KR20040016331A - Hair-restorer and the manufacturing process thereof - Google Patents
Hair-restorer and the manufacturing process thereof Download PDFInfo
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- KR20040016331A KR20040016331A KR1020020048607A KR20020048607A KR20040016331A KR 20040016331 A KR20040016331 A KR 20040016331A KR 1020020048607 A KR1020020048607 A KR 1020020048607A KR 20020048607 A KR20020048607 A KR 20020048607A KR 20040016331 A KR20040016331 A KR 20040016331A
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
Description
본 발명은 생약재 추출물을 주재로한 발모제 및 그의 제조방법에 관한 것으로서, 더욱 상세하게는 설상화, 흑지마, 사과락, 치자, 박하, 뽕나무, 알로에 및 건강 에서 추출한 추출물을 주요성분으로 함유한다.The present invention relates to a hair regrowth based on herbal extracts and a method for preparing the same, and more particularly, contains extracts extracted from sanghwa, black jima, apple rock, gardenia, mint, mulberry, aloe and health.
모발은 계속해서 생성되고, 자라나고, 탈모되는 과정을 거친다. 평균적으로 하루에 80개 전후의 탈모는 정상적인 생리과정으로 볼 수 있지만, 여러가지 원인에 의해 탈모되는 머리카락의 숫자가 비정상적으로 늘어나게 되면 탈모증이 되는 것이다. 결국 새로이 생성되는 머리카락의 수보다 빠지는 머리카락의 수가 늘어나면, 시간이 흐를수록 머리카락의 수가 적어지게 되어 탈모증에 이른다 할 것이다.Hair continues to be produced, grown, and depilated. On average, around 80 hair loss per day can be seen as a normal physiological process, but hair loss is caused by abnormally increased hair loss caused by various causes. Eventually, if the number of hairs falling out of the number of newly generated hairs increases, the number of hairs will decrease over time, leading to alopecia.
이러한 탈모증의 원인은 남성호르몬의 영향, 스트레스 등 이미 자세하게 밝혀지고 있고, 이에 대한 치료방법으로 다양한 제품들이 계속하여 개발되고 있지만, 그 효과나 부작용 등으로 인해 아직까지 만족할 만한 효과를 내지 못하고있는 실정이다.The cause of such alopecia is already revealed in detail, such as the effect of male hormones, stress, and various products have been developed as a treatment method for this, but due to its effects and side effects, it is still not satisfactory effect. .
본 발명은 모낭을 자극하여 두피의 모세혈관의 혈액순환을 원활하게 하고, 모발의 성장에 필요한 영양을 공급하여, 모발이 가늘어져 탈모되는 현상을 막고, 나아가 발모를 촉진하는 발모제 및 그 제조방법을 제공하고자 한다.The present invention stimulates the hair follicles to facilitate blood circulation of the capillaries of the scalp, supply the nutrients necessary for hair growth, prevent hair thinning and hair loss, further promote hair growth and a method for producing the same To provide.
본 발명에 따른 발모제는 설상화, 흑지마, 사과락, 치자, 박하, 뽕나무, 알로에 및 건강 추출물이 유효성분으로 함유된 것을 특징으로 한다.The hair regrowth agent according to the present invention is characterized by containing snow tongue, black horse, apple rock, gardenia, peppermint, mulberry, aloe and health extract as an active ingredient.
또한 본 발명은 설상화, 흑지마, 사과락, 치자, 박하 각각에 추출용매로서 에탄올을 1 : 9 의 중량비로 가하여 상온에서 40일간 침지하여 추출한 추출용액을 얻고, 뽕나무, 알로에, 건강 각각에 정제수를 1 : 15 의 중량비로 가하여 증류하여 추출한 추출용액을 준비한 후, 설상화 추출물 30 중량부, 흑지마 추출물 10 중량부, 사과락 추출물 3 중량부, 치자 추출물 3 중량부, 박하 추출물 14 중량부, 뽕나무 추출물 15 중량부, 알로에 추출물 20 중량부, 건강 추출물 15 중량부를 혼합하는 것을 특징으로 하는 발모제의 제조방법을 포함한다.In addition, the present invention is obtained by extracting the extract solution by immersion at room temperature for 40 days by adding ethanol in the weight ratio of 1: 9 to snow tongue, black jima, apple rock, gardenia, peppermint as an extraction solvent, and mulberry, aloe, health 1: 15 by weight ratio of distilled extract prepared by the extraction solution, 30 parts by weight of snow extract, 10 parts by weight of black jima extract, 3 parts by weight of apple rock extract, 3 parts by weight of gardenia extract, 14 parts by weight peppermint extract, mulberry extract 15 parts by weight, 20 parts by weight of aloe extract, 15 parts by weight of the health extract comprises a method for producing a hair regrowth, characterized in that mixing.
이하 본 발명을 상세히 설명하면 다음과 같다.Hereinafter, the present invention will be described in detail.
본 발명에 따른 생약재 중 설상화는 국화과의 한해살이풀인한련초(Eclipta prostrata) 꽃으로 스포닌(Sponin), 탄닌(tannin), 비타민 A와 여러 종류의 테르핀(terpene) 화합물이 함유되어 있으며, 지혈작용과 모발 성장 촉진 작용이 있고, 모발을 검게 만들고 항균 작용도 한다.Among the herbal medicines according to the present invention, the snow flower is an annual flower of Asteraceae (Eclipta prostrata), which contains sponin, tannin, vitamin A and various terpene compounds, and hemostatic action Has hair growth promoting action, black hair and antibacterial action.
흑지마는 참깨과의 한해살이풀인 참깨(Sesamum indicum)의 성숙한 종자로 지방유 45~55%, 세사민(sesamin), 세사놀린(sesanolin), 세사몰(sesamol), 비타민 E 등이 함유되어 있으며, 피부 점막의 염증 회복력을 촉진시키고, 혈액중의 콜레스테롤 함량을 줄이므로 동맥경화증 예방과 치료에 사용된다.Black horse is a mature seed of Sesamum indicum, a sesame plant, which contains 45 ~ 55% of fatty oil, sesamin, sesanolin, sesamol, vitamin E, etc. It is used to prevent and treat atherosclerosis because it promotes healing of inflammation and reduces cholesterol content in the blood.
사과락은 박과의 덩굴성 한해살이풀인 수세미오이(Lufa cylindrical)의 마른열매로 사포닌(saonin), 루페인(luffein), 다량의 점액 및 시트룰린(citrulline), 자일랜(xylan) 등이 함유되어있으며, 소염,진통작용과 피부세균감염증을 억제하는 살충작용이 있다.Apple Lac is a dried fruit of the lobular perennial plant, Lume cylindrical, containing saonin, luffein, large amounts of mucus and citrulline, xylan, etc. It has antiseptic action, anti-inflammatory, analgesic and skin bacterial infections.
치자는 꼭두서니과의 늘푸른떨기나무인 치자나무(Gardenia jasminoides for. Grandiflora)의 잘 익은 열매로 황색포도상구균, 뇌막염쌍구균 및 여러 종류의 피부진균에 억제 작용을 나타낸다.Gardenia is the ripe fruit of Gardenia jasminoides for Grandiflora, the evergreen evergreen tree of the locust family, and has inhibitory effect on Staphylococcus aureus, meningitis dicocci and various skin fungi.
박하는 꿀풀과의 여러해살이풀인 박하(Mentha arvensis var. piperascens)의 줄기와 잎으로 휘발성 정유가 함유되어 있으며, 주성분은 멘톨(menthol)이 77%함유되어 있으며, 발산 작용이 강하여 감기로 열이 나고 두통과 땀이 안 나는 증상을 다스리고, 두통과 눈의 충혈을 제거하며, 피부 가려움증에도 쓰이며, 여름철에 습기와 병원균이 침습해서 일어나는 복통 및 서사, 구토에 곽향을 배합해서 쓰며, 모세 혈관 확장작용을 한다.Peppermint is a stem and leaf of the perennial herb (Mentha arvensis var. Piperascens), which contains volatile essential oils.The main ingredient is 77% menthol, and its strong divergence acts as a cold. It cures headaches and sweating symptoms, removes headaches and redness of the eyes, itches the skin, and it is used in combination with the scent of abdominal pain, narrative and vomiting caused by invasion of moisture and pathogens in the summer. Do it.
뽕나무(Morus)는 뽕나무과 뽕나무속에 속하는 식물로, 해열ㆍ진통ㆍ이뇨제로 사용되며, 뽕나무 껍질을 약재로 사용한다.Mulberry (Morus) is a plant belonging to the genus Mulberry and Mulberry, it is used as antipyretic, analgesic, diuretic, mulberry bark is used as a medicinal herb.
알로에(Aloe)는 백합목 백합과의 한 속으로 세균과 곰팡이에 대한 살균력이 있고 독소를 중화하는 알로에틴이 들어 있으며, 궤양에 효과가 있는 알로에우르신과 항암효과가 있는 알로미틴이 들어 있다고 한다. 이 밖에도 스테로이드·아미노산·사포닌·항생물질·상처치유 호르몬·무기질 등 다양한 성분이 들어 있다. 알로에는 과로로 인한 피로 회복과 과음으로 인한 숙취 해소 등에 효과가 있고, 알로에의 잎을 잘라두면 유난히 쓴 황색 물질이 흘러나오는데, 이것은 변비에 특히 효과가 있다. 민간에서는 알로에 잎의 액즙을 위장병에 내복하고 외상이나 화상 등에도 이용한다. 또한 건성 피부와 지성 피부를 중성화시키고 피부 보습 효과가 있어 화장품 원료로도 쓰인다.Aloe is a genus of the genus Liliaceae, which contains aloetin, a bactericidal agent for bacteria and fungi, and neutralizes toxins. . In addition, it contains various ingredients such as steroids, amino acids, saponins, antibiotics, wound healing hormones, and minerals. Aloe is effective in recovering from fatigue caused by overwork and relieving hangovers caused by excessive drinking, and cutting aloe leaves extraordinarily bitter yellow material, which is particularly effective in constipation. In the private sector, aloe leaf juice is used for gastrointestinal diseases and used for trauma and burns. It also neutralizes dry and oily skin and moisturizes the skin, making it a cosmetic ingredient.
건강(乾薑)은 생강(生薑, ginger, Zingiber officinale)을 말린 것으로, 소화불량·구토·설사에 효과가 있고, 혈액 순환을 촉진하며, 항염증과 진통 효과가있다.Ginger (생강, ginger, Zingiber officinale) is a dried, effective in indigestion, vomiting, diarrhea, promotes blood circulation, anti-inflammatory and analgesic effect.
본 발명은 이상에서 설명한 8가지 생약재를 이용하여, 설상화, 흑지마, 사과락, 치자, 박하 각각에 추출용매로서 에탄올을 1 : 9 의 중량비로 가하여 상온에서 40일간 침지하여 추출한 추출용액을 얻고, 뽕나무, 알로에, 건강 각각에 정제수를 1 : 15 의 중량비로 가하여 증류하여 추출한 추출용액을 준비한 후, 설상화 추출물 30 중량부, 흑지마 추출물 10 중량부, 사과락 추출물 3 중량부, 치자 추출물 3 중량부, 박하 추출물 14 중량부, 뽕나무 추출물 15 중량부, 알로에 추출물 20 중량부, 건강 추출물 15 중량부를 혼합하는 데에 특징이 있으며, 상기 생약성분들의 함량은 각각 동일한 중량비로 함유시킨 것도 바람직하다.In the present invention, using the eight herbal medicines described above, ethanol is added as a solvent for the cultivation of snow tongue, black horse, apple lacquer, gardenia, and peppermint in a weight ratio of 1: 9 to obtain an extraction solution obtained by immersing at room temperature for 40 days, Mulberry, aloe, each of which was purified by distilled by adding purified water at a weight ratio of 1: 15, and then prepared by extracting the extracted solution, 30 parts by weight of snow extract, 10 parts by weight of black jima extract, 3 parts by weight of apple rock extract, 3 parts by weight of gardenia extract , Peppermint extract 14 parts by weight, mulberry extract 15 parts by weight, aloe extract 20 parts by weight, it is characterized in mixing 15 parts by weight of the health extract, the content of the herbal components are also preferably contained in the same weight ratio.
상기 에탄올 추출물은 모모세포를 자극하여 세포를 부활시키고, 모세혈관을 확장하여 두피의 혈액순환을 원활하게 해주며, 두피에 영양을 공급하는 역할을 맡고, 증류 추출물은 휘발성 정유성분이 두피의 항염ㆍ보습을 담당하는 역할을 함으로써 두피를 건강하게 하여 탈모 방지는 물론 발모를 촉진하며, 또한 생약추출물로 이루어져 부작용이 거의 없다는 장점을 갖는다.The ethanol extract stimulates hair cells to revive cells, expand capillaries to facilitate blood circulation of the scalp, and provide nutrition to the scalp. It plays a role in moisturizing the health of the scalp to prevent hair loss as well as promote hair growth, and also has the advantage that there are almost no side effects made of herbal extracts.
이하, 본 발명을 실시예를 통하여 더욱 자세히 설명한다. 다만 실시예는 본 발명을 예시하기 위한 것이지 본 발명이 실시예에 의해 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples. However, the examples are only for illustrating the present invention and the present invention is not limited by the examples.
실시예 1Example 1
1. 설상화, 흑지마, 사과락, 치자, 박하의 에탄올 추출1. Ethanol Extract of Snow White, Black Horse, Apple Rock, Gardenia, Mint
설상화, 흑지마, 사과락, 치자, 박하를 분말형태로 2 ㎏ 씩 준비한다. 각각의 약재를 에탄올을 18ℓ씩 가하여 상온에서 40일간 침지하여 각각 15ℓ의 추출물을 얻었다.Snowflakes, black horse, apple lacquer, gardenia and mint are prepared in powder form. Each medicinal herb was added 18 L of ethanol and soaked at room temperature for 40 days to obtain 15 L of extract.
2. 뽕나무, 알로에, 건강의 증류 추출2. Mulberry, Aloe, distilled extract of health
뽕나무 껍질, 알로에, 건강을 가늘게 썰어 3㎏ 씩 준비한다. 각각의 약재에 40ℓ의 정제수를 가하여 100℃의 온도에서 2시간 동안 끓인 다음 증류를 시작하여 7시간 동안 20ℓ의 추출물을 얻었다.Thinly cut mulberry bark, aloe, and health 3 kg each. 40 liters of purified water was added to each medicine, boiled at a temperature of 100 ° C. for 2 hours, and distillation was started to obtain 20 liters of extract for 7 hours.
3. 에탄올 추출물과 증류추출물의 혼합3. Mixing of ethanol extract and distillation extract
상기 추출을 통해서 얻은 설상화 추출물 30㏄, 흑지마 추출물 10㏄, 사과락 추출물 3㏄, 치자 추출물 3㏄, 박하 추출물 14㏄, 뽕나무 추출물 14㏄, 알로에 추출물 20㏄, 건강 추출물 14㏄을 혼합하여 100㏄의 발모제를 제조하였다.Snow extract extract 30㏄ obtained through the extraction, black 마 extract 10㏄, apple rock extract 3㏄, gardenia extract 3㏄, peppermint extract 14㏄, mulberry extract 14㏄, aloe extract 20㏄, health extract 14㏄ by mixing 100 발 hair restorer was prepared.
실시예 2Example 2
실시예 1에서, 에탄올 추출을 약제 각각에 대해서 행하는 대신에 설상화, 흑지마, 사과락, 치자, 박하를 분말형태로 골고루 섞어 2 ㎏ 준비하여 에탄올을 18ℓ가하여 동일한 방법으로 추출하여 15ℓ의 추출물을 얻고, 증류 추출을 약제 각각에 대해서 행하는 대신에 뽕나무 껍질, 알로에, 건강을 섞어 3㎏을 준비하여 40ℓ의 정제수로 동일한 방법으로 증류하여 20ℓ의 증류 추출물을 얻은 후, 에탄올 추출물 60㏄와 증류 추출물 40㏄를 혼합하여 100㏄의 발모제를 제조하였다.In Example 1, instead of performing ethanol extraction for each of the drugs, 2 kg of snow-flakes, black horses, apple lacquer, gardenia, and mint were mixed in a powder form, and 2 kg of ethanol was added to extract 18 L of ethanol. Instead of performing distillation extraction for each of the drugs, 3 kg of mulberry bark, aloe and healthy mixture were prepared and distilled in the same way with 40 L of purified water to obtain 20 L of distilled extract. To prepare a 100 ㏄ hair restorer by mixing.
실시예 3Example 3
(임상실험)(Clinical experiment)
현재까지 알려진 탈모의 유형 분류법 중 미녹시딜의 임상실험에서 사용한 바 있는 오가타 분류법(남성형 탈모 분류법), 원형탈모 및 여성형탈모환자에 대해 임상실험을 하였다. 오가타 분류법은 탈모의 형태에 따라 C형, O형, M형, M+O형 으로 크게 분류하고 있다.Among the known types of hair loss classification, Ogata classification (male hair loss classification), alopecia areata, and female alopecia are used in clinical trials of minoxidil. Ogata classification is classified into C, O, M, and M + O types according to the type of hair loss.
임상실험에 참여한 대상은 총 80명으로 이 중 남성 탈모환자 68명, 여성 탈모환자 12명으로 구성되었으며, 각 유형별로 무작위 선정을 통해 치료군과 대조군으로 구성하여 40명은 치료군, 40명은 대조군으로 구분하였다. 상기 치료군에게는 실시예 1의 발모제를, 대조군에게는 본 발명의 유효성분이 함유되지 않은 위약(가짜약)을 하루에 2번씩 1회에 1~2㏄씩 바르도록 하여 6개월간 실시하였다.이들을 대상으로 한 임상실험의 결과를 표1에 표시하였다.A total of 80 subjects participated in the clinical trials, including 68 male alopecia patients and 12 female alopecia patients. Each group consisted of a treatment group and a control group. . In the treatment group, the hair restorer of Example 1 was applied, and in the control group, a placebo (false medicine) containing no active ingredient of the present invention was applied twice a day, once or twice at once, for 6 months. The results of the clinical trials are shown in Table 1.
[표1]Table 1
상기 결과를 고찰해 볼 때 6개월 후 치료군에서는 80%의 발모율 및 47%의 모발수 증가율을 보였고, 대조군에서는 20%의 발모율 및 -4%의 모발수 증가율을 보였다. 이 실험에서 발모가 되었다는 것은 가로 0.5㎝, 세로 0.4㎝의 직사각형내에 있는 모발의 수를 표본조사하여 사용전의 모발의 수보다 사용 후의 모발의 수가 더 많아졌다는 것을 말한다.Considering the results, after 6 months, the treatment group showed 80% hair growth rate and 47% hair growth rate, and the control group showed 20% hair growth rate and -4% hair growth rate. In this experiment, hair growth means that the number of hairs in the rectangle 0.5cm long and 0.4cm long is sampled and the number of hairs after use is greater than the number of hairs before use.
상기 결과에서 보듯이 80명의 환자들에 대한 임상실험은 본 발명 발모제 조성물이 모발의 발모에 매우 효과적이다는 것을 보여주고, 탈모의 모든 유형에 모두 효과가 있다는 것을 보여준다.As shown in the above results, clinical trials on 80 patients show that the hair regrowth composition of the present invention is very effective for hair regrowth, and that it is effective for all types of hair loss.
본 발명의 조성물은 상기한 바와 같이 모모세포를 자극하여 세포를 부활시키고, 모세혈관을 확장하여 두피의 혈액순환을 원활하게 해주며, 두피에 영양을 공급해 주며, 두피의 항염ㆍ보습을 담당하는 역할을 함으로써 두피를 건강하게 하여 탈모 방지는 물론 발모를 촉진하며, 또한 생약추출물로 이루어져 부작용이 거의 없다는 장점을 갖는다.As described above, the composition of the present invention stimulates hair cells to revive cells, expand capillaries to facilitate blood circulation of the scalp, provide nutrition to the scalp, and play a role in anti-inflammatory and moisturizing the scalp. By making the scalp healthy by preventing hair loss as well as promoting hair growth, it also has the advantage of being made up of herbal extracts with little side effects.
Claims (2)
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| JP2019218306A (en) * | 2018-06-20 | 2019-12-26 | 日本メナード化粧品株式会社 | Zinc transporter expression promoter |
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