KR20200071200A - Compositions for sterilization and disinfection using hydrogen peroxide - Google Patents
Compositions for sterilization and disinfection using hydrogen peroxide Download PDFInfo
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Abstract
Description
본 발명은 과산화수소를 이용한 살균소독제 조성물에 관한 것으로, 보다 구체적으로는 과산화수소와 구연산, 디에틸렌 트리아민 펜타 아세트산(Diethylene triamine penta acetic acid, DTPA) 및 항균제를 포함하는 것을 특징으로 하며, 과산화수소를 안정화시키고 소독 효과가 더욱 향상되는 과산화수소를 이용한 살균소독제 조성물에 관한 것이다.The present invention relates to a disinfectant disinfectant composition using hydrogen peroxide, and more specifically, comprises hydrogen peroxide and citric acid, diethylene triamine penta acetic acid (DTPA), and an antibacterial agent, to stabilize hydrogen peroxide and It relates to a sterilization disinfectant composition using hydrogen peroxide to further improve the disinfection effect.
최근 사스, 신종플루와 같은 전염병 발병과 유행으로 소독에 대한 인식이 높아지고 있으며, 특히 병원 내 감염자에 의한 교차 감염 및 바이러스 확산으로 인한 감염 등에 대한 사회적 문제가 대두되고 있다.Recently, awareness of disinfection is increasing due to epidemics and epidemics such as SARS and H1N1 flu, and social problems have emerged, particularly in cross- infections and infections due to the spread of viruses.
특히, 2015년 중동호흡기증후군(MERS) 발병에 따른 환자 간 교차 감염에 의한 질환 확산이 증폭되어 커다란 사회적 혼란과 손실이 발생하였고, 그로 인해 더욱 소독과 그 관리의 중요성에 대한 인식이 증대되었다.In particular, the spread of disease caused by cross-infection among patients following the outbreak of Middle East Respiratory Syndrome (MERS) in 2015 has caused great social confusion and loss, and as a result, awareness of the importance of disinfection and its management has increased.
또한, 국내를 비롯한 해외에서도 사스(SARS), 조류독감(AI), 메르스(MERS) 등의 치사율이 높고 전염성이 강한 신종 감염질환들이 3~4년의 간격으로 주기적으로 발생하고 있는 실정이다.In addition, new infectious diseases with high mortality rates such as SARS, avian influenza (AI), and MERS (MERS), which are highly infectious in Korea and abroad, are occurring periodically at intervals of 3 to 4 years.
과산화수소는 비할로겐류 산화제로서 무색 투명한 점조 액체이며, 산화환원 작용이 있고, 빛, 열, 효소에 의해 분해되어 물과 산소로 된다. 과산화수소는 강력한 살균 및 표백작용이 있고 그 사용법이 간단하기 때문에 일반 창상의 소독뿐만 아니라 표백제, 산화제 유도체 제조 등에 광범위하게 사용되며, 최근에는 인쇄기관, 반도체 제조용, 섬유 및 화학 전자산업 등에서 그 사용량이 계속 증가하고 있다(Inhibitory effect on Hydrgen Peroxide on the Growth of Escherichia coli. J Basic Science Vol 19 : 113~117, 2004.).Hydrogen peroxide is a non-halogenated oxidizing agent that is a colorless transparent viscous liquid, has redox action, decomposes by light, heat, and enzymes to become water and oxygen. Hydrogen peroxide has a strong sterilization and bleaching action and is simple to use, so it is widely used not only for disinfection of ordinary wounds, but also for the manufacture of bleaching agents and oxidizing agent derivatives. Recently, its use continues in printing institutions, semiconductor manufacturing, textile and chemical electronics industries, etc. (Inhibitory effect on Hydrgen Peroxide on the Growth of Escherichia coli.J Basic Science Vol 19: 113~117, 2004.)
과산화수소에 의한 살균소독 효과는 과산화수소가 분해되면서 발생하는 산소 라디칼(Oxygen radical)이 세포막 성분과 결합하여 살균소독 효과를 나타내는 것으로써, 식의약품을 주로 취급하는 제조사나 의료기관에서는 표면 살균소독에 과산화수소를 흔히 사용하고 있으며, 과산화수소를 이용한 소독에는 3% 농도의 과산화수소가 주로 이용되고 있다(Microbial Contamination of Contact lens cases in multi - purpose solution care systems. Journal of Korean Ophthalmic Optics Society. Vol.5 No.1, 2000. pp.95 - 99.).The sterilization and disinfection effect by hydrogen peroxide is an oxygen radical generated by the decomposition of hydrogen peroxide, which combines with cell membrane components to show sterilization and disinfection, and manufacturers or medical institutions that mainly handle food and pharmaceuticals often use hydrogen peroxide for surface sterilization. 3% concentration of hydrogen peroxide is mainly used for disinfection with hydrogen peroxide (Microbial Contamination of Contact lens cases in multi-purpose solution care systems. Journal of Korean Ophthalmic Optics Society.Vol. 5 No. 1, 2000. pp.95-99.).
이러한 과산화수소를 이용한 살균소독제에 대한 선행기술 중에는, 한국공개특허 제10-2016-0032015호에서는 균의 수를 감소시키기 위해서 사용되는 과산화수소 수용액으로서, 필수 성분으로서 과산화수소, 인산염 및 알루미늄염을 함유하는 것을 특징으로 하는 과산화수소 수용액을 제공할 수 있고, 공기와, 상기 과산화수소 수용액의 미스트 및/또는 가스를 혼합한 후, 대상물에 접촉시키는 것을 특징으로 하는 살균 방법에 관해 개시하고 있다.Among the prior art for sterilizing and disinfecting agents using hydrogen peroxide, Korean Patent Publication No. 10-2016-0032015 is an aqueous hydrogen peroxide solution used to reduce the number of bacteria, and is characterized by containing hydrogen peroxide, phosphate and aluminum salt as essential components. Disclosed is a sterilization method characterized in that an aqueous hydrogen peroxide solution can be provided, and air and mist and/or gas of the aqueous hydrogen peroxide solution are mixed and then brought into contact with an object.
한국공개특허 제10-2012-0028413호에서는 과산화수소를 이용하여 저온 플라즈마 가스의 이온화(OH-, O 라디컬)를 신속하게 유도함과 동시에 오존 가스를 설정된 온도로 가열하여 피소독물이 투입된 밀폐형 챔버로 주입시킴으로써, O 라디컬 이온화 분리 시간을 크게 단축할 수 있게 되어, 피소독물의 멸균처리 효율을 극대화 할 수 있도록 한 과산화수소, 오존 및 저온 플라즈마를 이용한 소독 멸균장치 및 방법에 관해 개시하고 있다.Korea Patent Publication No. 10-2012-0028413 call the ionization of the low temperature plasma gas with hydrogen peroxide - by heating the ozone gas rapidly and at the same time induces a (OH, O radical) as a set temperature is injected into the sealed chamber is accused poison injected Disclosed is a sterilization sterilization apparatus and method using hydrogen peroxide, ozone, and low-temperature plasma that can greatly shorten the O-radical ionization separation time, thereby maximizing the sterilization treatment efficiency of an object to be poisoned.
그러나, 불안정한 과산화수소를 기계적으로 안정화 및 분사를 통해 표면소독 효과를 나타내는 기술이 대다수이다.However, there are many technologies that mechanically stabilize and spray unstable hydrogen peroxide to show the surface disinfection effect.
따라서, 본 발명에서는 불안정한 상태인 과산화수소를 안정화시키고 항균효과를 가진 천연 항균제를 이용하여 살균소독 효과가 더욱 향상될 수 있는 살균소독제 조성물에 대해 개시하고자 한다.Therefore, in the present invention, it is intended to disclose a sterilization disinfectant composition that can stabilize the hydrogen peroxide in an unstable state and further improve the sterilization effect using a natural antibacterial agent having an antibacterial effect.
본 발명은 상술한 것과 같은 문제점을 해결하고 필요한 기술을 제공하기 위해 안출된 것으로서, The present invention has been devised to solve the problems as described above and to provide the necessary technology,
본 발명은 과산화수소를 이용한 살균소독제 조성물을 제공하기 위하여 과산화수소, 구연산 및 디에틸렌 트리아민 펜타 아세트산(Diethylene triamine penta acetic acid, DTPA)가 혼합되어 조성되는 살균소독제혼합물 및 항균제로 조성되는 것을 특징으로 하는 과산화수소를 이용한 살균소독제 조성물을 제공함에 그 목적이 있다.The present invention is a hydrogen peroxide, characterized in that it is composed of a disinfectant disinfectant mixture and an antimicrobial agent is a mixture of hydrogen peroxide, citric acid and diethylene triamine penta acetic acid (DTPA) in order to provide a disinfectant composition using hydrogen peroxide. It is an object to provide a disinfectant composition using a disinfectant.
또한, 과산화수소, 구연산 및 디에틸렌 트리아민 펜타 아세트산이 혼합되어 조성되는 살균소독제혼합물 및 항균제로 조성되는 살균소독제 조성물로써, 과산화수소를 안정화 시키고, 소독 효과가 더욱 향상되는 특징이 있는 과산화수소를 이용한 살균소독제 조성물을 제공함에 다른 목적이 있다.In addition, as a sterilizing and disinfecting agent composition composed of a mixture of a hydrogen peroxide, citric acid and diethylene triamine pentaacetic acid and a disinfectant disinfectant composition and an antibacterial agent, stabilizes hydrogen peroxide and further improves disinfecting effect. There are other purposes to provide.
상기와 같은 목적을 달성하기 위한 본 발명의 일 실시 형태로서, As one embodiment of the present invention for achieving the above object,
본 발명의 일 실시형태는 과산화수소, 구연산 및 디에틸렌 트리아민 펜타 아세트산(Diethylene triamine penta acetic acid, DTPA)가 혼합되어 조성되는 살균소독제혼합물 및 항균제로 조성되는 것을 특징으로 하는 과산화수소를 이용한 살균소독제 조성물을 제공한다.One embodiment of the present invention is a disinfectant composition using hydrogen peroxide, characterized in that it is composed of a disinfectant disinfectant mixture and an antibacterial agent, which is a mixture of hydrogen peroxide, citric acid and diethylene triamine penta acetic acid (DTPA). to provide.
본 발명에 있어서, 상기 살균소독제혼합물은, 과산화수소 1000중량부에 대해 구연산 5 내지 10중량부 및 디에틸렌 트리아민 펜타 아세트산 0.5 내지 1.0중량부가 혼합되어 조성되는 것을 특징으로 할 수 있다.In the present invention, the disinfectant disinfectant mixture may be characterized in that 5 to 10 parts by weight of citric acid and 0.5 to 1.0 parts by weight of diethylene triamine pentaacetic acid are mixed with respect to 1000 parts by weight of hydrogen peroxide.
또한, 본 발명에 있어서, 상기 항균제는, 편백나무증류액(Phytoncide), 티트리 오일(Tee tree leaf Oil) 및 유칼립투스 오일(Eucalyptus Oil) 중 어느 하나인 것을 특징으로 할 수 있다.In addition, in the present invention, the antimicrobial agent, cypress distillate (Phytoncide), tea tree oil (Tee tree leaf Oil) and eucalyptus oil (Eucalyptus Oil) may be any one of the features.
또한, 본 발명에 있어서, 상기 살균소독제 조성물은, 살균소독제혼합물 5 내지 1000중량부에 대해 항균제 1중량부의 비율로 혼합되어 조성되는 것을 특징으로 할 수 있다.In addition, in the present invention, the sterilizing and disinfecting agent composition may be characterized in that the composition is mixed in a proportion of 1 part by weight of the antibacterial agent with respect to 5 to 1000 parts by weight of the sterilizing and disinfecting mixture.
아울러, 본 발명에 있어서, 상기 살균소독제 조성물은, 지오바실러스 스테아로써모필러스(Geobacillus stearothermophilus), 대장균(Escherichia coli), 녹농균(Pseudomonas aeruginosa) 및 포도상구균(Staphylococcus aureus) 중 선택된 어느 하나 이상의 균을 살균 또는 소독하는 것을 특징으로 할 수 있다.In addition, in the present invention, the sterilizing agent composition, sterilizing any one or more bacteria selected from Geobacillus stearothermophilus, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus Or it may be characterized by disinfection.
본 발명의 일 실시형태에 따른 과산화수소를 이용한 살균소독제 조성물은 불안정한 상태의 과산화수소를 안정화시키고, 소독 효과를 더욱 증진시킬 수 있다는 장점이 있다.The sterilizing and disinfecting agent composition using hydrogen peroxide according to an embodiment of the present invention has the advantage of stabilizing hydrogen peroxide in an unstable state and further enhancing the disinfecting effect.
이하, 본원의 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 본 발명의 실시형태를 들어 상세히 설명한다. 본 발명의 실시형태는 당업계에서 평균적인 지식을 가진 자에게 본 발명을 더욱 완전하게 설명하기 위해서 제공되는 것이다. 따라서, 본 발명의 실시형태는 여러 가지 다른 형태로 변형될 수 있으며, 본 발명의 범위가 이하 설명하는 실시형태로 한정되는 것은 아니다.Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art to which the present invention pertains may easily practice. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art. Therefore, the embodiments of the present invention can be modified in various other forms, and the scope of the present invention is not limited to the embodiments described below.
본 발명의 명세서 전체에서, 어떤 부분이 어떤 구성요소를 “포함”한다고 할 때, 이는 특별히 반대되는 기재가 없는 한 다른 구성요소를 제외하는 것이 아니라 다른 구성 요소를 더 포함할 수 있는 것을 의미한다.Throughout the specification of the present invention, when a part “includes” a certain component, it means that the component may further include other components, not to exclude other components, unless otherwise specified.
본 발명의 명세서 전체에서 사용되는 정도의 용어 “약”, “실질적으로” 등은 언급된 의미에 고유한 제조 및 물질 허용 오차가 제시될 때 그 수치에서 또는 그 수치에 근접한 의미로 사용되고, 본 발명의 이해를 돕기 위해 정확하거나 절대적인 수치가 언급된 개시 내용을 비양심적인 침해자가 부당하게 이용하는 것을 방지하기 위해 사용된다. The terms “about”, “substantially”, and the like used throughout the specification of the present invention are used in the sense or close to the value when manufacturing and material tolerances unique to the stated meaning are presented, and the present invention To help understand, accurate or absolute figures are used to prevent unscrupulous use of unintentional infringers by the disclosure.
본 발명은 과산화수소를 이용한 살균소독제 조성물을 제공한다.The present invention provides a disinfectant composition using hydrogen peroxide.
본 발명의 일 실시형태에 따르면, 과산화수소를 이용한 살균소독제 조성물은 과산화수소, 구연산 및 디에틸렌 트리아민 펜타 아세트산(Diethylene triamine penta acetic acid. 이하, DTPA)가 혼합되어 조성되는 살균소독제혼합물 및 항균제로 조성되는 것을 특징으로 할 수 있다.According to an embodiment of the present invention, the sterilization disinfectant composition using hydrogen peroxide is composed of a disinfectant disinfectant mixture and an antimicrobial agent, which is a mixture of hydrogen peroxide, citric acid and diethylene triamine penta acetic acid (DTPA) It can be characterized by.
상기 살균소독제혼합물은, 과산화수소 1000중량부에 대해 구연산 5 내지 10중량부 및 DTPA 0.5 내지 1.0중량부가 혼합되어 조성되는 것을 특징으로 한다.The disinfectant disinfectant mixture is characterized in that 5 to 10 parts by weight of citric acid and 0.5 to 1.0 parts by weight of DTPA are mixed with respect to 1000 parts by weight of hydrogen peroxide.
불안정한 상태의 과산화수소에 구연산과 DTPA를 혼합함으로써 과산화수소와 유기산의 수소결합을 통해 과산화수소의 안정성이 향상됨에 따라 소독력이 증진되어 안전하고 강한 소독력을 가진 소독제를 제조할 수 있다. 이때, 상기 구연산과 DTPA는 과산화수소 1000중량부에 대해 구연산 5 내지 10중량부, DTPA 0.5 내지 1.0중량부로 혼합하여 사용하는 것이 바람직한데, 이는 과산화수소를 가장 안정한 상태를 유지시킬 수 있는 농도이기 때문이다.By mixing citric acid and DTPA in unstable hydrogen peroxide, as the stability of hydrogen peroxide is improved through hydrogen bonding between hydrogen peroxide and organic acid, disinfecting power is enhanced, and a safe and strong disinfecting agent can be prepared. At this time, the citric acid and DTPA are preferably used in a mixture of 5 to 10 parts by weight of citric acid and 0.5 to 1.0 parts by weight of DTPA with respect to 1000 parts by weight of hydrogen peroxide, because it is a concentration capable of maintaining hydrogen peroxide in the most stable state.
또한, 상기 항균제는, 편백나무증류액(Phytpncide), 티트리 오일(Tee tree leaf Oil) 및 유칼립투스 오일(Eucalyptus Oil) 중 어느 하나인 것을 특징으로 한다.In addition, the antimicrobial agent is characterized in that any one of Cypress distillate (Phytpncide), tea tree oil (Tee tree leaf Oil) and eucalyptus oil (Eucalyptus Oil).
편백나무증류액, 티트리 오일 및 유칼립투스 오일 중 어느 하나의 항균제를 살균소독제에 첨가함으로써 살균력을 향상시킬 뿐만 아니라 과산화수소 특유의 시큼한 냄새를 상쇄시킬 수 있다.Cypress distillation, tea tree oil, and eucalyptus oil can be added to the antiseptic to improve the sterilizing power, as well as to counteract the sour odor peculiar to hydrogen peroxide.
또한, 상기 살균소독제 조성물은 살균소독제혼합물 5 내지 1000중량부에 대해 항균제 1중량부의 비율로 혼합되어 조성되는 것을 특징으로 한다.In addition, the sterilizing and disinfecting agent composition is characterized in that the composition is mixed in a proportion of 1 part by weight of the antibacterial agent with respect to 5 to 1000 parts by weight of the sterilizing and disinfecting agent mixture.
살균소독제 혼합물 5 내지 1000중량부에 대해 항균제 1중량부 미만으로 혼합하여 살균소독제를 제조할 경우 살균소독제 혼합물만을 이용하여 소독을 했을 때와 소독 효과 차이가 거의 미미하거나 나타나지 않을 수 있고, 과산화수소의 냄새가 과도하게 나 소독제 사용 시 불쾌감을 형성할 수 있다. 살균소독제 혼합물 5 내지 1000중량부에 대해 항균제 1중량부 초과하여 혼합하여 살균소독제를 제조할 경우, 살균소독제 혼합물만을 이용하여 소독을 했을 때보다 오히려 소독 효과가 감소되거나 과산화수소와 안정제에 비해 상대적으로 항균제의 원가가 높아 소독제 제조에 있어 원가 상승 요인이 될 수 있다. 이때, 항균제는 액상 또는 분말상인 것을 선택적으로 사용할 수 있다. 또한, 상기의 항균제 외에 다양한 수용성 항균제를 혼합할 수도 있다.When a sterilizing agent is prepared by mixing less than 1 part by weight of an antimicrobial agent with respect to 5 to 1000 parts by weight of a disinfectant disinfectant mixture, the difference in disinfecting effect may be little or no when disinfecting using only the disinfectant mixture, and the smell of hydrogen peroxide. If excessive or disinfectant is used, it may cause discomfort. When the sterilizing agent is prepared by mixing more than 1 part by weight of the antibacterial agent with respect to 5 to 1000 parts by weight of the sterilizing agent mixture, the disinfecting effect is reduced or the antibacterial agent is relatively reduced compared to hydrogen peroxide and stabilizer than when sterilizing using only the sterilizing agent mixture. As the cost of the product is high, it can be a factor of cost increase in the manufacture of disinfectants. At this time, the antibacterial agent may be used in the form of a liquid or powder. In addition, various water-soluble antibacterial agents may be mixed in addition to the above-mentioned antibacterial agents.
상기와 같은 본 발명의 과산화수소를 이용한 살균소독제 조성물은 기존 과산화수소 살균소독제가 사용되던 모든 대상에 적용하여 세균, 바이러스 등을 살균 및 소독할 수 있음은 물론이다. 특히, 본 발명의 과산화수소를 이용한 살균소독제는 지오바실러스 스테아로써모필러스(Geobacillus stearothermophilus. 이하, GS균), 대장균(Escherichia coli. 이하, ECO균), 녹농균(Pseudomonas aeruginosa. 이하, PAE균) 및 포도상구균(Staphylococcus aureus. 이하, SAU균) 등의 병원성 세균류 또는 이들의 변종의 살균 및 소독을 위해 사용될 수 있다. It is needless to say that the sterilizing and disinfecting composition using hydrogen peroxide of the present invention can be sterilized and sterilized by bacteria, viruses, etc., by applying to all objects in which the existing hydrogen peroxide disinfecting agent was used. Particularly, the sterilizing and disinfecting agent using hydrogen peroxide of the present invention is Geobacillus stearothermophilus. It can be used to sterilize and disinfect pathogenic bacteria such as Staphylococcus aureus.
이하, 본 발명을 구체적인 실시예에 따라 상세히 설명한다. 단, 하기의 실시예는 본 발명을 예시로 하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail according to specific embodiments. However, the following examples are only intended to illustrate the present invention, and the contents of the present invention are not limited to the following examples.
살균소독제 제조Disinfectant disinfection
1. 살균소독제혼합물 제조1. Preparation of disinfectant disinfectant mixture
3% 농도의 과산화수소 1000중량부에 대해 구연산 6.3중량부 및 DTPA 0.56중량부를 혼합하여 살균소독제혼합물을 제조한다.A disinfectant disinfectant mixture is prepared by mixing 6.3 parts by weight of citric acid and 0.56 parts by weight of DTPA with respect to 1000 parts by weight of hydrogen peroxide at a concentration of 3%.
2. 살균소독제 제조2. Preparation of sterilizing and disinfecting agents
상기의 살균소독제혼합물 5 내지 1000중량부에 대해 편백나무증류액(Phytoncide 100%. ㈜편백치드), 티트리 오일(Melaleuca Alternifolia TeeTree Leaf Oil 100%. Integria Healthcare Pty Ltd.(Australia)) 및 유칼립투스 오일(Eucalyptus Oil 100%. LIMS) 중 어느 하나를 1중량부 혼합하여 살균소독제를 제조한다. 이때, 항균제는 액상 또는 분말상인 것을 선택적으로 사용할 수 있다. 또한, 상기의 항균제 외에 다양한 수용성 항균제를 혼합할 수도 있다.5 to 1000 parts by weight of the above disinfectant disinfectant mixture, Cypress distillate (Phytoncide 100%. Cypress Chic), Tea Tree Oil (Melaleuca Alternifolia TeeTree Leaf Oil 100%. Integria Healthcare Pty Ltd. (Australia)) and Eucalyptus One of the oil (Eucalyptus Oil 100%. LIMS) is mixed with 1 part by weight to prepare a disinfectant. At this time, the antibacterial agent may be used in the form of a liquid or powder. In addition, various water-soluble antibacterial agents may be mixed in addition to the above-mentioned antibacterial agents.
실험 준비Experiment preparation
1. 실험 균주1. Experimental strain
실험에 사용한 균주는 GS균, ECO균, PAE균 및 SAU균이다.The strains used in the experiment are GS bacteria, ECO bacteria, PAE bacteria, and SAU bacteria.
실험 24시간 전에 냉장 또는 냉동 보관하고 있던 상기의 균주를 꺼내어 루프를 이용하여 고체 배지(Blood Agar 또는 Mueller Hinton Agar, 이하 MHA. 아산제약(주))에 각각 도말하여 GS균은 55±2℃, ECO균, PAE균 및 SAU균은 37±2℃에서 24±2시간 배양 후, 배양된 균주를 루프를 이용하여 채집하여 멸균증류수에 풀어 농도를 Macfaland 단위에 따라 초기 균수를 108 CFU/㎖로 맞춘다. 이때 Macfaland 단위는 EDN-18(Biosan사)를 이용해 측정한다.Take out the above-mentioned strains that were kept refrigerated or frozen 24 hours before the experiment and apply them to a solid medium (Blood Agar or Mueller Hinton Agar, hereinafter referred to as MHA. Asan Pharmaceutical Co., Ltd.) using a loop, respectively. ECO bacteria, PAE bacteria, and SAU bacteria were cultured at 37±2°C for 24±2 hours, and the cultured strain was collected using a loop and released in sterile distilled water, and the concentration was adjusted to 10 8 CFU/ml according to Macfaland units. Fit. At this time, the Macfaland unit is measured using EDN-18 (Biosan).
2. 소독효과 측정2. Measurement of disinfection effect
제조된 살균소독제와 배양하여 멸균증류수에 풀어 농도를 맞춘 균주를 각각 1:1로 혼합하여 마이크로튜브에 균주혼합액 1㎖를 만든 후, 상온(25±2℃)의 온도에서 방치하여 5분, 10분, 30분, 1시간, 2시간, 3시간, 4시간 및 5시간 간격으로 균주혼합액에서 10㎕씩 추출하여 MHA 배지에 분주하여 GS균은 55±2℃, ECO균, PAE균 및 ASU균은 37±2℃에서 24±2시간 배양 후 reduction을 관찰하였다. 이때, Control군은 멸균 증류수와 균주를 각각 1:1로 혼합하여 균주혼합액을 만들어 사용하였다.After incubating with the prepared sterilizing disinfectant and dissolving in sterile distilled water, the strains with the concentrations are mixed 1:1 to make 1 ml of the strain mixture in the microtube, and then left at room temperature (25±2℃) for 5 minutes, 10 GS bacteria are 55±2℃, ECO bacteria, PAE bacteria and ASU bacteria by extracting 10 µl each from the strain mixture at intervals of 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours and 5 hours and dispensing them in MHA medium. The reduction was observed after incubation for 24±2 hours at 37±2℃. At this time, the Control group was used to make a strain mixture by mixing sterile distilled water and the strain 1:1.
실험 결과Experiment result
1. 살균소독제혼합물 및 항균제에 대한 소독효과 측정 결과1. Measurement results of disinfecting effect on disinfectant disinfectant mixtures and antibacterial agents
GS균을 대표 균주로 하여 살균소독제혼합물 및 항균제에 대한 소독효과를 측정하였으며, 그 결과는 표 1 내지 3과 같다.Using GS bacteria as a representative strain, the disinfecting effect on the disinfectant disinfectant mixture and antibacterial agent was measured, and the results are shown in Tables 1 to 3.
GS균을 우선적으로 소독효과를 측정한 것은 ECO균 및 SAU균보다 살균에 강한 균이며, 과산화수소 저항성이 다른 균보다 강하여 일반적으로 과산화수소를 통한 멸균을 확인하는 생물학적 지표균(Biological Indicator, BI)으로 사용하기 때문이다.The first disinfecting effect of GS bacteria is a bacterium that is more resistant to sterilization than ECO and SAU, and is generally used as a biological indicator (BI) that confirms sterilization through hydrogen peroxide because it is more resistant to hydrogen peroxide than other bacteria. It is because.
상기 표 1 내지 3에서와 같이, GS균을 대표 균주로 하여 우선적으로 소독효과를 살펴본 결과, 3% 농도의 과산화수소에 구연산 및 DTPA를 혼합한 살균소독제 혼합물에 편백나무증류액, 티트리 오일 및 유칼립투스 오일 중 어느 하나의 항균제를 혼합하여 제조한 살균소독제의 소독효과가 가장 좋은 것으로 나타났다.As shown in Tables 1 to 3, as a result of first examining the disinfecting effect using GS as a representative strain, cypress distillate, tea tree oil, and eucalyptus in a disinfectant disinfectant mixture of citric acid and DTPA in hydrogen peroxide at a concentration of 3%. It was found that the disinfecting effect of a disinfectant prepared by mixing any one of the antibacterial agents in oil was the best.
2. 살균소독제에 대한 소독효과 측정 결과2. Measurement result of disinfecting effect on disinfectant
상기 표 1 내지 3의 실험 결과를 바탕으로, 3% 농도의 과산화수소에 구연산 및 DTPA를 혼합한 살균소독제혼합물에 편백나무증류액, 티트리 오일 및 유칼립투스 오일 중 어느 하나의 항균제를 혼합하여 제조한 살균소독제에 대해 GS균, ECO균, PAE균 및 SAU균에 대한 소독효과를 측정하였으며, 그 결과는 다음 표 4 내지 7과 같다.Based on the experimental results in Tables 1 to 3, sterilization prepared by mixing any antibacterial agent of cypress distillate, tea tree oil, and eucalyptus oil in a sterilization disinfectant mixture in which citric acid and DTPA are mixed with hydrogen peroxide at a concentration of 3%. For the disinfectant, the disinfecting effect of GS bacteria, ECO bacteria, PAE bacteria and SAU bacteria was measured, and the results are shown in Tables 4 to 7.
상기 표 4 내지 7에 나타낸 바와 같이, 본 발명의 과산화수소를 이용한 살균소독제는 GS균, ECO균, PAE균 및 SAU균에 대하여 우수한 살균소독력을 나타내었으며, 과산화수소에 구연산 및 DTPA로 구성된 살균소독제혼합물에 비해 살균소독제혼합물에 편백나무증류액, 티트리오일 또는 유칼립투스 추출물 중 어느 하나의 항균제를 혼합하여 제조한 살균소독제가 더욱 우수한 살균소독력을 나타내는 것을 확인할 수 있었다.As shown in Tables 4 to 7, the sterilizing and disinfecting agent using hydrogen peroxide of the present invention showed excellent sterilizing and disinfecting ability against GS bacteria, ECO bacteria, PAE bacteria, and SAU bacteria, and the sterilizing disinfectant mixture composed of citric acid and DTPA in hydrogen peroxide. In comparison, it was confirmed that the sterilizing and disinfecting agent prepared by mixing any one of the cypress distillate, tea tree oil, or eucalyptus extract in the sterilizing and disinfecting agent mixture exhibits more excellent sterilizing and disinfecting power.
이상, 실시예를 들어 본 발명을 상세하게 설명하였으나, 본 발명은 상기 실시예에 한정되지 않으며, 여러 가지 다양한 형태로 변형될 수 있고, 본 발명의 기술적 사상 내에서 당 분야에서 통상의 지식을 가진 자에 의하여 여러 가지 많은 변형이 가능함이 명백하다. 또한, 청구범위의 기재된 본 발명의 기술적 사상을 벗어나지 않는 범위 내에서 당 기술분야의 통상의 지식을 가진 자에 의해 다양한 형태의 치환, 변형 및 변경이 가능할 것이며, 이 또한 본 발명의 범위에 속한다고 할 것이다.As described above, the present invention has been described in detail with reference to examples, but the present invention is not limited to the above embodiments, and may be modified in various ways, and having ordinary knowledge in the art within the technical spirit of the present invention. It is clear that many variations are possible by the ruler. In addition, various forms of substitution, modification, and modification will be possible by a person having ordinary skill in the art without departing from the technical spirit of the present invention described in the claims, and this also belongs to the scope of the present invention. something to do.
Claims (5)
상기 살균소독제혼합물은,
과산화수소 1000중량부에 대해 구연산 5 내지 10중량부 및 디에틸렌 트리아민 펜타 아세트산 0.5 내지 1.0중량부가 혼합되어 조성되는 것을 특징으로 하는 과산화수소를 이용한 살균소독제 조성물.The method according to claim 1,
The antiseptic disinfectant mixture,
A sterilizing and disinfecting composition using hydrogen peroxide, characterized in that 5 to 10 parts by weight of citric acid and 0.5 to 1.0 parts by weight of diethylene triamine pentaacetic acid are mixed with respect to 1000 parts by weight of hydrogen peroxide.
상기 항균제는,
편백나무증류액(Phytoncide), 티트리 오일(Tee tree leaf Oil) 및 유칼립투스 오일(Eucalyptus Oil) 중 어느 하나인 것을 특징으로 하는 과산화수소를 이용한 살균소독제 조성물.The method according to claim 1,
The antibacterial agent,
Hysteride disinfectant composition using hydrogen peroxide, characterized in that it is any one of Phytoncide, Tea tree leaf Oil and Eucalyptus Oil.
상기 살균소독제 조성물은,
살균소독제혼합물 5 내지 1000중량부에 대해 항균제 1 중량부의 비율로 혼합되어 조성되는 것을 특징으로 하는 과산화수소를 이용한 살균소독제 조성물.The method according to claim 1,
The sterilizing agent composition,
Disinfectant disinfectant composition using hydrogen peroxide, characterized in that the composition is mixed in a proportion of 1 part by weight of the antibacterial agent with respect to 5 to 1000 parts by weight of the disinfectant disinfectant mixture.
상기 살균소독제 조성물은,
지오바실러스 스테아로써모필러스(Geobacillus stearothermophilus), 대장균(Escherichia coli), 녹농균(Pseudomonas aeruginosa) 및 포도상구균(Staphylococcus aureus) 중 선택된 어느 하나 이상의 균을 살균 또는 소독하는 것을 특징으로 하는 과산화수소를 이용한 살균소독제 조성물.The method according to claim 1,
The sterilizing agent composition,
A bactericidal disinfectant composition using a hydrogen peroxide, characterized by sterilizing or disinfecting any one or more selected from Geobacillus stearothermophilus, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. .
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Cited By (2)
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| KR102212915B1 (en) * | 2020-07-31 | 2021-02-08 | 주식회사 바이오씨씨 | Method of preparing eco-friendly tablet type peroxide-based disinfectant |
| KR102401357B1 (en) * | 2021-08-18 | 2022-05-23 | 윤찬헌 | Eco-friendly disinfectant and insecticide composition with hydrogen peroxide and sodium citrate and disinfectant and insecticide method thereof |
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