KR20170033339A - 새로운 인돌리진 유도체 및 신경변성 질환에서의 이들의 용도 - Google Patents

새로운 인돌리진 유도체 및 신경변성 질환에서의 이들의 용도 Download PDF

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KR20170033339A
KR20170033339A KR1020177003586A KR20177003586A KR20170033339A KR 20170033339 A KR20170033339 A KR 20170033339A KR 1020177003586 A KR1020177003586 A KR 1020177003586A KR 20177003586 A KR20177003586 A KR 20177003586A KR 20170033339 A KR20170033339 A KR 20170033339A
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South Korea
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mmol
compound
atoms
chloro
ring
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KR1020177003586A
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Korean (ko)
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스리니바사 알. 카라
안드레아스 고우토포우로스
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메르크 파텐트 게엠베하
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Publication of KR20170033339A publication Critical patent/KR20170033339A/ko

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
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    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
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    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177003586A 2014-07-31 2015-07-31 새로운 인돌리진 유도체 및 신경변성 질환에서의 이들의 용도 KR20170033339A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031237P 2014-07-31 2014-07-31
US62/031,237 2014-07-31
PCT/US2015/043090 WO2016019228A1 (en) 2014-07-31 2015-07-31 Indolizine derivatives which are applicable to neurodegenerative diseases

Publications (1)

Publication Number Publication Date
KR20170033339A true KR20170033339A (ko) 2017-03-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177003586A KR20170033339A (ko) 2014-07-31 2015-07-31 새로운 인돌리진 유도체 및 신경변성 질환에서의 이들의 용도

Country Status (15)

Country Link
US (2) US9546166B2 (es)
EP (1) EP3174877B1 (es)
JP (1) JP6571756B2 (es)
KR (1) KR20170033339A (es)
CN (1) CN107001356B (es)
AR (1) AR101395A1 (es)
AU (1) AU2015296210B2 (es)
BR (1) BR112017001221A2 (es)
CA (1) CA2954681A1 (es)
ES (1) ES2927587T3 (es)
IL (1) IL250267B (es)
MX (1) MX2017001103A (es)
RU (1) RU2017105133A (es)
SG (1) SG11201700140TA (es)
WO (1) WO2016019228A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010030111A1 (de) 2009-08-11 2011-02-17 Evonik Degussa Gmbh Wässrige Silansysteme für den Blankkorrosionsschutz und Korrosionsschutz von Metallen
WO2016171249A1 (ja) 2015-04-24 2016-10-27 塩野義製薬株式会社 6員複素環誘導体およびそれらを含有する医薬組成物
WO2018017368A1 (en) 2016-07-18 2018-01-25 Arthrosi Therapeutics, Llc Compounds, compositions and methods for treating or preventing a sympton associated with gout or hyperuricemia
CA3039458A1 (en) * 2016-10-17 2018-04-26 Shionogi & Co., Ltd. Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
PT3609868T (pt) 2017-03-13 2023-12-18 Raqualia Pharma Inc Derivados de tetra-hidroquinolina como antagonistas do recetor p2x7
US11530211B2 (en) 2018-01-18 2022-12-20 Daiichi Sankyo Company, Limited Dihydroindolizinone derivative
AU2020256166A1 (en) 2019-04-02 2021-10-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
CN114040966A (zh) * 2019-07-08 2022-02-11 国立大学法人东京工业大学 使用了二氢吲嗪酮衍生物的胰岛素生产细胞的制作法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731153A1 (de) * 1997-07-21 1999-01-28 Basf Ag 2-(Pyrazolyl- und Triazolyl-3'-oxymethylen)-phenyl-isoxazolone und -triazolone, Verfahren zu ihrer Herstellung und ihre Verwendung
WO2002009706A1 (en) 2000-07-27 2002-02-07 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
AU2007215161A1 (en) * 2006-02-14 2007-08-23 Vertex Pharmaceuticals Incorporated Pyrrolo(3,2-C) pyridines useful as inhibitors of protein kinases
MX2009010523A (es) * 2007-04-10 2009-12-15 Lundbeck & Co As H Análogos de amidas heteroarílicas como antagonistas de p2x7.
WO2012080727A2 (en) * 2010-12-14 2012-06-21 Electrophoretics Limited Casein kinase 1delta (ck1delta) inhibitors

Also Published As

Publication number Publication date
US9546166B2 (en) 2017-01-17
US9931324B2 (en) 2018-04-03
CA2954681A1 (en) 2016-02-04
AR101395A1 (es) 2016-12-14
US20170079965A1 (en) 2017-03-23
EP3174877A1 (en) 2017-06-07
ES2927587T3 (es) 2022-11-08
CN107001356A (zh) 2017-08-01
EP3174877B1 (en) 2022-06-29
IL250267B (en) 2021-05-31
AU2015296210A1 (en) 2017-02-02
MX2017001103A (es) 2017-04-27
JP6571756B2 (ja) 2019-09-04
US20160031879A1 (en) 2016-02-04
BR112017001221A2 (pt) 2017-11-28
RU2017105133A (ru) 2018-08-28
WO2016019228A1 (en) 2016-02-04
SG11201700140TA (en) 2017-02-27
IL250267A0 (en) 2017-03-30
AU2015296210B2 (en) 2019-08-15
JP2017522347A (ja) 2017-08-10
CN107001356B (zh) 2019-09-03

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