CN105687035B - A kind of compound ginkgo quintessence oil with antioxidation, delaying skin aging effect - Google Patents
A kind of compound ginkgo quintessence oil with antioxidation, delaying skin aging effect Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention belongs to quintessence oil technical field, be specifically related to a kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect.Each component of following weight portion should be included: Semen Ginkgo quintessence oil 8 15 parts, Semen Vitis viniferae quintessence oil 30 60 parts, Garden lavender quintessence oil 10 30 parts containing the composite essential oil of Semen Ginkgo quintessence oil, tea tree ethereal oil 28 parts, tea polyphenols 28 parts, wetting agent 0.3 3 parts, wherein, described wetting agent is polyalcohols wetting agent.Present invention also offers a kind of method preparing the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect.The present invention provide the composite essential oil containing Semen Ginkgo quintessence oil can significantly improve the hydroxyproline (HYP) in skin, superoxide dismutase (SOD), content, reduce malonaldehyde (MDA) and lipofuscin (LF) value, there is elimination free radical, moisturizing, the function of lock water, can be used for delay skin aging.And, the composite essential oil that should contain Semen Ginkgo quintessence oil is the most volatile, long shelf-life.
Description
Technical field
The invention belongs to quintessence oil technical field, be specifically related to a kind of there is antioxidation, the containing of delaying skin aging effect
The composite essential oil of Semen Ginkgo quintessence oil.
Background technology
Ginkgo has another name called maidenhair tree, is the rarity of China, rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth,
Its leaf, fruit, seed have the medical value that comparison is high, and its pharmacological action is constantly realized, and clinical application range progressively expands
Greatly.Research shows, main containing flavone, terpene lactone, phenol and phenolic acids, polysaccharide and Polyprenol etc. in Ginkgo biloba leaves and fruit
Want the compositions such as effective active composition, and a small amount of quininic acid, linoleic acid, vitamin, ascorbic acid and alkaloid.Wherein, yellow
Ketone, terpene lactone, phenol and phenolic acids are in the news and have antioxidation, removing free radical, and the effect that antiinflammatory is antibacterial, to improving brain function
Obstacle, arteriosclerosis, hypertension, dizziness, tinnitus, headache, senile dementia, hypomnesis etc. have positive effect.
In recent years, the developmental research to gingko resource, it is concentrated mainly on Folium Ginkgo.Aspect is utilized at ginkgo nut, with
Outlet or domestic dry fruit are main, and consumption is concentrated mainly on leisure food aspect.Such as, Chinese patent literature CN102160662B
" preparation method of a kind of leisure ginkgo nuts " i.e. discloses the preparation method of a kind of leisure ginkgo nuts.Chinese patent literature
CN101305777B then discloses the manufacture method of a kind of gingko pulp paste.Food containing gingko almond and Folium Ginkgo all have abundant activity
Beneficial, therefore, extracts, prepares ginkgo oil and Related product causes the attention of scientific research personnel.Such as, Chinese patent application
Document CN103039961A " a kind of ginkgo oil microcapsules and preparation method " i.e. disclose a kind of efficient, make Semen Ginkgo extrac obtain
To ginkgo oil microcapsules made full use of and preparation method thereof.Utilize microcapsule technology to overcome Semen Ginkgo fractions of active ingredient and meet water
Indissoluble, bitter in the mouth, it is impossible to directly edible problem.Also has Chinese patent application document CN101214046A " a kind of ginkgo biloba oil powder system
Preparation Method " use micro encapsulation embedding techniques to produce ginkgo biloba oil powder, ginkgo oil effective ingredient is used for nutraceutical, health care food
The fields such as product, cosmetics, medicine.Also Chinese patent application document CN102742902A " preparation method of a kind of gingkgo water " is
Ginkgo oil and Pulvis Talci and water are prepared a kind of gingkgo water by certain part by weight proportioning, takes needs with adapt to different crowd.
But ginkgo oil is mainly made medicine or food to reach certain therapeutic purposes with oral form by the said goods.
It is true that owing to Semen Ginkgo extrac has the strongest removing free radical and antioxidation, yellow glycoside in Folium Ginkgo,
Aminoacid and Amino acid synthesis collagen protein composition, to human body beauty treatment, suppression melanin growth, keep skin gloss and elastic tool
There is important effect.And, Semen Ginkgo is applied to cosmetics early has pertinent literature to report.Such as, Chinese patent
CN102988264B " Folium Ginkgo freckle removing and whitening frost and preparation method thereof " i.e. discloses a kind of Semen Ginkgo freckle removing and whitening frost.It provides
Preparation method overcomes the poisonous defect that should not extract of Folium Ginkgo, remains the beneficiating ingredient of Folium Ginkgo greatly, on the make
Avoid secondary pollution, be the cosmetics of complete green health environmental protection." Folium Ginkgo whitening is combined Chinese patent CN103387896B
Fancy soap " then disclose a kind of Folium Ginkgo whitening compound perfumed soap.This invention adds antibacterial, antioxidation in Folium Ginkgo extract
The additive such as agent, preservative makes, the composite soap of energy skin whitening low to skin irritation.
Quintessence oil, is from the flower of plant, leaf, stem, root or fruit, by steam distillation, squeezing and pressing method, cold-maceration or molten
Agent extraction method refines the volatile flavor of extraction.Quintessence oil has lipotropy, so being easy to permeate in skin, by means of skin
Blood capillary abundant under lower fat and enter internal, thus play and improve the metabolic effect of local organization.It is usually used in killing
Bacterium antiinflammatory, improve the aspects such as skin, toxin expelling, pleasure.
But up to now, yet there are no and the effective active composition of Semen Ginkgo is made quintessence oil be used for improving skin, delaying skin declines
The report of old aspect.
Summary of the invention
In order to solve the above-mentioned problems in the prior art, an object of the present invention is to provide one can improve flesh
Skin, has elimination free radical, antioxidation, the composite essential oil containing Semen Ginkgo quintessence oil of delaying skin aging effect.
It is a further object to provide and above-mentioned there is antioxidation, the containing of delaying skin aging effect a kind of preparation
The method of the composite essential oil of Semen Ginkgo quintessence oil.
In order to realize foregoing invention purpose, a technical scheme of the present invention provides one to be had antioxidation, delays flesh
The composite essential oil containing Semen Ginkgo quintessence oil of skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 8-15 part, Portugal
Grape seed quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part, tea polyphenols 2-8 part, wetting agent 0.3-3 part, its
In, described wetting agent is polyalcohols wetting agent.
Preferably, described wetting agent is C2-6One or more in polyhydric alcohol.
It is further preferred that described wetting agent be propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol and
One or more in sorbitol.
It is further preferred that described wetting agent is dipropylene glycol and propylene glycol.
Preferably, described in there is the composite essential oil containing Semen Ginkgo quintessence oil of antioxidation, delaying skin aging effect, it includes
Each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil
2-8 part, tea polyphenols 2-8 part, wetting agent 0.3-3 part.
There is described in it is further preferred that the composite essential oil containing Semen Ginkgo quintessence oil of antioxidation, delaying skin aging effect,
It includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 50-60 part, Garden lavender quintessence oil 20-30 part, tea
Tree quintessence oil 5-8 part, tea polyphenols 5-8 part, wetting agent 0.3-0.5 part.
It is further preferred that a kind of composite precision containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect
Oil, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 60 parts, Garden lavender quintessence oil 30 parts, Camellia sinensis essence
Oil 8 parts, tea polyphenols 8 parts, propylene glycol 0.3 part.
Another technical scheme of the application provides above-mentioned has antioxidation, delaying skin aging effect a kind of preparation
The method of the composite essential oil containing Semen Ginkgo quintessence oil, it follows the steps below:
1. preparation Semen Ginkgo quintessence oil
1) by dry Folium Ginkgo and ginkgo nut with weight ratio for 1:0.2-1 mix homogeneously after pulverize, after crossing 20-50 mesh sieve
It is placed in extraction kettle；
2) in extraction kettle input supercritical carbon dioxide fluid, extracting pressure be 25-35MPa, extraction temperature be 32-
50 DEG C, the flow velocity of carbon dioxide be to extract under the conditions of 20-60kg/h, extraction time is 3-8h；
3) CO 2 fluid after extracting is passed through successively in primary separator, second-stage separator and separates, dioxy
The flow velocity changing carbon is 10-30kg/h, and wherein, primary separator pressure is 4-6MPa, primary separator temperature 0-15 DEG C；Two fraction
From device pressure 5-7MPa, second-stage separator temperature 22-40 DEG C；Wax component is discharged from primary separator；From second-stage separator
Middle discharge ginkgo oil, heating demulsification type, after separating aqueous phase, obtain described Semen Ginkgo quintessence oil；
2. the preparation composite essential oil containing Semen Ginkgo quintessence oil
Semen Ginkgo quintessence oil, Semen Vitis viniferae quintessence oil, Garden lavender quintessence oil, tea tree ethereal oil, tea polyphenols and guarantor is weighed according to above-mentioned formula ratio
Humectant, uniformly mixes the Semen Ginkgo quintessence oil of formula ratio at 0-30 DEG C with Semen Vitis viniferae quintessence oil, is subsequently adding the Garden lavender of formula ratio
Quintessence oil, tea tree ethereal oil, tea polyphenols and wetting agent, stirring is merged completely to each component, obtains described being combined containing Semen Ginkgo quintessence oil
Quintessence oil.
Preferably, the extraction kettle in step 1) has been also added with entrainer and has carried out step 2) front first soak described Semen Ginkgo
Leaf and ginkgo nut mixture 2-5h, described entrainer is 1:200-500 with the weight ratio of Folium Ginkgo and ginkgo nut mixture, described
Entrainer is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.005-0.02(volume ratio) mixture.
Active component ginkgetin in Semen Ginkgo quintessence oil can accelerate cell metabolism, improves blood circulation, strengthens cell
Vigor, by helping blood vessel to recover elastic force, promotes the blood circulation of tiny blood vessels, delaying cell aging；
Active component bilobalide in Semen Ginkgo quintessence oil can protect the vascular endothelial cell of oxidativestress damage, plays and presses down
H processed2O2(a kind of important active oxygen species, can simultaneously facilitate hydroxy radical produce at extracellular inducing cell apoptosis, and induction is thin
Born of the same parents' lipid peroxidation, causes the endotheliocyte impaired and dead) caused by the effect of cell death；And flavonoid and Semen Ginkgo
Lactone can work in coordination with again the ultra-oxygen anion free radical in scavenger cell tissue and hydroxyl radical free radical, plays the work of delaying skin aging
With.
Semen Vitis viniferae quintessence oil mainly contains the compositions such as linoleic acid, procyanidin, linoleic acid, vitamin B, for it has been recognized that
The removing maximally effective Natural antioxidant of people's interior free yl.Due to characteristics such as its tenderness, little, the easy absorptions of zest, with it
Its quintessence oil mixing, can play diluting effect.
Garden lavender quintessence oil can quickly enter hair follicle, removes deposit in hair follicle, and dredging pore removes excess oil, plays
The effect of cleaning skin, the most also has the epidermis skin that compacts, and restrains pore, suppresses epidermis oils and fats excessive secretion, prevents again
Form corse sweat pore, promote cell regeneration, improve skin obscure, dry, aging.
Tea polyphenols is the general name of Polyphenols of Tea, including flavanol compound, anthocyanin class, flavonoid, flavonols
With phenolic acids etc..Tea polyphenols has the effect removing free radical, can suppress lipoxygenase and lipid peroxidation in skin line plastochondria
Effect, thus produce defying age effect.And, present in the antioxygen property of tea polyphenols and other quintessence oil, injection Vitamin B_6 plays increasing
Effect effect.
In tea tree ethereal oil, topmost chemical composition is ethylene, dipentene, limonene, cineol, Oleum sesami brain, Fructus Foeniculi
Element.Tea tree ethereal oil abnormal smells from the patient delicate fragrance, uniqueness are strong, and it has the antimicrobial acivity of All Pure Nature, sterilization, antibacterial activity, non-stimulated
Property, the advantage such as excellent percutaneous permeability.It can treat acne and sore, and comedo, mosquito bite, trick tinea etc., to seasick dizzy
Car symptom is the most effective in cure, can be used in mixed way with other quintessence oil with fixed attention, can play the collaborative effect promoting infiltration.
Wetting agent is auxiliary agent conventional in cosmetics preparation process, is used for increasing skin surface moisture.Polyalcohols
Wetting agent is one of conventional wetting agent.Because the polyhydroxy structure in polyol molecule so that it is can absorb from surrounding
Moisture, thus play the effect of moisture-absorbing moisture-keeping.Meanwhile, polyalcohols may also operate as the effect of preservative, and this is due to this kind of
Material can be had an effect with the cell membrane of antibacterial, causes its cell membrane arrangement disorder or breakage, and then makes that antibacterial is injured loses it
Physiological function, plays antiseptical effect.Additionally, due to the highly polar effect of hydroxyl, it is easy to other component (such as phenols, acids)
Produce intermolecular interaction, play the effect of hydrotropy.For volatile material, due to intermolecular interaction, permissible
Play minimizing quintessence oil effective ingredient volatilization, extend the effect of quintessence oil shelf-life.
The present invention provide the composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect in each
On the one hand component can suppress epidermis oils and fats excessive secretion, eliminates internal free radical, dredging pore, make while cleaning skin
Nutrient substance in quintessence oil is collaborative penetrates into deep skin (skin corium and basal layer), plays moisturizing, whitening, crease-resistant effect；Separately
On the one hand, should can work in coordination with containing each component in the composite essential oil of Semen Ginkgo quintessence oil and play a role, the highly polar of wetting agent can
The nutrient substance highly polar with other, such as alcohols, acids, interacts, and reduces the volatilization of effective ingredient, moreover it is possible to play anti-
Rotten effect, extends the shelf-life of quintessence oil.
Group in the composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect that the present invention provides
Point Semen Ginkgo quintessence oil is with the mixture of Folium Ginkgo and ginkgo nut as raw material, utilizes carbon dioxide supercritical extraction method to extract and obtains,
Gingko resource can be made full use of, more fully extract effective ingredient therein；It addition, add polarity folder in extraction process
Band agent, can farthest extract effective ingredient therein.
What the present invention provided have antioxidation, the composite essential oil containing Semen Ginkgo quintessence oil of delaying skin aging effect can be by
Following common usage uses: 1) massage uses, and adds 20-30 and drip the above-mentioned composite precision containing Semen Ginkgo quintessence oil in every 10mL emulsion
Oil, fully mixes, and carries out skin massaging；2) use with Sprayable after dilution, every 10mL pure water or distilled water add 20-
30 above-mentioned composite essential oils containing Semen Ginkgo quintessence oil, fully shake up, and carry out spraying diffusion；3) pick the most directly with instruments such as cotton swabs
Connect and smear in face, massage gently；4) take 20-30 to drip in the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil instillation facial film, spread on face
10-15 minute.
The composite essential oil containing Semen Ginkgo quintessence oil that the present invention provides can significantly improve the hydroxyproline (HYP) in skin, surpass
Superoxide dismutase (SOD), content, reduce malonaldehyde (MDA) with lipofuscin (LF) value, have elimination free radical, moisturizing, lock
The function of water, can be used for delay skin aging.And, the composite essential oil that should contain Semen Ginkgo quintessence oil is the most volatile, long shelf-life.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.These embodiments are only in order at purpose of explanation,
And do not limit the scope of the invention and essence.
In view of vegetatively, the factor such as growth conditions on Folium Ginkgo and the impact of ginkgo nut effective ingredient, used by the present invention
Folium Ginkgo be to pick up from Guizhou Zhengan County in April, 2015, the tender leaf of the raw ginkgo of 2-3.Ginkgo nut is to pick up from identical silver October
The mature fruit of apricot.
Semen Vitis viniferae quintessence oil, Garden lavender quintessence oil, tea tree ethereal oil and tea polyphenols used in the present invention is all by this area routine skill
Art means carry out extracting or directly buying finished product from market；Wetting agent is then for directly to buy from market, and specification is analytical pure.
Embodiment 1
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes following heavy
Each component of amount part: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 60 parts, Garden lavender quintessence oil 30 parts, tea tree ethereal oil 8 parts, tea polyphenols 8
Part, propylene glycol 0.3 part.
Wherein, component Semen Ginkgo quintessence oil prepares in accordance with the following steps:
1) by dry Folium Ginkgo and ginkgo nut with weight ratio for 1:0.2 mix homogeneously after pulverize, cross 20 mesh sieves and be placed on
Extraction kettle, the weight ratio ratio as 1:500 with entrainer and Folium Ginkgo, ginkgo nut mixture adds entrainer, folder wherein
Band agent is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.01(volume ratio)；Said mixture is continuously stirred
Soak 3h；
2) in extraction kettle, input supercritical carbon dioxide fluid, extracting pressure be 35MPa, extraction temperature be 32 DEG C,
The flow velocity of carbon dioxide is to extract under the conditions of 20kg/h, and extraction time is 8h；
3) CO 2 fluid after extracting sequentially enters in primary separator, second-stage separator and separates, dioxy
The flow velocity changing carbon is 10kg/h, and wherein, primary separator pressure is 4MPa, primary separator temperature 0 DEG C；Second-stage separator pressure
5MPa, second-stage separator temperature 22 DEG C；Wax component is discharged from primary separator；Ginkgo oil is discharged from second-stage separator,
Heating demulsification type, after separating aqueous phase, obtains Semen Ginkgo quintessence oil.
The Semen Ginkgo quintessence oil of formula ratio is uniformly mixed at 25 DEG C with Oleum Vitis viniferae, be then sequentially added into Garden lavender quintessence oil,
Tea tree ethereal oil, tea polyphenols, propylene glycol, stir to each component and merge completely, and subpackage seals.
Embodiment 2
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes following heavy
Each component of amount part: Semen Ginkgo quintessence oil 8 parts, Semen Vitis viniferae quintessence oil 50 parts, Garden lavender quintessence oil 20 parts, tea tree ethereal oil 5 parts, tea polyphenols 5 parts,
Sorbitol 0.1 part, glycerol 0.2 part, propylene glycol 0.2 part.
Wherein, component Semen Ginkgo quintessence oil prepares in accordance with the following steps:
1) by dry Folium Ginkgo and ginkgo nut with weight ratio for 1:1 mix homogeneously after pulverize, cross 50 mesh sieves and be placed on extraction
Taking still, the weight ratio ratio as 1:200 with entrainer and Folium Ginkgo, ginkgo nut mixture adds entrainer wherein, carries secretly
Agent is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.005(volume ratio)；By continuously stirred for said mixture leaching
Bubble 3h；
2) in extraction kettle, input supercritical carbon dioxide fluid, extracting pressure be 25MPa, extraction temperature be 50 DEG C,
The flow velocity of carbon dioxide is to extract under the conditions of 60kg/h, and extraction time is 3h；
3) CO 2 fluid after extracting sequentially enters in primary separator, second-stage separator and separates, dioxy
The flow velocity changing carbon is 30kg/h, and wherein, primary separator pressure is 6MPa, primary separator temperature 15 DEG C；Second-stage separator pressure
Strong 7MPa, second-stage separator temperature 40 DEG C；Wax component is discharged from primary separator；Semen Ginkgo is discharged from second-stage separator
Oil, heating demulsification type, after separating aqueous phase, obtain Semen Ginkgo quintessence oil.
The preparation method of the composite essential oil containing Semen Ginkgo quintessence oil is with embodiment 1.
Embodiment 3
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes following heavy
Each component of amount part: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 30 parts, Garden lavender quintessence oil 10 parts, tea tree ethereal oil 2 parts, tea polyphenols 2
Part, glycerol 0.2 part, propylene glycol 0.3 part.
The preparation method of the Semen Ginkgo quintessence oil in the composite essential oil containing Semen Ginkgo quintessence oil and the composite essential oil containing Semen Ginkgo quintessence oil
Preparation method with embodiment 1.
Embodiment 4
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes following heavy
Each component of amount part: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 50 parts, Garden lavender quintessence oil 20 parts, tea tree ethereal oil 5 parts, tea polyphenols 5
Part, dipropylene glycol 0.4 part, propylene glycol 0.1 part.
The preparation method of the Semen Ginkgo quintessence oil in the composite essential oil containing Semen Ginkgo quintessence oil and the composite essential oil containing Semen Ginkgo quintessence oil
Preparation method with embodiment 1.
Experimental example 1 becomes sour experiment
Respectively by the composite essential oil containing Semen Ginkgo quintessence oil of embodiment 1-4, carry out fill with dark brown vial, open wide bottle
Lid, is placed under room temperature 25 DEG C, relative humidity 75% environment, and continuous observation, concrete outcome see table 1.
Experimental example 2 Efficacy experiments
Take SPE level health Kunming kind rat 50,180-220g, male and female half and half.60 rats are randomly divided into 4 monthly ages
(young control), 12 monthly ages (Normal group), 12 monthly age experimental grouies (basic, normal, high dosage group), often group 10.Greatly
Mus is under identical natural conditions, and routine raises food drinking-water, and adaptability proceeds by experiment after raising.Test front shaver to slough
Hair 3cm × 3cm on mouse back centre skin, basic, normal, high dosage component not Yong in embodiment 1 preparation containing Semen Ginkgo essence
Being coated with (0.01g, 0.1g, 1g) outside the composite essential oil of oil, be coated with outside Normal group and young control deionized water, preservative film is protected
Protect 1h.Smear every day once, smear 1g every time, smear 35 days continuously.By sacrifice after having tested, measure its experiment skin
The hydroxyproline (HYP) at place, superoxide dismutase (SOD), malonaldehyde (MDA) and lipofuscin (LF) value.
The preparation of Skin Homogenate and the mensuration of HYP, SOD, MDA, LF:
Take back depilation after skin histology block about 0.5g, pre-cooled 0.9% sodium chloride solution rinsing, remove subcutaneous fat and
Other connective tissue, filter paper is wiped dry, weighs, and piece of tissue is poured in homogenate tube after shredding, and adds the pre-cooling of these 9 times of quality of piece of tissue
0.9% sodium chloride solution, makes 10% tissue homogenate (carrying out in frozen water) for 8 minutes with interior cut tissue refiner homogenate so that it is
The most broken, cellular content is completely free in the liquid phase.In Skin Homogenate, the mensuration of HYP, SOD, MDA, LF is all by this area
Routine techniques means are measured, and the method building up bio-engineering corporation's test kit description by Nanjing is measured.Wherein, by
The composite essential oil containing Semen Ginkgo quintessence oil that embodiment 1 prepares measures the impact knot of HYP, SOD, MDA, LF content in rat skin
The most as shown in table 2 below:
In table 2 embodiment 1, the composite essential oil containing Semen Ginkgo quintessence oil is to the shadow of HYP, SOD, MDA, LF content in rat skin
Ring
By upper table 2 it can be seen that the HYP content of Normal group, SOD activity relatively young control decline, MDA and LF contains
Measure relatively young control to dramatically increase；Low dose of the experimental group group the most same Normal group of effect, and middle and high dosage group is with the most right
Comparing according to group, then have obvious effect: HYP content, SOD activity relatively matched group increase, MDA and LF content compared with normal matched group drops
Low.
Test result indicate that, the composite essential oil containing Semen Ginkgo quintessence oil provided in embodiment of the present invention 2-4 also has substantially
Raise HYP content in skin histology, SOD activity, reduce effect of MDA and LF content.
Above-mentioned example is only used as descriptive purpose, and the scope of the present invention is not limited thereto.To those skilled in the art
For modify and be apparent from, the present invention is only limited by scope.
Claims (8)
1. having the composite essential oil containing Semen Ginkgo quintessence oil of antioxidation, delaying skin aging effect, it includes following weight
Each component of part: Semen Ginkgo quintessence oil 8-15 part, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part,
Tea polyphenols 2-8 part, wetting agent 0.3-3 part, wherein, the preparation method of described Semen Ginkgo quintessence oil is as follows:
1) by dry Folium Ginkgo and ginkgo nut with weight ratio for 1:0.2-1 mix homogeneously after pulverize, cross 20-50 mesh sieve and be placed on
Extraction kettle；
2) in extraction kettle input supercritical carbon dioxide fluid, extracting pressure be 25-35MPa, extraction temperature be 32-50
DEG C, the flow velocity of carbon dioxide be to extract under the conditions of 20-60kg/h, extraction time is 3-8h；
3) CO 2 fluid after extracting is passed through successively in primary separator, second-stage separator and separates, carbon dioxide
Flow velocity be 10-30kg/h, wherein, primary separator pressure is 4-6MPa, primary separator temperature 0-15 DEG C；Second-stage separator
Pressure 5-7MPa, second-stage separator temperature 22-40 DEG C；Wax component is discharged from primary separator；Arrange from second-stage separator
Go out ginkgo oil, heating demulsification type, after separating aqueous phase, obtain described Semen Ginkgo quintessence oil；
Described wetting agent is the one in propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol and sorbitol or many
Kind.
Composite essential oil containing Semen Ginkgo quintessence oil the most according to claim 1, wherein, described wetting agent is dipropylene glycol and third
Glycol.
3., according to the composite essential oil containing Semen Ginkgo quintessence oil according to any one of claim 1-2, it includes following weight portion
Each component: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part, tea polyphenols
2-8 part, wetting agent 0.3-3 part.
Composite essential oil containing Semen Ginkgo quintessence oil the most according to claim 3, it includes each component of following weight portion: Semen Ginkgo
Quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 50-60 part, Garden lavender quintessence oil 20-30 part, tea tree ethereal oil 5-8 part, tea polyphenols 5-8 part, wetting agent
0.3-0.5 part.
Composite essential oil containing Semen Ginkgo quintessence oil the most according to claim 4, it includes each component of following weight portion: Semen Ginkgo
Quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 60 parts, Garden lavender quintessence oil 30 parts, tea tree ethereal oil 8 parts, tea polyphenols 8 parts, propylene glycol 0.3 part.
6. one kind as described in any one of claim 1-5 have antioxidation, delaying skin aging effect containing Semen Ginkgo quintessence oil
The preparation method of composite essential oil, it follows the steps below:
1. preparation Semen Ginkgo quintessence oil
1) by dry Folium Ginkgo and ginkgo nut with weight ratio for 1:0.2-1 mix homogeneously after pulverize, cross 20-50 mesh sieve and be placed on
Extraction kettle；
2) in extraction kettle input supercritical carbon dioxide fluid, extracting pressure be 25-35MPa, extraction temperature be 32-50
DEG C, the flow velocity of carbon dioxide be to extract under the conditions of 20-60kg/h, extraction time is 3-8h；
3) CO 2 fluid after extracting is passed through successively in primary separator, second-stage separator and separates, carbon dioxide
Flow velocity be 10-30kg/h, wherein, primary separator pressure is 4-6MPa, primary separator temperature 0-15 DEG C；Second-stage separator
Pressure 5-7MPa, second-stage separator temperature 22-40 DEG C；Wax component is discharged from primary separator；Arrange from second-stage separator
Go out ginkgo oil, heating demulsification type, after separating aqueous phase, obtain described Semen Ginkgo quintessence oil；
2. the preparation composite essential oil containing Semen Ginkgo quintessence oil
Semen Ginkgo quintessence oil, Semen Vitis viniferae quintessence oil, Garden lavender quintessence oil, tea tree ethereal oil, tea polyphenols and wetting agent is weighed according to above-mentioned formula ratio,
The Semen Ginkgo quintessence oil of formula ratio is uniformly mixed at 0-30 DEG C with Semen Vitis viniferae quintessence oil, be subsequently adding formula ratio Garden lavender quintessence oil,
Tea tree ethereal oil, tea polyphenols and wetting agent, stirring is merged completely to each component, obtains the described composite essential oil containing Semen Ginkgo quintessence oil.
Preparation method the most according to claim 6, wherein, has been also added with entrainer and has entered in the extraction kettle in step 1)
Row step 2) front described Folium Ginkgo and the ginkgo nut mixture 2-5h of first soaking, described entrainer and Folium Ginkgo and ginkgo nut mixture
Weight ratio be 1:200-500.
Preparation method the most according to claim 7, wherein, described entrainer is acetone, ethanol, methanol, ethyl acetate, second
Acid is that the ratio of 1:2:1:1:0.005-0.02 is mixed to prepare by volume.
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| CN109810789A (en) * | 2018-07-25 | 2019-05-28 | 上海药辰生物科技有限公司 | A kind of extracting method of ginkgo essential oil |
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| CN112546205B (en) * | 2020-12-09 | 2023-06-30 | 建昌帮药业有限公司 | Composition with skin aging improving function and preparation method and application thereof |
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