KR20100078777A - Rapid antifungal handwash composition - Google Patents
Rapid antifungal handwash composition Download PDFInfo
- Publication number
- KR20100078777A KR20100078777A KR1020080137132A KR20080137132A KR20100078777A KR 20100078777 A KR20100078777 A KR 20100078777A KR 1020080137132 A KR1020080137132 A KR 1020080137132A KR 20080137132 A KR20080137132 A KR 20080137132A KR 20100078777 A KR20100078777 A KR 20100078777A
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- KR
- South Korea
- Prior art keywords
- hand
- skin
- composition
- hand cleaner
- cleaner composition
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/58—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/2034—Monohydric alcohols aromatic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/221—Mono, di- or trisaccharides or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/24—Organic compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/50—Perfumes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
Disclosed is an antibacterial hand cleaner composition which not only has a fast disinfecting effect (fast-acting) against bacteria present in the hand, but also has a low amount of antibacterial agent, protects the skin, and improves moisturizing power. The hand cleaner composition is 4-chloro-3-methyl-phenol represented by the following formula (1); And honey extracts.
[Formula 1]
Here, the total amount of the hand cleaner composition, the content of the 4-chloro-3-methyl-phenol is 0.1 to 2% by weight, the content of the honey extract is 0.1 to 2% by weight, the pH of the hand cleaner composition is 10 It is preferable that it is the following.
Description
The present invention relates to a hand cleaner composition, and more particularly, not only has a fast disinfecting effect (fast-acting) against bacteria present in the hand, but also has a low amount of antibacterial agent, protects the skin, and improves moisturizing power. The present invention relates to an antibacterial hand cleaner composition.
In general, hand soaps, such as liquid soaps, should have an appropriate amount of bubbles generated during use, should have a smooth surface feel, be well absorbed by the skin, and should have little skin irritation before and after use. In addition, the hand cleaner should not only have excellent stability of physical properties, such as high antibacterial activity and long lasting, but also should not crack when dried.
Human skin discharges sebum from the sebaceous glands through the pores to the surface of the skin, thereby suppressing evaporation of moisture of the skin and maintaining elasticity. However, if abnormal pores of the skin epithelial cells block the pores and sebum is not excreted on the skin surface, the sebum will clump in the pores, and anaerobic bacteria penetrate into it, causing inflammation or reddening of the skin. Also, in general, bacteria are infected through the hand, so the hands are frequently washed for the sterilization of the bacteria. Bacteria in the hand can be removed to some extent by rubbing only by hand, ie by physical force, without a cleaning agent, but bar soap is usually used. The bactericidal effect of soap is to utilize the surfactant activity of the soap, and it is usually sterilized for at least 1 minute to have a bactericidal effect. However, a typical hand wash time is about 30 seconds, so it is difficult to kill all bacteria in such a short time. In particular, in the case of infants, when washing hands using a soap bar, not only the rinsing of the soap is not easy, but also it is more difficult to kill germs mediated in sand, soil, toys, etc. of the playground in a short time.
On the other hand, as a fungicide generally used in cleaning agents, triclosan is used for removing odors and bacteria of the skin, and in addition, triclocabon is known to have a bactericidal effect. However, in the case of the above components, the deodorizing effect of the skin is excellent, but all of them are chemically prepared raw materials, the stability to light is not good, it is not suitable as a disinfectant for water soap (liquid detergent composition). Thus, as an antimicrobial agent for liquid water soap, triclosan, triclocaban, parachloromethaxylene (PCMX), dichlorophene, chlorohexidine salt, salicylic acid and the like are known, but these are due to problems of stimulation and stability to the human body, The amount is regulated by the Korean cosmetic raw material standard (jangwongi) and the US FDA.
The inventors of the present invention, while studying to solve the problems of the prior art, found a component for hand washing excellent in sterilization and stability to the skin.
Accordingly, it is an object of the present invention to provide a foam release type hand cleaner composition having antibacterial fastness, excellent skin moisturizing power, and easy baby use. Another object of the present invention is to provide a hand sanitizer composition having a fast antimicrobial activity against bacteria present in the skin without including an excessive amount of antimicrobial agent.
In order to achieve the above object, the present invention, 4-chloro-3-methyl-phenol represented by the formula (1); And it provides a hand cleaner composition comprising a honey extract.
[Formula 1]
Here, the total amount of the hand cleaner composition, the content of the 4-chloro-3-methyl-phenol is 0.1 to 2% by weight, the content of the honey extract is 0.1 to 2% by weight, the pH of the hand cleaner composition is 10 It is preferable that it is the following.
The hand sanitizer composition according to the present invention has excellent antibacterial activity against not only bacteria and fungi but also viruses, and particularly, against microorganisms such as pathogenic fungi, Escherichia coli and staphylococci, which cause eczema and scabies on skin and scalp, It has fast and excellent bactericidal and antibacterial efficacy. In addition, the hand cleaner composition according to the present invention is excellent in resistance to microorganisms and is less contaminated by microorganisms. In addition, the hand cleaner composition according to the present invention is particularly useful as a composition for disinfecting children, because it is excellent in the stability and moisturizing power to the skin.
Hereinafter, the present invention will be described in detail.
The hand cleaner composition according to the present invention is characterized by including 4-chloro-3-methyl-phenol (4-chloro-3-methyl-phenol) and honey extracts (Honey extracts) represented by the following general formula (1).
4-chloro-3-methyl-phenol represented by the formula (1) used in the hand cleaner composition according to the present invention is known as a disinfectant and has antibacterial effects against not only bacteria and fungi, but also viruses. In particular, the compound is a fast-acting substance that exhibits an antibacterial effect, and is excellent in stability to the skin, and also excellent in microorganisms such as pathogenic fungi, Escherichia coli, and staphylococci, which cause eczema and scabies caused by infection of the skin or scalp. It has bactericidal and antibacterial action. The content of the 4-chloro-3-methyl-phenol is 0.1 to 2% by weight, preferably 0.2 to 1.5% by weight based on the total hand cleaner composition. Here, if the content of the 4-chloro-3-methyl-phenol is too small, there is a fear that the antibacterial and bactericidal power of the hand cleaner composition is lowered, if too much, there is a risk of causing problems with the skin or lower the solubility.
Honey extracts used in the hand cleaner composition of the present invention are manufactured from natural honey as a raw material, and specifically, extracts obtained by extracting honey with an alcohol such as ethanol may be preferably used. The extract obtained by extracting honey with alcohol having 1 to 4 carbon atoms is used as it is, or the extract is dried or separated into pure water, and then, if necessary, amino acids, minerals, and the like, for example, 1 to 10% by weight It can be mixed and used in content. The honey extract is resistant to microorganisms, not only easily contaminated, but also enhances skin moisturizing power, and in particular, protects skin of infants. The content of the honey extract is 0.1 to 2% by weight, preferably 0.2 to 1.5% by weight based on the total hand cleaner composition. Here, if the content of the honey extract is too small, there is a fear that the skin moisturizing power of the hand cleaner composition is lowered, if too much, there is a fear that layer separation occurs.
The remaining components forming the hand cleaner composition according to the present invention are water and, if necessary, may further include conventional ingredients used in the cleaning composition, to the extent that they maintain the object of the present invention. For example, the liquid detergent composition according to the present invention may include surfactants such as anionic surfactants and cationic surfactants, and the anionic surfactants include sodium lauryl sulfate and sodium uranium derived from palm oil. Sodium sulfonates, sodium salts of alkylbenzenesulfonates, sodium cocoyl isethionates, alkali salts of sodium cocoyl glutamate, and the like can be used. Examples of the cationic surfactants include alkylbetaine and amidopropylbetaine. Can be used. In addition, the hand cleaner composition according to the present invention, in order to obtain a skin softening effect, together with natural oils, wax fatty alcohols, hydrocarbons, natural plant extracts, etc., glycerin, propylene glycol, sorbitol, etc. for obtaining skin moisturizing effect 1 It may contain more than one species. In addition, other additives may further include ethanol, perfume, colorant, metal ion blocking agent, and the like. The amount of the component including the surfactant, oil, wax, alcohol, fragrance, etc. may vary depending on the intended use, but is usually about 1 to 60% by weight, preferably 20 to 50% by weight based on the total detergent composition. .
On the other hand, while the pH of the general hand cleaner is about 10, the hand cleaner composition according to the present invention, in consideration of the skin of the infant, is maintained at pH 10 or less, preferably pH 8.5 to 8.0. The hand cleaner composition according to the present invention is prepared in a liquid state, and excellent in stability at low temperatures when preparing the composition. In addition, the hand cleaner composition according to the present invention does not contain a preservative which is a kind of antibacterial agent, can prevent skin trouble, and is particularly useful as a hand cleaner for 30 seconds antibacterial effect against bacteria.
Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. The following examples are intended to illustrate the present invention, but the scope of the present invention is not limited by the following examples.
A. 4- Chloro -3- methyl -Second fastness test of -phenol
This test is to confirm the 30 second fast-acting performance of 4-chloro-3-methyl-phenol against bacteria and to set the concentration for application to the cleaning agent. Staphylococcus aureus and Escherichia coli were used as test bacteria, and 1 wt% diluent of 4-chloro-3-methyl-phenol was prepared using dimethyl sulfoxide (DMSO) as a solvent. After diluting this dilution to 625 ppm by 2-fold dilution, 0.1 mL of each dilution was added and slowly mixed for 30 seconds. After 30 seconds, the diluted solution was inoculated into platinum loop (loop) and inoculated in TSB (Tryptic Soy Broth) medium, and after 24 hours, the growth of bacteria was observed.
From the above Table 1, in the case of 4-chloro-3-methyl-phenol, the concentration showing rapid efficacy for 30 seconds for both bacteria was 0.25% by weight, which means the minimum concentration of microbial inhibition (MIC) having rapid efficacy. . The test results, which were conducted under laboratory conditions, in practice in practical product applications, typically apply concentrations two to three times higher than MIC.
B. Antimicrobial Evaluation of Detergent Composition
In the liquid detergent composition of the present invention, when the optimum concentration of 4-chloro-3-methyl-phenol was tested, if 0.25 wt% or more of 4-chloro-3-methyl-phenol is present in the detergent composition, Could be maintained. On the other hand, most of the cleaning composition further comprises a preservative to prevent corruption, the composition of the present invention by adding the appropriate 4-chloro-3-methyl-phenol, has antiseptic effect, and also cause skin problems In order to minimize the possibility, the use of chemicals was restrained as much as possible. In order to confirm this, four detergent compositions (Examples 3 to 4) shown in Table 2 were prepared and tested for stability.
(Sodium lauroamphoacetate)
And Sodium Lauryl Glucose Carboxylate (and) Lauryl Glucoside
(Coconut fatty acid mono ethanol amide)
(Sodium Cocoyl Hydrolyzed Wheat Protein)
(Coceth-7 (and) PPG-1-PEG-9 Lauryl Glycol Ether (and) PEG-40 Hydrogenated Castor Oil)
From Table 2, depending on the fine content of potassium hydroxide (Potassium Hydroxide, KOH), it can be seen that the low temperature stability of the composition is different, the higher the pH, the better the stability. However, higher pH may cause skin problems. Therefore, the composition having the minimum pH, which is stable, is subjected to the antiseptic test, and thus the compositions of Examples 4 and 5 are selected and the antiseptic force is selected. The test was conducted.
The antiseptic test is to evaluate whether the product can be prevented from being contaminated by microorganisms during the shelf life or during the consumer's use. Labor-management, Salmonella typhimurium, Klebsiella pneumoniae and Enterobacter cloaca were used as the test strains, and the results of the antiseptic test are shown in Table 3. Evaluation index of microorganism detection of Table 3 is as shown in Table 4.
4
5
From Table 3, if the microorganism does not grow within 5 days in general antiseptic evaluation (Index: 0), it is judged to maintain the antiseptic power, and conventionally set the anti-corruption shelf life for microorganisms to about 1 year, Since the composition of the invention has a 30-second fast-acting effect, the microorganisms should be killed without growth even immediately after inoculation, and maintained for 5 days in such a state. Therefore, the result of Example 5 of an antiseptic test is evaluated to be the best.
C. Detergent Composition Skin moisture evaluation
Since the hand cleaner composition of the present invention contains a honey extract to minimize irritation to the skin and improve skin moisturizing power, the skin moisturizing power of the hand cleaner composition of the present invention was evaluated. Such a composition component for skin moisturizing power evaluation is shown in Table 5.
One
7
8
9
(Sodium lauroamphoacetate)
And Sodium Lauryl Glucose Carboxylate (and) Lauryl Glucoside
(Coconut fatty acid mono ethanol amide)
(Sodium Cocoyl Hydrolyzed Wheat Protein)
(Coceth-7 (and) PPG-1-PEG-9 Lauryl Glycol Ether (and) PEG-40 Hydrogenated Castor Oil)
In order to evaluate the skin moisturizing power of the hand cleaner composition of Table 5, 20 female subjects in their 30s were washed with water, and then lightly removed with a dry towel, and the amount of skin moisture after 1 hour was measured. Next, after washing the hands of each of five people with a hand cleaner prepared in each composition of Table 5, the water content after 6 hours was measured. Moisture measurement area was the back of the hand, MPA580 (Courage-Khazaka Electronnic Gmbh, Germany) was used as a moisture meter. Moisturizing power is 100% of the skin moisture (content value) measured after 1 hour in a state of lightly dried with a dry towel after washing with water, and measured after 6 hours after washing with the hand cleaner of Examples and Comparative Examples. The percentage change (%) of the (content value) was calculated and shown in Table 6. In addition, the satisfaction after washing (as an evaluation of the feeling after hand washing, softness, washing power, and moistness) was evaluated based on the sensory criteria of the individual. The sensory evaluation method was 5 points for very good, 4 points for good, 3 for normal 2 points | pieces and a point of dislikes were given, 1 point | pieces in the case of spicy hate, the result was averaged, and it was shown in Table 6 together.
From Table 6, when the content of the honey extract is increased, the moisturizing degree is increased, but the moisture content and satisfaction did not show the same result, which is considered to have a relatively low satisfaction due to the feeling that the disinfectant remains after hand washing. .
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020080137132A KR20100078777A (en) | 2008-12-30 | 2008-12-30 | Rapid antifungal handwash composition |
Applications Claiming Priority (1)
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KR1020080137132A KR20100078777A (en) | 2008-12-30 | 2008-12-30 | Rapid antifungal handwash composition |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101581163B1 (en) | 2015-07-28 | 2015-12-30 | 주식회사 바이오켐코리아 | Process for producing liquid detergent using waste ice cream and liquid detergent thereby the same that |
US20170071849A1 (en) * | 2014-05-06 | 2017-03-16 | Comvita Limited | Matrix-metalloproteinase (mmp) inhibitory extract and methods of use thereof |
WO2020086862A1 (en) * | 2018-10-24 | 2020-04-30 | Gojo Industries, Inc. | Alcohol containing biofiilm-inhibiting non-antimicrobial cleansing composition |
US11185483B2 (en) | 2017-05-01 | 2021-11-30 | Gojo Industries, Inc. | Alcohol containing non-antimicrobial cleansing composition |
DE202022104891U1 (en) | 2022-08-30 | 2022-10-24 | Jahid Akhtar | A device for making an antimicrobial herbal hand tonic |
-
2008
- 2008-12-30 KR KR1020080137132A patent/KR20100078777A/en not_active Application Discontinuation
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170071849A1 (en) * | 2014-05-06 | 2017-03-16 | Comvita Limited | Matrix-metalloproteinase (mmp) inhibitory extract and methods of use thereof |
US11273121B2 (en) * | 2014-05-06 | 2022-03-15 | Comvita Limited | Matrix-metalloproteinase (MMP) inhibitory extract and methods of use thereof |
KR101581163B1 (en) | 2015-07-28 | 2015-12-30 | 주식회사 바이오켐코리아 | Process for producing liquid detergent using waste ice cream and liquid detergent thereby the same that |
US11185483B2 (en) | 2017-05-01 | 2021-11-30 | Gojo Industries, Inc. | Alcohol containing non-antimicrobial cleansing composition |
US11185482B2 (en) | 2017-05-01 | 2021-11-30 | Gojo Industries, Inc. | Alcohol containing low-water cleansing composition |
US11633334B2 (en) | 2017-05-01 | 2023-04-25 | Gojo Industries, Inc. | Alcohol containing non-antimicrobial cleansing composition |
US11660258B2 (en) | 2017-05-01 | 2023-05-30 | Gojo Industries, Inc. | Alcohol containing non-antimicrobial cleansing composition |
US11712409B2 (en) | 2017-05-01 | 2023-08-01 | Gojo Industries, Inc. | Alcohol containing low-water cleansing composition |
US11998626B2 (en) | 2017-05-01 | 2024-06-04 | Gojo Industries, Inc. | Alcohol containing non-antimicrobial cleansing composition |
WO2020086862A1 (en) * | 2018-10-24 | 2020-04-30 | Gojo Industries, Inc. | Alcohol containing biofiilm-inhibiting non-antimicrobial cleansing composition |
DE202022104891U1 (en) | 2022-08-30 | 2022-10-24 | Jahid Akhtar | A device for making an antimicrobial herbal hand tonic |
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