetic comprises the following components in weight percent: 0.5-10% of ceramide, 5-25% of glycolipid, 14-37% of polar grease, 10-20% of polyalcohol, 5-8% of emulsifier, 0.3-3% of thickener, 0-1% of pH regulator, 0.1-1% of preservative and 100% of water.
In some embodiments, in the cosmetic of any of the above, the ceramide comprises at least one of ceramide EOP, ceramide NP, or ceramide AP.
In some embodiments, the polar oil comprises at least one of caprylic/capric triglyceride, cetyl ethylhexanoate, ethylhexyl palmitate, or C12-15 alcohol benzoate.
In some embodiments, the polyol comprises at least one of glycerol, diglycerol, butanediol, propylene glycol, dipropylene glycol, pentanediol, or hexanediol.
In some embodiments, the emulsifier comprises at least one of a PEG-based emulsifier, a polyglycerol-based emulsifier (, a higher fatty alcohol, or a glycoside-based emulsifier).
In some embodiments, the PEG-based emulsifier comprises at least one of PEG-100 stearate, PEG-20 methylgluco hemistearate, PEG-40 hydrogenated castor oil, PEG-4 polyglyceryl-2 stearate, PEG-60 hydrogenated castor oil, PEG-100 stearate, or PEG-40 stearate.
In some embodiments, the polyglycerol-based emulsifier comprises at least one of polyglycerol-3 methylglucose distearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-10 dioleate, polyglycerol-10 laurate, polyglycerol-10 isostearate, polyglycerol-10 oleate, polyglycerol-10 diisostearate, polyglycerol-6 laurate or polyglycerol-6 myristate.
In some embodiments, the higher fatty alcohol comprises at least one of ceteareth-12 or cetearyl alcohol.
In some embodiments, the glycoside emulsifier comprises at least one of cetearyl glucoside or coco glucoside.
In some embodiments, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid/C10-30 alkanol acrylate crosspolymer, ammonium acryloyldimethyl taurate/VP copolymer, or sodium polyacrylate.
In some embodiments, the pH adjusting agent comprises at least one of aminomethyl propanol, arginine, triethanolamine, potassium hydroxide, or tromethamine.
In some embodiments, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
In some embodiments, the cosmetic comprises a cream, a paste, or water.
In some embodiments, the cosmetic is a moisturizing cream.
In some embodiments, according to the high-content ceramide repairing and moisturizing cream provided by the invention, ceramide and glycolipid are synergistic, the glycolipid not only promotes the dissolution of ceramide, reduces the addition amount of dissolved ceramide grease and reduces the greasy feeling of the cream, but also the glycolipid can make the repairing and moisturizing effects of the product more remarkable.
In some embodiments, the moisturizing cream disclosed by the invention is simple in preparation process and convenient for large-scale production.
In some embodiments, the present invention provides a method of making any of the above cosmetics, comprising the steps of: putting deionized water and a thickening agent into a water phase pot, heating and stirring; putting polar oil, emulsifier, ceramide and glycolipid into an oil phase pot, heating, and dissolving to obtain a uniform transparent liquid; under the condition of stirring and homogenizing, putting the materials in the oil phase pot into the water phase pot, and completely emulsifying; cooling, adding pH regulator and antiseptic, stirring and dissolving.
In some embodiments, the method comprises the steps of: putting deionized water and a thickening agent into a water phase pot, heating to about 70-95 ℃, and stirring to obtain a uniform liquid; putting polar oil, emulsifier, ceramide and glycolipid into oil phase pot, heating to 705-10 deg.C, and dissolving to obtain uniform transparent liquid; under the condition of stirring and homogenizing, putting the materials in the oil phase pot into the water phase pot, and completely emulsifying; cooling to about 20-60 ℃, adding a pH regulator and a preservative, and stirring and dissolving uniformly.
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others based on the teachings of the present invention are within the scope of the invention.
In the examples herein below, the manufacturer sources of ceramide EOP, ceramide NP, and ceramide AP are as follows:
| substance(s) | Goods number | Manufacturer of the product |
| Ceramide EOP | Ceramide 1A | Wuhanla Bai pharmaceutical chemical Co Ltd |
| Ceramide NP | Ceramide NP | EVONIK SPECIALTY CHEMICALS (SHANGHAI) Co.,Ltd. |
| Ceramide AP | Ceramide AP | EVONIK SPECIALTY CHEMICALS (SHANGHAI) Co.,Ltd. |
In the examples below, the glycolipid is Ceramela, toyo kamura co.
Example 1 high ceramide-content repairing and moisturizing cream formula and preparation method thereof
Table 1 shows a high-ceramide repair moisturizing cream formula (the formula content is mass percent)
The preparation method comprises the following steps:
(1) putting deionized water and a thickening agent into a water phase pot, heating to about 85 ℃, and stirring to obtain uniform liquid;
(2) adding polar oil or nonpolar oil, emulsifier, ceramide or cholesterol, and glycolipid into oil phase pot, heating to 85-90 deg.C, and dissolving to obtain uniform transparent liquid;
(3) under the condition of stirring and homogenizing, the materials in the oil phase pot are put into the water phase pot, and the emulsification is completed.
Comparative example 5
The addition amount of the caprylic/capric triglyceride in the formula 1 is changed to be 8 percent by mass, and other materials and processes are not changed.
Comparative example 6
The addition amount of the caprylic/capric triglyceride in the formula 1 is changed to 45 percent by mass, and other materials and processes are not changed.
Comparative example 7
The ceramide in the formula 1 is equivalently replaced by the glycolipid, and other materials and processes are unchanged.
Test 1 stability test
The ceramide repairing and moisturizing cream prepared by the formulas 1 to 3 and the comparative examples 1 to 6 is subjected to high and low temperature/light/cold and heat cycle tests, and the test results are as follows:
table 2 stability test results
Remarking: the "\\" in Table 2 represents no further observation of the test.
As can be seen from the stability test results, the stability of formulations 1 to 3 and comparative example 4 was good, and the stability tests of comparative examples 1 to 3 and comparative examples 5 to 6 did not pass.
Comparative example 1 is that glycolipid equivalent is replaced by polar grease, and the comparison of the stability test results of formula 1 and comparative example 1 shows that glycolipid is helpful for dissolving ceramide, and the stability of the product is improved.
Comparative example 2 equal amount of ceramide is replaced by cholesterol with repairing and moisturizing effects, and as can be seen from the stability test results of formula 1 and comparative example 2, glycolipids have excellent compatibility and solubility with ceramide, and have no obvious advantage in dissolving other similar substances.
Comparative example 3 the polar oil caprylic/capric triglyceride was equally replaced with the non-polar oil mineral oil, and as can be seen from the stability test results of formulation 1 and comparative example 3, the polar oil contributed to the dissolution of ceramide.
From the stability results of the formula 1 and the comparative examples 5 to 6, it is known that the dissolution of ceramide is affected when the addition amount of polar oil is too small, and the product is unstable and water-oil separation occurs when the addition amount of polar oil is too high.
From the stability results of formula 1 and comparative example 4, it can be seen that the glycolipid can contribute to the dissolution of ceramide by adding the same amount of ceramide, greatly reducing the amount of polar oil and fat, and reducing the greasy feeling of the paste.
Test 2 human efficacy test
To verify the synergistic effect of glycolipids and ceramides, the creams of formula 1 and comparative examples 4 and 7 were tested for efficacy, respectively, as follows:
70 women with sensitive, dry, rough and easily reddened skin at 18-45 years old were selected and randomized into 2 groups, designated group A and group B, of 35 individuals each. After each group of testers cleaned their face every morning and evening (same cleansing product), the skin was tested by applying the formula 1 sample to the left face and the comparative sample to the right face, and during the test period, the skin was tested 28 days after continuous use without using other skin care products. The test indexes include moisture content of stratum corneum, skin percutaneous water loss rate, and eliminating facial redness.
Principle of testing
Skin moisture content: the difference of the dielectric constants of water and other substances in the capacitance method for measuring the water content of human skin cutin is obvious. The skin capacitance is measured differently and the parameter can represent the moisture content of the skin. An increase in the value indicates an increase in the water content of the stratum corneum.
Skin transdermal water loss rate: and (3) obtaining a trans-epidermal water loss value based on the water vapor partial pressure gradient of different points on unit time and unit cross-sectional area of Fick diffusion law. A decrease in the number indicates a slower rate of skin moisture evaporation and an improved skin barrier function.
Skin red zone scoring: VISIA-CR was used for facial Image acquisition, and the facial images were analyzed by Image-Pro-Plus analysis software to calculate the skin color a values. The a value indicates the degree of the red-green value of the skin color. The smaller the value of a, the less red the skin color.
The test results were as follows:
TABLE 3 human efficacy test (mean)
From the results of the human efficacy test, it can be known that: A. after the two groups of testers in the group B trial for 28 days, the formula 1 is compared with the formula in the comparative example 7, and the water content, the transdermal water loss rate and the skin color a value of the human skin are greatly improved after the formula 1 sample is used. The glycolipid and the ceramide have mutual synergistic effect, and the repairing and moisturizing effects are more remarkable.
Test 3 human trial self-evaluation
After the test population in test 2 was completed, the sample was rated for freshness, absorbency, moisture retention, ease of repair, and overall preference. The full score was 5, 1 was very unsatisfactory, 2 was less satisfactory, 3 was acceptable, 4 was more satisfactory, and 5 was very satisfactory. The test results were as follows:
table 4 human body trial self-appraising table
According to the human body trial self-evaluation results, the indexes of the formula 1 sample in terms of freshness, absorptivity, moisture retention, repairing and relieving performance and overall preference degree are far higher than those of the comparative example 4 and the comparative example 7, which shows that the glycolipid can promote the dissolution of ceramide, greatly reduces the dosage of polar grease, and is beneficial to the refreshing feeling of the paste. Meanwhile, the glycolipid and the ceramide have obvious synergistic effect, so that the repairing and moisturizing effects of the product are more remarkable.
Claims (10)
1. The composition is characterized by comprising the following components in parts by weight: 0.1-20 parts of ceramide, 1-30 parts of glycolipid and 10-40 parts of polar oil.
2. The composition of claim 1, comprising the following components in parts by weight: 0.3-15 parts of ceramide, 3-30 parts of glycolipid and 12-37 parts of polar oil;
preferably, the composition comprises the following components in parts by weight: 0.5-10 parts of ceramide, 5-25 parts of glycolipid and 14-37 parts of polar oil.
3. The composition of claim 1, further comprising a polyol, an emulsifier, a thickener;
preferably, the composition also comprises 5-25 parts by weight of polyol, 2-10 parts by weight of emulsifier and 0.1-5 parts by weight of thickener;
preferably, the composition also comprises 7-25 parts by weight of polyol, 3-8 parts by weight of emulsifier and 0.3-4 parts by weight of thickener;
preferably, the composition also comprises 10-20 parts by weight of polyol, 5-8 parts by weight of emulsifier and 0.3-3 parts by weight of thickener;
preferably, a pH regulator and a preservative are also included;
preferably, the preservative also comprises 0-3 parts by weight of pH regulator and 0.01-1 part by weight of preservative;
preferably, the preservative also comprises 0-2 parts by weight of pH regulator and 0.05-1 part by weight of preservative;
preferably, the liquid also comprises 0-1 part by weight of pH regulator and 0.1-1 part by weight of preservative;
preferably, the composition further comprises 10 to 80 parts by weight of water;
preferably, the composition further comprises 10-70 parts by weight of water;
preferably, the composition further comprises 10 to 60 parts by weight of water.
4. The composition of any one of claims 1-3, wherein the ceramide comprises at least one of ceramide EOP, ceramide NP, or ceramide AP;
preferably, the polar oil comprises at least one of caprylic/capric triglyceride, cetyl ethylhexanoate, ethylhexyl palmitate or C12-15 alcohol benzoate;
preferably, the polyol comprises at least one of glycerol, diglycerol, butanediol, propylene glycol, dipropylene glycol, pentanediol, or hexanediol;
preferably, the emulsifier comprises at least one of a PEG-based emulsifier, a polyglycerol-based emulsifier (, a higher fatty alcohol, or a glycoside-based emulsifier;
preferably, the PEG-based emulsifier includes at least one of PEG-100 stearate, PEG-20 methylglucose sesquistearate, PEG-40 hydrogenated castor oil, PEG-4 polyglyceryl-2 stearate, PEG-60 hydrogenated castor oil, PEG-100 stearate or PEG-40 stearate;
preferably, the polyglycerin-based emulsifier includes at least one of polyglycerin-3 methylglucose distearate, polyglycerin-10 stearate, polyglycerin-10 myristate, polyglycerin-10 dioleate, polyglycerin-10 laurate, polyglycerin-10 isostearate, polyglycerin-10 oleate, polyglycerin-10 diisostearate, polyglycerin-6 laurate or polyglycerin-6 myristate;
preferably, the higher fatty alcohol comprises at least one of ceteareth-12 or cetearyl alcohol;
preferably, the glycoside emulsifier comprises at least one of cetearyl glucoside or coco glucoside;
preferably, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid/C10-30 alkanol acrylate crosspolymer, ammonium acryloyldimethyl taurate/VP copolymer or sodium polyacrylate;
preferably, the pH adjusting agent comprises at least one of aminomethyl propanol, arginine, triethanolamine, potassium hydroxide, or tromethamine;
preferably, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
5. A cosmetic comprising the composition according to any one of claims 1 to 4.
6. The cosmetic is characterized by comprising the following components in percentage by weight:
0.1-20% of ceramide, 1-30% of glycolipid, 10-40% of polar grease, 5-25% of polyalcohol, 2-10% of emulsifier, 0.1-5% of thickener, 0-3% of pH regulator, 0.01-1% of preservative and 100% of water;
preferably, the cosmetic comprises the following components in percentage by weight: 0.3-15% of ceramide, 3-30% of glycolipid, 12-37% of polar grease, 7-25% of polyalcohol, 3-8% of emulsifier, 0.3-4% of thickener, 0-2% of pH regulator, 0.05-1% of preservative and 100% of water.
7. The cosmetic of claim 6, wherein the cosmetic comprises the following components in percentage by weight: 0.5-10% of ceramide, 5-25% of glycolipid, 14-37% of polar grease, 10-20% of polyalcohol, 5-8% of emulsifier, 0.3-3% of thickener, 0-1% of pH regulator, 0.1-1% of preservative and 100% of water.
8. The cosmetic of any one of claims 6-7, wherein the ceramide comprises at least one of ceramide EOP, ceramide NP, or ceramide AP;
preferably, the polar oil comprises at least one of caprylic/capric triglyceride, cetyl ethylhexanoate, ethylhexyl palmitate or C12-15 alcohol benzoate;
preferably, the polyol comprises at least one of glycerol, diglycerol, butanediol, propylene glycol, dipropylene glycol, pentanediol, or hexanediol;
preferably, the emulsifier comprises at least one of a PEG-based emulsifier, a polyglycerol-based emulsifier, a higher fatty alcohol, or a glycoside-based emulsifier;
preferably, the PEG-based emulsifier includes at least one of PEG-100 stearate, PEG-20 methylgluco sesquistearate, PEG-40 hydrogenated castor oil, PEG-4 polyglyceryl-2 stearate, PEG-60 hydrogenated castor oil, PEG-100 stearate or PEG-40 stearate;
preferably, the polyglycerol-based emulsifier includes at least one of polyglycerol-3 methylglucose distearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-10 dioleate, polyglycerol-10 laurate, polyglycerol-10 isostearate, polyglycerol-10 oleate, polyglycerol-10 diisostearate, polyglycerol-6 laurate or polyglycerol-6 myristate;
preferably, the higher fatty alcohol comprises at least one of ceteareth-12 or cetearyl alcohol;
preferably, the glycoside emulsifier comprises at least one of cetearyl glucoside or coco glucoside;
preferably, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid/C10-30 alkanol acrylate crosspolymer, ammonium acryloyldimethyl taurate/VP copolymer or sodium polyacrylate;
preferably, the pH adjusting agent comprises at least one of aminomethyl propanol, arginine, triethanolamine, potassium hydroxide, or tromethamine;
preferably, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
9. The cosmetic according to any one of claims 5 to 8, wherein the cosmetic comprises a cream, a paste or water;
preferably, the cosmetic is a moisturizing cream.
10. A process for preparing a cosmetic product according to any one of claims 5 to 8, comprising the steps of:
putting deionized water and a thickening agent into a water phase pot, heating and stirring;
putting polar oil, emulsifier, ceramide and glycolipid into an oil phase pot, heating, and dissolving to obtain a uniform transparent liquid;
under the condition of stirring and homogenizing, putting the materials in the oil phase pot into the water phase pot, and completely emulsifying;
cooling, adding a pH regulator and a preservative, and stirring and dissolving uniformly;
preferably, the method comprises the steps of:
putting deionized water and a thickening agent into a water phase pot, heating to about 70-95 ℃, and stirring to obtain a uniform liquid;
putting polar oil, emulsifier, ceramide and glycolipid into an oil phase pot, heating to about 705-10 ℃, and dissolving to obtain a uniform and transparent liquid;
under the condition of stirring and homogenizing, putting the materials in the oil phase pot into the water phase pot, and completely emulsifying;
cooling to about 20-60 ℃, adding a pH regulator and a preservative, and stirring and dissolving uniformly.
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