KR20100004487A - Functional composition taking anti-wrinkle effect - Google Patents
Functional composition taking anti-wrinkle effect Download PDFInfo
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- KR20100004487A KR20100004487A KR1020080064680A KR20080064680A KR20100004487A KR 20100004487 A KR20100004487 A KR 20100004487A KR 1020080064680 A KR1020080064680 A KR 1020080064680A KR 20080064680 A KR20080064680 A KR 20080064680A KR 20100004487 A KR20100004487 A KR 20100004487A
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- weight
- gold
- wrinkle
- effect
- adenosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
Abstract
Description
본 발명은 피부 주름개선효과를 갖는 기능성 조성물에 관한 것으로써, 더욱 상세하게는 나노화된 금 입자를 포함하는 피부 주름개선효과를 갖는 기능성 조성물에 관한 것이다. The present invention relates to a functional composition having an anti-wrinkle effect, and more particularly, to a functional composition having an anti-wrinkle effect comprising nanoparticles of gold.
금(gold)은 반자성물질로서 이온작용으로 인한 혈액순환을 촉진시켜 피부노화방지 및 기미제거에 좋고, 호르몬 분비촉진으로 인한 피부활성화로 피부주름방지 및 주근깨제거 등에 효과가 있으며, 해독작용으로 인한 상처치유로 인하여 피부염증방지 및 여드름치유에 효과가 있고, 면역기능을 강화시키며, 심장, 비장, 췌장, 근육에서의 손상된 세포를 재생시키는 효능이 있고, 뇌하수체 내분비선을 자극하여 영양성분 흡수를 개선하는 효과가 있는 것으로 알려져있음(대한민국특허 제10-0539111호). Gold is a diamagnetic material that promotes blood circulation due to ionic effects, which is good for skin aging and removal of blemishes.It is effective for preventing skin wrinkles and freckles by activating skin due to stimulating hormone secretion. It is effective in preventing skin inflammation and healing acne, strengthening immune function, regenerating damaged cells in the heart, spleen, pancreas, and muscle, and stimulating the pituitary gland to improve nutrient absorption. It is known that there is (Korean Patent No. 10-0539111).
이러한 이유로 최근 들어 금을 함유한 화장품제품들이 등장하고 있으며, 대한민국특허출원 제10-2004-26472호 에서와 같이 금분을 첨가한 화장품 제조방법이 개시된 바 있으나 주로 마이크로단위로 가공된 금을 사용하고 있으며, 이 경우 피부의 보 습성 및 흡수성이 약한 단점이 있음. For this reason, cosmetic products containing gold have been recently introduced, and a cosmetic manufacturing method containing gold powder has been disclosed as in Korean Patent Application No. 10-2004-26472, but mainly processed gold is used in micro units. In this case, the skin's moisture and absorption are weak.
최근 활발한 연구가 진행되고 있는 나노기술은 각종 소재분야에 적용되어 그 기존의 단점을 개선하는 획기적인 대안으로 제시되고 있는데, 대한민국특허 10-0586273호는 기존의 반자성 금입자를 상자성 나노입자 분말로 가공하여 흡수율을 개선시킬 수 있는 가능성을 보고하였고, 대한민국특허 제10-0732249호에서는 금과 은 합금 나노입자를 이용한 안료조성물로서 사용 가능성을 제시한바 있음. Nanotechnology, which is being actively researched recently, has been proposed as a groundbreaking alternative to various conventional material fields and to improve the existing shortcomings. Korean Patent No. 10-0586273 discloses a process for treating diamagnetic gold particles with paramagnetic nanoparticle powder. The possibility of improving the absorption rate was reported, and Korean Patent No. 10-0732249 suggested the possibility of using it as a pigment composition using gold and silver alloy nanoparticles.
따라서 본 발명의 목적은 상기와 같은 문제점을 해결하여 높은 피부 주름개선효과를 갖는 기능성 조성물을 제공하는데 있다. Therefore, an object of the present invention is to solve the above problems to provide a functional composition having a high skin wrinkle improvement effect.
상기 목적을 달성하기 위해 본 발명은 나노화된 금입자를 포함하는 피부 주름개선 기능성 조성물을 제공하는데 있다.In order to achieve the above object, the present invention is to provide a skin wrinkle improvement functional composition comprising nanoparticles of gold.
본 발명에 따르면 나노화된 금입자를 포함하는 조성물이 높은 피부주름개선 효과를 나타냄을 발견하였고, 이것은 나노화된 금입자와 주름개선 성분들의 시너지효과에서 유래하는 것임을 실험으로 입증하였다.According to the present invention, it was found that the composition containing the nanonized gold particles exhibited a high skin wrinkle improvement effect, and it was experimentally proved that this resulted from the synergistic effect of the nanonized gold particles and the wrinkle improvement components.
본 발명은 평균 1 ~ 500nm 크기의 금입자를 0.001중량% ~ 0.1중량% 함유하고, 아데노신 0.01 ~ 0.1중량%를 혼합하여 제조하며, 더욱 바람직하게는 평균 50nm 크기의 금입자를 0.1중량% 함유하고 아데노신 0.04중량%를 혼합하여 제조한다.The present invention contains 0.001% to 0.1% by weight of gold particles having an average size of 1 to 500nm, prepared by mixing 0.01 to 0.1% by weight of adenosine, more preferably 0.1% by weight of gold particles having an average size of 50nm Prepared by mixing 0.04% by weight of adenosine.
이하 본 발명은 비한정적인 실시예를 통해 상세히 설명한다.Hereinafter, the present invention will be described in detail through non-limiting examples.
(실시예1) 세포에서 주름개선효과 Example 1 Wrinkle Improvement Effect in Cells
아데노신 0.04중량%에 평균 50nm 크기의 금입자를 0.001중량%부터 0.1중량%까지 세포배양액에 희석하여 시료를 준비하였다. 섬유아세포를 2x105/ml로 96 well에 접 종하고 다음날 준비된 시료를 10 ul 씩 각 well에 첨가하여 48시간 동안 배양하였다. 각 시간대 별로 배양된 세포 상층액을 취해 세포 밖으로 유리된 MMP-1의 양을 MMP-1 ELISA kit(Amersham)를 사용하여 측정하였다. Samples were prepared by diluting gold particles having an average size of 50 nm to 0.04% by weight of adenosine from 0.001% by weight to 0.1% by weight of the cell culture solution. Fibroblasts were inoculated into 96 wells at 2x10 5 / ml and the samples prepared the next day were incubated for 48 hours by adding 10 ul to each well. Cell supernatants cultured at each time zone were taken and the amount of free MMP-1 out of the cells was measured using the MMP-1 ELISA kit (Amersham).
표 1에 나타난 바와같이 나노화된 금입자 함량 0.01중량%를 첨가한 조건에서 70% 정도로 가장 높은 MMP-1 저해효과를 나타냈고, 그 이상의 농도에서는 비슷한 효과를 나타냈으며, 대조군1의 아데노신만 첨가시에는 80%저해 효과를 나타냈다. 이것은 나노골드가 MMP-1 발현저해 효과가 있으며 아데노신의 항주름 효과가 한층 증가키는 시너지효과를 통해 항주름 효과를 나타내는 것으로 사료되었다. As shown in Table 1, it showed the highest MMP-1 inhibitory effect at about 70% under the condition of adding 0.01% by weight of the nanoparticles of gold particles, and showed a similar effect at higher concentrations. Showed 80% inhibition effect. This suggests that nanogold has anti-wrinkle effect through synergistic effect that MMP-1 expression is inhibited and adenosine anti-wrinkle effect is further increased.
<표1> 인간섬유아세포에서 나노골드의 MMP-1 생성저해효과 Table 1 Effects of Nanogold on MMP-1 Production in Human Fibroblasts
(실시예2) 나노골드 에센스 제조 Example 2 Preparation of Nano Gold Essence
Pillulan 2중량%, 히아루론산 0.005중량%, 아데노신 0.04중량%, 글리세린 10중량%, 나노골드 0.01중량%, 50메쉬 골드 0.03중량%, 증류수 87.9중량%를 혼합하여 에센스 제형의 화장료를 제조한다.Pillulan 2% by weight, hyaluronic acid 0.005% by weight, adenosine 0.04% by weight, glycerin 10% by weight, nano gold 0.01% by weight, 50 mesh gold 0.03% by weight, distilled water 87.9% by weight to prepare a cosmetic of the essence formulation.
(실시예3) 피부효능효과검사 Example 3 Skin Efficacy Test
나노화된 금입자의 주름개선효과를 알아보기 위해 상기 실시예 2의 나노골드 에센스의 화장품 시료를 성인 여성(나이 20-50세) 60명을 대상으로 사용전후의 설문 조사를 6개월간 실시하였다. 효과에 대한 유효성은 미국 특허 No.5126135의 방법에 따라 이것에 의해 효과가 있을 때 2점, 조금 있을 때 1점, 효과가 없을 때 0점으로 그 점수를 산출해서 유효성을 [합계점/(조사 인원수 X 2)]*100으로 표시한 결과는 표 2와 같다. 나타난 바와 같이 주름개선 효과에 대한 유효성이 90이상으로 매우 우수하게 나타났다. In order to investigate the anti-wrinkle effect of the nanoparticles of gold particles, a questionnaire was conducted for six months before and after using the nanogold essence cosmetic sample of Example 2 for 60 adult women (age 20-50). The effectiveness of the effect is calculated according to the method of US Patent No. 5126135 by calculating the score as 2 points when there is an effect, 1 point when there is a little, and 0 points when there is no effect. The results expressed in number of people X 2)] * 100 are shown in Table 2. As shown, the effectiveness of the wrinkle improvement effect was over 90, which was very excellent.
<표2> 피부효능효과검사 <Table 2> Skin Efficacy Test
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| KR1020080064680A KR20100004487A (en) | 2008-07-04 | 2008-07-04 | Functional composition taking anti-wrinkle effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479552A (en) * | 2011-08-25 | 2014-01-01 | 唯美度科技（北京）有限公司 | Anti-wrinkle revitalizing eye cream and preparation method |
| CN111821214A (en) * | 2019-04-18 | 2020-10-27 | 郦楹国际股份有限公司 | Small-molecule hyaluronic acid-gold particle material and preparation method thereof |
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2008
- 2008-07-04 KR KR1020080064680A patent/KR20100004487A/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479552A (en) * | 2011-08-25 | 2014-01-01 | 唯美度科技（北京）有限公司 | Anti-wrinkle revitalizing eye cream and preparation method |
| CN103479551A (en) * | 2011-08-25 | 2014-01-01 | 唯美度科技（北京）有限公司 | Toner and preparation method |
| CN111821214A (en) * | 2019-04-18 | 2020-10-27 | 郦楹国际股份有限公司 | Small-molecule hyaluronic acid-gold particle material and preparation method thereof |
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