KR20080002213A - 암세포의 성장 및 전이 억제 활성을 갖는 폴리펩타이드또는 그의 융합 단백질 - Google Patents
암세포의 성장 및 전이 억제 활성을 갖는 폴리펩타이드또는 그의 융합 단백질 Download PDFInfo
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- KR20080002213A KR20080002213A KR1020060060890A KR20060060890A KR20080002213A KR 20080002213 A KR20080002213 A KR 20080002213A KR 1020060060890 A KR1020060060890 A KR 1020060060890A KR 20060060890 A KR20060060890 A KR 20060060890A KR 20080002213 A KR20080002213 A KR 20080002213A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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Abstract
Description
Claims (12)
- 서열번호 1의 94 ∼ 97번의 펩타이드를 포함하는 4 내지 130개의 아미노산으로 이루어진 폴리펩타이드로서, 암세포의 성장 또는 전이 억제 활성을 갖는 폴리펩타이드.
- 제1항에 있어서, 상기 폴리펩타이드가 서열번호 2 내지 4 및 6 내지 9의 폴리펩타이드로 이루어진 군으로부터 선택되는 것을 특징으로 하는 폴리펩타이드.
- 제1항 또는 제2항의 폴리펩타이드와 폴리히스티딘(poly-His) 영역과의 융합 단백질.
- 제3항에 있어서, 상기 폴리히스티딘 영역이 서열번호 10의 아미노산 서열을 갖는 것을 특징으로 하는 융합 단백질.
- 제1항 또는 제2항의 폴리펩타이드를 코딩하는 폴리뉴클레오티드.
- 제5항에 있어서, 서열번호 11 내지 13 및 15 내지 18의 폴리뉴클레오티드로 이루어진 군으로부터 선택되는 것을 특징으로 하는 폴리뉴클레오티드.
- 제1항 또는 제2항의 폴리펩타이드를 코딩하는 폴리뉴클레오티드를 포함하는 벡터.
- 제7항에 있어서, 상기 벡터가 폴리히스티딘(poly-His) 영역을 코딩하는 cDNA가 삽입되어 있는 것을 특징으로 하는 벡터.
- 제7항의 벡터로 숙주세포를 형질전환시킨 형질전환체.
- 제9항에 있어서, 상기 숙주세포가 에스케리치아 속(Escherichia genus) 균주 또는 피키아 속(Pichia genus) 균주인 것을 특징으로 하는 형질전환체.
- 제1항 또는 제2항의 폴리펩타이드를 유효성분으로 포함하고, 약제학적으로 허용가능한 담체를 포함하는 암세포의 성장 또는 전이 억제용 약학 조성물.
- 제1항 또는 제2항의 폴리펩타이드와 폴리히스티딘(poly-His) 영역과의 융합 단백질을 유효성분으로 포함하고, 약제학적으로 허용가능한 담체를 포함하는 암세포의 성장 또는 전이 억제용 약학 조성물.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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KR1020060060890A KR100793947B1 (ko) | 2006-06-30 | 2006-06-30 | 암세포의 성장 및 전이 억제 활성을 갖는 폴리펩타이드또는 그의 융합 단백질 |
PCT/KR2006/003728 WO2007037601A1 (en) | 2005-09-28 | 2006-09-20 | Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof |
US11/991,310 US8207128B2 (en) | 2005-09-28 | 2006-09-20 | Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof |
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KR1020060060890A KR100793947B1 (ko) | 2006-06-30 | 2006-06-30 | 암세포의 성장 및 전이 억제 활성을 갖는 폴리펩타이드또는 그의 융합 단백질 |
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KR20080002213A true KR20080002213A (ko) | 2008-01-04 |
KR100793947B1 KR100793947B1 (ko) | 2008-01-16 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20120245091A1 (en) * | 2009-10-23 | 2012-09-27 | Supadelixir Inc. | Polypeptide or fused protein thereof inhibiting the extravasation of white blood cells or the growth and/or metastasis of cancer cells |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100941678B1 (ko) | 2007-12-17 | 2010-02-12 | 강원대학교산학협력단 | 암세포의 전이 억제 활성을 갖는 폴리펩타이드 또는 그의융합 단백질 |
Family Cites Families (1)
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WO2001068131A1 (en) | 2000-03-13 | 2001-09-20 | Cornell Research Foundation, Inc. | Blocking leukocyte emigration and inflammation by interfering with cd99/hec2 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120245091A1 (en) * | 2009-10-23 | 2012-09-27 | Supadelixir Inc. | Polypeptide or fused protein thereof inhibiting the extravasation of white blood cells or the growth and/or metastasis of cancer cells |
JP2013507954A (ja) * | 2009-10-23 | 2013-03-07 | スパデリクサー インコーポレイテッド | 白血球の血管外遊出またはガン細胞の成長及び/もしくは転移を抑制するポリペプチドまたはその融合蛋白質 |
US8530421B2 (en) * | 2009-10-23 | 2013-09-10 | Supadelixir Inc. | Isolated polypeptides used for treatment of inflammatory diseases and inhibiting cancer metastasis |
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