KR20170042190A - Manufacturing method and apparatus for thread having hyaluronate - Google Patents

Manufacturing method and apparatus for thread having hyaluronate Download PDF

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Publication number
KR20170042190A
KR20170042190A KR1020150141862A KR20150141862A KR20170042190A KR 20170042190 A KR20170042190 A KR 20170042190A KR 1020150141862 A KR1020150141862 A KR 1020150141862A KR 20150141862 A KR20150141862 A KR 20150141862A KR 20170042190 A KR20170042190 A KR 20170042190A
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KR
South Korea
Prior art keywords
solution
hyaluronate
yarn
aqueous solution
alcohol
Prior art date
Application number
KR1020150141862A
Other languages
Korean (ko)
Inventor
김정동
배정현
정도현
Original Assignee
주식회사 라파스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 주식회사 라파스 filed Critical 주식회사 라파스
Priority to KR1020150141862A priority Critical patent/KR20170042190A/en
Priority to PCT/KR2016/009738 priority patent/WO2017061700A1/en
Publication of KR20170042190A publication Critical patent/KR20170042190A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
    • D06B19/00—Treatment of textile materials by liquids, gases or vapours, not provided for in groups D06B1/00 - D06B17/00
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
    • D06B19/00—Treatment of textile materials by liquids, gases or vapours, not provided for in groups D06B1/00 - D06B17/00
    • D06B19/0005—Fixing of chemicals, e.g. dyestuffs, on textile materials
    • D06B19/0011—Fixing of chemicals, e.g. dyestuffs, on textile materials by heated air
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
    • D06B3/00—Passing of textile materials through liquids, gases or vapours to effect treatment, e.g. washing, dyeing, bleaching, sizing, impregnating
    • D06B3/04—Passing of textile materials through liquids, gases or vapours to effect treatment, e.g. washing, dyeing, bleaching, sizing, impregnating of yarns, threads or filaments

Abstract

The present invention relates to a method for producing a yarn containing a hyaluronic acid salt which can be used for a soldering method or the like. The method for producing a hyaluronate salt according to the present invention comprises the steps of: preparing an aqueous solution containing a hyaluronate; discharging an aqueous solution containing the hyaluronate into a solution for solution made of an alcohol solution or an acidic solution; To produce an emulsion in the form of an emulsion.

Description

[0001] The present invention relates to a manufacturing method and apparatus for producing a hyaluronate-

The present invention relates to a method and apparatus for producing a seal comprising a hyaluronate.

In recent years, for the purpose of skin beauty such as wrinkle removal and the like, it has been widely practiced to perform insertion surgery for inserting a thread into skin. Regarding such a marketing technique, patents such as Korean Patent No. 10-1396672 (name of invention: a rope for a soldering procedure) and Korean Patent No. 10-1379546 (name of invention: needle for soldering operation) There is a bar.

On the other hand, PDO (polydioxane), which is an absorbable suture, However, PDO has a problem that heating at 100 DEG C or more is required in the production process, and mixing with water-soluble components is not easy.

Korean Registered Patent No. 10-1396672 (Name of invention: Stitch ropes) Korean Registered Patent No. 10-1379546 (Name of invention: needle for soldering operation)

SUMMARY OF THE INVENTION The present invention has been made in order to solve the above-mentioned problems, and an object of the present invention is to provide a method and apparatus for producing a hyaluronic acid salt-containing thread,

The method for producing a hyaluronate-containing thread according to the present invention comprises the steps of: providing an aqueous solution containing a hyaluronate; and discharging the aqueous solution containing the hyaluronate to a solution of an alcohol solution or an acid solution And then solidifying the mixture to form an emulsion.

According to the present invention, it is preferable to maintain the concentration of the alcohol solution at 90% or more.

Also, according to the present invention, it is preferable that the rate of the hyaluronic acid aqueous solution is 0.005 to 1 ml / min.

In addition, according to the present invention, it is preferable that the method further comprises coating the water-insoluble material on the surface of the yarn after drying the coagulated yarn.

According to the present invention, it is preferable that the aqueous solution containing the hyaluronate further comprises a water-soluble functional material.

In addition, according to the present invention, it is preferable that the aqueous solution containing the hyaluronate is discharged at a distance of 1 to 10 mm from the surface of the solid solution.

A thread manufacturing apparatus including a hyaluronate according to the present invention comprises a water tank containing a solution for solid solution made of an alcohol solution or an acid solution, a nozzle for discharging an aqueous solution containing hyaluronate as the solid solution, It is preferable that the aqueous solution containing the hyaluronate is allowed to contact with the solution so as to collect the thread to be manufactured while being solidified.

According to the present invention, it is preferable to further include a supply line for supplying the alcohol or the acidic solution to the water tank so that the alcohol concentration or the acidity of the solid solution is maintained within a predetermined range.

In addition, according to the present invention, it is preferable that a coating part for coating a water-insoluble material on the surface of the yarn collected by the water receiving part and a drying part for spraying air to the yarn to dry the yarn.

In addition, according to the present invention, it is preferable to further include a measurement sensor for measuring an alcohol concentration or an acidity of the solid solution.

According to the present invention, a yarn containing hyaluronate can be produced.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic block diagram of a thread manufacturing apparatus including a hyaluronate according to an embodiment of the present invention; FIG.

Hereinafter, an apparatus and a method for manufacturing a thread including a hyaluronate according to a preferred embodiment of the present invention will be described with reference to the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic block diagram of a thread manufacturing apparatus including a hyaluronate according to an embodiment of the present invention; FIG.

Referring to FIG. 1, a thread manufacturing apparatus 100 including a hyaluronic acid salt according to the present embodiment includes a water tank 10, a nozzle 20, a water rejection unit, drying units 41 and 42, (50).

In the inside of the water tank 10, an immersion solution capable of solidifying an aqueous solution containing hyaluronate (hereinafter referred to as 'hyaluronate aqueous solution') is stored. The aqueous solution of hyaluronate solidifies upon contact with an acidic or alcoholic solution, and the solid solution comprises an acidic solution or an alcoholic solution. At this time, the acidic solution preferably has a pH of 1 to 5. As the alcohol solution, methanol, ethanol, buthanol, propanol, etc. may be used. In this case, it is preferable that the alcohol concentration is maintained at 90% or more in the alcohol solution. This is because when the alcohol concentration is 90% or less, the solidification rate of the hyaluronate aqueous solution is lowered.

The nozzle 20 is disposed above the water tank 10, and discharges the aqueous solution of hyaluronate by the solid solution stored in the water tank 10. In particular, in the case of the present embodiment, an aqueous solution of sodium hyaluronate is used as a hyaluronate aqueous solution. When the aqueous solution of hyaluronate discharged from the nozzle 20 is brought into contact with the solution for solidification, the hyaluronic acid component in the aqueous solution of hyaluronate solidifies into a solid form.

At this time, the concentration of hyaluronic acid in the hyaluronate aqueous solution is preferably 10 to 50% (weight ratio), and the higher the content of hyaluronic acid, the faster the coagulation speed.

The diameter of the nozzle 20 is preferably 1 mm or less, and the nozzle 20 is preferably spaced apart from the solid solution (surface) at intervals of 1 mm to 10 mm. It is preferable that the rate at which the hyaluronate aqueous solution is discharged from the nozzle is 0.005 to 1 ml / min. When the discharge rate is less than 0.005 ml / min, the amount of hyaluronate aqueous solution to be supplied is too small, And when the discharge speed is 1 ml / min or more, the hyaluronic acid solidifies and clumps, and the surface of the yarn becomes uneven and bends.

Further, the aqueous solution of hyaluronate may further contain a water-soluble functional material. For reference, the thread including the hyaluronate produced according to the present embodiment is used for medical or cosmetic purposes (for example, for picking or sealing). The functional material means a substance that causes a predetermined pharmacological effect in the human body, and for example, cellulose, chitosan, or the like may be employed as a functional material.

On the other hand, when the aqueous hyaluronate solution is supplied to the solid solution as described above, the alcohol concentration or the acidity of the solid solution is lowered by the water contained in the hyaluronate aqueous solution. Accordingly, the present invention provides a means for maintaining the alcohol concentration or acidity of the solid solution in a predetermined range.

More specifically, as shown in FIG. 1, a measurement sensor 13 is provided in the water tank 10, and the measurement sensor 13 measures the alcohol concentration or acidity of the solid solution. The water tank 10 is provided with a supply line 11 and a discharge line 12. An alcohol solution (a high concentration alcohol solution) or an acid solution (a strong acid solution) is supplied to the supply line 11, and a solid solution in the water tank is discharged to the discharge line 12. At this time, the amount of the hyaluronate aqueous solution supplied from the nozzle 20, the amount of the alcohol solution (or acidic solution) supplied to the supply line 11, and the amount of the solid solution discharged into the discharge line 12 The alcohol concentration or the acidity can be maintained within a predetermined range while the amount of the solid solution stored in the water tank 10 is kept constant.

The rejection is for collecting hyaluronic acid solidified in the form of a solid solution within the solid solution. In this embodiment, the rejection includes a roller 30 that is rotatably installed. 1, the end of the solidified seal is attached to the roller 30. When the roller 30 rotates in accordance with the speed at which the aqueous solution of hyaluronate is discharged from the nozzle 20 in this state (that is, And rotated to the speed at which the yarn is manufactured), so that the solidified yarn is wound on the roller 30. [ For reference, an auxiliary roller 31 may be additionally provided to set the path along which the yarn is moved.

The drying units 41 and 42 are for drying the yarn. In this embodiment, two drying units are provided, and air (or high-temperature air) is blown toward the yarn, and the yarn is dried accordingly.

The coating portion 50 is for coating a water-insoluble material on the surface of the yarn. The coating portion 50 is disposed between the two drying portions 41 and 42 and ejects the water-insoluble material toward the yarn which is moved by the roller 30. [ For reference, the reason why the water-insoluble substance is coated on the surface of the yarn is to increase the time in which the yarn dissolves in the human body, and the water-insoluble matter can be appropriately determined according to the dissolution time. For reference, as the water-insoluble substance, PLA (polylactide), PLLA (poly-L-lactide), PGA (polyglycolide), PLGA (poly lactide-co-glycolide), PDO (polydioxanone) In addition, since the physical properties (strength, tensile properties, hardness, etc.) of the yarn vary depending on the water-insoluble material to be coated, the water-insoluble material can be determined in consideration of this.

Hereinafter, a process for producing a yarn containing a hyaluronic acid salt in a yarn manufacturing apparatus including the hyaluronate as described above will be described.

When the hyaluronate aqueous solution is discharged through the nozzle 20, the aqueous solution of hyaluronate is contacted with the solution for solidification, and the hyaluronic acid is solidified in an actual form. The coagulated yarn moves to the roller 30 and is wound. During this process, the yarn is dried while passing through the first drying unit 41, and the non-water soluble The material is applied and the non-aqueous material is dried and coated while passing through the second drying section 42. [ Then, the yarn is wound on the rollers.

As described above, according to the present invention, a yarn containing a hyaluronic acid salt can be produced. As a reference, since the hyaluronic acid has already been proved to be used as a filler for the purpose of skin beauty treatment, the thread including the hyaluronate can also be used for medical treatment or cosmetic treatment. Further, since the hyaluronate has water-solubility, another functional material having water-solubility can be easily added, and a yarn having excellent functions for cosmetic or medical use can be produced.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be taken by way of limitation in the embodiment in which said invention is directed. It will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the appended claims.

100 ... yarn manufacturing apparatus including hyaluronate
10 ... water tank 20 ... nozzle
30 ... rollers 41, 42 ... dryer
50 ... Coating portion

Claims (11)

Providing an aqueous solution comprising hyaluronate; And
And discharging the aqueous solution containing the hyaluronate into a solution for solid solution comprising an alcohol solution or an acidic solution and solidifying the aqueous solution to prepare an aqueous solution. The method according to claim 1,
Wherein the concentration of the alcohol solution is maintained at 90% or more. The method according to claim 1,
Wherein the aqueous solution containing the hyaluronate has an ejection speed of 0.005 to 1 ml / min. The method according to claim 1,
Drying the coagulated yarn, and then coating the surface of the yarn with a water-insoluble material. ≪ RTI ID = 0.0 > 11. < / RTI > The method according to claim 1,
Wherein the aqueous solution containing the hyaluronate further comprises a functional material having water solubility. The method according to claim 1,
Wherein the aqueous solution containing the hyaluronate is discharged at a distance of 1 to 10 mm from the surface of the solution for hyaluronic acid. A yarn comprising a hyaluronate, which is produced by a process for producing a yarn comprising a hyaluronate as set forth in any one of claims 1 to 6. A water tank in which an emulsification solution consisting of an alcohol solution or an acid solution is stored;
A nozzle for discharging an aqueous solution containing hyaluronate as the solid solution; And
Wherein the hyaluronic acid salt-containing solution is contacted with the solid solution, and the aqueous solution containing the hyaluronic acid salt is solidified to collect the product. 9. The method of claim 8,
Further comprising a supply line for supplying the alcohol or the acidic solution to the water tank so that the alcohol concentration or the acidity of the solid solution is maintained within a predetermined range. The hyaluronate- . 10. The method of claim 9,
A coating part for coating a surface of the yarn collected by the receiving part with a water-insoluble material; And
And a drying unit for spraying air to the yarn to dry the yarn. ≪ RTI ID = 0.0 > 8. < / RTI > 11. The method of claim 10,
And a measurement sensor for measuring an alcohol concentration or an acidity of the solid solution.
KR1020150141862A 2015-10-08 2015-10-08 Manufacturing method and apparatus for thread having hyaluronate KR20170042190A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020150141862A KR20170042190A (en) 2015-10-08 2015-10-08 Manufacturing method and apparatus for thread having hyaluronate
PCT/KR2016/009738 WO2017061700A1 (en) 2015-10-08 2016-08-31 Method and device for manufacturing thread including hyaluronate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020150141862A KR20170042190A (en) 2015-10-08 2015-10-08 Manufacturing method and apparatus for thread having hyaluronate

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KR20170042190A true KR20170042190A (en) 2017-04-18

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WO (1) WO2017061700A1 (en)

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Publication number Priority date Publication date Assignee Title
US11065428B2 (en) 2017-02-17 2021-07-20 Allergan, Inc. Microneedle array with active ingredient

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KR100571478B1 (en) * 2003-10-28 2006-04-17 이승진 Fibrous porous support made of biodegradable polymer and method for preparing same
JP5649264B2 (en) * 2007-03-01 2015-01-07 ミドリホクヨー株式会社 Solubilized collagen fiber and method for producing the same
AU2009288118B2 (en) * 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
CZ302994B6 (en) * 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronic fibers, process of their preparation and use
CZ304303B6 (en) * 2012-11-27 2014-02-19 Contipro Biotech S.R.O. Fibers based on hydrophobized hyaluronate, process for their preparation and use, fabric based thereon and use thereof

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