KR20180111015A - Composition for preventing hair loss or stimulating hair growth comprising herbal oil as effective component - Google Patents
Composition for preventing hair loss or stimulating hair growth comprising herbal oil as effective component Download PDFInfo
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- KR20180111015A KR20180111015A KR1020170041330A KR20170041330A KR20180111015A KR 20180111015 A KR20180111015 A KR 20180111015A KR 1020170041330 A KR1020170041330 A KR 1020170041330A KR 20170041330 A KR20170041330 A KR 20170041330A KR 20180111015 A KR20180111015 A KR 20180111015A
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- South Korea
- Prior art keywords
- hair
- oil
- growth
- composition
- hair loss
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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Abstract
Description
본 발명은 라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 조성물에 관한 것이다. The present invention relates to a composition for preventing hair loss or promoting hair growth comprising lavender, lemon grass, rosemary, chamomile and peppermint oil as an active ingredient.
인체의 모발은 약 10만~15만 개 정도이며, 각각의 모발은 서로 다른 모주기를 가지고 성장기(anagen), 퇴행기(catagen) 및 휴지기(telogen)를 반복하며 생성, 성장 및 탈락하는데, 그 결과 전체 모발의 약 15%에 해당하는 모발이 휴지기와 퇴행기에 놓여 있어 일일 평균 50∼100개의 모발이 정상적으로 탈락하고 재생산된다. 이러한 모발의 생장주기는 약 3∼6년을 사이클로 반복한다. 일반적으로, 탈모증이라 함은 모발주기의 성장기(anagen)에 해당하는 기간이 여러 원인으로 인해 짧아져 퇴행기와 휴지기 모발의 비율이 상대적으로 많아져 모발이 탈락하는 수가 평균치보다 많아지는 것을 말하며, 원인으로는 유전적 안드로겐 호르몬의 작용, 국소혈류 장애에 의한 영양 장애, 자율신경계 장애, 자가면역질환, 내분비 장애가 있으나 현재까지 탈모에 관한 명확한 원인은 밝혀지지 않은 상태이며, 전술한 원인이 복합적으로 작용하여 발생하는 것으로 알려져 있다. The hair of the human body is about 100,000 to 150,000, and each hair has a different parenting cycle and is repeatedly produced, grown and dislodged by anagen, catagen and telogen, Approximately 15% of the total hair is placed in the dormant period and the retrograde period, so that an average of 50 to 100 hairs are normally dropped and reproduced. These hair growth cycles repeat about 3-6 years in cycles. In general, alopecia refers to the fact that the period corresponding to the anagen of the hair cycle is shortened due to various causes, the ratio of the retrograde hair to the resting hair is relatively increased, and the number of hair dropping is larger than the average value. Has a genetic androgen-hormone action, malnutrition due to local blood flow disorder, autonomic nervous system disorder, autoimmune disease, endocrine disorder, but the cause of hair loss has not been clarified to date. .
모발이 자라는 모근의 뿌리부분은 모구(hair bulb)라고 하고, 그 아랫부분의 움푹 들어간 부분을 모유두라고 한다. 모유두는 모발의 발생에 있어 가장 중요한 부분으로, 모유두에는 혈관이나 신경이 있고, 바로 그 위에 있는 모모세포에 영양분을 공급하여 모발의 성장을 촉진하게 된다. 이러한 모유두의 수는 태어날 때 결정되는데, 모유두가 없어지고 그 수가 감소할수록 모발의 수도 감소하게 된다.The roots of hair growth hair roots are called hair bulbs, and the depressions in the lower part are called the papillae. The papilla is the most important part in the development of hair. The papilla has blood vessels and nerves, and nourishes the hair cells just above it, thereby promoting hair growth. The number of these papillae is determined at birth, and as the number of papillae disappears, the number of hairs decreases.
최근 식생활의 변화, 생활습관의 변화, 사회 환경에 의한 과한 스트레스의 증가 등으로 비정상적인 탈모를 유발하고 있는 인구가 점차 증가하는 추세이며, 특히 청년 및 장년과 여성 탈모 인구가 증가하고 있는 상황이다. 한편, 머리카락이나 털이 어떤 원인에 의하여 정상보다 적거나 없는 상태를 의미하는 탈모는 모발이 휴지기 상태에서 빠지는 일반적인 탈모 현상(휴지기 탈모, telogen effluvium)과 비정상적인 탈모 현상인 성장기 탈모 현상(anagen effluvium)으로 구별할 수 있는 데, 일반적으로 탈모증이라 함은 후자를 일컫는다. 탈모증의 형태에는 원형 탈모증(alopecia areata), 조기 탈모증, 여성 탈모증(androgen alopecia in women), 매독성 탈모증, 장년성 탈모증(male pattern baldness) 등이 있다. Recently, the number of people causing abnormal hair loss due to changes in dietary habits, lifestyle changes, and excessive stress due to the social environment is gradually increasing. Especially, the number of young people, elderly people and women hair loss is increasing. On the other hand, hair loss, which means that hair or hairs are less or no more than normal due to any cause, is distinguished from general hair loss phenomenon (telogen effluvium) in which hair comes off from resting state and anagen effluvium which is abnormal hair loss phenomenon The term "alopecia" generally refers to the latter. The forms of alopecia include alopecia areata, early alopecia, androgen alopecia in women, alopecia alopecia, and male pattern baldness.
탈모를 위해 개발된 가장 대표적인 탈모방지제로서 피나스테라이드(finasteride)를 들 수 있는데, 이는 직접적인 탈모 원인 물질인 디하이드로테스토스테론을 생성하는 5-α환원효소의 활성을 저해하는 약물이다. 그러나 피나스테라이드 제제의 경우는 임산부에게는 태아의 기형을 유발할 수 있으며, 장기간 투여시 성욕감퇴, 발기부전, 사정장애 등의 부작용이 보고되어 있어 복용에 주의해야 하는 단점이 있다. 이 외에 널리 사용되고 있는 미녹시딜(minoxidil) 함유 발모제 또한 FDA에서 일반의약품으로 승인을 받은 제제이지만, 여성에게는 투여할 수 없고 피부자극, 가려움, 홍조, 탈모의 악화 등의 부작용이 있는 단점이 있다. 따라서, 남녀 모두에게 안전하고 부작용이 없으면서 탈모방지 및 발모 효과가 있는 물질을 개발할 필요성이 있다.Finasteride is the most representative anti-hair restorer developed for hair loss, which is a drug that inhibits the activity of 5-alpha reductase, which produces dihydrotestosterone, which is a direct hair loss causative substance. However, in the case of the finasteride formulation, it may cause fetal malformations in pregnant women, and side effects such as loss of libido, erectile dysfunction, and ejaculatory disorders are reported during long-term administration, so there is a drawback that they should be taken into consideration. In addition, minoxidil-containing hair growth supplements, which are widely used, are approved by the FDA as generic drugs, but they can not be administered to women and have disadvantages such as skin irritation, itching, redness and deterioration of hair loss. Therefore, there is a need to develop a substance that is safe for both men and women and has hair loss prevention effect and hair growth effect without side effects.
한편, 라벤더(Lavanduia officinalis)는 지중해 연안이 원산지이다. 라벤더 에센셜 오일은 심신을 안정시키고, 스트레스 해소와 피로를 회복시켜 주는 것으로 알려져 있으며, 그리스·로마시대부터 입욕제로 쓰였고, 중세에는 세탁물의 향을 내는데도 사용되었다. 라벤더는 항균, 항염, 항산화 효과가 우수하여 피부 진정 효과가 뛰어나고 외부 유해물질로부터 피부를 보호하는 효과 또한 우수하다.Meanwhile, Lavanduia officinalis ) is the origin of the Mediterranean coast. Lavender Essential Oil is known to stabilize the mind and body, relieve stress and restore fatigue. It has been used as a bathing agent from Greek and Roman times, and was also used to incense laundry in the Middle Ages. Lavender has excellent antimicrobial, anti-inflammatory and antioxidant effect, so it has excellent skin soothing effect and also protects skin from harmful substances.
레몬그라스(Cymbopogon citratus)는 외떡잎식물 벼목 화본과의 여러해살이풀로 향료를 채취하기 위하여 열대지방에서 재배한다. 레몬그라스의 주성분은 페네솔, 세리니올, 네롤, 시트롤, 시트로네랄, 리모넨, 밀센 등이며 레몬그라스는 혈액을 좋게 하여 모공에 효과적이고 여드름과 같은 트러블 완화 효과 및 피지분비의 균형을 좋게 하는 것으로 알려져 있다.Lemongrass ( Cymbopogon citratus ) is a perennial herb that grows in the tropics in order to extract spices. The main components of lemon grass are Fenesol, Celignol, Nerol, Citrrol, Citronellal, Limonene, and Mulsen. Lemon Grass is effective on pores by improving the blood, and helps balance troubles such as acne and relieve sebum secretion. .
로즈마리(Rosmarinus officinalis)는 라틴어 로즈마리누스(Rosmarinus) 즉, 로즈(Ros:이슬)와 마리누스(Marinus:바다)가 어원으로 "바다의 이슬"이라는 의미에서 유래 되었다. 줄기, 잎, 꽃을 모두 이용하는데 유럽에서는 기원전 1세기부터 약초로 쓰였으며 요리, 차, 입욕제, 화장수, 방향제 등에 널리 쓰인다. 로즈마리는 살균, 소독력이 뛰어나 외부로부터 피부를 보호하며 피부를 재생시켜 피부 노화를 방지하는 효과가 있는 것으로 알려져 있다. Rosmarinus ( Rosmarinus officinalis ) is derived from the Latin word Rosmarinus, meaning rosin and marinus (sea) as "sea dew". It is used as a herb since the first century BC in Europe, and it is widely used in cooking, tea, bath salts, lotion, perfume, etc. Rosemary is known to be effective in sterilizing and disinfecting, protecting skin from the outside, and regenerating skin to prevent skin aging.
캐모마일(Matricaria chamomilla)은 국화과의 여러해살이풀로 음료, 과자 등에 사용되는 향미료의 원료인 방향유를 제조하거나, 꽃으로 허브차를 제조한다. 꽃, 정유에는 플라보노이드 성분이 많이 함유되어 있어 항산화 및 항염 효과에 우수하다. 해열작용이 있어 피부 혈행 개선, 모세혈관보호 등 피부 진정효과를 갖는 것으로 알려져 있다.Chamomile (Matricaria chamomilla ) is a perennial plant of Asteraceae that produces aromatic oil, a raw material for spices used in beverages and confectionery, or produces herbal tea with flowers. Flowers, essential oils contain a large amount of flavonoids, so they are excellent in antioxidant and anti-inflammatory properties. It has been known to have a sedative effect on the skin such as improvement of the skin blood circulation and capillary protection due to the antipyretic action.
페파민트(Mentha piperita)는 서양박하라고도 불리우며, 가장 역사가 오래되었고 수요도 많은 허브이다. 페파민트의 멘톨 성분은 피부 가려움증과 피부 염증에 효과적이며 해열작용으로 인해 피부를 진정시키는 효과를 갖는다. 또한, 모공을 청결히 하고 수렴작용이 뛰어나 몸에 난 여드름에 효과를 볼 수 있는 것으로 알려져 있다. Peppermint ( Mentha piperita ), also known as Western peppermint, is the oldest and most demanding hub. The peppermint menthol ingredient is effective for skin itching and skin irritation, and has the effect of soothing the skin due to the antipyretic action. In addition, it is said to be effective in cleansing pores and having excellent astringent effect on body acne.
한편, 한국등록특허 제1050427호에는 허브추출물 및 영양캡슐을 포함하는 두피 및 모발의 보호 및 세정 조성물이 개시되어 있고, 한국공개특허 제2002-0037796호에는 라벤더 및 로즈마리 오일이 포함된 발모제 조성물 및 샴푸가 개시되어 있으나, 본 발명의 라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 조성물에 대해 개시된 바 없다.Korean Patent No. 1050427 discloses a composition for protecting and cleaning scalp and hair comprising herbal extracts and nutritional capsules. In Korean Patent Publication No. 2002-0037796, a hair growth inhibitor composition containing lavender and rosemary oil and a shampoo composition However, the composition for preventing hair loss or promoting hair growth containing lavender, lemon grass, rosemary, chamomile and peppermint oil of the present invention as an effective ingredient has not been disclosed.
본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명은 라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트 오일을 인간 모유두 세포(human dermal papilla cell, hDPC)에 처리했을 때, 모발성장인자인 IGF-1 및 VEGF의 발현이 증가하고, 항산화 및 모발성장관련 신호전달과정인 Wnt/β-catenin 신호전달이 활성화 되며, INF-γ를 처리한 모유두 탈모 세포 모델에서 탈모환자에서 감소하는 것으로 알려진 HO-1의 발현이 오일 처리시 다시 증가하는 것을 확인함으로써, 본 발명을 완성하였다. SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned needs, and it is an object of the present invention to provide a hair growth promoting agent for treating a human dermal papilla cell (hDPC) comprising lavender, lemon grass, rosemary, chamomile and peppermint oil, 1 and VEGF, and activation of Wnt / β-catenin signaling, a signal transduction pathway related to antioxidant and hair growth, and HO-1, which is known to decrease in patients with hair loss in INF- Was increased again in the oil treatment, thereby completing the present invention.
상기 과제를 해결하기 위하여, 본 발명은 허브 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 화장료 조성물을 제공한다.In order to solve the above-mentioned problems, the present invention provides a cosmetic composition for preventing hair loss or promoting hair growth, comprising a herbal oil as an active ingredient.
또한, 본 발명은 허브 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 피부외용제를 제공한다.The present invention also provides a skin external preparation for preventing hair loss or promoting hair growth comprising herbal oil as an effective ingredient.
또한, 본 발명은 허브 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 건강기능식품 조성물을 제공한다.Further, the present invention provides a health functional food composition for preventing hair loss or promoting hair growth comprising herbal oil as an active ingredient.
본 발명에 따르면, 라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트 오일을 모유두 세포에 처리하였을 때, 모발성장인자의 발현을 증가시키고, 항산화 활성 및 모발성장관련 신호전달을 활성화하며, 탈모 세포 모델에서 HO-1의 발현을 증가시키는 효과가 있으므로, 탈모예방 또는 탈모개선을 위한 화장료 또는 건강기능식품 조성물 또는 탈모예방 또는 탈모치료를 위한 피부외용제로 유용하게 사용될 수 있다.According to the present invention, when lavender, lemon grass, rosemary, chamomile and peppermint oil are treated with dermal papilla cells, expression of hair growth factors is increased, antioxidative activity and signaling related to hair growth are activated, -1, it can be effectively used as a cosmetic or health functional food composition for alopecia prevention or alopecia improvement, or as an external preparation for skin for preventing hair loss or alopecia treatment.
도 1은 인간 모유두 세포에 대한 오일의 세포 독성을 확인한 결과이다.
도 2는 인간 모유두 세포에 오일 처리시 모발성장인자의 발현을 확인한 결과이다.
도 3은 인간 모유두 세포에 오일 처리시 모발성장관련 신호전달과정인 Wnt/β-catenin의 활성화를 루시퍼레이즈(luciferase) 분석법으로 확인한 결과이다. 대조군은 아무것도 처리하지 않은 음성대조군이고, 미녹시딜은 양성대조군이다.
도 4는 오일의 ROS 제거능을 DCFDA 분석법을 이용하여 형광활성화세포분류기(fluorescence activated cell sorter, FACS)로 확인한 결과이다. Control은 아무것도 처리하지 않은 음성대조군이고, UVB는 자외선을 조사하여 ROS 생성을 유도한 군이다.
도 5는 인간 모유두 세포에 오일 처리시 항산화효소의 발현을 확인한 결과이다.
도 6은 오일 처리에 따른 Nrf-2 발현을 인간 모유두 세포에서 확인한 결과이다.
도 7은 인간 모유두 세포에 자외선 조사 후 오일 처리에 따른 Nrf-2 발현을 면역세포화학염색법(Immunocytochemistry, ICC)을 이용하여 확인한 결과이다. DAPI는 파란색으로 핵을 염색한 것이고, Nrf-2는 녹색으로 Nrf-2를 염색한 것이며, A는 아무것도 처리하지 않은 음성대조군, B는 자외선 조사군, C는 라벤다 오일 처리 후 자외선을 조사한 군, D는 레몬그라스 오일 처리 후 자외선을 조사한 군, E는 로즈마리 오일 처리 후 자외선을 조사한 군, F는 캐모마일 오일 처리 후 자외선을 조사한 군, G는 페파민트 오일 처리 후 자외선을 조사한 군, H는 청유자 오일 처리 후 자외선을 조사한 군 및 I는 유자씨 오일 처리 후 자외선을 조사한 군이다.
도 8은 모유두 탈모 세포 모델에서 HO-1의 발현을 확인한 결과이다. 대조군은 아무것도 처리하지 않은 음성대조군이고, INF-γ는 탈모를 유도한 대조군이다. Figure 1 shows the result of confirming the cytotoxicity of oil to human dermal papilla cells.
FIG. 2 shows the results of confirming the expression of hair growth factors in oil treatment of human dermal papilla cells.
FIG. 3 shows the results of confirming the activation of Wnt / β-catenin, a signal transduction process related to hair growth during oil treatment in human dermal papilla cells, by luciferase assay. The control group is a negative control group with no treatment, and minoxidil is a positive control group.
FIG. 4 shows the result of confirming the ROS elimination ability of the oil with a fluorescence activated cell sorter (FACS) using a DCFDA assay. Control is a negative control without any treatment, and UVB is a group that induces ROS generation by irradiation with ultraviolet light.
FIG. 5 shows the results of confirming the expression of antioxidant enzymes in oil treatment of human dermal papilla cells.
FIG. 6 shows the result of confirming Nrf-2 expression in human dermal papilla cells by oil treatment.
FIG. 7 shows the result of confirming Nrf-2 expression by oil treatment after UV irradiation on human dermal papilla cells using Immunocytochemistry (ICC). DAPI is a blue nucleus staining, Nrf-2 is green, Nrf-2 staining, A is a negative control without any treatment, B is an ultraviolet irradiation group, C is a group irradiated with ultraviolet rays after lavender oil treatment, D is the group irradiated with lemon grass oil after UV treatment, E is irradiated with ultraviolet rays after rosemary oil treatment, F is irradiated with ultraviolet rays after chamomile oil treatment, G is irradiated with ultraviolet rays after treating with peppermint oil, The treated group was irradiated with ultraviolet rays, and the group I was irradiated with ultraviolet rays after treatment with citron seed oil.
FIG. 8 shows the results of confirming the expression of HO-1 in a model of human hair loss hair cells. The control group was a negative control group treated with nothing, and INF-gamma was a control group that induced hair loss.
본 발명은 허브 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 화장료 조성물에 관한 것이다. 상기 허브 오일은 라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트 오일로 이루어진 군에서 선택된 하나 이상으로 구성될 수 있다. The present invention relates to a cosmetic composition for preventing hair loss or for promoting hair growth comprising a herbal oil as an effective ingredient. The herbal oil may be at least one selected from the group consisting of lavender, lemon grass, rosemary, chamomile, and peppermint oil.
본 발명의 허브 오일은 모유두 세포의 성장을 촉진하는 것일 수 있으나 이에 제한되지 않는다. The herbal oil of the present invention may be one that promotes the growth of the dermal papilla cells, but is not limited thereto.
또한, 상기 화장료 조성물은 헤어토닉, 헤어컨디셔너, 헤어에센스, 헤어로션, 헤어영양로션, 헤어샴푸, 헤어린스, 헤어트리트먼트, 헤어크림, 헤어영양크림, 헤어모이스처크림, 헤어맛사지크림, 헤어왁스, 헤어에어로졸, 헤어팩, 헤어영양팩, 헤어비누, 헤어클렌징폼, 모발건조제, 모발보존처리제, 모발염색제, 모발용 웨이브제, 모발탈색제, 헤어겔, 헤어글레이즈, 헤어드레싱어, 헤어래커, 헤어모이스처라이저, 헤어무스 또는 헤어스프레이의 제형으로 제조되는 것일 수 있으나, 이에 제한되지 않는다.The cosmetic composition may further comprise at least one selected from the group consisting of hair tonic, hair conditioner, hair essence, hair lotion, hair nourishing lotion, hair shampoo, hair rinse, hair treatment, Hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair moisturizers, But are not limited to, those made from formulations of mousse or hairspray.
또한, 상기 화장료 조성물은 본 발명의 허브 오일에 추가로 지방 물질, 유기 용매, 용해제, 농축제 및 겔화제, 연화제, 항산화제, 현탁화제, 안정화제, 발포제(foaming agent), 방향제, 계면활성제, 물, 이온형 또는 비이온형 유화제, 충전제, 금속이온봉쇄제 및 킬레이트화제, 보존제, 비타민, 차단제, 습윤화제, 필수 오일, 염료, 안료, 친수성 또는 친유성 활성제, 지질 소낭 또는 화장품에 통상적으로 사용되는 임의의 다른 성분과 같은 화장품학 분야에서 통상적으로 사용되는 보조제를 함유할 수 있다.In addition, the cosmetic composition may contain, in addition to the herbal oil of the present invention, a lipid, an organic solvent, a solubilizing agent, a thickening agent and a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, Water, ionic or non-ionic emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics Such as, for example, cosmetics, cosmetics, pharmaceuticals, cosmetics, pharmaceuticals,
또한, 본 발명은 허브 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 피부외용제에 관한 것이다. The present invention also relates to a skin external preparation for preventing hair loss or promoting hair growth, which contains herbal oil as an active ingredient.
본 발명의 탈모방지 또는 발모촉진용 피부외용제는 크림, 젤, 패취, 연고, 경고제, 로션제, 액제, 유탁액, 파우더제 또는 스프레이의 제형으로 제조되는 것일 수 있으나, 이에 제한되지 않는다.The skin external preparation for hair loss prevention or hair growth promotion of the present invention may be manufactured by formulations of cream, gel, patch, ointment, warning agent, lotion, liquid agent, emulsion, powder or spray, but is not limited thereto.
본 발명의 제형이 크림 또는 젤인 경우에는 담체 성분으로서 동물섬유, 식물섬유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a cream or a gel, animal fibers, plant fibers, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
본 발명의 제형이 액제 또는 유탁액인 경우에는 담체 성분으로서 용매, 용매화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌글리콜 또는 소르비탄의 지방산에스테르가 있다.When the formulation of the present invention is a liquid or an emulsion, a solvent, a solvent or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
또한, 본 발명은 허브 오일을 유효성분으로 함유하는 탈모방지 또는 발모촉진용 건강기능식품 조성물에 관한 것이다.Further, the present invention relates to a health functional food composition for preventing hair loss or promoting hair growth comprising herbal oil as an active ingredient.
본 발명의 건강기능식품 조성물을 식품첨가물로 사용하는 경우, 상기 건강기능식품 조성물을 그대로 첨가하거나 다른 식품 또는 식품성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분의 양은 그의 사용 목적(예방 또는 개선)에 따라 적절하게 사용될 수 있다. 일반적으로, 식품 또는 음료의 제조시 본 발명의 건강기능식품 조성물은 원료에 대하여 15 중량부 이하, 바람직하게는 10 중량부 이하의 양으로 첨가된다. 그러나 건강을 목적으로 하는 장기간의 섭취인 경우에 상기 양은 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로 사용될 수 있다.When the health functional food composition of the present invention is used as a food additive, the health functional food composition may be added as it is, or may be used together with other food or food ingredients, and suitably used according to a conventional method. The amount of the active ingredient can be suitably used depending on its use purpose (prevention or improvement). Generally, the health functional food composition of the present invention is added in an amount of not more than 15 parts by weight, preferably not more than 10 parts by weight based on the raw material, when the food or beverage is produced. However, in the case of long-term intake for health, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount exceeding the above range.
상기 건강기능식품의 종류에 특별한 제한은 없다. 상기 건강기능식품 조성물을 첨가할 수 있는 식품의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강식품을 모두 포함한다.There is no particular limitation on the kind of the health functional food. Examples of the foods to which the health functional food composition can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen and other noodles, gums, ice cream, soups, Drinks, alcoholic beverages, and vitamin complexes, all of which include health foods in a conventional sense.
또한, 본 발명의 건강기능식품 조성물은 식품, 특히 기능성 식품으로 제조될 수 있다. 본 발명의 기능성 식품은 식품 제조 시에 통상적으로 첨가되는 성분을 포함하며, 예를 들어, 단백질, 탄수화물, 지방, 영양소 및 조미제를 포함한다. 예컨대, 드링크제로 제조되는 경우에는 유효성분 이외에 천연 탄수화물 또는 향미제를 추가 성분으로서 포함시킬 수 있다. 상기 천연 탄수화물은 모노사카라이드(예컨대, 글루코오스, 프럭토오스 등), 디사카라이드(예컨대, 말토스, 수크로오스 등), 올리고당, 폴리사카라이드(예컨대, 덱스트린, 시클로덱스트린 등) 또는 당알코올(예컨대, 자일리톨, 소르비톨, 에리쓰리톨 등)인 것이 바람직하다. 상기 향미제는 천연 향미제(예컨대, 타우마틴, 스테비아 추출물 등)와 합성 향미제(예컨대, 사카린, 아스파르탐 등)를 이용할 수 있다.In addition, the health functional food composition of the present invention can be produced as a food, particularly a functional food. The functional food of the present invention includes components that are ordinarily added in food production, and includes, for example, proteins, carbohydrates, fats, nutrients, and seasonings. For example, in the case of a drink, a natural carbohydrate or a flavoring agent may be included as an additional ingredient in addition to the active ingredient. The natural carbohydrate may be selected from the group consisting of monosaccharides (e.g., glucose, fructose, etc.), disaccharides (e.g., maltose, sucrose etc.), oligosaccharides, polysaccharides (e.g., dextrin, cyclodextrin, , Xylitol, sorbitol, erythritol, etc.). The flavoring agent may be a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.).
상기 건강기능식품 조성물 이외에 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등을 더 함유할 수 있다. 이러한 상기 첨가되는 성분의 비율은 크게 중요하진 않지만 본 발명의 건강기능식품 조성물 100 중량부에 대하여, 0.01 내지 0.1 중량부의 범위에서 선택되는 것이 일반적이다.
In addition to the above health functional food composition, it is also possible to use various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickening agents, pH adjusters, stabilizers, preservatives, glycerin, A carbonating agent used in beverages, and the like. Although the ratio of the above-mentioned ingredients is not critical, it is generally selected in the range of 0.01 to 0.1 part by weight based on 100 parts by weight of the health functional food composition of the present invention.
이하, 제조예 및 실시예를 이용하여 본 발명을 더욱 상세하게 설명하고자 한다. 이들 제조예 및 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로 본 발명의 범위가 이들에 의해 제한되지 않는다는 것은 당해 기술분야에서 통상의 지식을 가진 자에게 있어 자명한 것이다.
Hereinafter, the present invention will be described in more detail with reference to Preparation Examples and Examples. It is to be understood by those skilled in the art that these preparations and examples are merely intended to explain the present invention more specifically and that the scope of the present invention is not limited thereto.
제조예Manufacturing example 1. 오일의 제조 1. Manufacture of oil
라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트 오일을 제조하기 위하여 라벤다, 레몬그라스, 로즈마리, 캐모마일 및 페파민트를 세척하여 물기를 제거하고, 상업용 오일 추출기 탱크에 원료를 각각 투입하고 추출기를 3시간 30분 동안 가동하여 오일 추출물을 제조하였다. 보다 구체적으로 원료를 추출기 탱크에 250㎏ 넣고, 스팀 보일러 가동으로 정제된 스팀 수증기를 추출 탱크에 흡입시키며, 1시간 동안 예열 가동한다. 이때 감압을 걸어서 원료를 열 수증기와 압력으로 자동 분류되도록 한다. 추출 탱크 온도가 100℃에 이르면 증기 배출 밸브를 열어서 1차 혼합 증기를 약 3분 정도 밖으로 배출시켜 추출기 안의 증기를 순화시키고, 다시 감압을 걸어서 압력을 높인 후 추출 탱크의 온도가 110℃에 이르고 압력이 1.5kgf 걸렸을 때, 증기 추출 밸브와 냉각수 밸브를 열어서 정유 분리 작업을 시작한다. 정유 분리 작업은 2시간 30분 동안 수행되며, 분류 탱크에서 오일과 하이드로졸이 분리되면 약 3회에 걸쳐 하이드로졸을 받고, 최종 오일을 함유한 하이드로졸 잔류물을 받아서 분리기를 통해 하이드로졸과 오일을 분리한다. 분리된 오일층에서 순수 오일을 취득하기 위해서 1차 분리된 오일을 냉동실에 1일 동안 보관해서 얼지 않은 오일만 채취한다. Lavender, lemon grass, rosemary, chamomile and peppermint were washed to remove lye, lemon grass, rosemary, chamomile and peppermint oil, and the raw material was added to each of the commercial oil extractor tanks and the extractor was heated for 3 hours and 30 minutes To produce an oil extract. More specifically, 250 kg of the raw material is put into the extractor tank, the steam steam refined by operating the steam boiler is sucked into the extraction tank, and the preheating operation is performed for 1 hour. At this time, decompression is applied to automatically sort the raw material into heat steam and pressure. When the temperature of the extraction tank reaches 100 ° C, the steam discharge valve is opened to discharge the primary mixed steam to the outside for about 3 minutes to purify the steam in the extractor, and then the pressure is raised by depressurizing again, When it is 1.5kgf, open the steam extraction valve and the coolant valve to start the oil separation operation. The oil separation operation is carried out for 2 hours and 30 minutes. When the oil and the hydrozole are separated from the separation tank, the hydrozole is received about 3 times, and the hydrazole residue containing the final oil is received, . In order to obtain pure oil from the separated oil layer, firstly separated oil is stored in the freezer for 1 day and only the unfrozen oil is collected.
청유자 오일을 추출하기 위해 청유자를 세척한 후 내부의 씨 및 유자과즙을 제거하고 건조한다. 그 후 열을 가하지 않은 상태에서 압착을 진행하고, 착유한 청유자 오일을 여과하여 고순도 청유자 오일만 추출한다.After extracting blue citrus oil, wash the yellow oil and remove the inner seed and citron juice and dry. Thereafter, the squeezing process is continued without applying heat, and the squeezed oleaginous oil is filtered to extract only the high purity sperm oil.
유자씨 오일을 추출하기 위해 유자씨를 선별하여 이물 제거 후, 세척을 통해 산 및 점액질을 제거한다. 그 후 유자씨를 수분 함량 14% 이하로 건조하고, 건조된 유자씨를 저온상태로 스크류 압착식 방법을 통해 착유한다. 착유된 유자씨 오일은 여과기를 통과시켜 고순도 유자씨 오일을 추출한다.
Citron seeds are selected to extract citron seed oil, and then acid and mucilage are removed through washing after removing foreign bodies. After that, the seeds are dried to a water content of 14% or less, and the dried seeds are milked through a screw compression method at a low temperature. Milk yielded citron seed oil is passed through a filter to extract high purity citron seed oil.
실시예Example 1. 세포생존율 측정 1. Cell viability measurement
모발 성장에 중요한 인간 모유두 세포(human dermal papilla cell, hDPC)에 제조예 1의 오일 추출물을 처리하였을 때 나타나는 세포 독성을 MTT 분석법을 통하여 확인하였다. 그 결과, 도 1에 나타난 바와 같이 레몬그라스 오일은 0.005 중량% 이하 농도에서, 청유자 오일 및 라벤다 오일은 0.01 중량% 이하 농도에서, 로즈마리 오일 및 페파민트 오일은 0.02 중량% 이하 농도에서, 캐모마일 오일은 0.04 중량% 이하 농도에서, 유자씨 오일은 0.25 중량% 이하 농도에서 각각 세포 독성을 나타내지 않음을 확인하였으며, 이하 실시예에서 각각의 농도 이하로 처리하여 실험을 진행하였다.
The cytotoxicity of the human dermal papilla cell (hDPC), which is important for hair growth, when treated with the oil extract of Preparation Example 1 was confirmed by MTT assay. As a result, as shown in Fig. 1, the concentration of the lemon grass oil at the concentration of 0.005 wt% or less, the concentration of the citron oil and lavender oil at the concentration of 0.01 wt% or less, the concentration of the rosemary oil and the peppermint oil at the concentration of 0.02 wt% At a concentration of 0.04% by weight or less, it was confirmed that citronella seed oil did not exhibit cytotoxicity at concentrations of 0.25% by weight or less. Experiments were carried out in the following examples.
실시예Example 2. 모발성장인자 발현 변화 측정 2. Measurement of expression of hair growth factor
모유두 세포에 제조예 1의 오일을 처리하여 모발 성장인자인 TGF-β, IGF-1 및 VEGF의 발현을 RT-PCR을 통하여 분석하였다. 오일의 농도는 실시예 1의 MTT 분석법을 참고하여 설정하였다. 그 결과, 도 2에 나타난 바와 같이 TGF-β는 오일 무처리군과 비교하여 발현의 변화가 거의 나타나지 않았지만, IGF-1의 발현은 모든 오일 처리군에서 증가하였으며, VEGF의 발현은 레몬그라스 오일 0.0025 중량% 및 로즈마리 오일 0.005 중량%를 제외한 처리군에서 증가하였다. 따라서 라벤다 오일, 레몬그라스 오일, 로즈마리 오일, 캐모마일 오일, 페파민트 오일, 청유자 오일 또는 유자씨 오일은 모발 성장인자인 IGF-1 및 VEGF의 발현을 증가시킴으로써 모발의 성장에 긍정적 효과를 가져 올 수 있다.
The expression of TGF-beta, IGF-1 and VEGF, which are hair growth factors, was analyzed by RT-PCR by treating the dermal papilla cells with the oil of Preparation Example 1. The concentration of the oil was set by referring to the MTT analysis method of Example 1. As a result, as shown in FIG. 2, expression of IGF-1 was increased in all of the oil-treated groups, while expression of TGF-β was little changed compared to that of the oil-untreated group. Expression of VEGF was 0.0025 By weight, and 0.005% by weight of rosemary oil. Thus, lavender oil, lemongrass oil, rosemary oil, chamomile oil, peppermint oil, blue citron oil or citronella oil may have positive effects on hair growth by increasing the expression of hair growth factors IGF-1 and VEGF .
실시예Example 3. 3. WntWnt /β-/ β- catenincatenin 신호전달의 활성화 측정 Measuring activation of signaling
모발성장 관련 Wnt/β-catenin 신호전달의 활성화 정도를 확인하기 위하여, TOP-Flash 플라스미드 벡터(plasmid vector)를 형질주입시킨 모유두 세포에 제조예 1의 오일을 처리한 후, 루시퍼레이즈 분석법으로 발광 정도를 비교분석하였다. 양성 대조군으로는 현재 시판중인 미녹시딜을 2 중량% 처리하였다. 그 결과, 도 3에 나타난 바와 같이 모든 오일 처리군에서 아무것도 처리하지 않은 대조군에 비하여 신호전달이 활성화 하는 것을 확인하였으며, 특히 라벤다 오일, 로즈마리 오일, 페파민트 오일, 청유자 오일 및 유자씨 오일은 양성대조군인 미녹시딜에 비해서 높은 Wnt/β-catenin 신호전달의 활성화 정도를 나타냄을 확인할 수 있었다. 이를 통해 제조예 1의 오일 추출물들은 Wnt/β-catenin 신호전달의 활성화를 통하여 모발성장에 관여함을 알 수 있다.
In order to confirm the degree of activation of Wnt / [beta] -catenin signal transduction related to hair growth, the oil of Preparation Example 1 was treated with the TOP-Flash plasmid vector-transduced dermal papilla cells and the luciferase analysis Respectively. As a positive control, 2% by weight of currently available minoxidil was treated. As a result, as shown in FIG. 3, it was confirmed that signal transduction was activated in all the oil-treated groups as compared with the control group treated with nothing. Especially, lavender oil, rosemary oil, peppermint oil, And that the activation of Wnt / β-catenin signaling is higher than that of intramuscular minoxidil. Thus, it can be seen that the oil extracts of Preparation Example 1 are involved in hair growth through activation of Wnt / β-catenin signal transduction.
실시예Example 4. 4. ROSROS 제거능Removability 평가 evaluation
제조예 1의 오일의 ROS 제거 효능을 평가하기 위해 모유두 세포에 제조예 1의 오일을 처리한 후, 자외선(UVB)을 조사하여 ROS 제거 효능을 DCFDA 분석법을 이용하여 형광활성화세포분류기(fluorescence activated cell sorter, FACS)로 확인하였다. 그 결과, 도 4에 나타난 바와 같이 자외선을 조사한 UVB군에서는 아무것도 처리하지 않은 음성대조군인 Control 군에 비해 370%의 ROS가 발생하였으며, 제조예 1의 오일을 처리한 경우, UVB에 의한 ROS 생성을 저해하는 효과를 확인하였다. To evaluate the ROS removal efficiency of the oil of Preparation Example 1, the dermal papilla cells were treated with the oil of Preparation Example 1 and irradiated with ultraviolet light (UVB) to determine the ROS removal efficiency using a fluorescence activated cell sorter sorter, FACS). As a result, as shown in FIG. 4, in the UVB group irradiated with ultraviolet rays, 370% of the ROS was generated compared to the control group, which was the negative control group, and when the oil of Preparation Example 1 was treated, UVB- Inhibitory effect.
라벤다, 레몬그라스, 로즈마리, 캐모마일, 페파민트, 청유자 및 유자씨 오일은 각각 자외선 조사군에 비해 41.3, 19.2, 51.6, 35.9, 58.1, 49.7 및 53.3%의 ROS 제거 효능이 있다. 따라서 자외선에 의해 발생된 ROS를 라벤다 오일, 레몬그라스 오일, 로즈마리 오일, 캐모마일 오일, 페파민트 오일, 청유자 오일 또는 유자씨 오일이 제거함을 확인함으로써 자외선에 대한 오일의 세포 보호 효과를 검증하였다.
Listeria, lemon grass, rosemary, chamomile, peppermint, celery, and citronella have ROS removal efficiencies of 41.3, 19.2, 51.6, 35.9, 58.1, 49.7 and 53.3%, respectively, Therefore, we confirmed the effect of ultraviolet light on the cell protection by confirming that ROS generated by ultraviolet rays are removed by Lavender oil, lemongrass oil, rosemary oil, chamomile oil, peppermint oil, blue citron oil or citronella seed oil.
실시예Example 5. 항산화 효소 발현 확인 5. Identification of antioxidant enzyme expression
모유두 세포에 제조예 1의 오일을 처리하여 항산화 효소(HO-1, NQO-1, GSTpi, GSTA4 및 GCLM)의 발현 변화를 RT-PCR을 통하여 확인하였다. 그 결과, 도 5에 나타난 바와 같이 오일 처리시 특정 농도에 따라 항산화 효소의 발현이 증가하였다. HO-1, NQO-1 및 GSTpi는 레몬그라스 오일 0.0025 중량%, 로즈마리 오일 0.005 중량% 및 페파민트 오일 0.005 및 0.02 중량%를 제외한 나머지 군에서 발현이 증가하였고, GSTA4 및 GCLM은 로즈마리 0.005 중량% 처리군을 제외한 나머지 군에서 발현이 증가하는 것을 확인하였다.
The expression of antioxidant enzymes (HO-1, NQO-1, GSTpi, GSTA4 and GCLM) was confirmed by RT-PCR by treating the dermal papilla cells with the oil of Preparation Example 1. As a result, as shown in FIG. 5, the expression of antioxidant enzyme was increased according to the specific concentration in the oil treatment. HO-1, NQO-1 and GSTpi increased in the other groups except 0.0025% by weight of lemon grass oil, 0.005% by weight of rosemary oil, and 0.005% by weight and 0.02% by weight of peppermint oil. GSTA4 and GCLM were treated with 0.005% And the expression of the protein was increased in the other groups.
실시예Example 6. 항산화 효소 발현 기전 확인 6. Identification of antioxidant enzyme expression mechanism
제조예 1의 오일을 처리하였을 때 항산화 효소의 발현을 증가시키는 기전을 확인하기 위하여 항산화를 유도하는 핵심 전사인자인 Nrf-2의 발현을 확인하였다. 그 결과, 도 6에 나타난 바와 같이 모유두 세포에 제조예 1의 오일을 처리하였을 경우, 로즈마리 오일 0.005 중량% 처리군을 제외한 모든 처리군에서 음성대조군에 비하여 Nrf-2의 발현이 증가하였다. 이는 세포에서 ROS의 생성과 상관없이 오일 처리에 따라 항산화 효소인 Nrf-2의 발현이 증가함을 의미한다. 이를 통해 허브 오일은 ROS와 무관하게 Nrf-2의 발현을 증가시키고, 증가된 Nrf-2의 발현을 통하여 항산화 효소의 발현이 조절됨으로써 항산화 작용이 일어남을 알 수 있다.
Expression of Nrf-2, a key transcription factor that induces antioxidation, was confirmed in order to confirm the mechanism of increasing the expression of antioxidant enzyme when the oil of Preparation Example 1 was treated. As a result, when the oil of Preparation Example 1 was treated with the dermal papilla cells as shown in Fig. 6, the expression of Nrf-2 was increased in all treatment groups except rosemary oil treated group at 0.005 wt%, compared with the negative control group. This indicates that the expression of Nrf-2, an antioxidant enzyme, increases with oil treatment irrespective of the production of ROS in cells. Thus, it can be seen that the herbal oil increases the expression of Nrf-2 irrespective of ROS, and the antioxidant activity is controlled by the expression of the antioxidant enzyme through the increased expression of Nrf-2.
실시예Example 7. 7. NrfNrf -2 단백질 발현 확인-2 protein expression confirmation
모유두 세포에 제조예 1의 오일을 처리한 후 자외선을 조사하여 나타나는 Nrf-2의 활성 변화를 면역화학염색법을 이용하여 공초점현미경(confocal microscope)을 통해 분석하였다. 그 결과, 도 7에 나타난 바와 같이 음성대조군(A)에서는 Nrf-2의 발현이 확인되지 않는 반면 자외선을 조사하였을 때(B)는 항산화를 유도하는 전사인자인 Nrf-2의 발현이 증가됨을 확인하였고, 허브 오일, 유자씨 또는 청유자 오일을 처리하였을 경우(C~I) Nrf-2는 활성화 되어 핵내로의 이동이 더욱 증진됨을 확인할 수 있었다.
The changes in the activity of Nrf-2, which is produced by irradiating UV rays to the dermal papilla cells treated with the oil of Preparation Example 1, were analyzed by confocal microscopy using immunochemical staining. As a result, as shown in FIG. 7, the expression of Nrf-2 was not observed in the negative control group (A), whereas the expression of Nrf-2, which is a transcription factor inducing antioxidation, (C ~ I) in the case of treatment with herbal oil, citron or citrus oil, it was confirmed that Nrf-2 was activated and the migration into nucleus was further enhanced.
실시예Example 8. 8. 모유두Dairy cattle 탈모 세포 모델에서 In the model of hair loss cells HOHO -1의 발현변화 확인-1
모유두 세포에 INF-γ를 처리하여 탈모 세포 모델을 만든 후, 제조예 1의 오일을 처리하여 HO-1의 발현을 확인하였다. HO-1은 정상인에 비해 탈모환자에서 발현이 감소하는 유전자다. 그 결과, 도 8에 나타난 바와 같이 모유두 세포에 INF-γ를 처리하면 HO-1 유전자의 발현이 감소하고, 제조예 1의 오일을 처리하였을 경우 감소한 HO-1 유전자의 발현이 다시 증가하는 것을 확인하였다. 특히 라벤다 오일, 페파민트 오일 또는 유자씨 오일을 처리하였을 경우, INF-γ 처리에 의해 감소된 HO-1의 발현이 현저히 증가하였으며, 이는 아무것도 처리하지 않은 대조군에 비해서도 더욱 증가하는 결과를 나타냈다. 따라서 허브 오일은 탈모방지에 이용할 수 있다.The dermal papilla cells were treated with INF-y to produce a model of hair loss cells, and the oil of Preparation Example 1 was treated to confirm the expression of HO-1. HO-1 is a gene whose expression is decreased in patients with hair loss compared to normal individuals. As a result, as shown in Fig. 8, when the dermal papilla cells were treated with IFN-γ, the expression of the HO-1 gene decreased, and when the oil of Preparation Example 1 was treated, the expression of the decreased HO-1 gene again increased Respectively. In particular, when treated with lavender oil, peppermint oil or citronella seed oil, the expression of HO-1, which was reduced by IFN-γ treatment, was significantly increased, which was even higher than that of the control group without any treatment. Therefore, hub oil can be used to prevent hair loss.
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Cited By (3)
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KR20210083943A (en) | 2019-12-27 | 2021-07-07 | (주)엔비바이오컴퍼니 | Hair cosmetic composition for preventing hair loss, promoting hair growth and protecting scalp comprising natural herb extract |
KR102434209B1 (en) * | 2022-01-28 | 2022-08-19 | 전기열 | Hair composition for preventing hair loss and promoting hair growth comprising natural oils |
KR102461687B1 (en) | 2022-05-12 | 2022-11-03 | 주식회사 엠앤케이코리아 | Cosmetic composition for scalp having antioxidant and anti-aging effect and method for preparing the same |
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KR20210083943A (en) | 2019-12-27 | 2021-07-07 | (주)엔비바이오컴퍼니 | Hair cosmetic composition for preventing hair loss, promoting hair growth and protecting scalp comprising natural herb extract |
KR102434209B1 (en) * | 2022-01-28 | 2022-08-19 | 전기열 | Hair composition for preventing hair loss and promoting hair growth comprising natural oils |
KR102461687B1 (en) | 2022-05-12 | 2022-11-03 | 주식회사 엠앤케이코리아 | Cosmetic composition for scalp having antioxidant and anti-aging effect and method for preparing the same |
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