KR20110027149A - Food composition for anti-stress and skin antiaging using an extract of horse plancenta - Google Patents
Food composition for anti-stress and skin antiaging using an extract of horse plancenta Download PDFInfo
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- KR20110027149A KR20110027149A KR1020090085111A KR20090085111A KR20110027149A KR 20110027149 A KR20110027149 A KR 20110027149A KR 1020090085111 A KR1020090085111 A KR 1020090085111A KR 20090085111 A KR20090085111 A KR 20090085111A KR 20110027149 A KR20110027149 A KR 20110027149A
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- extract
- food composition
- horse placenta
- horse
- stress
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/204—Animal extracts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
본 발명은 말 태반 추출물을 이용한 항스트레스 및 항피부노화 식품 조성물에 관한 것이다.The present invention relates to an antistress and anti skin aging food composition using horse placenta extract.
스트레스는 어떤 외부 자극에 대한 반응으로 인체에 나타나는 비특이적 전신증후군을 말한다. Stress is a nonspecific systemic syndrome that appears in the body in response to an external stimulus.
이러한 스트레스에 대한 반응은 인체에 다양한 증상을 유발하는데, 그러한 증상으로서 피로감, 불면, 피부 거칠어짐(피부 노화) 등을 비롯하여 편두통, 소화불량, 탈모, 위궤양 등을 들 수 있다. This response to stress causes various symptoms in the human body, such as fatigue, insomnia, skin roughness (skin aging), and migraine, indigestion, hair loss, stomach ulcers, and the like.
이러한 스트레스를 해소할 수 있는 종래의 기술로서는 항스트레스의 유효성분으로서 어성초 추출물, 목련 추출물, 녹차 추출물 등을 개시하고 있는 대한민국 공개특허 제2001-0109607호나, 가시오가피 엑기스, 두충 엑기스, 쥐오줌풀 추출물 등을 개시하고 있는 한국 공개특허 제1997-0064445호 등을 들 수 있다.Conventional techniques capable of relieving such stress include Korean Patent Laid-Open No. 2001-0109607, which discloses Echo extract, Magnolia extract, Green tea extract, etc. as an active ingredient of anti-stress, Prickly Pear Extract, Tofu Extract, Valerian Extract, etc. Korean Unexamined Patent Publication No. 1997-0064445 disclosed.
본 발명도 말 태반 추출물을 이용하여 항스트레스제 활성과 항피부노화 활성을 갖는 식품 조성물을 개시한다.The present invention also discloses a food composition having antistress agent activity and anti-skin ageing activity using horse placenta extract.
본 발명의 기술적 과제는 말 태반 추출물을 이용한 항스트레스제 식품 조성물을 제공하는 데 있다.An object of the present invention is to provide an antistress food composition using a horse placenta extract.
본 발명의 다른 기술적 과제는 말 태반 추출물을 이용한 항피부노화 식품 조성물을 제공하는 데 있다.Another technical problem of the present invention is to provide an anti-skin aging food composition using a horse placenta extract.
상기 기술적 과제의 해결을 위하여, 본 발명자는 단백분해효소의 처리에 의하여 말 태반 추출물을 제조하고 이를 이용하여 음료를 제조한 후 이를 시음케 하여 임상테스트를 실시하였으며, 그 결과 대부분의 참가자에게서 피로감을 없애고 불면증을 감소시키며 피부 거칠어짐이 개선된다는 사실을 확인할 수 있었다. 특히 단백분해효소의 처리에 의하여 얻은 말 태반 추출물의 이러한 활성은 산 가수분해에 의하여 얻은 말 태반 추출물의 활성보다 높았다.In order to solve the above technical problem, the present inventors prepared a horse placenta extract by the treatment of protease and prepared a drink using the same, and then performed a clinical test by tasting it, and as a result, most participants feel fatigue Eliminates, reduces insomnia and improves skin roughness. In particular, the activity of horse placenta extract obtained by the treatment of protease was higher than that of horse placenta extract obtained by acid hydrolysis.
또 본 발명자는 음료 제조시에 문주란 잎 추출물을 단백분해효소의 처리에 의하여 얻은 말 태반 추출물과 함께 사용한 경우에 상기 항스트레스 효과 및 항피부노화 효과가 향상됨과 함께 문주란 추출물 자체도 상기 항스트레스 효과 및 항피부노화 효과를 가짐을 알 수 있었다.In addition, the present inventors have improved the anti-stress effect and anti-skin aging effect when the moon extract extract was used in combination with the horse placenta extract obtained by the treatment of protease, and the extract was also the anti-stress effect itself. It can be seen that it has an anti-skin aging effect.
본 발명은 이러한 실험 결과에 기초하여 완성된 것이다. The present invention has been completed based on these experimental results.
일 측면에 있어서, 본 발명은 (Ⅰ) 단백분해효소의 처리에 의하여 얻은 말 태반 추출물 및/또는 (Ⅱ) 문주란 잎을 물, 에탄올 또는 이들의 혼합 용매에 침지시켜 얻어진 문주란 잎 추출물을 유효성분으로 포함하는 항스트레스제 식품 조성물로 파악할 수 있으며, 다른 측면에 있어서는 (Ⅰ) 단백분해효소의 처리에 의하여 얻은 말 태반 추출물 및/또는 (Ⅱ) 문주란 잎을 물, 에탄올 또는 이들의 혼합 용매에 침지시켜 얻어진 문주란 잎 추출물을 유효성분으로 포함하는 항피부노화 식품 조성물로 파악할 수 있다.In one aspect, the present invention is (1) horse placenta extract obtained by the treatment of protease and / or (II) moonju egg leaves obtained by immersing in the water, ethanol or a mixed solvent thereof as an active ingredient It can be seen as an anti-stress food composition comprising, in another aspect, (I) horse placenta extract obtained by the treatment of protease and / or (II) moonju egg leaves are immersed in water, ethanol or a mixed solvent thereof It can be grasped | ascertained by the anti-aging food composition containing the obtained moonju egg extract as an active ingredient.
본 발명의 항스트레스제 식품 조성물 및 항피부노화 식품 조성물(이하 "본 발명의 식품 조성물")에 유효성분으로 사용되는 말 태반 추출물은 말 태반에 단백분해효소를 처리하고 가수분해시켜 얻어진 것을 말한다. 이러한 추출물은 여과에 의하여 정제된 형태이거나, 반응용매가 제거된 농축된 액상의 형태나 고형상의 형태일 수 있다. The horse placenta extract used as an active ingredient in the antistress agent food composition and the anti-aging food composition of the present invention (hereinafter, the "food composition of the present invention") refers to a horse placenta obtained by treating and hydrolyzing the protease. Such extract may be in the form of purified form by filtration or in the form of a concentrated liquid or solid form from which the reaction solvent is removed.
충분한 가수분해 효과를 거두기 위해서 단백분해효소는 말 태반 100 중량부 기준 0.5 중량부 이상, 특히 2 중량부 이상 첨가되는 것이 바람직하다. 구체적으로는 사용되는 단백분해효소에 따라서 최적의 첨가량이 결정될 것이다. 가수분해시의 반응 온도는 사용된 단백분해효소의 활성을 최대화할 수 있는 반응 온도를 선택하면 된다. 통상은 35℃ 내지 55℃ 범위 내에서 선택될 것이다. 반응 온도가 너무 높으면 효소의 불활성화의 문제가 있을 수 있으며, 너무 낮으면 가수분해의 효율이 떨어질 수 있다. 단백분해효소는 미생물, 식물 또는 동물 유래의 임의의 것을 사용할 수 있으며, 특별한 제한은 없으나, 파파인, 펩신, 트립신 등이 주로 사용될 것이다. In order to achieve a sufficient hydrolytic effect, the protease is preferably added at least 0.5 parts by weight, in particular at least 2 parts by weight, based on 100 parts by weight of the horse's placenta. Specifically, the optimal amount of addition will be determined depending on the protease used. The reaction temperature at the time of hydrolysis may be selected to maximize the activity of the protease used. Usually it will be selected within the range of 35 ° C to 55 ° C. If the reaction temperature is too high, there may be a problem of inactivation of the enzyme, if it is too low, the efficiency of hydrolysis may be reduced. Proteases may be any of microorganisms, plants or animals, and there is no particular limitation, but papain, pepsin, trypsin and the like will mainly be used.
아래의 실시예는 산 가수분해에 의하여 얻은 말 태반 추출물이 단백분해효소의 처리에 의하여 얻은 말 태반 추출물보다 아미노산 함량이 낮고 또한 항스트레스 효과 및 항피부노화 효과도 낮음을 보여준다. 이는 추측컨대 산 가수분해 과정에서 각종 아미노산이 분해되거나 태반에 포함된 우론산, 클리코사미노글리칸, 시알산, 상피세포촉진인자 등 각종 생리활성물질이 불활성화되기 때문인 것으로 보인다.The following example shows that the horse placenta extract obtained by acid hydrolysis has lower amino acid content and lower antistress and anti-aging effects than horse placenta extract obtained by treatment with protease. It is presumed that this is because various amino acids are decomposed during acid hydrolysis or various bioactive substances such as uronic acid, glycosaminoglycan, sialic acid and epithelial cell promoters are inactivated.
본 발명의 식품 조성물에 유효성분으로 포함되는 문주란 잎 추출물은 그 자체가 항스트레스 활성을 갖는 이외에 말 태반 추출물과 혼합될 경우 그 항스트레스 활성을 높이는 효과도 갖고 있다. 따라서 본 발명의 항스트레스제 조성물에는 단백분해효소의 처리에 의하여 얻어진 말 태반 추출물 이외에 문주란 잎 추출물도 함께 포함되는 것이 바람직하다.Moonjuran leaf extract included as an active ingredient in the food composition of the present invention has the effect of enhancing its antistress activity when mixed with horse placenta extract in addition to itself having antistress activity. Therefore, it is preferable that the anti-stress composition of the present invention also includes a munjoran leaf extract in addition to the horse placenta extract obtained by the treatment of protease.
문주란 잎 추출물은 추출 대상인 문주란 잎을 추출 용매인 물, 에탄올 또는 이들의 혼합 용매에 침지하여 얻어진 추출물을 말하며, 추출 방법에는 특별한 제한이 없다. 따라서 추출 방법으로서는 가온, 초음파 처리, 교반 등 임의의 방법이 적용될 수 있다. 문주란 잎 추출물도 여과에 의하여 정제된 형태이거나 추출 용매 등이 제거된 농축된 액상의 형태 또는 고형상의 형태일 수 있다. 일찍이 문주란의 잎은 진통, 해독, 소종 등의 효능을 가진다고 알려져 왔다. Moonjuran leaf extract refers to an extract obtained by immersing the moonjuran leaf to be extracted in water, ethanol or a mixed solvent of the extraction solvent, there is no particular limitation on the extraction method. Therefore, as the extraction method, any method such as heating, ultrasonication, stirring, or the like may be applied. Moonjuran leaf extract may also be purified form by filtration or in the form of a concentrated liquid or solid form in which the extraction solvent is removed. The leaves of Munjuran have been known to have effects such as analgesic, detoxification, and seedling.
본 명세서에서, 상기 "유효성분"의 의미는 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In the present specification, the term "active ingredient" means a component that can exhibit activity alone or in combination with a carrier which is not active in itself.
또 본 명세서에서, 상기 "항스트레스"는 스트레스가 일으키는 신체의 증상 중 피로감 및/또는 불면의 감소, 예방 또는 제거를 의미한다.In addition, in the present specification, the "anti-stress" refers to the reduction, prevention or elimination of fatigue and / or insomnia among the symptoms of the body caused by stress.
또 본 명세서에서, 상기 "항피부노화"는 스트레스가 일으키는 신체의 증상 중 피부거칠어짐의 감소, 예방 또는 제거를 의미한다.In addition, in the present specification, the "anti-skin aging" means the reduction, prevention or removal of skin roughness among the symptoms of the body caused by stress.
본 발명의 식품 조성물에 포함되는 유효성분의 함량은 식품의 종류에 따라서 임의의 양으로 포함될 수 있다. 통상은 식품 조성물 전체 중량을 기준으로 할 때 0.5 중량% 내지 35.0 중량%의 범위로 포함될 것이다.The content of the active ingredient included in the food composition of the present invention may be included in any amount according to the type of food. It will typically be included in the range of 0.5% to 35.0% by weight based on the total weight of the food composition.
본 발명의 식품 조성물은 구체적인 양태에 있어서, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류, 음료, 차, 비탄민제 등으로 제품화될 수 있으며, 바람직하게는 음료로 제품화되는 경우이다.In a specific embodiment, the food composition of the present invention may be commercialized with sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, ice creams, beverages, tea, non-fatting agents, and the like. Is when it is commercialized as a beverage.
본 발명의 식품 조성물에는 그 유효성분 이외에 감미제, 풍미제, 생리활성 성분, 미네랄 등이 포함될 수 있다.The food composition of the present invention may include sweeteners, flavoring agents, bioactive ingredients, minerals, etc. in addition to the active ingredients.
감미제는 식품이 적당한 단맛을 나게 하는 양으로 사용될 수 있으며, 천연의 것이거나 합성된 것일 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. Sweeteners may be used in amounts that give the food a suitable sweet taste, and may be natural or synthetic. Preferably, natural sweeteners are used. Examples of natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
풍미제는 맛이나 향을 좋게 하기 위하여 사용될 수 있는데, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼 (홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제는 에스테르, 알콜, 알데하이드, 테르펜 등의 형태의 것들이 이용될 수 있다. Flavoring agents can be used to enhance the taste or aroma, both natural and synthetic. Preferably, a natural one is used. When using natural ones, the purpose of nutritional fortification can be performed in addition to the flavor. The natural flavor may be obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or may be obtained from green tea leaves, round leaves, jujube leaves, cinnamon, chrysanthemum leaves, jasmine and the like. In addition, ginseng (red ginseng), bamboo shoots, aloe vera, ginkgo and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. In some cases, synthetic flavoring agents may be used, and synthetic flavoring agents may be used in the form of esters, alcohols, aldehydes, terpenes and the like.
생리 활성 물질로서는 카테킨, 에피카테킨, 갈로가테킨, 에피갈로카테킨 등의 카테킨류나, 레티놀, 아스코르브산, 토코페롤, 칼시페롤, 티아민, 리보플라빈 등의 비타민류 등이 사용될 수 있다.As the physiologically active substance, catechins such as catechin, epicatechin, gallocatechin, epigallocatechin, vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine, riboflavin, and the like can be used.
미네랄로서는 칼슘, 마그네슘, 크롬, 코발트, 구리, 불소화물, 게르마늄, 요오드, 철, 리튬, 마그네슘, 망간, 몰리브덴, 인, 칼륨, 셀레늄, 규소, 나트륨, 황, 바나듐, 아연 등이 사용될 수 있다.As minerals, calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium, zinc and the like can be used.
또한 본 발명의 식품 조성물은 상기 감미제 등 이외에도 필요에 따라 보존제, 유화제, 산미료, 점증제 등을 포함할 수 있다. In addition, the food composition of the present invention may contain a preservative, an emulsifier, an acidulant, a thickener, and the like, in addition to the sweetener.
이러한 보존제, 유화제 등은 그것이 첨가되는 용도를 달성할 수 있는 한 극미량으로 첨가되어 사용되는 것이 바람직하다. "극미량"이란 수치적으로 표현할 때 식품 조성물 전체 중량을 기준으로 할 때 0.0005중량％ 내지 약 0.5중량％ 범위를 의미한다.Such preservatives, emulsifiers and the like are preferably added and used in very small amounts as long as the use to which they are added can be achieved. "Ultra trace" means numerically expressed in the range from 0.0005% to about 0.5% by weight based on the total weight of the food composition.
사용될 수 있는 보존제로서는 소듐 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등을 들 수 있다. Examples of preservatives that can be used include sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid), and the like.
사용될 수 있는 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등을 들 수 있다.Emulsifiers that can be used include acacia gum, carboxymethylcellulose, xanthan gum, pectin and the like.
사용될 수 있는 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등을 들 수 있다. 이러한 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다.Examples of acidulants that may be used include lead acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, and the like. Such acidulant may be added so that the food composition is at an appropriate acidity for the purpose of inhibiting the growth of microorganisms in addition to the purpose of enhancing taste.
사용될 수 있는 점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등을 들 수 있다. Thickeners that can be used include suspending implements, sedimenters, gel formers, swelling agents and the like.
또한 본 발명의 식품 조성물은 향미나 기호성을 향상시키고 다른 기능성(예컨대 관절염 또는 골다공증 예방)을 부가하여 가지도록 한약재가 추가될 수 있는데, 추가될 수 있는 한약재로서는 두충 추출물, 속단 추출물, 녹용 추출물, 홍화인 추출물, 토사자 추출물, 숙지황 추출물, 별갑 추출물, 산수유 추출물, 구기자 추출물, 감초 추출물, 당귀 추출물, 갈근 추출물, 강진향 추출물, 합환피 추출물, 산두근 추출물, 괴화 추출물, 고삼 추출물 등이 예시될 수 있다.In addition, the herbal composition may be added to the food composition of the present invention to improve flavor and palatability and to add other functionalities (such as prevention of arthritis or osteoporosis), which may be added as a medicinal herb extract, soybean extract, antler extract, safflower Phosphorus extract, Tosa extract, Sukjihwang extract, Tortoiseshell extract, Cornus extract, Goji berry extract, Licorice extract, Angelica extract, Root extract, Gangjinhyang extract, Haphwanpi extract, Sandugeun extract, Cultivated extract, Red ginseng extract may be exemplified. .
전술한 바와 같이, 본 발명에 따르면 단백분해효소의 처리에 의하여 얻어진 말 태반 추출물을 이용한 항스트레스제 식품 조성물 및 항피부노화 식품 조성물을 제공할 수 있다.As described above, according to the present invention, it is possible to provide an antistress food composition and an anti-skinning food composition using a horse placenta extract obtained by the treatment of protease.
본 발명의 식품 조성물은 특히 음료로서 이용될 수 있다.The food composition of the present invention can be used in particular as a beverage.
이하 본 발명을 실시예, 비교예 및 실험예를 참조하여 설명한다. 그러나 본 발명의 범위가 이러한 실시예, 비교예 및 실험예에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to Examples, Comparative Examples, and Experimental Examples. However, the scope of the present invention is not limited to these examples, comparative examples and experimental examples.
<실시예> <Examples> 효소 처리에 의한 말 태반 추출물의 제조 및 문주란 추출물의 제조Preparation of Horse Placenta Extract and Enzyme Processing
<실시예 1> 말 태반 추출물의 제조 Example 1 Preparation of Horse Placenta Extract
동결된 말 태반을 해동시켜 태반의 양막과 탯줄을 제거하고 태반 융모조직만을 수거한 후 물로 수회 세척하여 혈액을 제거하였다. 다음 태반 융모조직을 잘게 짤라 융모조직 1kg, 증류수 2L 그리고 50g의 프로테아제(파파인, Sigma-Aldich)를 넣고 항온수조에서 55℃로 16시간 동안 교반하면서 반응시켰다. 다음 95℃에서 30분간 가열하여 효소 반응을 정지시키고 5㎛ 필터로 여과한 후 여과액을 감압농축하여 물을 증발시키고 여기에 1%(w/w)의 활성탄을 넣어 20분 동안 교반시키고 5㎛ 필터로 다시 여과시켰다. 0.45㎛ 필터로 여과시킨 후 동결건조시켜 고형상의 말 태반 추출물을 제조하였다.The frozen horse placenta was thawed to remove the amnion and cord from the placenta, and only placental chorionic tissue was collected and washed several times with water to remove blood. Next, the placental chorionic tissue was finely chopped, and 1 kg of chorionic tissue, 2 L of distilled water and 50 g of protease (papaine, Sigma-Aldich) were added and reacted with stirring at 55 ° C. for 16 hours in a constant temperature water bath. Next, the enzyme reaction was stopped by heating at 95 ° C. for 30 minutes, filtered through a 5 μm filter, the filtrate was concentrated under reduced pressure, water was evaporated, 1% (w / w) activated carbon was added thereto, stirred for 20 minutes, and 5 μm. Filtration again with filter. After filtering with a 0.45㎛ filter lyophilized to prepare a solid horse placenta extract.
<실시예 2> 문주란 추출물의 제조 Example 2 Preparation of Moonjuran Extract
문주란 잎 분쇄물 500g에 80%(v/v) 에탄올 2L을 가하고 상온에서 48시간 교반하면서 추출한 후 5㎛ 필터로 여과하고 동결건조하여 고형상의 문주란 잎 추출물을 제조하였다. 2L of 80% (v / v) ethanol was added to 500 g of munjoran leaf pulverized, and extracted with stirring for 48 hours at room temperature, filtered through a 5㎛ filter and lyophilized to prepare a solid munjuran leaf extract.
<비교예> Comparative Example 산 가수분해에 의한 말 태반 추출물의 제조Preparation of Horse Placenta Extracts by Acid Hydrolysis
동결된 말 태반을 해동시켜 태반의 양막과 탯줄을 제거하고 태반 융모조직만을 수거한 후 물로 수회 세척하여 혈액을 제거하였다. 다음 태반 융모조직을 잘게 짤라 융모조직 1kg에 3N HCl 500㎖을 첨가하여 5시간 동안 가수분해를 실시하였다. 그 가수분해 결과물을 5㎛ 필터로 여과한 후 감압농축하고 pH를 7로 조정한 후 여기에 1%(w/w)의 활성탄을 넣어 20분 동안 교반시키고 5㎛ 필터로 다시 여과시켰다. 0.45㎛ 필터로 여과시킨 후 동결건조시켜 고형상의 말 태반 추출물을 제조하였다.The frozen horse placenta was thawed to remove the amnion and cord from the placenta, and only placental chorionic tissue was collected and washed several times with water to remove blood. Next, the placental chorionic tissue was finely chopped and hydrolyzed for 5 hours by adding 500 ml of 3N HCl to 1 kg of the chorionic tissue. The hydrolyzed product was filtered through a 5 μm filter, concentrated under reduced pressure, pH was adjusted to 7, and then 1% (w / w) of activated carbon was added thereto, stirred for 20 minutes, and filtered again using a 5 μm filter. After filtering with a 0.45㎛ filter lyophilized to prepare a solid horse placenta extract.
<실험예> Experimental Example 말 태반 추출물의 아미노산 성분 분석 및 항스트레스 및 항피부노화 테스트Amino Acid Constituents and Antistress and Anti-Skin Aging Tests of Horse Placenta Extracts
<실험예 1> 말 태반 추출물의 아미노산 성분 분석 Experimental Example 1 Analysis of Amino Acid Components of Horse Placenta Extract
상기 <실시예 1>에서 얻어진 단백분해효소의 처리에 의한 말 태반 추출물과 상기 비교예에서 얻어진 산 가수분해에 의한 말 태반 추출물의 아미노산 성분 함량을 분석하였다.The amino acid content of the horse placenta extract by treatment of the protease obtained in <Example 1> and the horse placenta extract by acid hydrolysis obtained in the comparative example were analyzed.
아미노산 분석은 AccQ-Tag amino acid analysis method (Waters)에 의하여 분석하였다. 분석조건은 HPLC(Waters 2695, USA)를 사용하여 컬럼은 AccQ-Tag(3.9 × 150 mm)을 사용하여 형광검출기(EX : 250 nm, EM : 395 nm)로 검출하였다.Amino acid analysis was performed by AccQ-Tag amino acid analysis method (Waters). Analytical conditions were detected by HPLC (Waters 2695, USA) and the column was detected by a fluorescence detector (EX: 250 nm, EM: 395 nm) using AccQ-Tag (3.9 × 150 mm).
결과를 아래의 <표 1>에 나타내었다.The results are shown in Table 1 below.
상기 <표 1>의 결과는 말 태반을 효소 처리하여 얻은 말 태반 추출물의 각 아미노산 함량이 말 태반을 산 가수분해시켜 얻은 말 태반 추출물에 비하여 크게 증가하였음을 보여준다. The results in Table 1 show that the amino acid content of the horse placenta extract obtained by enzymatic treatment of horse placenta increased significantly compared to horse placenta extract obtained by acid hydrolysis of horse placenta.
<실험예 2> 항스트레스 효과 및 항피부노화 효과 측정 실험 Experimental Example 2 Antistress Effect and Anti-Aging Effect Measurement Experiment
상기 실시예 및 비교예에서 얻어진 말 태반 추출물과 문주란 추출물이 항스트레스 효과(피로감 및 불면의 개선 효과) 및 항피부노화 효과(피부 거칠어짐의 개선 효과)를 임상적으로 측정하였다. The horse placenta extract and Moonjuran extract obtained in Examples and Comparative Examples were clinically measured for antistress effect (improving fatigue and insomnia) and anti-skin aging (improving skin roughness).
먼저 임상 테스트를 위해서 상기 실시예 또는 비교예의 말 태반 추출물 그리고 문주란 추출물을 함유시킨 음료를 아래와 <표 2>와 같이 제조하였다.First, a beverage containing the horse placenta extract and Moonjuran extract of Examples or Comparative Examples for the clinical test was prepared as shown in Table 2 below.
임상실험 참가자 120명을 대상으로 30명씩 1군으로 나누고 각 참가자에게 40병을 공급하여 1일 2회 아침, 저녁으로 식사 전에 마시게 하여 20일간 수행하였다. Thirty participants were divided into 1 group of 120 participants, and 40 bottles were given to each participant. Twice a day, morning and evening, were taken before meals for 20 days.
개선도를 7점 만점으로 하여, 4점 이하는 효과 없음으로 하고, 4점-6점 다소 효과 있음으로 하였으며, 6점 이상은 우수한 효과가 있는 것으로 구분하였다.The improvement degree was a perfect score of 7 points, 4 points or less was no effect, 4 points-6 points were somewhat effective, 6 points or more were classified as having an excellent effect.
테스트 결과는 아래의 <표 3 내지 6>과 같다. The test results are shown in Tables 3 to 6 below.
전체적으로 단백분해효소 처리 말 태반 추출물이 산 가수분해 말 태반 추출물과 비교하여 효과가 높음을 보여준다. Overall, the protease-treated horse placenta extract showed a higher effect than the acid hydrolyzed horse placenta extract.
그리고 문주란 추출물도 대체적으로 항스트레스 및 항피부노화 효과가 있음을 보여준다. 특히 효소 처리 말 태반 추출물과 문주란 추출물이 모두 포함된 음료의 경우 항스트레스 및 항피부노화 효과가 가장 높았다. Moonjuran extract also showed anti-stress and anti-aging effects. In particular, the anti-stress and anti-aging effects were the highest in beverages containing both placenta extract and moon juran extract.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101251976B1 (en) * | 2011-07-07 | 2013-04-08 | 주식회사 한국지네틱팜 | Method producing for healthy food |
| CN103393177A (en) * | 2013-07-18 | 2013-11-20 | 安徽宜康食品有限公司 | Lily beverage and preparation method thereof |
| CN105192713A (en) * | 2015-09-17 | 2015-12-30 | 戚佳奉 | Food therapy formula conditioning gastric ulcers and preparation method of formula |
| EP2995313A4 (en) * | 2013-05-09 | 2016-10-19 | Ibiden Co Ltd | Placenta extracts and method for preparing same |
| JP2019010098A (en) * | 2017-06-29 | 2019-01-24 | クラシエ製薬株式会社 | Flavor deterioration inhibitor and flavor deterioration inhibition method |
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| KR100932183B1 (en) * | 2008-10-22 | 2009-12-16 | 주식회사 한국천연물사이언스 | Extraction Method of Horse Placenta and Food Composition Using the Same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101251976B1 (en) * | 2011-07-07 | 2013-04-08 | 주식회사 한국지네틱팜 | Method producing for healthy food |
| EP2995313A4 (en) * | 2013-05-09 | 2016-10-19 | Ibiden Co Ltd | Placenta extracts and method for preparing same |
| CN103393177A (en) * | 2013-07-18 | 2013-11-20 | 安徽宜康食品有限公司 | Lily beverage and preparation method thereof |
| CN105192713A (en) * | 2015-09-17 | 2015-12-30 | 戚佳奉 | Food therapy formula conditioning gastric ulcers and preparation method of formula |
| JP2019010098A (en) * | 2017-06-29 | 2019-01-24 | クラシエ製薬株式会社 | Flavor deterioration inhibitor and flavor deterioration inhibition method |
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