KR20010003063A - 미녹시딜 함유 외용 에멀젼 조성물 - Google Patents
미녹시딜 함유 외용 에멀젼 조성물 Download PDFInfo
- Publication number
- KR20010003063A KR20010003063A KR1019990023201A KR19990023201A KR20010003063A KR 20010003063 A KR20010003063 A KR 20010003063A KR 1019990023201 A KR1019990023201 A KR 1019990023201A KR 19990023201 A KR19990023201 A KR 19990023201A KR 20010003063 A KR20010003063 A KR 20010003063A
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- minoxidil
- fatty acid
- oil
- surfactants
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Q6h(누적 투과량 : ㎍/㎠) | 투과율(Jss)(㎍/㎠/hr) | ||||
1 hr | 2 hr | 4 hr | 6 hr | ||
실시예 1 | 249.8(±7.2) | 1020.0(±91.1) | 2037.8(±272.1) | 3135.9(±105.6) | 575.2 |
실시예 5 | 16.8(±5.4) | 107.0(±46.9) | 349.5(±92.1) | 587.5(±128.9) | 114.1 |
비교예 1 | 1.1(±0.4) | 12.7(±6.2) | 110.0(±44.1) | 326.1(±70.8) | 65.2 |
로게인 2% | 5.1(±2.6) | 11.0(±3.5) | 34.0(±14.0) | 65.7(±38.3) | 12.1 |
마이녹실 5% | 6.4(±1.1) | 14.6(±1.2) | 32.1(±4.4) | 37.5(±6.8) | 6.2 |
Claims (5)
- 활성 성분으로서 미녹시딜과 그 유도체 및 그의 염; 공계면활성제인 유기용제; 계면활성제; 및 오일을 포함하는, 미녹시딜 함유 외용 에멀젼 조성물.
- 제 1 항에 있어서,조성물의 총량을 기준으로 하여 상기 미녹시딜 1 내지 10 w/v%, 공계면활성제인 유기용제 10 내지 90 w/v%, 계면활성제 2 내지 30 w/v% 및 오일 1 내지 30 w/v%를 포함하는 것을 특징으로 하는 조성물.
- 제 1 항 또는 제 2 항에 있어서,상기 공계면활성제가 1,2-프로필렌 글리콜, 벤질알코올, 에탄올, 이소프로필 알콜, 트랜스큐톨(transcutol: 디에틸렌글리콜 모노에틸에테르), 디메틸이소소르비드, N-메틸-2-피롤리돈 또는 프로필렌카보네이트인 것을 특징으로 하는 조성물.
- 제 1 항 또는 제 2 항에 있어서,상기 계면활성제가 천연 또는 수소화 식물성 오일과 에틸렌글리콜의 반응 생성물, 폴리옥시에틸렌-소르비탄-지방산 에스테르, 폴리옥시에틸렌 지방산 에스테르, 폴리옥시에틸렌-폴리옥시프로필렌 블록 공중합체, 디옥틸설포숙신산 나트륨, 라우릴 설포산 나트륨, 인지질, 프로필렌 글리콜 모노 또는 디-지방산 에스테르, 천연 식물성 오일 트리글리세라이드와 폴리알킬렌 폴리올의 트랜스-에스테르화 반응 생성물 또는 소르비탄 지방산 에스테르인 것을 특징으로 하는 조성물.
- 제 1 항 또는 제 2 항에 있어서,상기 오일 성분이 중급 지방산 트리글리세라이드, 지방산 모노글리세라이드, 유리지방산 또는 천연 식물성 오일인 것을 특징으로 하는 조성물.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990023201A KR100352088B1 (ko) | 1999-06-21 | 1999-06-21 | 미녹시딜 함유 외용 에멀젼 조성물 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990023201A KR100352088B1 (ko) | 1999-06-21 | 1999-06-21 | 미녹시딜 함유 외용 에멀젼 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010003063A true KR20010003063A (ko) | 2001-01-15 |
KR100352088B1 KR100352088B1 (ko) | 2002-09-12 |
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KR1019990023201A KR100352088B1 (ko) | 1999-06-21 | 1999-06-21 | 미녹시딜 함유 외용 에멀젼 조성물 |
Country Status (1)
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KR (1) | KR100352088B1 (ko) |
Cited By (19)
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KR20030021707A (ko) * | 2001-09-07 | 2003-03-15 | 주식회사 엘지생활건강 | 미녹시딜을 함유한 o/o/w 다중 에멀젼 및 이의 제조방법 |
WO2003055454A1 (en) * | 2001-12-21 | 2003-07-10 | Ponsus Pharma Ab | New composition |
WO2005067873A1 (en) * | 2003-12-22 | 2005-07-28 | Regrowth, Llc | Topical solutions comprising high concentrations of piperidinopyrimidine derivatives and methods of use thereof |
US9622947B2 (en) | 2002-10-25 | 2017-04-18 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9636405B2 (en) | 2003-08-04 | 2017-05-02 | Foamix Pharmaceuticals Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
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US9713643B2 (en) | 2002-10-25 | 2017-07-25 | Foamix Pharmaceuticals Ltd. | Foamable carriers |
US9795564B2 (en) | 2007-12-07 | 2017-10-24 | Foamix Pharmaceuticals Ltd. | Oil-based foamable carriers and formulations |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
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US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
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Families Citing this family (1)
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---|---|---|---|---|
WO2021201310A1 (ko) | 2020-03-30 | 2021-10-07 | 현대바이오사이언스 주식회사 | 비타민과 덱스판테놀이 봉입된 에토좀 조성물 및 이의 제조방법 |
-
1999
- 1999-06-21 KR KR1019990023201A patent/KR100352088B1/ko not_active IP Right Cessation
Cited By (44)
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KR20030021707A (ko) * | 2001-09-07 | 2003-03-15 | 주식회사 엘지생활건강 | 미녹시딜을 함유한 o/o/w 다중 에멀젼 및 이의 제조방법 |
WO2003055454A1 (en) * | 2001-12-21 | 2003-07-10 | Ponsus Pharma Ab | New composition |
US10821077B2 (en) | 2002-10-25 | 2020-11-03 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US11033491B2 (en) | 2002-10-25 | 2021-06-15 | Vyne Therapeutics Inc. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US9622947B2 (en) | 2002-10-25 | 2017-04-18 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9713643B2 (en) | 2002-10-25 | 2017-07-25 | Foamix Pharmaceuticals Ltd. | Foamable carriers |
US10322085B2 (en) | 2002-10-25 | 2019-06-18 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US9636405B2 (en) | 2003-08-04 | 2017-05-02 | Foamix Pharmaceuticals Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
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US9682021B2 (en) | 2006-11-14 | 2017-06-20 | Foamix Pharmaceuticals Ltd. | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
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US10946101B2 (en) | 2009-10-02 | 2021-03-16 | Vyne Therapeutics Inc. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
US10967063B2 (en) | 2009-10-02 | 2021-04-06 | Vyne Therapeutics Inc. | Surfactant-free, water-free formable composition and breakable foams and their uses |
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US10086080B2 (en) | 2009-10-02 | 2018-10-02 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
US10849847B2 (en) | 2016-09-08 | 2020-12-01 | Foamix Pharamaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
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US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
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Also Published As
Publication number | Publication date |
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KR100352088B1 (ko) | 2002-09-12 |
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