KR20040045146A - the natural medicines for the removing hangover and its healthy foods - Google Patents
the natural medicines for the removing hangover and its healthy foods Download PDFInfo
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- KR20040045146A KR20040045146A KR1020020073180A KR20020073180A KR20040045146A KR 20040045146 A KR20040045146 A KR 20040045146A KR 1020020073180 A KR1020020073180 A KR 1020020073180A KR 20020073180 A KR20020073180 A KR 20020073180A KR 20040045146 A KR20040045146 A KR 20040045146A
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- South Korea
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- weight
- vitamin
- powder
- fatigue recovery
- hangover
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Abstract
Description
본 발명은, 숙취 제거 및 피로회복을 위한 생약 조성물 및 이를 이용한 건강보조식품에 관한 것으로써, 특히 섭취시 체내 알코올 대사 기능을 강화하여 음주 전후의 숙취를 해소할 수 있으며, 알코올리즘에 의한 영양약리 요법 및 한방요법(치료프로그램을 통한 알코올리즘 환자들의 병식 개선/ 김종성 외 2000 가정의학회지, 알코올리즘 환자의 회복과정에 대한 이해/ 김종성 1998 가정의학회지 205, 알코올리즘의 생물학적 연구와 약물치료/만성길 1997 중독정신의학 1.1, 알코올리즘의 치료/ 최인근 1990 한림 대학인문학과 156)국내에 이미 발표된 각종 연구자료)등을 근거로 한 숙취제거 및 피로회복을 위한 생약 조성물 및 이를 이용한 건강보조식품에 관한 것이다.The present invention relates to a herbal composition for eliminating hangovers and to recovering from fatigue, and to health supplements using the same, and in particular, to relieve hangovers before and after drinking by strengthening the body's alcohol metabolism function, and nutritional pharmacological therapy by alcoholism. And Herbal Therapy (Improvement of Alcoholism Patients Through Treatment Program / Jong-Sung Kim et al. 2000 Journal of Family Medicine, Understanding the Recovery Process of Alcoholism Patients / Jong-Sung Kim 1998 Family Medicine Journal 205, Biology of Alcoholism and Drug Therapy / Mongil-gil 1997 Addiction Spirit The present invention relates to a herbal composition for hangover removal and fatigue recovery based on medicine 1.1, treatment of alcoholism, and Choi In-keun 1990 Department of Humanities, Hallym University, Korea.
현대사회가 점점 고도화되고 복잡해짐에 따라, 사회생활등에 따른 스트레스가 증가하고, 이를 음주로 해소하려는 경향이 늘어나고 있다. 이는 전체적으로 술의 소비량을 증가시키고 있다. 이와 같이 술은 인류에게 즐거움을 주고 스트레스를 해소시켜줄 뿐 아니라 어혈을 풀어주고 신체를 보하는 효능이 있어 적당히 음용하는 경우에는 보약으로 불릴 정도로 인체에 유익하다. 하지만 이는 습관성이 강하여 계속 마시거나 폭주하는 경우에는 간세포에 축적된 에탄올 또는 아세트 알데히드의 독작용으로 인해, 갈증, 전신권태, 피로감, 기억상실, 복부 팽만감, 소화불량, 구토, 설사, 비타민 결핍 현상을 일으키며 고혈압을 유발한다. 또한 만성적 알코올의 섭취는 간, 췌장, 십이지장, 중추신경계를 파괴할 뿐만 아니라 면역기능까지도 파괴한다. 또 간의 소화 효소 생성을 억제하여 단백질, 지방의 흡수를 저해하고, 인체의 지용성 비타민의 이용률을 저하하고 수용성 비타민과 비타민 B복합체의 이용률을 저하한다. 결국 뇌신경을 파괴하여 정신질환에 이르게 되기도 한다,.As the modern society becomes more advanced and complicated, the stress caused by social life is increasing, and the tendency to solve it by drinking is increasing. This is increasing the consumption of alcohol as a whole. In this way, alcohol not only relieves humanity and relieves stress, but also releases blood and protects the body. However, it is a habit, and if you continue drinking or runaway, due to the poisoning of ethanol or acetaldehyde accumulated in liver cells, thirst, general boredom, fatigue, memory loss, abdominal bloating, indigestion, vomiting, diarrhea, vitamin deficiency Causing high blood pressure. In addition, chronic alcohol consumption not only destroys the liver, pancreas, duodenum and central nervous system, but also immune function. It also inhibits the production of digestive enzymes in the liver, inhibits the absorption of proteins and fats, lowers the utilization of fat-soluble vitamins in the human body, and lowers the utilization of water-soluble vitamins and vitamin B complexes. Eventually destroy the brain nerves lead to mental illness ,.
이에 따라 음주 후의 숙취 제거 또는 스트레스와 노무로 인한 피로회복을 위하여, 각 종 인공제제 또는 생약제제를 단독으로 또는 혼합하여 제조한 다수의 드링크제제, 제제가 개발되어 시판되고 있으나, 일부 드링크제, 특히 인공제제는 음용시에 두통, 복통 및 구토등의 부작용을 유발하는 문제점을 일으키는 한편, 종래의 생약제제는 고가의 생약제를 일부, 소량 선택하여 취함으로써 제품의 가격만 상승시킬 뿐, 숙취해소 및 피로회복에 큰 효과를 나타내지 못했다. 또한 드링크제의 경우 음용시 독특한 생약제의 냄새로 인하여 복용하기가 거북하였으며, 장시간 방치할 경우 침전물이 생겨 시각적으로 좋지 못하였다.Accordingly, in order to remove hangovers after drinking alcohol or to recover from fatigue due to stress and labor, a large number of drink preparations and preparations prepared by combining various artificial preparations or herbal preparations have been developed and marketed, but some drink preparations, especially artificial While the drug causes side effects such as headache, abdominal pain and vomiting when drinking, the conventional herbal medicines only increase the price of the product by taking a small amount of expensive herbal medicines, and relieves hangovers and recovers from fatigue. Did not show a great effect on. In addition, the drink was difficult to take due to the smell of the unique herbal medicine when drinking, and if left for a long time, precipitates were not good visually.
또한 기존의 숙취 제거용 드링크들은 모두들 어느정도의 숙취 제거 효과를 나타내기는 하나 음주로 인한 신체적인 손상을 치료하기 위하여는 그 효능이 부족하였고 또한 피로회복 효과도 부족한 편이었다. 설령 숙취제거와 함께 신체적인 손상을 치료하기 위한 효과를 동시에 가졌다 하더라도 이는 몇 가지의 한정적인 생약성분, 또는 인공제제의 효능에 의존하고 있고 또한 약사의 임의적인 판단에 따라 여러 약제의 혼합복용이 이루어져 그 효과가 일정치 못한 점이 있었다.In addition, all of the existing hangover drinks show a certain hangover removal effect, but the effect is insufficient to cure the physical damage caused by drinking and also the fatigue recovery effect was on the side. Even if it had the effect of treating hangover with the removal of hangover at the same time, it depends on the efficacy of some limited herbal ingredients or artificial preparations. The effect was inconsistent.
이에 본 발명은 상기의 문제점 또는 한계점을 극복하기 위하여 이루어진 것으로, 음주전후의 숙취현상을 보다 효과적으로 해소할 수 있을 뿐 아니라, 음주로 인해 결핍된 인체의 영양성분을 보충하여 신체를 보호하는 작용을 갖는, 숙취 제거및 피로회복을 위한 생약 조성물 및 이를 이용한 건강보조식품을 제공하기 위한 것이다.Accordingly, the present invention has been made to overcome the above problems or limitations, not only can effectively solve the hangover phenomenon before and after drinking, but also has a function of protecting the body by supplementing the nutritional components of the body deficient due to drinking. To provide a herbal composition and a dietary supplement using the same for the hangover removal and fatigue recovery.
또한 과학적인 알코올리즘 요법에 의한 효과를 고려하여 제조함으로써 인체의 부작용이 전혀 없고, 정제, 캅셀의 형태로 제조함으로써 복용이 간편하며 장기보관하여도 변질이 없는, 숙취 제거 및 피로회복을 위한 생약 조성물 및 이를 이용한 건강보조식품을 제공하기 위한 것이다.In addition, by taking into consideration the effects of scientific alcoholism therapy, there are no side effects of the human body, and because it is prepared in the form of tablets, capsules are easy to take and no alteration even in long-term storage, herbal composition for hangover removal and fatigue recovery and To provide health supplements using the same.
또한 한정된 일부 성분의 혼합물을 약사의 임의 처방에 의한 무작위적인 복용이 아닌, 숙취해소에 좋은 성분을 그 형태에 따라 정제, 연질 캅셀, 경질 캅셀의 형태로 제조하여 패키지로 포장함으로써 균일한 효과를 볼 수 있는, 숙취제거 및 피로회복을 위한 생약 조성물 및 이를 이용한 건강보조식품을 제공하기 위한 것이다.In addition, a mixture of a limited number of ingredients is not randomly prescribed by a pharmacist's prescription, but a good ingredient for the hangover is prepared in the form of tablets, soft capsules, hard capsules, and packaged according to the form. It is possible to provide a herbal composition and a dietary supplement using the same for hangover removal and fatigue recovery.
또한 연질캅셀, 경질캅셀, 정제의 형태로 만들어 휴대의 편리성을 도모하고 , 값비싼 원료를 사용하지 않음으로써 경제적으로 제조할 수 있는, 숙취제거 및 피로회복을 위한 생약 조성물 및 이를 이용한 건강보조식품을 제공하기 위한 것이다.Also, in the form of soft capsules, hard capsules, and tablets, it promotes convenience of portability, and can be economically manufactured by not using expensive raw materials, herbal compositions for hangover removal and fatigue recovery, and health supplements using the same It is to provide.
이에 본 발명은 상기의 목적을 달성하기 위하여 과학적인 알코올리즘에 의한 영양약리요법을 근거로 하여 다수의 한약재와 천연산 재료, 및 비타민등의 영양성분등을 그 종류와 배합비를 달리하여 수없이 시행착오를 거친 결과, 체내의 알코올 대사 기능을 강화하여 음주에 따르는 신체적 손상을 치료할 수 있고, 피로회복을 할 수 있는 건강식품의 조성물을 발견하여, 연구를 거듭한 결과, 본 발명을 완성하기에 이르렀다.In order to achieve the above object, the present invention is based on nutritional pharmacological therapy based on scientific alcoholism. As a result, by strengthening the body's alcohol metabolism function to treat the physical damage caused by drinking, found a composition of a health food that can recover from fatigue, repeated research, as a result of the present invention was completed.
본 발명에 이용되는 각 각의 조성물은 유산균, 홍삼, 효모, 정제어유, 각 종 식물추출물, 미네랄, 비타민등을 주 성분으로 하여, 정제, 경질캅셀, 연질캅셀 형태로 만드는 것을 특징으로 한다.Each composition to be used in the present invention is characterized in that the lactic acid bacteria, red ginseng, yeast, refined fish oil, various plant extracts, minerals, vitamins and the like as a main component, to form tablets, hard capsules, soft capsules.
이하 본 발명에 있어서, 조성물과, 캅셀, 정제를 제조하기 위한 공정을 설명하면,Hereinafter, in the present invention, a process for producing a composition, a capsule, and a tablet will be described.
원료를 구입하여 분말화 및 추출하는 단계와,Purchasing raw materials and powdering and extracting them,
상기의 분말 및 추출물을 성분 및 배합비율에 따라 정밀히 칭량하고 충분히 혼합하는 공정과,Precisely weighing and sufficiently mixing the powders and extracts according to ingredients and blending ratios;
상기의 혼합물을 각 각의 성상에 맞게 정제, 연질캅셀, 경질캅셀의 형태로 제조하는 공정과,Preparing the mixture in the form of tablets, soft capsules, hard capsules according to their properties;
성형이 끝나면 건조실로 옮겨 충분히 건조하는 공정과,After molding, transfer to the drying room to dry sufficiently,
선별한 후 제품규격 기준에 따라 시험하고, 포장하는 공정으로 이루어진 숙취제거 및 피로회복을 위한 생약조성물과 이를 이용한 건강보조식품에 대한 제조방법인 것이다.After selection and testing according to the product standard standards, packaging is a herbal composition for the hangover removal and fatigue recovery and a manufacturing method for health supplements using the same.
상기 제조공정에 의거하여 제조공정을 설명하고, 각 각의 성상에 맞는 조성물을 설명하기로 한다.The manufacturing process will be described based on the manufacturing process, and the composition suitable for each property will be described.
(제 1공정)(First process)
하기에 (2공정) 제시되는 원료를 구입하여 분말화하는 공정 및 추출액을 얻는 공정The process of obtaining and powdering the raw material presented below (step 2)
본 발명을 구성하고 있는 한약재 재료, 비타민 및 식물 추출물 중 시중에서 구입할 수 있는 원료는 구입하여 사용하고, 분말화 및 추출해야 하는 원료들은 산업분야에서 통상적으로 사용되는 일반적인 방법에 따라 제조한다.Raw materials commercially available among the herbal ingredients, vitamins and plant extracts constituting the present invention are purchased and used, and the raw materials to be powdered and extracted are manufactured according to a general method commonly used in the industry.
분말화에 있어서는,In powdering,
원료를 세척한 후, 수분함량이 8%이하가 되도록 열풍건조실에서 건조 한다. 8%이하로 하는 것은 분말의 용이화를 돕기 위함이며, 또한 미생물의 생육을 막기 위한 것이다. 상기의 건조된 원료는 분쇄기를 통해 분말로 제조하는데, 그 분말입자의 크기는 통상적으로 정제, 연질캅셀, 경질캅셀 제조시 이용되는 입자와 동일하게 한다.After washing the raw material, it is dried in a hot air drying room so that the moisture content is 8% or less. 8% or less is to help facilitate the powder and to prevent the growth of microorganisms. The dried raw material is made into a powder through a pulverizer, the size of the powder particles are usually the same as the particles used in the manufacture of tablets, soft capsules, hard capsules.
추출에 있어서는,In extraction,
100℃의 끓는 물에 원료를 4:1(물:원료)의 혼합비로 혼합하여, 6시간동안 수용성 성분을 추출하는 공정과, 상기의 열수 추출액에 3배의 식용에탄올(70% ETOH)을 혼합하여 4시간 동안 환류 추출하는 공정으로 한다. 열수 추출과 환류 추출을 끝낸 식물 추출물등은 식용에탄올의 휘발을 위해 농축과정을 거치는데 이는 감압농축기에서 수분함량이 70중량%( 즉 가용성 고형분의 함량이 30중량%가 되도록 한다.)가 되도록 한다. 이 역시 산업사회에서 통상적으로 사용되는 추출법을 이용한다.Mixing the raw materials in a boiling ratio of 4: 1 (water: raw material) to 100 ℃ boiling water, and extracting the water-soluble components for 6 hours, and three times edible ethanol (70% ETOH) to the hot water extract To reflux extraction for 4 hours. After extracting hot water and reflux, plant extracts are concentrated for volatilization of edible ethanol, so that the water content in the vacuum condenser is 70% by weight (ie, 30% by weight of soluble solids). . This also uses the extraction method commonly used in industrial society.
추출물 분말에 있어서는,In extract powder,
또한 본 발명에 이용되고 있는 추출물 분말은 상기의 추출법에 따라 추출한 추출액을 분무건조하여 제조한다. 분무건조는 산업상 이용하는 일반적인 분무건조 과정을 거치며, 그 입자 또한 정제, 연질캅셀, 경질캅셀을 제조할 시 사용되는 입자의 크기를 따르도록 한다. 즉 150~200℃로 가열되어진 공기를 건조실로 보내고 여기에 50℃로 가열되어진 추출액을 압력노즐식분무장치, 회전원반식분무장치 등을 이용하여 분사한다. 150℃ 이하로 가열된 공기는 분사되어지는 추출액의 순간적인 증발을 일으킬 수 없으며 200℃ 이상의 온도는 고온으로 인한 추출액 성분의 파괴를 일으킬 수 있으므로 부적합한 것이 된다. 이로써 0.5mm~1.0mm의 입자크기를 갖는 추출물 분말을 얻을 수 있다.In addition, the extract powder used in the present invention is prepared by spray drying the extract liquid extracted according to the above extraction method. Spray drying is a general spray drying process used in industry, the particles also follow the size of the particles used in the manufacture of tablets, soft capsules, hard capsules. That is, the air heated to 150 ~ 200 ℃ is sent to the drying chamber and the extract liquid heated to 50 ℃ is sprayed using a pressure nozzle spray device, a rotary disk spray device and the like. Air heated to 150 ° C. or lower is not suitable because it cannot cause instantaneous evaporation of the extract to be sprayed and a temperature of 200 ° C. or higher can cause destruction of the extract component due to high temperature. As a result, an extract powder having a particle size of 0.5 mm to 1.0 mm can be obtained.
(2공정)(2 steps)
원료를 성분 및 배합비율에 따라 정밀히 칭량하고 충분히 혼합하는공정Process to weigh raw materials precisely according to ingredients and blending ratio and mix well
상기의 공정을 거친 생약제의 분말과 추출액, 추출물 분말을 혼합탱크에 넣어 혼합한다.The powder, extract and extract powder of the herbal medicines subjected to the above process are mixed in a mixing tank.
그 혼합비율은 다음과 같다.The mixing ratio is as follows.
차 후(此 後) 정제의 형태로 만들 조성물은,The composition to be made into the form of subsequent tablets,
결정성 셀룰로오스 40~66중량%, 유당 9~12중량%, 전분 1~5중량%, 비타민 C 20~30중량%, 아세로라 추출물 2~6중량%, 감잎추출물분말 1~5중량%, 스테아린산마그네슘 1~2중량%를 혼합한다.Crystalline cellulose 40-66 wt%, lactose 9-12 wt%, starch 1-5 wt%, vitamin C 20-30 wt%, acerola extract 2-6 wt%, persimmon leaf extract powder 1-5 wt%, magnesium stearate Mix 1-2 wt%.
상기 본 말명의 구성비에 있어서, 그 함량이 규정치 보다 작을 경우는 숙취제거 및 피로회복의 효과가 미비하고, 또한 그 함량이 많을 경우는 효과의 기대치가 더 이상 상승하지 못하므로 불필요한 것이 된다.In the composition ratio of the present terminology, when the content is smaller than the prescribed value, the effects of hangover removal and fatigue recovery are inadequate, and when the content is high, the expected value of the effect does not increase any more, which is unnecessary.
차 후(此 後) 연질캅셀의 형태로 만들 조성물은,The composition to be made in the form of a later soft capsule,
정제어유 20~60중량%, 비타민 E 오일 10~18중량%, 달맞이꽃 종자유 10~17.6중량%, 소맥배아유 12~16중량%, 대두유 5~14중량%, 레시틴 1~3중량%, 마늘오일 1~8중량%, 비타민 B20.1~0.7중량%, 비타민 B60.1~0.7중량%, 비타민 C 0.8~2중량%를 혼합한다.20 ~ 60% by weight of refined fish oil, 10 ~ 18% by weight of vitamin E oil, 10 ~ 17.6% by weight of evening primrose oil, 12 ~ 16% by weight of wheat germ oil, 5 ~ 14% by weight of soybean oil, 1-3% of lecithin, garlic oil 1 to 8% by weight, vitamin B 2 0.1 to 0.7% by weight, vitamin B 6 0.1 to 0.7% by weight, vitamin C 0.8 to 2% by weight is mixed.
상기 본 말명의 구성비에 있어서, 그 함량이 규정치 보다 작을 경우는 숙취제거 및 피로회복의 효과가 미비하고, 또한 그 함량이 많을 경우는 효능의 기대치가 더 이상 상승하지 못하므로 불필요한 것이 된다.In the composition ratio of the present terminology, when the content is smaller than the prescribed value, the effects of hangover removal and fatigue recovery are inadequate, and when the content is high, the expected value of the efficacy is no longer raised, which is unnecessary.
차 후 두 가지의 경질캅셀로 만들 조성물은,The composition to make two hard capsules afterwards,
그 중 하나(경질캅셀(1))는 혼합유산균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상) 13~55중량%, 홍삼분말 12~20중량%, 해조칼슘 3~8중량%, 타우린 1~5중량%, 대추엑스분말 1~3중량%, 구기자 엑스분말 1~3중량%, 베타카로틴 0.6~2.0중량%, 비타민 A 분말 0.2~1.0중량%, 비타민 E 분말 0.2~2.0중량%, 엽산 0.2~2.0중량%, 젖산철 0.2~1.0중량%, 비오틴 0.2~3.0중량%, 산화아연 3~7중량%, 비타민 B62~3중량%, 비타민 B120.4~2.0중량%, 비타민 C 3~5중량%, 스테아린산마그네슘 1~2중량%, 결정성셀룰로오스 16~ 18중량%를 혼합한다.One (hard capsule (1)) is mixed lactobacillus (Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g or more) 13-55% by weight, red ginseng powder 12-20% by weight, seaweed calcium 3-8 Weight%, Taurine 1 ~ 5%, Jujube Extract 1 ~ 3%, Wolfberry X Powder 1 ~ 3%, Beta Carotene 0.6 ~ 2.0%, Vitamin A Powder 0.2 ~ 1.0%, Vitamin E Powder 0.2 ~ 2.0 wt%, folic acid 0.2-2.0 wt%, iron lactate 0.2-1.0 wt%, biotin 0.2-3.0 wt%, zinc oxide 3-7 wt%, vitamin B 6 2-3 wt%, vitamin B 12 0.4-2.0 wt% %, 3 to 5% by weight of vitamin C, 1 to 2% by weight of magnesium stearate, and 16 to 18% by weight of crystalline cellulose are mixed.
또 다른 하나는(경질캅셀(2)), 건조효모 10~50중량%, 건조맥주효모 8~15중량%, 혼합유산균균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상) 9~13중량%, 밀크씨슬 1.5~3중량%, 엘-시스틴 1.5~4중량%, 엘-알기닌 1.5~4중량%, 결명자추출분말 1~4중량%, 복분자추출분말 1~4중량%, 니코틴산아미드 1~3중량%, 판토텐산칼슘(Ca 8중량%) 1~3중량%, 베타카로틴 1~3중량%, 비타민 B1염산연 0.5~3중량%, 비타민 B23~6중량%, 퍼미자임 0.5~2.0중량%, 콜루푸린 0.5~3.0중량%, 스테아린산마그네슘 1.5~2.0중량%, 결정성셀룰로오스 17.5~18중량%를 혼합한다.Another one (hard capsule (2)), dry yeast 10-50% by weight, dry beer yeast 8-15% by weight, mixed lactic acid bacteria (Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g or more) 9-13% by weight, milk thistle 1.5-3%, L-cystine 1.5-4%, L-arginine 1.5-4%, 1 ~ 4% by weight of sperm extract powder, 1-4% by weight of bokbunja extract powder , Nicotinic acid amide 1-3% by weight, calcium pantothenate (Ca 8% by weight) 1-3%, beta-carotene 1-3%, vitamin B 1 lead hydrochloric acid 0.5-3%, vitamin B 2 3-6% by weight , 0.5% to 2.0% by weight of permezyme, 0.5% to 3.0% by weight of glupurin, 1.5% to 2.0% by weight of magnesium stearate, and 17.5% to 18% by weight of crystalline cellulose.
상기 본 말명의 구성비에 있어서, 그 함량이 규정치 보다 작을 경우는 숙취제거 및 피로회복의 효과가 미비하고, 또한 그 함량이 많을 경우는 효과의 기대치가 더 이상 상승하지 못하므로 불필요한 것이 된다.In the composition ratio of the present terminology, when the content is smaller than the prescribed value, the effects of hangover removal and fatigue recovery are inadequate, and when the content is high, the expected value of the effect does not increase any more, which is unnecessary.
(3공정)(3 steps)
각 각의 조성물 성상에 맞게 정제, 연질캅셀, 경질캅셀 형태로 가공하는 공정Process in the form of tablet, soft capsule, hard capsule according to the composition of each composition
상기의 모든 공정을 거친 조성물은 대한약전 제제총칙에 따라 정제, 연질캅셀, 경질캅셀 성형기에 넣어 각 각 상기 제형으로 제조한다.The composition after all the above process is prepared in each of the above formulation in a tablet, soft capsule, hard capsule molding machine according to the Korean Pharmacopoeia General Regulations.
정제에 있어서.In tablets.
상기의 2)공정을 거쳐 제조된 결정성 셀룰로오스 40~66중량%, 유당 9~12중량%, 전분 1~5중량%, 비타민 C 20~30중량%, 아세로라 추출물 2~6중량%, 감잎추출물분말 1~5중량%, 스테아린산마그네슘 1~2중량%으로 이루어진 혼합물을 정제 성형기에 넣어 700mg용 정제로 만든다.Crystalline cellulose 40 to 66% by weight, lactose 9 to 12% by weight, starch 1 to 5% by weight, vitamin C 20 to 30% by weight, acerola extract 2 to 6% by weight, persimmon leaf extract A mixture consisting of 1 to 5% by weight of powder and 1 to 2% by weight of magnesium stearate is placed in a tablet molding machine to form a tablet for 700 mg.
연질캅셀에 있어서,In soft capsule,
캅셀의 외피는 젤라틴 75중량%, 글리세린 22.9중량%, D-솔비톨 2중량%, E-V(에칠 바닐린) 0.01%, 식용색소 0.09중량%, 의 비율로 혼합탱크에 혼합하여 100℃로 가열한다. 이 때 가열정도는 젤라틴이 모두 녹을 때까지 하는 것으로 하며 그 가열 시간은 본 발명의 구현시 그 양에 따라 달라질 수 있다.The outer shell of the capsule is mixed with a mixing tank at a ratio of 75% by weight of gelatin, 22.9% by weight of glycerin, 2% by weight of D-sorbitol, 0.01% of E-V (ethyl vanillin), 0.09% by weight of food coloring, and heated to 100 ° C. At this time, the degree of heating is until all the gelatin is dissolved and the heating time may vary depending on the amount of the embodiment of the present invention.
이상의 젤라틴 조제액과, 상기에서 2)공정을 거쳐 제조된 정제어유 20~60중량%, 비타민 E 오일 10~18중량%, 달맞이꽃 종자유 10~17.6중량%, 소맥배아유 12~16중량%, 대두유 5~14중량%, 레시틴 1~3중량%, 마늘오일 1~8중량%로, 비타민 B20.1~0.7중량%, 비타민 B60.1~0.7중량%, 비타민 C 0.8~2.0중량% 이루어진 혼합물을 연질캅셀 성형기에 옮겨 통상적인 연질캅셀의 제조방법에 의해 500mg용 연질캅셀을 제조한다.20 to 60% by weight of the above gelatin preparation solution and refined fish oil prepared through 2) process, 10 to 18% by weight of vitamin E oil, evening primrose seed oil 10 to 17.6% by weight, wheat germ oil 12 to 16% by weight, soybean oil 5 to 14% by weight, 1 to 3% by weight of lecithin, 1 to 8% by weight of garlic oil, 0.1 to 0.7% by weight of vitamin B 2, 0.1 to 0.7% by weight of vitamin B 6 , 0.8 to 2.0% by weight of vitamin C The soft capsule for 500 mg is prepared by a conventional soft capsule manufacturing method by transferring to a soft capsule molding machine.
경질캅셀에 있어서,In hard capsules,
경질캅셀은 2가지 형태의 조성물로 제조하는데,Hard capsules are prepared in two types of compositions,
그 중 하나(경질캅셀 1)는 상기의 2)공정을 거쳐 제조된 혼합유산균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상) 13~55중량%, 홍삼분말 12~20중량%, 해조칼슘 3~8중량%, 타우린 1~5중량%, 대추엑스분말 1~3중량%, 구기자 엑스분말 1~3중량%, 베타카로틴 0.6~2.0중량%, 비타민 A 분말 0.2~1.0중량%, 비타민 E 분말 0.2~2.0중량%, 엽산 0.2~2.0중량%, 젖산철 0.2~1.0중량%, 비오틴 0.2~3중량%, 산화아연 3~7중량%, 비타민 B62~3중량%, 비타민 B120.4~2.0중량%, 비타민 C 3~5중량%, 스테아린산마그네슘 1~2중량%, 결정성셀룰로오스 16~18중량%로 이루어진 혼합물을 경질캅셀 성형기에 넣어 300mg용 경질캅셀을 제조한다.One (hard capsule 1) is 13-55% by weight of mixed lactic acid bacteria (Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g or more) prepared through the above 2) process, 12-20 weight of red ginseng powder %, Seaweed calcium 3-8%, taurine 1-5%, jujube powder 1-3%, wolfberry X powder 1-3%, beta carotene 0.6-2.0%, vitamin A powder 0.2-1.0% %, Vitamin E powder 0.2-2.0 wt%, Folic acid 0.2-2.0 wt%, Iron lactate 0.2-1.0 wt%, Biotin 0.2-3 wt%, Zinc oxide 3-7 wt%, Vitamin B 6 2-3 wt%, A mixture of 0.4 to 2.0% by weight of vitamin B 12 , 3 to 5% by weight of vitamin C, 1 to 2% by weight of magnesium stearate, and 16 to 18% by weight of crystalline cellulose is placed in a hard capsule molding machine to prepare a hard capsule for 300 mg.
2가지 형태 중 다른 나머지 하나는(경질캅셀 2),The other of the two forms (hard capsule 2),
상기의 2)공정을 거쳐 제조된 건조효모 10~50중량%, 건조맥주효모 8~15중량%, 혼합유산균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상) 9~13중량%, 밀크씨슬 1.5~3.0중량%, 엘-시스틴 1.5~4.0중량%, 엘-알기닌 1.5~4.0중량%, 결명자추출분말 1~4중량%, 복분자추출분말 1~4중량%, 니코틴산아미드 1~3중량%, 판토텐산칼슘(Ca 8중량%) 1~3중량%, 베타카로틴 1~3중량%, 비타민 B1염산연 0.5~3.0중량%, 비타민 B23~6중량%, 퍼미자임 0.5~2.0중량%, 콜루푸린 0.5~3.0중량%, 스테아린산마그네슘 1.5~2.0중량%, 결정성셀룰로오스 17.5~18중량%를 혼합하여 경질캅셀 성형기에 넣어 300mg용 경질캅셀을 제조한다.Dry yeast 10 to 50% by weight, dry beer yeast 8 to 15% by weight, mixed lactic acid bacteria (Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g or more) 9 ~ 13 weight %, Milk Thistle 1.5-3.0% by weight, L-cystine 1.5-4.0% by weight, L-arginine 1.5-4.0% by weight, 1-4% by weight of Cultivator extract powder, 1-4% by weight of Bokbunja extract powder, Nicotinamide 1 ~ 3% by weight, calcium pantothenate (Ca 8% by weight) 1-3%, beta-carotene 1-3%, vitamin B 1 lead hydrochloric acid 0.5-3.0% by weight, vitamin B 2 3-6% by weight, permizyme 0.5 ~ 2.0% by weight, glupurin 0.5-3.0% by weight, magnesium stearate 1.5-2.0% by weight, crystalline cellulose 17.5-18% by weight is mixed into a hard capsule molding machine to prepare a 300mg hard capsule.
상기에 언급한 비타민 B2, B6, 및 C는 음주 후에 체내에 부족현상을 일으키는 비타민을 보충하기 위해 첨가된 것이다. 비타민 B군과 비타민 B12비타민 B1은 간에서 당분과 지방을 연소시킬 때 반드시 필요한 영양소이며, B2, B3, B6등은 간세포의 재생을 돕는 대표적인 비타민이다. 최근 B1은 음주후 기억력 회복과 상관관계가 있음이 밝혀져 더욱더 관심의 대상이 되고 있다.Vitamins B 2 , B 6 , and C mentioned above are added to supplement vitamins that cause deficiency in the body after drinking. Vitamin B Group and Vitamin B 12 Vitamin B 1 is an essential nutrient for burning sugar and fat in the liver. B 2 , B 3 and B 6 are representative vitamins that help the regeneration of liver cells. Recently, B 1 has been found to be correlated with recovery of memory after drinking alcohol, which is of increasing interest.
(4공정)(4 steps)
상기의 (3공정)을 끝낸 각 각의 정제, 연질캅셀, 경질캅셀을 건조실로 옮겨 충분히 건조하는 공정.A step of transferring each of the tablets, soft capsules, and hard capsules that have completed the above (3 steps) to a drying chamber to sufficiently dry them.
이 또한 대한약전 제제총칙에 준하여 실행한다.This shall also be carried out in accordance with the Korean Pharmaceutical Regulations.
(5공정)(5 steps)
상기의 (4공정)을 끝낸 정제, 연질캅셀, 경질캅셀(1)과 (2)를 선별한 후 제품규격 기준에 따라 시험하고, 포장하는 공정.The step of screening tablets, soft capsules, hard capsules (1) and (2) after the above (4 step) is tested according to the product standard, and packaging.
규격 기준 시험은 식품공전의 일반적 분석 시험에 준하여 실행하고, 포장은 상기에서 완성된 정제, 연질캅셀, 경질캅셀 (1), (2)를 각 각 한 알씩 함께 포장하여 1회 복용할 수 있게끔 하도록 하는 것이다.The standard test is carried out in accordance with the general analytical test of the Food Code, and the packaging is packaged so that each of the tablets, soft capsules, hard capsules (1) and (2) completed above can be packaged and taken once. It is.
이상의 공정을 통하여 제조되는 조성물에 사용되는 원료들은 이미 그 효능에 대해서 『본초강목』, 『동의보감』등의 문헌에 기재되어 있을 뿐 아니라, 한방 관련 분야에 종사하는 당업자에게 있어서 널리 공지된 것들이다.The raw materials used in the composition prepared through the above process are already described in the literatures such as Herbal Wood, Consent Bogam, etc., and are well known to those skilled in the field of oriental medicine.
따라서 하기에는 본 발명에 이용된 원료들의 특성과 효능을 적는 바이나 그 대표적인 성분의 효능만을 나열하겠다.Therefore, the following list the characteristics and efficacy of the raw materials used in the present invention, but only the efficacy of the typical components will be listed.
감잎에는 비타민 C가 다량 들어 있어서 차를 만들어 마시면 독성이나 부작용이 없는 이뇨제로서도 좋고, 감기, 괴혈병, 각종 성인병의 예방과 치료에 효과가 좋을 뿐만 아니라 여성들의 피부미용에도 매우 좋다. 잎차의 가장 큰 효과는 비타민 C의 함량이 어느 차보다 월등히 높아 비타민 C의 보급원으로서 가치가 높다는 것이다.Persimmon leaves contain a large amount of vitamin C, making tea a diuretic with no toxic or side effects. It is also effective for the prevention and treatment of colds, scurvy, and various adult diseases, as well as for the skin care of women. The biggest effect of green tea is that its content is much higher than any other tea, making it a valuable source of vitamin C.
유산균은 비피더스균 등 식용가능한 생균을 배양하여 식품에 혼합한 것을 제제화한 것이다. 유산균에 속하는 주요 균은 유산 간균, 유산 구균, 비피더스균 등으로 그 이용성은 발효유, 유산균음료, 치즈, 된장, 김치등의 식품에서 의약품에 이르기까지 그 범위가 광대하다. 인체는 장내에서 유익한 균(유산균)과 무해한 균의 균형을 유지하며 음식물의 소화, 흡수, 배설을 증진시키고 있다. 그러나 이러한 장내세균층이 균형을 잃어서 유산균이 부족하면 음식물의 소화과정에서 인체의 유해한 노폐물, 특히 간기능에 악 영향을 주는 암모니아가 과도하게 발생하게 되고 이것은 장점막을 자극하면서 혈중으로 흡수되어, 간에서 요소 싸이클(urea cycle)에 의해 무독화한 물질인 요소로 변하여 체외로 배설된다. 이는 간기능에 부담을 주는 것이다. 따라서 유산균 복용으로 장내 세균층의 균형을 유지하여 간의 부담을 줄여 주는 것이 간질환 치료에 매우 중요하다.The lactic acid bacteria are formulated by culturing edible live bacteria such as bifidus and mixing them into food. The major bacteria belonging to lactic acid bacteria are lactobacillus, lactic acid cocci, bifidus bacteria, etc., and their utilization ranges from foods such as fermented milk, lactic acid bacteria drink, cheese, miso, and kimchi to medicines. The human body maintains a balance between beneficial bacteria (lactic acid bacteria) and harmless bacteria in the intestines and promotes digestion, absorption and excretion of food. However, when the intestinal bacterial layer is unbalanced and lack of lactic acid bacteria, the digestion process of food causes excessive generation of harmful wastes, especially ammonia, which adversely affects liver function, which is absorbed into the blood while stimulating the mesenteric membrane. It is converted into urea, a detoxified substance, and excreted by the urea cycle. This is a burden on liver function. Therefore, it is very important to treat liver disease to reduce the burden on the liver by balancing the intestinal bacterial layer by taking lactic acid bacteria.
홍삼분말은 중추신경에 대해서 진정작용과 흥분작용이 있으며, 순환계에 작용하여 고혈압이나 동맥경화의 예방효과가 있다. 또한 조혈작용과 혈당치를 저하시키는 작용, 알코올 분해 및 간독성 제거작용, 항염 및 항종양 작용, 방사선에 대한 방어효과등이 있다. 내분비계에 작용하여 성기능이나 생식효과에 간접적으로 유효하게 작용하며, 피부를 보호하며 부드럽게 하는 작용도 있다. 홍삼의 경우 중요한것은 어댑토겐(adaptogen: 적응소)효과로서 주위 환경으로부터 각종 유해작용인 누병, 각 종 스트레스 등에 대해 방어능력을 증가시켜 생체가 보다 쉽게 적응하도록 하는 능력이 과학적으로 입증되고 있다.Red ginseng powder has a sedative and arousing effect on the central nervous system, and has a protective effect on hypertension or arteriosclerosis by acting on the circulation. In addition, hematopoietic and hypoglycemic action, alcohol degradation and hepatotoxicity, anti-inflammatory and anti-tumor action, and radiation protective effect. It acts on the endocrine system and indirectly works on sexual and reproductive effects. It also protects and softens the skin. What is important for red ginseng is the adaptogen effect, which has been scientifically proven to increase the ability of the living body to adapt more easily by protecting against various harmful effects such as leakage and various stresses from the surrounding environment.
타우린은 소의 담즙을 가수분해하고 정제하여 얻어지거나 어패류를 물로 추출하고 정제하여 얻어지는 물질로, 체내 알코올 대사 및 각종 해독기능을 강화시키고 혈압을 조절하는 기능을 갖고 있다.Taurine is obtained by hydrolyzing and purifying bovine bile in cattle or by extracting and purifying fish and shellfish with water. It has the function of strengthening alcohol metabolism and various detoxification functions and regulating blood pressure.
대추는 이가 가지고 있는 비타민류나 식이성 섬유, 플라보노이드, 미네랄등은 노화방지와 항암효과를 가지고 있다. 식이성 섬유를 많이 먹으면 장내 여분의 담즙산을 줄이므로 담즙산의 독성을 줄이는 효과가 나타난다. 담즙은 지방분을 많이 섭취하면 그 분비량이 증가한다. 그래서 많아진 담즙산은 장내세균에 의해 발암물질로 변하므로 장에서 머무는 시간이 길어지면 암의 위험성이 커지는 것이다. 그러한 발암물질을 흡착배출하는 좋은 식이성섬유를 대추는 가지고 있다. 뿐만 아니라 베타카로틴은 체내 유해 활성산소를 제독하는 힘을 가지고 있어 건강장수에 도움이 있다.Jujube has vitamins, dietary fiber, flavonoids, and minerals that have anti-aging and anticancer effects. Eating a lot of dietary fiber will reduce the amount of bile acids in your gut, thus reducing the toxicity of bile acids. Bile intake of a large amount of fat increases its secretion. Therefore, the amount of bile acid is changed to carcinogens by intestinal bacteria, so the longer the intestinal stay, the greater the risk of cancer. Jujube has a good dietary fiber that adsorbs and releases such carcinogens. In addition, beta-carotene has the power to detoxify the harmful free radicals in the body, which is beneficial for longevity.
구기자는 『신농본초경』에 의하면 “신을 보하고 폐를 윤택하게 하고, 체액을 생성하고, 정기를 점차 번창하게 하고, 내분비의 기능을 높이고, 피로에 의한 내열을 제거하고, 양분을 보충하고 노화를 막는다”라고 되어 있다. 특히 구기자의풍부한 비타민, 미네랄은 간장의 작용을 높이고, 간 세포의 보호나 재생에 도움이 되며 신진 대사를 높인다. 또한 혈당 강하 작용이나, 지방이 간장에 침착하는 것을 막는다.Gugija said, “Non-concentrated herbaceous menarche,” said, “It protects the gods and strengthens the lungs, produces body fluids, thrives regularly, improves endocrine function, removes heat from fatigue, replenishes nutrients and ages. Prevent it. ” In particular, the rich vitamins and minerals of goji bolsters the action of the liver, helps protect or regenerate liver cells, and increases metabolism. It also lowers blood sugar and prevents fat from depositing in the liver.
맥주효모 제제는 인체에서 일어나는 약 300만 가지의 효소반응에 필요한 효소의 성분이여서, 효소성분 부족으로 생기는 중간 노폐물의 생성을 막아줌으로써 간질환에는 없어서는 안 될 중요한 제제라고 할 수 있다. 맥주효모는 50%상당의 양질의 단백질을 함유하고 있는 식물성 단백질의 공급원이다. 특히 신경영양에 중요한 비타민 B5와 아미노 엑시드가 많이 함유되어 있다. 이것은 위궤양 치료에 응용되며 육류가 제한된 식이요법으로 적절하다. 또한 미네랄 공급원으로서 흔히 소화제로 사용되는 것은 효소가 풍부하기 때문에다. 맥주효모는 정장작용과 소화촉진 및 식욕증진제로 널리 이용되고 있다. 따라서 저단백 식사나 비타민 B군 결핍증, 여성들의 철분결핍증과 미네랄 결핍증 등 모든 영양부족 문제의 대부분을 해결해 줄 수 있는 건강식품이다. 음주로 인하여 아미노산이 부족하게 되면 파괴된 간세포의 재생을 위해서는 반드시 양질의 필수 아미노산의 섭취가 필요하다. 이로써 양질의 아미노산이 많은 효모제품의 섭취는 필수적이라 하겠다.Brewer's yeast formulation is an essential component of enzymes necessary for about 3 million enzyme reactions occurring in the human body, and thus prevents the production of intermediate wastes caused by the lack of enzyme components. Brewer's yeast is a source of vegetable protein containing 50% of the quality protein. In particular, it contains a lot of vitamin B 5 and amino acid which are important for neuro nutrition. It is applied in the treatment of gastric ulcers and is suitable as a meat-limited diet. It is also commonly used as a digestive agent as a mineral source because it is rich in enzymes. Brewer's yeast is widely used as a formal function, digestion and appetite enhancer. Therefore, it is a health food that can solve most of all nutritional problems such as low protein diet, vitamin B group deficiency, iron deficiency and mineral deficiency of women. When amino acids are insufficient due to drinking, it is necessary to consume high quality essential amino acids for regeneration of destroyed hepatocytes. Therefore, the intake of yeast products containing high quality amino acids is essential.
레시틴은 대두에서 분리한 인지질로서 분말, 과립, 정제, 캅셀로 제제화한 것이다. 이 레시틴은 리놀레익 산(linoleic acid), 콜린(choline), 포스포릭 산(phosphoric acid), 글리세롤(glycerol)의 네가지 성분으로 되어 있다. 이 레시틴은 세포막의 구성성분으로 세포의 기능을 활성화하고 지방 유화작용이 있어 혈중콜레스테롤을 유화하여 콜레스테롤의 동맥 벽 침착을 방지하며 지방간의 증상에 지방을 제거하여 준다.Lecithin is a phospholipid isolated from soybean, formulated into powder, granules, tablets and capsules. This lecithin consists of four components: linoleic acid, choline, phosphoric acid, and glycerol. This lecithin is a constituent of the cell membrane that activates the function of the cell and has a fat emulsification effect to emulsify cholesterol in the blood to prevent arterial wall deposition of cholesterol and to remove fat from fatty liver symptoms.
마늘은 강력한 살균작용, 정장, 이뇨, 위기능강화, 동맥경화, 고혈압, 각기병, 강정작용, 피로회복, 폐결핵등 다양한 효능이 있는 것으로 알려져 있다. 그 중 마늘의 가장 큰 효과는 혈액순환을 원활하게 하고 적혈구를 증가시켜 몸속에 신선한 혈액을 공급하기 때문에 세포를 젊게 하여 노화를 막고 체력을 증진시킴으로서 건강을 유지케한다. 또 혈관의 신진대사를 좋게하고 끈끈해진 혈액을 깨끗하고 유연하게 함으로서 성인병의 가장 큰 주범인 암이나 심잘질환 뇌혈관 질환을 예방하기도 하고 동맥경화에도 좋다. 『본초강목』에는 "쇠약한 몸을 보하고 입이 마른 것을 고치며 심폐를 기르고 열독을 없애며 피부를 윤기나게 하며, 마늘과 함께 우유를 마시면 냉증에 좋으며, 노인은 삶아서 먹는 것이 좋다. 여기에 생강이나 파를 넣어서 먹으면 어린아이의 구역질에 좋다"라고 기록되어 있다. 또한 비타민 B1과 결합하여 원래 흡수되기 어려운 비타민 B1의 허용량을 훨씬 초과하여 흡수시키는 능력이 있기 때문에 피로회복이나 체력증진의 강장작용을 갖는다. 해독 작용이 있어 간장에 좋다.Garlic is known to have a variety of effects, such as strong bactericidal action, suit, diuretic, gastric function, arteriosclerosis, hypertension, each disease, gangjeong, fatigue recovery, pulmonary tuberculosis. Among them, garlic's greatest effect is to improve blood circulation and increase red blood cells, thereby supplying fresh blood to the body, thereby keeping the cells young, preventing aging and improving stamina. In addition, by improving the metabolism of blood vessels and clean and flexible sticky blood to prevent cancer, heart disease and cerebrovascular disease, the biggest culprit of adult disease, and also good for atherosclerosis. 『Herbaceous japonica』 indicates "to weaken the body, to fix the dry mouth, to cultivate the heart, to remove heat poison, to shine the skin, to drink cold milk with garlic is good for coldness. Eating green onions are good for nausea of children. " Also have tonic action of relieving fatigue and physical strength, because the capability of absorption and much more difficult than the tolerance of the vitamin B 1 is the original absorption in combination with vitamin B 1. Detoxification is good for the liver.
밀크씨슬에 대해 설명하면, 밀크씨슬에서 추출되는 후라보노이드 화합물인 실리마린(silymarin)은 간이 손상되는 것을 막아주고 해독과정을 강화시키는데 큰 효과가 있다. 실리마린은 항산화제 작용하여 간의 손상을 막아준다. 이는 비타민 E와 비타민 C의 항산화작용에 배해 몇배 강력한 것이다. 또한 실리마린은 알코올 질환자에게 좋다는 것이 밝혀졌으며, 간경화환자의 면역기능을 증대시킬 수 있다는 보고가 있다.As for milk thistle, silymarin, a flavonoid compound extracted from milk thistle, is effective in preventing liver damage and enhancing detoxification process. Silymarin acts as an antioxidant to prevent liver damage. It is several times as powerful as the antioxidants of vitamin E and vitamin C. Silymarin has also been found to be good for alcoholics and has been reported to increase immune function in cirrhosis patients.
복분자는 장미과에 속하는 복분자 딸기와 산딸기 나무의 열매을 말린 것으로 간을 보호하므로 몸의 피로회복과 기운을 도우며 눈을 밝게 해주며 남자의 신기부족, 여자의 불임에 효과가 있고 피를 맑게 하며 성인병 예방효과가 있다.Bokbunja is a dried fruit of the bokbunja strawberry and raspberry belonging to the rosaceae to protect the liver, so it helps the body to recover from fatigue, brighten the eyes, brighten the eyes, and is effective for men's lack of novelty and women's infertility. There is.
달맞이 꽃 종자유는 리놀레산, 감마 리놀레산이 주를 이루고 있고 그 밖에 지방산들도 대략 25.0% 정도 차지 하고 있다. 달맞이 꽃의 감마 리놀렌산은 건강할 때는 필요한 만큼 만들 수 있지만 과음을 했거나 동물성 지방의 과다섭취, 미네랄이나 비타민 B6의 부족, 질병등에 의해 체내에서 만들어질 수 없게 된다. 더욱 중요한 것은 감마리놀렌산을 직접함유하고 있는 것은 모유와 달맞이꽂 종자유 밖에 없다는 것이다.Evening primrose oil is mainly composed of linoleic acid and gamma linoleic acid, and other fatty acids account for about 25.0%. Of gamma-linolenic acid Evening Primrose can make as much as you need when you are healthy but not excessive drinking or to be made by the body due to excessive intake of animal fat, lack of minerals and vitamins B 6, diseases. More importantly, the only direct inclusion of gamma-linolenic acid is breast milk and evening seed oil.
베타카로틴은 이를 함유한 식물류, 조류등에서 성분을 추출, 분리, 정제, 농축한 것으로 당근, 고구마, 자소, 호박, 망고, 시금치, 쑥갓, 물냉이 등에 많이 포함되어 있다. 베타카로틴은 짙은 오렌지색의 화합물로서 필요에 따라 인체에서 비타민 A로 전환하는 항산화제의 일종이다. 비타민 A는 과잉섭취하면 간장해등의 부작용이 있으나 이 베타카로틴은 과잉섭취해도 부작용이 없다. 이의 생리활성작용으로는 먼저 암예방을 들 수 있다. 일본의 암학회에 따르면 이는 인체의 종양에 특효가 있음을 보고 하였다. 그리고 항산화작용이 있어 활성산소를 억제하거나 제거하여 간장 세포가 유리기의 공격으로부터 방어하는 작용을 한다. 기타 순환기 동맥질환을 개선시켜주는 효과가 있어 심근경색, 뇌졸증으로 인한 사망이 반감된다. 이 베타카로틴은 지용성 성분이므로 흡수를 좋게 하기 위해서는 기름과 같이 섭취하는 것이 좋다.Beta-carotene is extracted, separated, purified, and concentrated in plants, algae, etc. containing it, it is contained in carrots, sweet potatoes, vinegar, pumpkin, mango, spinach, garland chrysanthemum, watercress. Beta-carotene is a dark orange compound, a type of antioxidant that converts vitamin A into the body as needed. If vitamin A is ingested excessively, there are side effects such as liver damage. However, beta-carotene does not have side effects even when ingested excessively. Its physiological activity is first to prevent cancer. According to the Japanese Cancer Society, this has been shown to be effective for human tumors. And because of the antioxidant action to inhibit or eliminate free radicals, hepatic cells act to defend against free radical attack. Other effects of improving circulatory arterial disease are halved due to myocardial infarction and stroke. This beta carotene is a fat-soluble ingredient, so it is recommended to take it with oil to improve absorption.
비타민 B군과 비타민 B12,비타민 B1은 간에서 당분과 지방을 연소시킬 때 반드시 필요한 영양소이며, B2, B3, B6등은 간세포의 재생을 돕는 대표적인 비타민이다. 또한 탄수화물과 지방을 대사할 때 반드시 필요한 비타민이므로 이것이 결핍되면 간은 이들 물질들을 원활하게 대사시키지 못하여 노폐물을 생산하고 간의 지방침착을 촉진하게 되다. 간에 이상이 생기면 담즙분비가 잘 되지 않아서 소화에 문제가 발생하며 이는 비타민 B12의 결핍을 유발할 수 있다. B12는 그 외에도 적혈구를 형성, 재생하여 빈혈증을 예방하고 새로운 세포가 만들어지는데 도움을 주고 세포를 튼튼하게 하는 작용이 있다. 또 신경세포를 강화하여 신경계통의 건간을 유지시키며 성장을 촉진하고 식욕을 증진시킨다. 비타민 B12가 결핍되어 나타나는 증상은 지방간, 악성빈혈, 기억력 저하, 소화장애, 눈질환등이 있다. 비타민 B12는 수용성으로 빨간색을 띄며 소량으로도 효과가 나타난다.Vitamin B group, vitamin B 12, and vitamin B 1 are essential nutrients for burning sugar and fat in the liver, and B 2 , B 3 and B 6 are representative vitamins that help regeneration of liver cells. It is also a vitamin that is essential for metabolizing carbohydrates and fats. When this is deficient, the liver cannot metabolize these substances smoothly, producing waste products and promoting hepatic attachment. If the liver is abnormal, bile secretion is poor, causing digestive problems, which can lead to vitamin B 12 deficiency. B 12 also forms and regenerates red blood cells, preventing anemia, helping new cells to be formed, and strengthening cells. It also strengthens nerve cells, maintaining the roots of the nervous system, promoting growth and enhancing appetite. Symptoms of vitamin B 12 deficiency include fatty liver, pernicious anemia, memory loss, digestive problems and eye diseases. Vitamin B 12 is water soluble and red in color.
비타민E는 혈관을 확장하여 혈액순환을 좋게 함으로써 간세포에의 혈류를 촉진한다. 특히 지방간으로 들어가는 혈관이 울혈되어서 간으로 혈액공급이 원활하지 못할때 혈류를 촉진한다. 또 독성으로 인한 손상으로 부터 간을 보호한다. 많이 함유된 식품 저온압착 식물유( 특히 소맥배아유, 콩기름), 완전곡류의 싹눈, 견과류, 밀, 소맥배아(오래된 것은 비타민 E가 없기 때문에 1주일 이상 된것은 피한다.)가 있다.Vitamin E promotes blood flow to liver cells by expanding blood vessels to improve blood circulation. In particular, blood vessels entering the fatty liver are congested, which promotes blood flow when the blood supply to the liver is not smooth. It also protects the liver from toxic damage. Many foods are low-temperature pressed vegetable oils (especially wheat germ oil, soybean oil), whole grain sprouts, nuts, wheat, and wheat germ (the old ones are free of vitamin E, avoiding more than a week).
이상으로 본 발명을 구성하고 있는 성분들의 대략적 설명을 마치고 이하는 상기의 구성성분을 규정된 제조공정에 따라 제조한 실시예를 제공함으로써 본 발명의 좀더 쉬운 이해를 돕고자 한다. 그러나 하기에 언급될 실시예를 통하여 본 발명을 한정하고자 하는 것은 아님을 밝혀둔다.After the general description of the components constituting the present invention as described above to provide an embodiment in which the above-described components were prepared in accordance with the prescribed manufacturing process to help easier understanding of the present invention. However, it should be understood that the present invention is not intended to be limited by the examples mentioned below.
(실시예1)Example 1
정제의 제조Manufacture of tablets
비타민 C, 아세로라 추출물분말, 감잎 추출물분말, 활택제로서의 스테아린산마그네슘, 정제를 만들기 위한 유당, 전분, 결정성셀룰로오스를 원료로 하는 정제를 다음과 같이 제조하였다.A tablet made of vitamin C, acerola extract powder, persimmon leaf extract powder, magnesium stearate as a lubricant, lactose for making tablets, starch, and crystalline cellulose was prepared as follows.
(1공정)(1 step)
감잎 추출물분말과, 아세로라 추출물분말은 직접 제조하고, 나머지 것들은구입하여 사용하였는데, 추출물분말은 본 발명의 구성에서 제시하고 있는 추출의 과정을 거친 후 분무건조하였다. 즉 가열장치에서 200℃로 가열되어진 공기를 건조실로 이동하고, 여기에 50℃로 가열되어진 추출액을 압력식 노즐분무장치를 통하여 분사하여 0.7mm의 입자를 갖는 추출분말을 제조하였다.Persimmon leaf extract powder, acerola extract powder was prepared directly, the rest were purchased and used, the extract powder was spray-dried after the extraction process proposed in the configuration of the present invention. That is, the air heated to 200 ° C. in the heating apparatus was moved to a drying chamber, and the extract liquid heated to 50 ° C. was sprayed through a pressure nozzle sprayer to prepare an extract powder having particles of 0.7 mm.
(2공정)(2 steps)
원료를 성분 및 배합비율에 따라 정밀히 칭량하고 충분히 혼합하는 공정Process to precisely weigh raw materials according to ingredients and blending ratio
상기의 과정을 거친 생약제의 분말과 추출액은 혼합탱크에 넣어 혼합하였다.The powder and extract of the herbal medicines subjected to the above process were mixed in a mixing tank.
그 혼합량은 다음과 같다.The mixing amount is as follows.
비타민 C 1.8kg, 아세로라추출물분말 0.2kg, 감잎추출물분말 0.15kg, 스테아린산마그네슘 0.07kg, 유당 0.7kg, 전분 0.14kg, 결정셀룰로오스 3.94kg을 혼합하여 총 질량이 7kg 이 되도록 하였다.1.8 kg of vitamin C, 0.2 kg of acerola extract powder, 0.15 kg of persimmon leaf extract powder, 0.07 kg of magnesium stearate, 0.7 kg of lactose, 0.14 kg of starch, and 3.94 kg of crystalline cellulose were mixed so that the total mass was 7 kg.
(3공정)(3 steps)
상기의 조성물을 정제 형태로 가공하는 공정Process of processing the above composition into tablet form
상기의 조성물을 대한약전 제제총칙에 따라 정제 성형기에 넣어 700mg용 정제 10000정을 제조하였다.The composition was put in a tablet molding machine according to the Pharmacopoeia General Regulations to prepare 10000 tablets for 700 mg.
정제 1정에 대한 구성은,The composition for one tablet of tablets,
비타민 C 180mg, 아세로라추출물분말 20mg, 감잎추출물분말 15mg, 스테아린산마그네슘 7mg, 유당 70mg, 전분 14mg, 결정셀룰로오스 394mg으로 구성한다.Vitamin C 180mg, acerola extract powder 20mg, persimmon leaf extract powder 15mg, magnesium stearate 7mg, lactose 70mg, starch 14mg, crystalline cellulose 394mg.
(4공정)(4 steps)
상기의 3)공정을 끝낸 정제를 건조실로 옮겨 충분히 건조하는 공정.The process of carrying out the above-mentioned 3) refinement | purification to a drying chamber, and drying enough.
이 또한 대한약전 제제총칙에 준하여 실행한다.This shall also be carried out in accordance with the Korean Pharmaceutical Regulations.
(5공정)(5 steps)
상기의 4)공정을 끝낸 정제를 선별한 후 제품규격 기준에 따라 시험하는 공정4) The process of screening the finished tablets and testing according to the product standard
규격 기준 시험은 식품공전의 일반적 분석 시험에 준하여 실행한다.Standard testing is carried out in accordance with the general analytical tests of the Food Code.
(실시예2)Example 2
연질캅셀의 제조Preparation of soft capsule
정제어유, 비타민 E오일, 달맞이꽃종자유, 소맥배아유, 대두유, 레시틴, 마늘오일을 원료로 하는 연질캅셀을 다음과 같이 제조하였다.Soft capsules made from refined fish oil, vitamin E oil, evening primrose oil, wheat germ oil, soybean oil, lecithin, and garlic oil were prepared as follows.
(1공정)(1 step)
원료의 준비 공정Raw material preparation process
상기 언급된 구성요소들 모두를 산업상에서 이용하는 것으로 구입하였다.All of the above mentioned components were purchased for industrial use.
(2공정)원료를 성분 및 배합비율에 따라 정밀히 칭량하고 충분히 혼합하는공정 (Step 2) Process of precisely weighing and mixing the raw materials according to the ingredients and blending ratio
상기의 과정을 거친 생약제의 분말과 추출액은 혼합탱크에 넣어 혼합하였다.The powder and extract of the herbal medicines subjected to the above process were mixed in a mixing tank.
그 혼합량은 다음과 같다.The mixing amount is as follows.
정제어유 2kg, 비타민 E 오일 0.625kg, 달맞이꽂 종자유 0.65kg, 소맥배아유 0.70kg, 대두유 0.55kg, 레시틴 0.10kg, 마늘오일 0.25kg, 비타민 B20.025kg, 비타민 B60.025kg, 비타민 C 0.075kg을 혼합하여 총 질량이 5kg이 되도록 하였다.2kg refined fish oil, 0.625kg vitamin E oil, evening primrose oil 0.65kg, wheat germ oil 0.70kg, soybean oil 0.55kg, lecithin 0.10kg, garlic oil 0.25kg, vitamin B 2 0.025kg, vitamin B 6 0.025kg, vitamin C 0.075 The kg was mixed to bring the total mass to 5 kg.
(3공정)(3 steps)
상기의 조성물을 연질캅셀의 형태로 가공하는 공정Process of processing the above composition in the form of soft capsule
상기의 조성물을 대한약전 제제총칙에 따라 연질캅셀 성형기에 넣어 500mg용 정제 10000알을 제조하였다.The above composition was put into a soft capsule molding machine according to the Korean Pharmaceutical Formulation General Regulations, and 10000 tablets for 500 mg were prepared.
캅셀의 외피는 젤라틴 3.75kg, 글리세린 1.145kg, D-솔비톨 0.1kg, E-V(에칠 바닐린) 0.0005kg, 식용색소 0.0045kg로 혼합하여 100℃에서 3시간동안 녹여 젤라틴 조제액 5kg을 만들었다.The outer shell of the capsule was mixed with 3.75 kg of gelatin, 1.145 kg of glycerin, 0.1 kg of D-sorbitol, 0.0005 kg of E-V (Ethyl vanillin), and 0.0045 kg of food coloring, and melted at 100 ° C. for 3 hours to prepare 5 kg of gelatin preparation.
상기의 과정을 통해 제조된 연질캅셀의 외피액과 2)공정을 통하여 완성된 조성물을 연질캅셀 제조기에 넣어 500mg용 연질캅셀 10000정을 제조하였다. 이 때 외피액과 조성물의 혼합비는 연질캅셀 제조 공정의 통상적인 방법을 따른다.The soft capsule 10000 tablets for 500 mg were prepared by putting the outer capsule of the soft capsule prepared by the above process and the composition obtained through the 2) process into the soft capsule maker. At this time, the mixing ratio of the shell liquid and the composition follows the conventional method of the soft capsule manufacturing process.
연질캅셀 1정에 대한 구성은,The constitution for one soft capsule,
정제어유 200mg, 비타민 E오일 62.5mg, 달맞이꽂 종자유 65mg, 소맥배아유70mg, 대두유 55mg, 레시틴 10mg, 마늘오일 25mg, 비타민 B22.5mg, 비타민 B62.5mg, 비타민 C 7.5mg으로 구성하였다.It consists of purified fish oil 200mg, vitamin E oil 62.5mg, evening primrose seed oil 65mg, wheat germ oil 70mg, soybean oil 55mg, lecithin 10mg, garlic oil 25mg, vitamin B 2 2.5mg, vitamin B 6 2.5mg, vitamin C 7.5mg.
(4공정)(4 steps)
상기의 3)공정을 끝낸 정제를 건조실로 옮겨 충분히 건조하는 공정.The process of carrying out the above-mentioned 3) refinement | purification to a drying chamber, and drying enough.
이 또한 대한약전 제제총칙에 준하여 실행한다.This shall also be carried out in accordance with the Korean Pharmaceutical Regulations.
(5공정)(5 steps)
상기의 4)공정을 끝낸 정제를 선별한 후 제품규격 기준에 따라 시험하는 공정4) The process of screening the finished tablets and testing according to the product standard
규격 기준 시험은 식품공전의 일반적 분석 시험에 준하여 실행한다.Standard testing is carried out in accordance with the general analytical tests of the Food Code.
(실시예3)Example 3
경질캅셀 (1)의 제조Preparation of Hard Capsule (1)
혼합유산균, 홍삼분말, 해조칼슘, 타우린, 대추엑스분말, 구기자엑스분말, 베타카로틴, 비타민 A분말, 비타민 E분말, 엽산, 젖산철, 비오틴, 산화아연을 원료로 하는 경질캅셀(1)을 다음과 같이 제조하였다.Hard capsule (1) made from mixed lactic acid bacteria, red ginseng powder, seaweed calcium, taurine, jujube extract powder, gojija extract powder, beta carotene, vitamin A powder, vitamin E powder, folic acid, iron lactate, biotin, zinc oxide It was prepared as follows.
(1공정)(1 step)
원료의 준비 공정Raw material preparation process
구기자엑스분말, 대추엑스분말은 본 발명의 구성을 통하여 제시된 추출, 분말의 과정을 거쳤고, 나머지 것들은 비용의 절감을 위해서 산업적으로 이용하는 것을 구입하여 사용하였다.Gojijax powder, jujube extract powder was subjected to the process of extraction, powder presented through the configuration of the present invention, the rest were used to buy industrial use for the reduction of cost.
(2공정)(2 steps)
원료를 성분 및 배합비율에 따라 정밀히 칭량하고 충분히 혼합하는 공정Process to precisely weigh raw materials according to ingredients and blending ratio
상기의 과정을 거친 생약제의 분말과 추출액은 혼합탱크에 넣어 혼합하였다.The powder and extract of the herbal medicines subjected to the above process were mixed in a mixing tank.
그 혼합량은 다음과 같다.The mixing amount is as follows.
혼합유산균 1.02kg, 홍삼분말 0.48kg, 해조칼슘 0.165kg, 타우린 0.09kg, 대추엑스분말 0.06kg, 구기자 엑스분말 0.06kg, 베타카로틴 0.039, 비타민 A 분말 0.018kg, 비타민 E 분말 0.033kg, 엽산 0.033kg, 젖산철 0.018kg, 비오틴 0.048kg, 산화아연 0.15kg, 비타민 B60.075kg, 비타민 B120.036kg, 비타민 C 0.12kg, 스테아린산마그네슘 0.045kg, 결정성셀룰로오스 0.51kg을 혼합하여 총질량이 3kg이 되도록 하였다.Mixed Lactobacillus 1.02kg, Red Ginseng Powder 0.48kg, Seaweed Calcium 0.165kg, Taurine 0.09kg, Jujube Extract Powder 0.06kg, Wolfberry X Powder 0.06kg, Beta Carotene 0.039, Vitamin A Powder 0.018kg, Vitamin E Powder 0.033kg, Folic Acid 0.033kg Ferric lactate 0.018kg, biotin 0.048kg, zinc oxide 0.15kg, vitamin B 6 0.075kg, vitamin B 12 0.036kg, vitamin C 0.12kg, magnesium stearate 0.045kg, crystalline cellulose 0.51kg It was made.
(3공정)(3 steps)
상기의 조성물을 연질캅셀의 형태로 가공하는 공정Process of processing the above composition in the form of soft capsule
상기의 조성물을 대한약전 제제총칙에 따라 경질캅셀 성형기에 넣어 300mg용 경질캅셀(1)을 10000정 제조한다.The composition is placed in a hard capsule molding machine according to the Pharmacopoeia General Regulations to prepare 10000 hard capsules (1) for 300 mg.
경질캅셀 (1) 1정에 대한 구성은,The composition for hard capsule (1) 1 tablet,
혼합유산균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상 102mg, 홍삼분말 48mg, 해조칼슘 16.5mg, 타우린 9mg, 대추엑스분말 6mg, 구기자 엑스분말 6mg, 베타카로틴 3.9mg, 비타민 A 분말 1.8mg, 비타민 E 분말 3.3mg, 엽산 3.3mg, 젖산철 1.8mg, 비오틴 4.8mg, 산화아연 15mg, 비타민 B67.5mg, 비타민 B12 3.6mg, 비타민 C 12mg, 스테아린산마그네슘 4.5mg, 결정성셀룰로오스 51mg로 구성한다.Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g and more Powder 1.8mg, Vitamin E Powder 3.3mg, Folic Acid 3.3mg, Iron Lactate 1.8mg, Biotin 4.8mg, Zinc Oxide 15mg, Vitamin B 6 7.5mg, Vitamin B12 3.6mg, Vitamin C 12mg, Magnesium Stearate 4.5mg, Crystalline Cellulose It consists of 51mg.
(4공정)(4 steps)
상기의 3)공정을 끝낸 정제를 건조실로 옮겨 충분히 건조하는 공정.The process of carrying out the above-mentioned 3) refinement | purification to a drying chamber, and drying enough.
이 또한 대한약전 제제총칙에 준하여 실행한다.This shall also be carried out in accordance with the Korean Pharmaceutical Regulations.
(5공정)(5 steps)
상기의 4)공정을 끝낸 정제를 선별한 후 제품규격 기준에 따라 시험하는 공정4) The process of screening the finished tablets and testing according to the product standard
규격 기준 시험은 식품공전의 일반적 분석 시험에 준하여 실행한다.Standard testing is carried out in accordance with the general analytical tests of the Food Code.
(실시예4)Example 4
경질캅셀 (2)의 제조Preparation of Hard Capsule (2)
건조효모, 건조맥주효모, 혼합유산균, 밀크씨슬, 엘-시스틴, 엘-알기닌, 결명자추출분말, 복분자추출물분말, 니코틴산아미드, 판토텐산칼슘, 베타카로틴을 원료로 하는 경질캅셀(2)을 다음과 같이 제조하였다.Dried yeast, dried beer yeast, mixed lactobacillus, milk thistle, L-cystine, L-arginine, C. extract powder, bokbunja extract powder, nicotinic acid amide, pantothenate, and beta-carotene. Prepared as.
(1공정)(1 step)
원료의 준비 공정Raw material preparation process
결명자추출분말, 복분자추출물분말은 본 발명의 구성을 통하여 제시된 추출, 분말의 과정을 거쳤고, 나머지 것들은 비용의 절감을 위해서 산업적으로 이용하는 것을 구입하여 사용하였다.Clarifier extract powder, bokbunja extract powder was subjected to the process of extraction, powder presented through the configuration of the present invention, the rest were used to buy industrial use for the reduction of cost.
(2공정)(2 steps)
원료를 성분 및 배합비율에 따라 정밀히 칭량하고 충분히 교반, 혼합하는 공정 Process to weigh raw materials precisely according to ingredients and blending ratio
상기의 과정을 거친 생약제의 분말과 추출액은 혼합탱크에 넣어 혼합하였다.The powder and extract of the herbal medicines subjected to the above process were mixed in a mixing tank.
그 혼합량은 다음과 같다.The mixing amount is as follows.
건조효모 0.9kg, 건조맥주효모 0.345kg, 혼합유산균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상) 0.33kg, 밀크씨슬 0.069kg, 엘-시스틴 0.084kg, 엘-알기닌 0.084kg, 결명자추출물분말 0.075kg, 복분자추출물분말 0.06kg, 니코틴산아미드 0.06kg, 판토텐산칼슘(Ca8%) 0.06kg, 베타카로틴 0.06kg, 비타민B1 염산염 0.054kg, 비타민B2 0.135kg, 퍼미자임 0.039kg, 콜루푸린 0.054kg, 스테아린산마그네슘 0.054kg, 결정성셀룰로오스 0.537kg를 혼합하여 3kg를 만들었다.Dry Yeast 0.9kg, Dry Beer Yeast 0.345kg, Mixed Lactobacillus (Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g or more) 0.33kg, Milk Thistle 0.069kg, L-cystine 0.084kg, L-arginine 0.084 kg, Cassia extract extract powder 0.075kg, bokbunja extract powder 0.06kg, nicotinic acid amide 0.06kg, calcium pantothenate (Ca8%) 0.06kg, beta carotene 0.06kg, vitamin B1 hydrochloride 0.054kg, vitamin B2 0.135kg, permizyme 0.039kg, colu 0.05 kg of purine, 0.054 kg of magnesium stearate, and 0.537 kg of crystalline cellulose were mixed to make 3 kg.
(3공정)(3 steps)
상기의 조성물을 경질캅셀 형태로 가공하는 공정Process of processing the composition in the form of hard capsules
상기의 조성물을 대한약전 제제총칙에 따라 경질캅셀 성형기에 넣어 300mg용 경질캅셀을 제조한다.The above composition is put into a hard capsule molding machine according to the Pharmacopeia General Formulation to prepare a hard capsule for 300 mg.
경질캅셀(2) 1정에 대한 구성은,The constitution for one hard capsule (2),
건조효모 90mg, 건조맥주효모 34.5mg, 혼합유산균(Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1×107CFU/g 이상) 33mg, 밀크씨슬 6.9mg, 엘-시스틴 8.4mg, 엘-알기닌 8.4mg, 결명자추출물분말 7.5mg, 복분자추출물분말 6mg, 니코틴산아미드 6mg, 판토텐산칼슘(Ca8%) 6mg, 베타카로틴 6mg, 비타민 B1염산염 5.4mg, 비타민B213.5mg, 퍼미자임 3.9mg, 콜루푸린 5.4mg, 스테아린산마그네슘 5.4mg, 결정성셀룰로오스 53.7mg로 구성하였다.Dry Yeast 90mg, Dry Beer Yeast 34.5mg, Mixed Lactobacillus (Lactobacillus acidophillus, Lactobacillus salivarius, Bifidobacterium longum 1 × 10 7 CFU / g or more) 33mg, Milk Thistle 6.9mg, L-cystine 8.4mg, L-arginine 8.4mg, Clarifier extract powder 7.5mg, bokbunja extract powder 6mg, nicotinic acid amide 6mg, calcium pantothenate (Ca8%) 6mg, beta-carotene 6mg, vitamin B 1 hydrochloride 5.4mg, vitamin B 2 13.5mg, permizyme 3.9mg, cholupurine 5.4mg, It was composed of 5.4 mg of magnesium stearate and 53.7 mg of crystalline cellulose.
(4공정)(4 steps)
상기의 3)공정을 끝낸 정제를 건조실로 옮겨 충분히 건조하는 공정.The process of carrying out the above-mentioned 3) refinement | purification to a drying chamber, and drying enough.
이 또한 대한약전 제제총칙에 준하여 실행한다.This shall also be carried out in accordance with the Korean Pharmaceutical Regulations.
(5공정)(5 steps)
상기의 4)공정을 끝낸 경질캅셀을 선별한 후 제품규격 기준에 따라 시험하는 공정4) process to test according to the product standard after selecting the hard capsules finished the above process
규격 기준 시험은 식품공전의 일반적 분석 시험에 준하여 실행한다.Standard testing is carried out in accordance with the general analytical tests of the Food Code.
상기의 실시예 1), 2), 3), 4)를 통하여 제조된 정제, 연질캅셀, 경질캅셀(1), (2)은 1회에 동시복용할 수 있게 끔 기본 패키지로 구성하는 것으로 한다.The tablets, soft capsules, hard capsules (1) and (2) prepared in Examples 1), 2), 3), and 4) above are to be configured as a basic package so that they can be used simultaneously at one time. .
(실험예)Experimental Example
상기의 실시예를 통하여 제조된 정제, 연질캅셀, 경질캅셀 (1), (2)를 임상실험을 해보았다.Tablets, soft capsules, hard capsules (1) and (2) prepared through the above examples were clinically tested.
유의차를 줄이기 위하여 동일 나이인 40살의 남성 30명(대조군 5명, 실험군25명)을 실험대상으로 하였으며, 실험의 정확도를 기하기 위하여 본 실험이 있기 전 10일전에서 부터 음주를 경험하지 못하게 하였다.In order to reduce the significant difference, 30 male 40-year-olds (5 control and 25 experimental groups) of the same age were used as test subjects, and in order to ensure the accuracy of the experiment, they were not allowed to experience drinking from 10 days before the experiment. .
또한 취하는 정도를 동일하게 하기 위하여, 비슷한 주량을 가진 남성을 대상으로 동일한 음주량(소주 1병 반)을 동일한 시간(2시간)에 걸쳐 먹도록 하였으며 음주 후 5시간 후에 복용하게 끔 하여 평가하였다. 결과는 5점 점수법으로 채점하여 평균하여 나타내었다.In addition, in order to equal the degree of ingestion, the same drinking amount (1 and a half bottles of soju) was eaten over the same time (2 hours) for men with similar alcohol levels, and evaluated to be taken after 5 hours after drinking. Results were averaged by scoring with a five-point scoring method.
1.아주나쁨 2.나쁨 3.보통 4.좋음 5.아주좋음1.Very bad 2.Poor 3.Normal 4.Good 5.Very good
대조군: 술만 마셨을 뿐 어떠한 회복제도 복용하지 않은 군-5명Control group: 5 patients who drank only alcohol but did not take any recovery agent
실험군1: 본 발명에 의한 정제, 연질캅셀, 경질캅셀 (1), (2)를 패키지로 복용한 군-5명Experimental group 1: group of 5 people who took the tablet, soft capsule, hard capsule (1), (2) according to the present invention as a package
실험군2: 본 발명에 의한 정제만 복용한 군-5명Experimental Group 2: Group 5-Taken Only Tablets According to the Present Invention
실험군3: 본 발명에 의한 연질캅셀만 복용한 군-5명Experimental group 3: group 5 patients taking only soft capsule according to the present invention
실험군4: 본 발명에 의한 경질캅셀 (1)만 복용한 군-5명Experimental group 4: group 5 patients who took only hard capsule (1) according to the present invention
실험군5: 본 발명에 의한 경질캅셀 (2)만 복용한 군-5명Experimental group 5: group 5 patients who took only hard capsule (2) according to the present invention
이로써 본 발명에 의한 정제, 연질캅셀, 경질캅셀 (1), (2)는 비록 대표적인 숙취현상만을 대상으로 실험은 하였으나 알코올로 섭취로 인한 부대적 현상에 대해 유의적인 효과가 있음이 판명되었으며, 또한 각 각의 제제만을 복용하는 것보다 패키지로 하여 복용하는 것이 더욱더 상승된 효과를 나타낸다는 것도 또한 본 실험을 통하여 알 수 있다.Thus, tablets, soft capsules, hard capsules (1) and (2) according to the present invention, although the experiment only on the typical hangover phenomenon, it has been found to have a significant effect on the incidental phenomenon caused by alcohol intake, and also It can also be seen from the experiment that taking a package rather than taking each agent alone shows a much higher effect.
본 발명은 알코올리즘 영양약리 요법 및 한방요법을 근거로 하여 홍삼분말,레시틴, 밀크씨슬, 알기닌, 정제어유, 유산균, 항산화제, 각종영양소 및 생약성분등 40여종을 원료 성분으로 배합하여 건강보조식품으로 만듦으로써, 음주로 인해 결핍된 인체의 영양성분을 보충하여 신체를 보호할 수 있게 되었다.The present invention is based on alcoholism nutritional pharmacological therapy and herbal therapy based on red ginseng powder, lecithin, milk thistle, arginine, refined fish oil, lactic acid bacteria, antioxidants, various nutrients and herbal ingredients as a raw ingredient to supplement health supplements By making it, it is possible to protect the body by supplementing the nutrients of the human body deficient due to drinking.
또한 과학적인 알코올리즘 요법에 의한 효과를 고려하여 제조함으로써 인체의 부작용이 전혀 없고, 정제, 캅셀의 형태로 제조함으로써 복용이 간편하며 장기보관하여도 변질이 없는, 숙취제거 및 피로회복을 위한 조성물 및 이를 이용한 건강보조식품을 제공할 수 있게 되었다.In addition, by taking into consideration the effects of scientific alcoholism therapy, there are no side effects of the human body, it is easy to take by preparing in the form of tablets, capsules, and there is no deterioration even in long-term storage, and the composition for the hangover removal and fatigue recovery It was possible to provide the health supplements used.
또한 한정된 일부 성분의 혼합물을 약사의 임의 처방에 의한 무작위적인 복용이 아닌, 숙취해소에 좋은 성분을 그 형태에 따라 정제, 연질 캅셀, 경질 캅셀의형태로 제조하여 패키지로 포장하고 섭취함으로써 균일한 효과를 볼 수 있게 되었다.In addition, the combination of a limited number of ingredients are not randomly prescribed by a pharmacist's prescription, but instead are prepared in the form of tablets, soft capsules, and hard capsules according to the form, and then packaged and ingested in a package for uniform effect. You can see.
또한 정제, 연질캅셀, 경질캅셀의 형태로 만들어 휴대의 편리성을 도모하고 , 값비싼 원료를 사용하지 않음으로써 경제적인 숙취해소용 조성물 및 이를 이용한 건강보조식품을 제공할 수 있게 되었다.In addition, tablets, soft capsules, hard capsules in the form of a mobile convenience to promote the use of expensive raw materials to eliminate hangovers and to provide a health supplement using the same.
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KR910002461A (en) * | 1989-07-06 | 1991-02-25 | 유광근 | Alcoholic beverage additives and method for manufacturing hangover |
KR950007867A (en) * | 1993-09-22 | 1995-04-15 | 성우경 | Herbal composition for prevention and treatment of hangover symptoms |
KR950010794A (en) * | 1993-10-14 | 1995-05-15 | 김정순 | Hangover beverage composition |
KR20010055274A (en) * | 1999-12-10 | 2001-07-04 | 김재수 | Health augmentation food for the anti fatigue |
KR20040035197A (en) * | 2002-10-18 | 2004-04-29 | (주)바이오뉴트리젠 | A composition for reducing alcoholic hangup containing plant extracts or powders |
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