KR20110131855A - Atopic cosmetics with purple sweet potato extract - Google Patents
Atopic cosmetics with purple sweet potato extract Download PDFInfo
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- KR20110131855A KR20110131855A KR1020100051512A KR20100051512A KR20110131855A KR 20110131855 A KR20110131855 A KR 20110131855A KR 1020100051512 A KR1020100051512 A KR 1020100051512A KR 20100051512 A KR20100051512 A KR 20100051512A KR 20110131855 A KR20110131855 A KR 20110131855A
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- sweet potato
- purple sweet
- potato extract
- triclosan
- atopic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
Description
본 발명은 자색고구마 추출물을 함유한 아토피용 화장품에 관한 것으로, 보다 상세하게는 아토피원인균인 스테피로코쿠스 아우레우스(Staphylococcus aureus)에 트리클로산과 자색고구마를 함께 함유하여 상승효과를 나타내는 것으로 이것을 이용한 아토피용 화장품, 의약외품, 의약품으로의 응용에 관한 것이다.The present invention relates to cosmetics for atopic dermatitis containing purple sweet potato extract, and more particularly, to a synergistic effect by containing triclosan and purple sweet potato together in the atopy-causing bacterium Stephylococcus aureus (Staphylococcus aureus) It is about the application to cosmetics, quasi-drugs, and pharmaceuticals.
아토피 질환에 대한 원인은 피부 면역기능의 불균형, 피부 각질세포의 비정상화 등많이 존재하였지만 아직까지 만족할만한 안전한 치료약제가 미흡하다. 세라마이드등 피부장벽기능을 도와주는 제재는 그 효과가 부족하고, 스테로이드 등은 효과는 좋지만 중독성 등 많은 부작용을 일으킨다. 아토피 질환은 피부자극에 대단히 민감하므로 치료제 개발에 있어서 효과도 중요하지만 그 피부자극에 대한 세심한 연구가 필요하다.There are many causes of atopic disease, such as imbalance of skin immune function and abnormalities of keratinocytes of skin, but there are still insufficient satisfactory safe therapeutic drugs. Agents that help skin barrier functions such as ceramides lack the effect, steroids, such as good effect, but causes many side effects such as addictive. Atopic disease is very sensitive to skin irritation, so the effect is important in the development of therapeutics, but careful study of the skin irritation is necessary.
본 발명은 상기된 문제점을 해결하기 위하여 아토피 질환에 대한 원인균으로 알려진 스테피로코쿠스 아우레우스에 대한 항균력을 나타내는 천연추출물을 개발하여 기존에 알려진 트리클로산과 상승효과를 나타내는 천연물질을 검색하고자 하였다.In order to solve the problems described above, the present invention was developed to find a natural extract exhibiting antimicrobial activity against Stepilococcus aureus known as a causative bacterium for atopic diseases, and to search for a conventionally known triclosan and natural substances.
아토피 질환을 일으키는 원인균인 스테피로코쿠스 아우레우스가 건강한 피부에서는 30% 이내로 존재하였지만, 아토피 피부에서는 70% 이상 존재하였다. 스테피로코쿠스 아우레우스가 정상인 피부에 비해 과하게 증식되어있는 것이다. 이로 인해 아토피원인균으로 스테피로코쿠스 아우레우스로 발명되었다.Stephylococcus aureus, the causative agent of atopic disease, was present in less than 30% of healthy skin, but more than 70% of atopic skin. Stepirococcus aureus is overproliferated compared to normal skin. Because of this, it was invented as Stepilococcus aureus as an atopic causative organism.
피부자극이 적은 화장품에만 사용되고 스테피로코쿠스 아우레우스에 대한 항균력이 알려진 트리클로산과 상승효과를 나타내는 천연물질을 대상으로 항균력 실험을 실시하였다. 스테피로코쿠스 아우레우스에 대한 항균력을 테스트하기 위하여 최소저해농도측정법(MIC, Minimum Inhibition Concentration)을 이용하였다. 그 결과 화장품에 항균제로 사용되는 트리클로산과 자색고구마 추출물이 상승효과를 나타내었고, 이를 통해 발명을 완성하게 되었다. The antimicrobial activity was tested on triclosan, which is used only in cosmetics with low skin irritation, and known synergistic effect against Stepirococcus aureus. Minimum Inhibition Concentration (MIC) was used to test the antimicrobial activity against S. aureus. As a result, triclosan and purple sweet potato extract used as antibacterial agents in cosmetics showed a synergistic effect, thereby completing the invention.
본 발명에 의하여 아토피 원인균인 스테피로코쿠스 아우레우스에 대한 항균력이 알려진 트리클로산과 자색고구마 추출물을 함께 함유하였을 때 상승효과가 나타남을 알 수 있었고, 이를 함유한 아토피용 화장품, 의약외품, 의약품에 관한 것이다.According to the present invention was found to have a synergistic effect when a combination of triclosan and purple sweet potato extract known to have a known antimicrobial activity against the atopy-causing bacteria Stepirococcus aureus, it relates to atopy cosmetics, quasi-drugs, pharmaceuticals .
이하 본 발명에서의 실시를 위한 구체적인 내용에 대해 상세히 설명한다. 본 발명에서 밝혀진 아토피 원인균인 스테피로코쿠스 아우레우스에 대한 항균력을 측정한 결과 트리클로산과 자색고구마 추출물을 함계 함유한 복합물에 대한 항균력 결과 트리클로산에 대한 MIC가 0.3 ppm 이였고, 자색고구마 추출물의 MIC는 5 ppm이고, 트리클로산과 자색고구마 추출물을 같이 함유한 복합추출물의 MIC는 0.1 ppm의 시험결과를 나타내었다.Hereinafter will be described in detail for the practice in the present invention. The antimicrobial activity of the complex containing triclosan and purple sweet potato extract was 0.3 ppm and the MIC for triclosan was 0.3 ppm, and the MIC of purple sweet potato extract was measured. The MIC of the composite extract containing 5 ppm of triclosan and purple sweet potato extract showed a test result of 0.1 ppm.
표 1은 트리클로산과 자색고구마 추출물을 함유한 화장품과 의약외품, 의약품을 구성한 것이다. 비교예는 전형적인 크림이나 연고의 처방이고 실시예 1은 항균제인 트리클로산을 함유한 처방이고 실시예2는 자색고구마 추출물을 함유한 처방이며, 실시예 3은 트리클로산과 자색고구마 추출물을 동시에 함유한 처방이다. Table 1 is composed of cosmetics, quasi-drugs, and medicines containing triclosan and purple sweet potato extract. Comparative Example is a prescription of a typical cream or ointment, Example 1 is a prescription containing triclosan, an antimicrobial agent, Example 2 is a prescription containing a purple sweet potato extract, Example 3 is a prescription containing both triclosan and a purple sweet potato extract .
2
3
4
5
6One
2
3
4
5
6
세토스테아릴알코올
액상파라핀
스쿠알란
실리콘
정제수Stearic acid
Cetostearyl alcohol
Liquid paraffin
Squalane
silicon
Purified water
2.5
12.0
1.0
1.0
To 1003.0
2.5
12.0
1.0
1.0
To 100
2.5
12.0
1.0
1.0
To 1003.0
2.5
12.0
1.0
1.0
To 100
2.5
12.0
1.0
1.0
To 1003.0
2.5
12.0
1.0
1.0
To 100
2.5
12.0
1.0
1.0
To 1003.0
2.5
12.0
1.0
1.0
To 100
87
8
자색고구마 추출물Triclosan
Purple Sweet Potato Extract
--
-
-1.0
-
1.0-
1.0
1.01.0
1.0
다음은 표 2에서 보는 바와 같이, 아토피질환에 대한 패널테스트를 실시하였다. 아토피가 심한 나이 1-10세로 구성된 100여명(남자 46명, 여자 64명)을 대상으로 25명씩 4그룹으로 비교예와 실시예1,2,3을 매일 3회씩 4주간 도포하여 아토피 시험을 평가하였다. 평가항목은 설문을 통한 패널 테스트로 진행하였다. Next, as shown in Table 2, a panel test for atopic disease was conducted. To evaluate the atopy test by applying the comparative example and Examples 1, 2, 3 three times daily for 4 weeks in 25 groups of 100 persons (46 males, 64 females) composed of 1-10 years of severe atopic dermatitis. It was. Evaluation items were conducted by panel test through a questionnaire.
- 패널 테스트 척도 -Panel test scale
100 % : 완전치유100%: complete healing
50 % : 상당히 치유 50%: fairly healed
25 % : 약간 개선 25%: Slightly improved
0 % : 억제효과없음 0%: No inhibitory effect
위의 결과에서 나타난 것처럼 실시예1의 트리클로산을 함유한 처방이 실시예2의 자색고구마 추출물을 함유한 처방보다 더욱 효과적인 것을 나타내고 있으며. 실시예3에서 보는 바와 같이 트리클로산과 자색고구마 추출물을 동시에 함유할 때 예상치않게 상승효과가 나타나는 것을 알 수 있었다.As shown in the above results, it is shown that the formulation containing triclosan of Example 1 is more effective than the formulation containing purple sweet potato extract of Example 2. As shown in Example 3, it was found that the synergistic effect unexpectedly appeared when the triclosan and purple sweet potato extract at the same time.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200134960A (en) | 2019-05-24 | 2020-12-02 | 태안농산 영농조합법인 | Cosmetic composition for comprising sweet potato extract |
KR20230159672A (en) | 2022-05-14 | 2023-11-21 | 정유진 | Atopy, acne, skin irritation improved functional cosmetics containing hydrogen and natural derived preservation substance and their manufacturing method |
-
2010
- 2010-06-01 KR KR1020100051512A patent/KR20110131855A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200134960A (en) | 2019-05-24 | 2020-12-02 | 태안농산 영농조합법인 | Cosmetic composition for comprising sweet potato extract |
KR20230159672A (en) | 2022-05-14 | 2023-11-21 | 정유진 | Atopy, acne, skin irritation improved functional cosmetics containing hydrogen and natural derived preservation substance and their manufacturing method |
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