KR20030009453A - 저장 안정성이 개선된 약제학적 제형용 피복제 및 결합제, 이의 제조방법 및 이를 포함하는 약제학적 제형 - Google Patents
저장 안정성이 개선된 약제학적 제형용 피복제 및 결합제, 이의 제조방법 및 이를 포함하는 약제학적 제형 Download PDFInfo
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Abstract
Description
실시예 번호 | 성분(b)[공중합체를 기준으로 한 %] | 성분(c)[공중합체를 기준으로 한 %] | 분산 온도 | 분산 시간(h) | 분산 완료 여부 | 건조 필름의 특성 | 수증기 투과율[g/m2/d] |
1 | Na 라우릴 설페이트7 | 라우르산15 | RT | 약 3 | 완료 | 유연하고 투명함 | 324 |
2 | Na 라우릴 설페이트7 | 미리스트산15 | RT | 약 4 | 완료 | 유연하고 약간 혼탁함 | 324 |
3 | Na 라우릴 설페이트7 | 팔미트산15 | RT | 약 6 | 완료 | 유연하고 약간 혼탁함 | 168 |
4 | Na 라우릴 설페이트7 | 스테아르산15 | RT | 약 6 | 완료 | 유연하고 약간 혼탁함 | 179 |
5 | Na 라우릴 설페이트7 | 스테아르산20 | RT | 약 6 | 완료 | 유연하고 약간 혼탁함 | 213 |
6 | Na 라우릴 설페이트7 | 스테아르산30 | RT | 약 5 | 완료 | 유연하고 약간 혼탁함 | 289 |
7 | Na 라우릴 설페이트7 | 스테아르산30 | RT 내지 73℃ | 약 4 | 완료 | 유연하고 약간 혼탁함 | 186 |
8 | Na 라우릴 설페이트10 | 스테아르산10 | RT | 약 6 | 완료 | 유연하고 약간 혼탁함 | 125 |
9 | Na 라우릴 설페이트10 | 스테아르산15 | RT | 약 6 | 완료 | 취성이고 약간 혼탁함 | 96 |
10 | Na 라우릴 설페이트10 | 라우릴 알콜15 | RT | 약 24 | 완료 | 유연하고 투명함 | 264 |
11 | Na 라우릴 설페이트10 | 라우릴 알콜10 | RT | 약 3 | 완료 | 유연하고 투명함 | 112 |
비교 실시예 | |||||||
12 | Na 라우릴 설페이트7 | 세박산 15 | RT | 약 2 | 완료 | 취성 결정 | 454 |
13 | Na 라우릴 설페이트7 | 베헨산 15 | RT | - | 미완료 | - | - |
선행 기술 | |||||||
14 | Na 라우릴 설페이트7 | 디에틸 세바케이트 15 | 444 | ||||
15 | - | - | 유기 용액으로부터의 오이드라기트 E 12.5 (이소프로판올-아세톤 = 6:4) | 336 |
수행 번호 | 수행하는 실험의 조성물 번호 | 이형제(Copo를 기준으로 한 %) | Copo의 mg/cm2 | 붕해 시간(분) | 맛 차단 | |
MS | H2O | |||||
16 | 4 | 안료42 | 2 | 2.1 | 5.3 | > 8분 |
17 | 4 | 탈크50 | 24 | 1.31.7 | 3.67.3 | n.d.n.d. |
18 | 14 | Mg 스테아레이트35 | 24 | 1.72 | 17.221.5 | n.d.n.d. |
19 | 8 | Mg 스테아레이트 15안료 15 | 2 | 1.2 | 2.2 | > 6분 |
20 | 15 | 탈크50 | 24 | 1.11.7 | >60>60 | n.d.n.d. |
21 | 4 | Mg 스테아레이트35 | 24 | 1.71.97 | 3.96.4 | n.d.n.d. |
Copo = 공중합체붕해 시간은 유럽 약전의 방법에 따라 측정한다. |
조성 | 흡수율(%) | |||||
1시간 후 | 2시간 후 | 4시간 후 | 6시간 후 | 10시간 후 | 24시간 후 | |
실시예 20에 따름 | 0.48 | 1.07 | 2.16 | 3.04 | 4.80 | 9.06 |
실시예 18에 따름 | 0.67 | 1.62 | 2.71 | 3.79 | 5.93 | 11.19 |
실시예 21에 따름 | 0.34 | 0.69 | 1.36 | 1.92 | 3.11 | 6.55 |
비교 값:HPMC | 2.68 | 5.31 | 9.46 | 12.30 | 14.80 | 15.10 |
비교 값:실리카 겔 정제(피복되지 않음) | 7.71 | 11.94 | 14.61 | 15.10 | 15.16 | 15.64 |
흡수율은 중량 분석법으로 측정한다. |
Claims (9)
- 유리 라디칼 중합된 아크릴산 또는 메타크릴산의 C1내지 C4-에스테르와 관능성 4급 암모늄 그룹을 함유하는 추가의 (메트)아크릴레이트 단량체로 이루어지고, 평균 입자 크기가 1 내지 40㎛인 분말 형태로 존재하는 공중합체(a),HLB가 14 이상인 유화제(b) 3 내지 15중량%(성분(a)을 기준으로 함) 및C12내지 C18-모노카복실산 또는 C12내지 C18-하이드록실 화합물(c) 5 내지 50중량%(성분(a)을 기준으로 함)로 필수적으로 이루어진, 경구용 또는 피부용 약제학적 제형을 제조하기 위한 피복제 및 결합제의 제조방법으로서,성분(a), 성분(b) 및 성분(c)을, 물을 첨가하거나 첨가하지 않고, 경우에 따라, 약제학적 활성 화합물 및 추가의 통상적인 첨가제를 가하여 서로 블렌딩 또는 혼합하고,당해 혼합물을 용융, 캐스팅, 스프레딩, 분무 또는 과립화시켜 피복제 및 결합제를 제조하는 방법.
- 제1항에 있어서, 이형제가, 필름 피복 층이 아닌 최종 층(non-film-coating final layer)으로서 피복제 및 결합제에 도포됨을 특징으로 하는 방법.
- 제1항에 있어서, 안료가, 필름 피복 층이 아닌 최종 층으로서 피복제 및 결합제에 도포됨을 특징으로 하는 방법.
- 제1항 내지 제3항 중의 어느 한 항에 따라 제조할 수 있는, 약제학적 제형용 피복제 및 결합제.
- 제4항에 따르는 피복제 및 결합제와 약제학적 활성 화합물을 포함하는 약제학적 제형.
- 제5항에 있어서, 진통제, 항류마티스제, 위궤양 치료제, 항생제, 저혈압 치료제, 항우울제, 갑상선 치료제, 항파킨슨병제, 불안 치료제 및 신경 이완제로 이루어진 활성 화합물 부류로부터 선택된 수분 민감성 약제학적 활성 화합물이 포함됨을 특징으로 하는 약제학적 제형.
- 제6항에 있어서, 존재하는 수분 민감성 약제학적 활성 화합물이 아세틸살리실산, 카베녹솔론, 세팔로틴, 에피네프린, 이미프라민, 요오드화칼륨, 케토프로펜, 레보도파, 니트라제팜, 니트로프루시드, 옥시테트라사이클린 HCl, 프로메타진, 오메프라졸 또는 다른 벤즈이미다졸 유도체, 또는 스트렙토마이신임을 특징으로 하는 약제학적 제형.
- 활성 화합물을 함유하는 약제학적 조성물용 수분 차단 피막으로서의 제4항에따르는 피복제 및 결합제의 용도.
- 활성 화합물을 함유하는 약제학적 조성물용 맛 차단 피막으로서의 제4항에 따르는 피복제 및 결합제의 용도.
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PCT/EP2001/002018 WO2002067906A1 (de) | 2001-02-27 | 2001-02-27 | Überzugs- und bindemittel für arzneimittelformulierungen mit verbesserter lagerstabilität |
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US7303763B2 (en) * | 2001-02-12 | 2007-12-04 | Watson Laboratories, Inc. | Compositions for conjugated estrogens and associated methods |
DE10149674A1 (de) * | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
US20060159743A1 (en) * | 2001-10-25 | 2006-07-20 | Depomed, Inc. | Methods of treating non-nociceptive pain states with gastric retentive gabapentin |
US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
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CN1419445A (zh) | 2003-05-21 |
BRPI0110321B1 (pt) | 2017-12-19 |
ATE305774T1 (de) | 2005-10-15 |
DE50107641D1 (de) | 2005-11-10 |
HK1054195B (zh) | 2005-09-09 |
ES2248291T3 (es) | 2006-03-16 |
HUP0300388A2 (hu) | 2003-06-28 |
IL151151A0 (en) | 2003-04-10 |
HU229344B1 (en) | 2013-11-28 |
BG65879B1 (bg) | 2010-04-30 |
WO2002067906A1 (de) | 2002-09-06 |
HK1054195A1 (en) | 2003-11-21 |
SK13712002A3 (sk) | 2004-02-03 |
JP4938204B2 (ja) | 2012-05-23 |
CA2403831A1 (en) | 2002-09-20 |
JP2004518750A (ja) | 2004-06-24 |
MX229421B (es) | 2005-07-25 |
CA2403831C (en) | 2009-11-24 |
KR100510356B1 (ko) | 2005-08-24 |
IN2002CH01723A (ko) | 2005-02-11 |
HUP0300388A3 (en) | 2005-03-29 |
BRPI0110321B8 (pt) | 2021-05-25 |
PL356961A1 (en) | 2004-07-12 |
US20030064036A1 (en) | 2003-04-03 |
CN1192767C (zh) | 2005-03-16 |
IL151151A (en) | 2008-03-20 |
BG107148A (bg) | 2003-07-31 |
BR0110321A (pt) | 2003-01-07 |
PL200270B1 (pl) | 2008-12-31 |
MXPA02010382A (es) | 2004-01-28 |
US7160558B2 (en) | 2007-01-09 |
EP1368007A1 (de) | 2003-12-10 |
EP1368007B1 (de) | 2005-10-05 |
SK288049B6 (sk) | 2013-03-01 |
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