KR102184823B1 - Antioxidant composition containing blackcurrant, lingonberry and sea buckthorn extract - Google Patents
Antioxidant composition containing blackcurrant, lingonberry and sea buckthorn extract Download PDFInfo
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- KR102184823B1 KR102184823B1 KR1020200087321A KR20200087321A KR102184823B1 KR 102184823 B1 KR102184823 B1 KR 102184823B1 KR 1020200087321 A KR1020200087321 A KR 1020200087321A KR 20200087321 A KR20200087321 A KR 20200087321A KR 102184823 B1 KR102184823 B1 KR 102184823B1
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- extract
- lingonberry
- antioxidant
- blackcurrant
- antioxidant composition
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Abstract
Description
본 발명은 블랙커런트, 링곤베리 및 씨벅손 추출물을 포함하는 항산화 조성물에 관한 것으로, 보다 상세하게는, 우수한 항산화 및 항염증 효과를 나타내어 면역기능을 강화시킬 수 있고, 체내 콜레스테롤 및 중성지방을 배출시킴으로써 다이어트 효과를 나타낼 수 있으며, 이에 따라 건강기능식품으로서 활용될 수 있는, 블랙커런트, 링곤베리 및 씨벅손 추출물을 포함하는 항산화 조성물에 관한 것이다.The present invention relates to an antioxidant composition comprising black currant, lingonberry and seabuckthorn extract, and more particularly, it can enhance immune function by showing excellent antioxidant and anti-inflammatory effects, and by releasing cholesterol and triglycerides in the body. It relates to an antioxidant composition comprising black currant, lingonberry and seabuckthorn extract, which can exhibit a diet effect, and thus can be used as a health functional food.
일반적으로, 생명체는 대부분 공기 중의 산소를 산화시켜 얻어지는 에너지를 이용하여 생명을 유지한다. 상기와 같이 산소가 요구되는 대사과정에서, 불가피하게 세포를 파괴시키는 독성 물질들을 부산물로 생성시키는데 이것을 활성 산소라고 한다. 상기 활성 산소는 DNA, 지질, 단백질에 손상을 주어 세포의 정상적인 기능 유지를 어렵게 할 수 있다. In general, most living organisms maintain life by using energy obtained by oxidizing oxygen in the air. In the metabolic process that requires oxygen as described above, toxic substances that inevitably destroy cells are produced as by-products, which are called active oxygen. The active oxygen may damage DNA, lipids, and proteins, making it difficult to maintain normal functions of cells.
활성 산소의 증가는 산화적 스트레스(oxidative stress)를 유발하여 세포에 손상을 입히며, 그 결과 당뇨, 심혈관계 질환, 신경계 질환 및 DNA 손상에 따른 암(cancer)을 유발하고 노화를 촉진시키는 등 다양한 형태의 병리적 이상을 초래한다. 또한, 활성 산소종(reactive oxygen species, ROS)이 파골세포(osteoclast) 생성의 신호전달에 관여하여 파골세포의 생성을 촉진한다는 연구 결과를 고려해볼 때, 활성 산소로부터 우리 몸을 보호하여야 하며 활성 산소를 증가시키는 요인을 제거하고 항산화 물질이 많이 함유된 식품을 충분히 섭취해야 한다. Increased free radicals induce oxidative stress and damage cells, resulting in diabetes, cardiovascular disease, nervous system disease, and cancer due to DNA damage, promoting aging, etc. Causes pathological abnormalities of the. In addition, considering the results of research showing that reactive oxygen species (ROS) is involved in the signal transmission of osteoclast production and promotes the production of osteoclasts, it is necessary to protect our body from free radicals. Eliminate the factors that increase it and eat enough foods high in antioxidants.
하지만, 활성 산소를 증가시키는 요인을 제거하고 항산화 물질이 많이 함유된 식품을 일상에서 항상 섭취하기 쉽지 않다. 그래서, 쉽게 접할 수 있는 식품에 항산화 활성을 지닌 천연 성분의 재료를 첨가할 경우, 천연 항산화제를 꾸준히 섭취하는 것으로서 인체의 건강 증진에 있어 긍정적인 효과를 나타낼 것이라 사료된다.However, it is not easy to always consume foods containing a lot of antioxidants in daily life by removing factors that increase free radicals. Therefore, it is believed that when ingredients of natural ingredients with antioxidant activity are added to foods that are easily accessible, they will show a positive effect in promoting human health by steadily ingesting natural antioxidants.
근래에 들어, 항산화 활성을 나타내는 다양한 과채류에 대한 연구들이 많이 진행되고 있으며, 이를 이용한 건강기능식품에 대한 수요도 꾸준히 증가하는 추세이다.In recent years, a lot of studies on various fruits and vegetables showing antioxidant activity are in progress, and the demand for health functional foods using them is also steadily increasing.
그러나, 이러한 건강기능식품은 대부분 특정 과채류의 성분을 단일 성분으로 포함한 것일 뿐, 항산화 효능이 인정되는 여러 성분을 혼합하여 항산화 활성을 더욱 증진시킬 수 있는 조성물에 대한 연구는 계속 진행 중에 있다.However, most of these health functional foods contain only the ingredients of a specific fruit or vegetable as a single ingredient, and research on a composition that can further enhance antioxidant activity by mixing several ingredients recognized for antioxidant efficacy is ongoing.
따라서 상기와 같은 현대인들의 건강 관련 니즈를 충족시켜 줄 수 있는 항산화 조성물, 또는 항산화 건강기능식품 조성물에 대한 개발 필요성이 증가되고 있다.Accordingly, there is an increasing need to develop an antioxidant composition or an antioxidant health functional food composition that can meet the health-related needs of modern people as described above.
본 발명은 상기와 같은 문제점을 해결하기 위한 것으로서, 블랙커런트, 링곤베리 및 씨벅손 추출물을 포함함으로써, 우수한 항산화 및 항염증 효과를 나타내어 건강기능식품으로서 활용될 수 있는, 항산화 조성물을 제공하고자 한다.The present invention is to solve the above problems, by including black currant, lingonberry and sea buckthorn extract, it is intended to provide an antioxidant composition that can be used as a health functional food by showing excellent antioxidant and anti-inflammatory effects.
본 발명의 상기 및 다른 목적과 이점은 바람직한 실시예를 설명한 하기의 설명으로부터 분명해질 것이다.The above and other objects and advantages of the present invention will become apparent from the following description of preferred embodiments.
상기 목적은, 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물을 포함하는 항산화 조성물에 의해 달성될 수 있다.The above object can be achieved by an antioxidant composition comprising blackcurrant extract, lingonberry extract, and seabuckthorn extract.
구체적으로, 상기 항산화 조성물의 농도는 0.25 내지 1 mg/ml로 포함되는 것을 특징으로 할 수 있다.Specifically, the concentration of the antioxidant composition may be characterized in that contained in 0.25 to 1 mg / ml.
구체적으로, 상기 항산화 조성물은, 건강기능식품 조성물, 화장료 조성물, 또는 약학적 조성물일 수 있다. 바람직하게, 상기 항산화 조성물이 건강기능식품 조성물일 경우, 식품학적으로 허용되는 첨가물, 풍미제, 착색제, 충진제 등을 추가로 포함할 수 있다.Specifically, the antioxidant composition may be a health functional food composition, a cosmetic composition, or a pharmaceutical composition. Preferably, when the antioxidant composition is a health functional food composition, it may additionally include food additives, flavors, colorants, fillers, and the like.
본 발명에 따른 항산화 조성물은, 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물을 포함하여 제조된 것으로서, 항산화 활성 및 염증 억제 활성을 나타내어 면역 기능을 강화시킬 수 있는 효과를 갖는다.The antioxidant composition according to the present invention is prepared including blackcurrant extract, lingonberry extract, and seabuckthorn extract, and has an effect of enhancing immune function by exhibiting antioxidant activity and anti-inflammatory activity.
또한, 본 발명에 따른 항산화 조성물은, 체내 콜레스테롤 및 중성지방을 배출시킴으로써 체지방 감소에 도움을 주어 다이어트 효과를 나타낼 수 있으며, 그에 따라 건강기능식품으로서도 활용될 수 있다는 장점을 갖는다.In addition, the antioxidant composition according to the present invention has the advantage of being able to exhibit a diet effect by helping to reduce body fat by releasing cholesterol and triglycerides in the body, and thus can be utilized as a health functional food.
다만, 본 발명의 효과들은 이상에서 언급한 효과로 제한되지 않으며, 언급되지 않은 또 다른 효과들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.However, the effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.
도 1 내지 도 4는, 본 발명의 일 실시예에 따른 항산화 조성물의 농도별 DPPH 라디칼 소거 활성을 나타낸 그래프이다.1 to 4 are graphs showing DPPH radical scavenging activity by concentration of an antioxidant composition according to an embodiment of the present invention.
이하, 본 발명의 실시예와 도면을 참조하여 본 발명을 상세히 설명한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위해 예시적으로 제시한 것일 뿐, 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가지는 자에 있어서 자명할 것이다.Hereinafter, the present invention will be described in detail with reference to embodiments of the present invention and drawings. These examples are only illustratively presented to illustrate the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples. .
또한, 달리 정의하지 않는 한, 본 명세서에서 사용되는 모든 기술적 및 과학적 용어는 본 발명이 속하는 기술 분야의 숙련자에 의해 통상적으로 이해되는 바와 동일한 의미를 가지며, 상충되는 경우에는, 정의를 포함하는 본 명세서의 기재가 우선할 것이다.In addition, unless otherwise defined, all technical and scientific terms used in the present specification have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs, and in case of conflict, the present specification including definitions The description of will take precedence.
도면에서 제안된 발명을 명확하게 설명하기 위해서 설명과 관계없는 부분은 생략하였으며, 명세서 전체를 통하여 유사한 부분에 대해서는 유사한 도면 부호를 붙였다. 그리고, 어떤 부분이 어떤 구성 요소를 "포함"한다고 할 때, 이는 특별히 반대되는 기재가 없는 한 다른 구성 요소를 제외하는 것이 아니라 다른 구성 요소를 더 포함할 수 있는 것을 의미한다. 또한, 명세서에서 기술한 "부"란, 특정 기능을 수행하는 하나의 단위 또는 블록을 의미한다.In order to clearly describe the invention proposed in the drawings, parts not related to the description are omitted, and similar reference numerals are attached to similar parts throughout the specification. And, when a part "includes" a certain component, it means that other components may be further included rather than excluding other components unless specifically stated to the contrary. In addition, "unit" described in the specification means one unit or block that performs a specific function.
각 단계들에 있어 식별부호(제1, 제2, 등)는 설명의 편의를 위하여 사용되는 것으로 식별부호는 각 단계들의 순서를 설명하는 것이 아니며, 각 단계들은 문맥상 명백하게 특정 순서를 기재하지 않는 이상 명기된 순서와 다르게 실시될 수 있다. 즉, 각 단계들은 명기된 순서와 동일하게 실시될 수도 있고 실질적으로 동시에 실시될 수도 있으며 반대의 순서대로 실시될 수도 있다.In each step, the identification code (first, second, etc.) is used for convenience of description, and the identification code does not describe the order of each step, and each step does not clearly describe a specific sequence in the context. It may be implemented differently from the order specified above. That is, each of the steps may be performed in the same order as the specified order, may be performed substantially simultaneously, or may be performed in the reverse order.
이하, 첨부된 도면을 참조하여 본원의 구현예 및 실시예를 상세히 설명한다. 그러나, 본원의 이러한 구현예 및 실시예와 도면에 제한되지 않을 수 있다.Hereinafter, embodiments and examples of the present application will be described in detail with reference to the accompanying drawings. However, it may not be limited to these embodiments and examples and drawings of the present application.
본원의 일 측면은, 블랙커런트 추출물(black currant extracts), 링곤베리 추출물(lingonberry extracts), 및 씨벅손 추출물(sea buckthorn extracts)을 포함하는 항산화 조성물을 제공한다.One aspect of the present application provides an antioxidant composition comprising black currant extracts, lingonberry extracts, and sea buckthorn extracts.
일 실시예에 있어서, 상기 블랙커런트 추출물은 장미목 범의귀과의 낙엽관목인 커런트의 열매로부터 추출된 것을 의미하며, 즙이 많고 신맛이 강한 특징을 갖는다. 상기 블랙커런트 열매는 특별한 원산지의 것으로 국한되지 않으며, 필요 시 세척 등의 전처리 과정을 수행한 후 사용될 수 있다.In one embodiment, the blackcurrant extract means that the extract is extracted from the fruit of the currant, a deciduous shrub of the family Rosaceae, and has a strong sour taste. The blackcurrant fruit is not limited to those of a particular origin, and may be used after performing a pretreatment process such as washing, if necessary.
일 실시예에 있어서, 상기 블랙커런트 추출물은 블랙커런트 열매를 에탄올 수용액을 이용하여 질소를 퍼징하면서 추출된 것일 수 있다. 구체적으로, 상기 블랙커런트 추출물은 추출 용매로서 약 30% 내지 약 60% 함량(v/v)의 에탄올을 포함하는 에탄올 수용액을 사용하여 용매순환방법에 의해 추출하되, 추출 시 질소를 퍼징하면서 추출된 것일 수 있다. 만약, 상기 에탄올 수용액의 에탄올 함량이 약 30% 미만일 경우 추출 수율이 하락할 수 있으며, 약 60%를 초과할 경우 유해 성분이 함께 추출될 수 있다.In one embodiment, the blackcurrant extract may be extracted while purging blackcurrant fruit with nitrogen using an aqueous ethanol solution. Specifically, the blackcurrant extract is extracted by a solvent circulation method using an aqueous ethanol solution containing ethanol of about 30% to about 60% content (v/v) as an extraction solvent, but extracted while purging nitrogen during extraction. Can be. If the ethanol content of the aqueous ethanol solution is less than about 30%, the extraction yield may decrease, and if it exceeds about 60%, harmful components may be extracted together.
일 실시예에 있어서, 상기 추출은 약 37℃ 내지 약 60℃의 온도 범위에서 수행되는 것일 수 있다. 만약, 상기 추출이 약 37℃ 미만에서 수행될 경우 추출 수율이 하락할 수 있으며, 약 60℃를 초과할 경우 블랙커런트 열매에 포함된 여러 생리활성물질들이 파괴될 수 있다.In one embodiment, the extraction may be performed at a temperature range of about 37 ℃ to about 60 ℃. If the extraction is performed at less than about 37°C, the extraction yield may decrease, and when it exceeds about 60°C, various physiologically active substances contained in the blackcurrant fruit may be destroyed.
일 실시예에 있어서, 상기 블랙커런트 추출물은 안토시아닌, 감마리놀렌산, 알파리놀렌산, 및 스테라리돈산을 풍부하게 포함함으로써, 항산화 효과, 면역력 강화 효과, 및 혈행개선 효과를 나타낼 수 있다. 구체적으로, 상기 블랙커런트 추출물에 포함된 안토시아닌은 단백질 로돕신의 재생을 촉진시켜 안구와 뇌의 피로를 개선시키며, 항염증 효과로 인해 관절염으로 인해 발생하는 통증을 완화시킬 수 있다. 또한, 상기 블랙커런트 추출물에 포함된 감마리놀렌산, 알파리놀렌산, 및 스테라리돈산 등의 지방산은 심장과 뇌로 가는 혈류를 향상시켜 동맥경화 등의 심혈관계 질환 및 뇌 질환을 예방할 수 있다. In one embodiment, the blackcurrant extract may exhibit an antioxidant effect, an immunity strengthening effect, and a blood circulation improvement effect by abundantly containing anthocyanin, gammalinolenic acid, alpha linolenic acid, and steraridonic acid. Specifically, the anthocyanin contained in the blackcurrant extract promotes the regeneration of the protein rhodopsin to improve eye and brain fatigue, and can relieve pain caused by arthritis due to its anti-inflammatory effect. In addition, fatty acids such as gamma linolenic acid, alpha linolenic acid, and steraridonic acid contained in the blackcurrant extract can improve blood flow to the heart and brain, thereby preventing cardiovascular diseases such as arteriosclerosis and brain diseases.
일 실시예에 있어서, 상기 링곤베리 추출물은 북유럽의 야생에서 수확되는 베리류의 일종인 링곤베리로부터 추출된 것을 의미한다. 상기 링곤베리는 달콤하면서도 시큼한 맛을 나타내며, 스웨덴에서 식재료로서 주로 사용된다.In one embodiment, the lingonberry extract means extracted from lingonberry, a kind of berries harvested in the wild in Northern Europe. The lingonberry has a sweet and sour taste, and is mainly used as a food ingredient in Sweden.
일 실시예에 있어서, 상기 링곤베리 추출물은 링곤베리를 효소 반응시켜 착즙 및 저온살균하여 수득된 것일 수 있다. 구체적으로, 상기 링곤베리 추출물은 약 -40℃ 내지 -20℃의 온도 범위에서 약 10 시간 내지 약 24 시간 동안 냉각한 링곤베리 열매를 약 20℃ 내지 약 40℃까지 가열한 뒤, 팬자임(panzyme) 효소를 약 100 내지 200 ml/th. 첨가하여 약 1 시간 내지 약 8 시간 동안 효소 반응시킨 후 착즙하여 약 70℃ 내지 약 90℃의 온도 범위에서 약 35 초 동안 저온살균함으로써 수득되는 것일 수 있으나, 이에 제한되지 않는다.In one embodiment, the lingonberry extract may be obtained by enzymatic reaction of lingonberry juice and pasteurization. Specifically, the lingonberry extract is heated to about 20 ℃ to about 40 ℃ lingonberry fruit cooled for about 10 to about 24 hours in a temperature range of about -40 ℃ to -20 ℃, panzyme (panzyme ) Enzyme from about 100 to 200 ml/th. It may be obtained by adding and enzymatic reaction for about 1 hour to about 8 hours, followed by juice and pasteurization for about 35 seconds at a temperature range of about 70° C. to about 90° C., but is not limited thereto.
일 실시예에 있어서, 상기 링곤베리 추출물은 폴리페놀인 레스베라트롤을 포함함으로써, 비타민C의 약 30 배 이상의 항산화력을 나타낼 수 있다. 구체적으로, 상기 링곤베리 추출물은 레스베라트롤을 포함하며, 상기 레스베라트롤은 장수 유전자인 시트루인 단백질 효소를 활성화시켜 세포 노화를 억제하고 대사량을 증대시킬 수 있으며, 이에 따라 항산화 효과, 면역력 향상 효과, 및 다이어트 효과를 나타낼 수 있다.In one embodiment, the lingonberry extract may exhibit about 30 times more antioxidant power than vitamin C by including resveratrol, which is a polyphenol. Specifically, the lingonberry extract contains resveratrol, and the resveratrol can inhibit cellular aging and increase metabolism by activating the enzyme citruin protein enzyme, which is a longevity gene, and thus has an antioxidant effect, an immunity enhancing effect, and a diet effect. Can represent.
일 실시예에 있어서, 상기 씨벅손 추출물은 북아시아와 유럽이 원산지인 밝은 오렌지색의 씨벅손의 열매에서 추출된 것을 의미한다. 상기 씨벅손은 산자나무 또는 시베리아 파인애플이라고도 불리우며, 씨벅손의 열매는 밝은 오렌지색으로 시큼한 맛을 나타내어 식재료 또는 스킨케어 제품으로 사용될 수 있다.In one embodiment, the sea buckthorn extract means extracted from the fruit of a bright orange sea buckthorn, which is native to North Asia and Europe. The sea buckthorn is also called a birch tree or a Siberian pineapple, and the fruit of the sea buckthorn has a bright orange color and has a sour taste, so it can be used as a food ingredient or a skin care product.
일 실시예에 있어서, 상기 씨벅손 추출물은 씨벅손으로부터 채취된 열매를 착즙 및 저온살균하여 수득된 것일 수 있다. 구체적으로, 상기 씨벅손 추출물은 약 -40℃ 내지 -20℃의 온도 범위에서 약 10 시간 내지 약 24 시간 동안 냉각한 씨벅손으로부터 채취한 열매를 약 20℃ 내지 약 40℃까지 가열하여 착즙한 뒤, 약 70℃ 내지 약 90℃의 온도 범위에서 약 35 초 동안 저온살균함으로써 수득되는 것일 수 있다. In one embodiment, the sea buckthorn extract may be obtained by juicing and pasteurizing the fruit collected from sea buckthorn. Specifically, the Seabuckthorn extract is juiced by heating the fruit collected from Seabuckson cooled for about 10 to about 24 hours in a temperature range of about -40°C to -20°C to about 20°C to about 40°C. , It may be obtained by pasteurization for about 35 seconds at a temperature range of about 70 ℃ to about 90 ℃.
일 실시예에 있어서, 상기 씨벅손 추출물은 비타민, 플라보노이드, 필수 아미노산, 및 지방산을 포함함으로써, 높은 항산화 및 항염증 효과, 여성질환 예방 효과, 및 다이어트 효과를 나타낼 수 있다. 구체적으로, 상기 씨벅손 추출물은 풍부한 티아민, 리보플라빈, 피리독신 등의 비타민 B, 비타민 A, 비타민 K, 및 비타민 E를 포함함에 따라 피부에 활기를 부여하고 탄력을 주며, 갱년기 및 생리통과 같은 여성질환을 예방할 수 있으며, 주름 및 노화를 방지할 수 있다. 또한, 상기 씨벅손 추출물은 필수 아미노산과 오메가 3, 오메가 6, 오메가 7 등의 지방산을 포함함에 따라 체내 콜레스테롤과 중성지방을 배출시켜 다이어트 효과를 나타낼 수 있다.In one embodiment, the sea buckthorn extract contains vitamins, flavonoids, essential amino acids, and fatty acids, thereby exhibiting a high antioxidant and anti-inflammatory effect, a female disease prevention effect, and a diet effect. Specifically, the sea buckthorn extract contains abundant thiamin, riboflavin, and vitamin B such as pyridoxine, vitamin A, vitamin K, and vitamin E, thereby providing vitality and elasticity to the skin, and for female diseases such as menopause and menstrual pain. It can be prevented, and wrinkles and aging can be prevented. In addition, since the sea buckthorn extract contains essential amino acids and fatty acids such as omega 3, omega 6 and omega 7, it may exhibit a diet effect by releasing cholesterol and triglycerides in the body.
일 실시예에 있어서, 상기 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물은, 약 1 내지 2 : 약 1 내지 2 : 약 1 내지 2 중량비로 포함될 수 있다. 만약, 상기 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물이 상기 중량비와 상이한 범위로 포함될 경우, 상기 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물에 포함된 약리적 효과가 충분히 발휘되지 않거나, 침전물이 발생할 수 있다.In one embodiment, the blackcurrant extract, lingonberry extract, and seabuckthorn extract may be included in a weight ratio of about 1 to 2: about 1 to 2: about 1 to 2 weight ratio. If the blackcurrant extract, lingonberry extract, and seabuckthorn extract are included in a range different from the weight ratio, the pharmacological effect contained in the blackcurrant extract, lingonberry extract, and seabuckthorn extract is not sufficiently exhibited, or a precipitate This can happen.
일 실시예에 있어서, 상기 추출물은 기능성 성분을 포함하는 다양한 형태일 수 있으며, 예를 들어, 분말, 추출액, 또는 착즙액을 포함하는 것일 수 있으나, 이에 제한되지 않는다.In one embodiment, the extract may be in various forms including a functional ingredient, for example, may include a powder, an extract, or a juice, but is not limited thereto.
일 실시예에 있어서, 상기 항산화 조성물의 농도는 약 0.25 내지 약 1 mg/ml 범위일 수 있다. 만약, 상기 항산화 조성물의 농도가 약 0.25 mg/ml 미만일 경우 항산화 효과를 충분히 발휘하지 못할 수 있고, 약 1 mg/ml를 초과할 경우, 침전물이 발생할 수 있다.In one embodiment, the concentration of the antioxidant composition may range from about 0.25 to about 1 mg/ml. If the concentration of the antioxidant composition is less than about 0.25 mg/ml, the antioxidant effect may not be sufficiently exhibited, and if it exceeds about 1 mg/ml, a precipitate may occur.
일 실시예에 있어서, 상기 항산화 조성물은 마늘 추출물을 추가 포함할 수 있다.In one embodiment, the antioxidant composition may further include garlic extract.
일 실시예에 있어서, 상기 마늘 추출물은 마늘을 효소 반응시켜 착즙 및 저온살균하여 수득된 것일 수 있다. 구체적으로, 상기 마늘 추출물은 약 -40℃ 내지 -20℃의 온도 범위에서 약 10 시간 내지 약 24 시간 동안 냉각한 마늘을 약 20℃ 내지 약 40℃까지 가열한 뒤, 스페자임(spezyme) 효소를 약 50 내지 100 ml/th. 첨가하여 약 1 시간 내지 약 6 시간 동안 효소 반응시킨 후 착즙하여 약 70℃ 내지 약 90℃의 온도 범위에서 약 35 초 동안 저온살균함으로써 수득되는 것일 수 있으나, 이에 제한되지 않는다.In one embodiment, the garlic extract may be obtained by juice and pasteurization by enzymatic reaction of garlic. Specifically, the garlic extract is heated to about 20 ℃ to about 40 ℃ cooled garlic for about 10 hours to about 24 hours in a temperature range of about -40 ℃ to -20 ℃, spezyme (spezyme) enzyme About 50 to 100 ml/th. It may be obtained by adding and enzymatic reaction for about 1 hour to about 6 hours, followed by juice and pasteurization for about 35 seconds at a temperature range of about 70° C. to about 90° C., but is not limited thereto.
일 실시예에 있어서, 상기 마늘은 주요 생리활성 성분으로서 알리신 (allicin)을 포함할 수 있다. 구체적으로, 상기 마늘은 분쇄될 때 마늘의 유기황 화합물의 주요성분인 알린 (alliin)이 마늘의 특유의 냄새를 생성하는 효소인 알리네이즈 (alliinase)의 작용으로 알리신으로 전환되는 것일 수 있다.In one embodiment, the garlic may contain allicin as a major physiologically active ingredient. Specifically, when the garlic is pulverized, allin, which is a major component of the organosulfur compound of garlic, may be converted to allicin by the action of allinase, an enzyme that generates a characteristic odor of garlic.
일 실시예에 있어서, 상기 마늘의 주요성분인 알리신은 강력한 항균 작용을 나타내어 세균성 질병을 예방해 면역력을 향상시킬 수 있으며, 체내의 비타민 B6와 결합해 혈소판 응집과 혈액응고를 억제하여 고혈압, 동맥경화, 뇌졸중과 같은 심장 및 뇌 질환을 예방하는 효과를 나타낼 수 있다.In one embodiment, allicin, which is a major component of garlic, exhibits a strong antibacterial action to improve immunity by preventing bacterial diseases, and binds with vitamin B6 in the body to inhibit platelet aggregation and blood coagulation to prevent hypertension, arteriosclerosis, It may be effective in preventing heart and brain diseases such as stroke.
일 실시예에 있어서, 상기 마늘의 주요 생리활성 성분으로서 칼륨을 포함하며, 상기 칼륨은 나트륨 배출에 도움을 주어 다이어트 효과를 나타낼 수 있다.In one embodiment, the garlic contains potassium as a major physiologically active ingredient, and the potassium may help to excrete sodium to exhibit a diet effect.
일 실시예에 있어서, 상기 블랙커런트 추출물 및 마늘 추출물은, 약 1 내지 2 : 약 0.1 내지 1의 중량비로 포함될 수 있다. 만약, 상기 마늘 추출물이 상기 중량비와 상이한 범위로 포함될 경우, 상기 마늘 추출물에 포함된 약리적 효과가 충분히 발휘되지 않거나, 마늘의 강한 향으로 인하여 기호도가 감소할 수 있다.In one embodiment, the blackcurrant extract and garlic extract may be included in a weight ratio of about 1 to 2: about 0.1 to 1. If the garlic extract is included in a range different from the weight ratio, the pharmacological effect contained in the garlic extract may not be sufficiently exhibited, or the preference may be reduced due to the strong flavor of garlic.
일 실시예에 있어서, 상기 항산화 조성물은 아귀 추출물을 추가 포함할 수 있다.In one embodiment, the antioxidant composition may further include an extract of acornfish.
일 실시예에 있어서, 상기 아귀 추출물은 건조한 아귀를 에탄올 수용액을 이용하여 추출하여 수득된 것일 수 있다. 구체적으로, 상기 아귀 추출물은 아귀를 수분량이 10% 이하가 될 때까지 건조한 후, 추출 용매로서 약 40% 내지 약 50% 함량(v/v)의 에탄올을 포함하는 에탄올 수용액을 사용하여 용매순환방법에 의해 약 37℃ 내지 약 60℃의 온도 범위에서 추출하여 수득된 추출액을 약 70℃ 내지 약 90℃의 온도 범위에서 약 35 초 동안 저온살균하여 수득된 것일 수 있다.In one embodiment, the anglerfish extract may be obtained by extracting dried anglerfish using an aqueous ethanol solution. Specifically, the anglerfish extract is a solvent circulation method using an aqueous ethanol solution containing about 40% to about 50% content (v/v) of ethanol as an extraction solvent after drying the anglerfish until the moisture content is 10% or less. The extract obtained by extracting at a temperature range of about 37° C. to about 60° C. may be obtained by pasteurizing for about 35 seconds at a temperature range of about 70° C. to about 90° C.
일 실시예에 있어서, 상기 아귀 추출물은 아미노산의 일종인 타우린을 포함함으로써 피로 회복 효과를 나타낼 수 있으며, 콜레스테롤을 개선시켜 혈행개선효과를 나타낼 수 있다. 또한, 단백질을 고함량으로 포함함으로써 이에 따라 관절염 개선 효과를 함께 나타낼 수 있다.In one embodiment, the extract of Acornfish may exhibit a fatigue recovery effect by containing taurine, which is a kind of amino acid, and may exhibit an effect of improving blood circulation by improving cholesterol. In addition, by including the protein in a high content, the arthritis improvement effect may be exhibited accordingly.
일 실시예에 있어서, 상기 블랙커런트 추출물 및 아귀 추출물은, 약 1 내지 2 : 약 0.1 내지 1의 중량비로 포함될 수 있다. 만약, 상기 아귀 추출물이 상기 중량비와 상이한 범위로 포함될 경우, 상기 아귀 추출물에 포함된 약리적 효과가 충분히 발휘되지 않거나, 침전물이 발생할 수 있다.In one embodiment, the blackcurrant extract and the blackcurrant extract may be included in a weight ratio of about 1 to 2: about 0.1 to 1. If, when the anglerfish extract is included in a range different from the weight ratio, the pharmacological effect contained in the anglerfish extract may not be sufficiently exhibited, or a precipitate may occur.
일 실시예에 있어서, 상기 항산화 조성물은 알로에베라잎즙을 추가 포함할 수 있다. In one embodiment, the antioxidant composition may further include aloe vera leaf juice.
상기 알로에베라잎은 아프리카가 원산지인 백합과의 다년초 알로에베라(Aloe Vera)의 잎의 기부를 잘라 추출된 맑은 수액을 의미하며, 일 실시예에 있어서, 상기 알로에베라는 다당체를 함유함으로써 면역 기능을 강화할 수 있으며, 화상과 관절염을 치료하는 효과를 나타낼 수 있다.The aloe vera leaf refers to a clear sap extracted by cutting off the base of the leaf of the perennial Aloe Vera of the lily family, which is native to Africa, and in one embodiment, the aloe vera contains a polysaccharide, thereby enhancing immune function. It can strengthen, and it can be effective in treating burns and arthritis.
일 실시예에 있어서, 상기 블랙커런트 추출물 및 알로에베라잎즙은, 약 1 내지 2 : 약 0.1 내지 1의 중량비로 포함될 수 있다. 만약, 상기 알로에베라잎즙이 상기 중량비와 상이한 범위로 포함될 경우, 상기 알로에베라잎즙에 포함된 약리적 효과가 충분히 발휘되지 않거나, 침전물이 발생할 수 있다.In one embodiment, the blackcurrant extract and aloe vera leaf juice may be included in a weight ratio of about 1 to 2: about 0.1 to 1. If the aloe vera leaf juice is included in a range different from the weight ratio, the pharmacological effect contained in the aloe vera leaf juice may not be sufficiently exhibited, or a precipitate may occur.
일 실시예에 있어서, 상기 항산화 조성물은, 건강기능식품 조성물, 화장료 조성물, 또는 약학적 조성물일 수 있으며, 바람직하게는 건강기능식품 조성물일 수 있다.In one embodiment, the antioxidant composition may be a health functional food composition, a cosmetic composition, or a pharmaceutical composition, preferably a health functional food composition.
일 실시예에 있어서, 상기 항산화 조성물이 건강기능식품 조성물일 경우, 그 종류는 크게 제한되지 않으며, 예를 들어, 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 또는 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올 음료 및 비타민 복합제 등일 수 있으나, 이에 제한되지 않는다.In one embodiment, when the antioxidant composition is a health functional food composition, the type is not limited, for example, meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, It may be a dairy product including gums or ice cream, various soups, beverages, teas, drinks, alcoholic beverages and vitamin complexes, but is not limited thereto.
일 실시예에 있어서, 상기 항산화 조성물이 건강기능식품 조성물일 경우, 환제, 분말, 과립, 침제, 정제, 캡슐 또는 음료인 형태로 사용할 수 있으며, 통상적인 의미에서의 건강기능식품을 모두 포함하는 것일 수 있다.In one embodiment, when the antioxidant composition is a health functional food composition, it can be used in the form of pills, powders, granules, needles, tablets, capsules, or beverages, and includes all health functional foods in the usual sense. I can.
일 실시예에 있어서, 상기 항산화 조성물이 건강기능식품 조성물일 경우, 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있으나, 이에 제한되지 않는다.In one embodiment, when the antioxidant composition is a health functional food composition, various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and thickening agents (cheese, chocolate, etc.) , Pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like, but are not limited thereto.
이하, 구체적인 실시예와 비교예를 통하여 본 발명의 구성 및 그에 따른 효과를 보다 상세히 설명하고자 한다. 그러나, 본 실시예는 본 발명을 보다 구체적으로 설명하기 위한 것이며, 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.Hereinafter, the configuration of the present invention and effects thereof will be described in more detail through specific examples and comparative examples. However, the present examples are for explaining the present invention more specifically, and the scope of the present invention is not limited to these examples.
[제조예 1: 블랙커런트 추출물 제조][Preparation Example 1: Preparation of black currant extract]
블랙커런트 열매를 채취하여 40℃의 온도에서 50% 함량(v/v)의 에탄올 수용액을 이용해 용매순환방법에 의해 추출하였다. 추출 시, 질소를 지속적으로 퍼징하여 추출하고, 80℃에서 35 초 동안 저온살균하여 블랙커런트 추출물을 수득하였다.The blackcurrant fruit was collected and extracted by a solvent circulation method using an aqueous ethanol solution of 50% content (v/v) at a temperature of 40°C. During extraction, nitrogen was continuously purged for extraction, and pasteurized at 80° C. for 35 seconds to obtain a black currant extract.
[제조예 2: 링곤베리 추출물 제조][Production Example 2: Preparation of lingonberry extract]
링곤베리 열매를 채취하여 -40℃ 내지 -20℃의 온도 범위에서 약 20 시간 동안 냉각하였다. 냉각한 링곤베리 열매를 35℃까지 가열한 뒤, 팬자임(panzyme) 효소를 150 ml/th. 첨가하여 6 시간 동안 효소 반응시켰다. 효소 반응 후, 링곤베리 열매를 착즙하여 70℃에서 35 초 동안 저온살균하여 링곤베리 추출물을 수득하였다.The lingonberry fruit was collected and cooled for about 20 hours at a temperature range of -40°C to -20°C. After heating the cooled lingonberry fruit to 35°C, panzyme enzyme was added to 150 ml/th. Then, the enzyme was reacted for 6 hours. After the enzymatic reaction, the lingonberry fruit was juiced and pasteurized at 70° C. for 35 seconds to obtain a lingonberry extract.
[제조예 3: 씨벅손 추출물 제조][Production Example 3: Preparation of Sea Buckson Extract]
씨벅손 열매를 채취하여 -40℃ 내지 -20℃의 온도 범위에서 약 20 시간 동안 냉각하였다. 냉각한 씨벅손 열매를 35℃까지 가열한 뒤, 착즙하여 70℃에서 35 초 동안 저온살균함으로써 씨벅손 추출물을 수득하였다.Seabuckthorn fruit was collected and cooled for about 20 hours at a temperature range of -40°C to -20°C. The cooled sea buckthorn fruit was heated to 35° C., then juiced and pasteurized at 70° C. for 35 seconds to obtain a sea buckthorn extract.
[제조예 4: 마늘 추출물 제조][Production Example 4: Preparation of garlic extract]
마늘을 준비하여 -40℃ 내지 -20℃의 온도 범위에서 약 20 시간 동안 냉각하였다. 냉각한 마늘을 35℃까지 가열한 뒤, 스페자임(spezyme) 효소를 75 ml/th. 첨가하여 4 시간 동안 효소 반응시켰다. 효소 반응 후, 마늘을 착즙하여 70℃에서 35 초 동안 저온살균하여 마늘 추출물을 수득하였다.Garlic was prepared and cooled for about 20 hours in a temperature range of -40°C to -20°C. After heating the cooled garlic to 35°C, spezyme enzyme was added to 75 ml/th. It was added and subjected to enzyme reaction for 4 hours. After the enzymatic reaction, garlic was juiced and pasteurized at 70° C. for 35 seconds to obtain a garlic extract.
[제조예 5: 아귀 추출물 제조][Preparation Example 5: Preparation of an earmuff extract]
생물 아귀를 준비하여 수분량이 10% 이하가 될 때까지 건조하였다. 건조한 아귀를 50% 함량(v/v)의 에탄올 수용액을 사용하여 50℃의 온도에서 용매순환방법에 의해 추출하고, 수득된 추출액을 70℃에서 35 초 동안 저온살균하여 아귀 추출물을 수득하였다.A biological anglerfish was prepared and dried until the moisture content was 10% or less. The dried anglerfish was extracted by a solvent circulation method at a temperature of 50 DEG C using an aqueous ethanol solution of 50% content (v/v), and the obtained extract was pasteurized at 70 DEG C for 35 seconds to obtain an extract of Crampons.
[실시예][Example]
상기 제조예에서 제조된 추출물을 하기 표 1의 조성과 같이 배합하여 실시예 1 내지 4의 항산화 조성물을 제조하였다. 실시예 5의 항산화 조성물의 경우, 상기 제조예에서 제조된 추출물 외에 알로에베라잎즙을 하기 표 1의 조성으로 추가 혼합하여 제조하였다.The antioxidant compositions of Examples 1 to 4 were prepared by blending the extract prepared in Preparation Example as shown in Table 1 below. In the case of the antioxidant composition of Example 5, in addition to the extract prepared in Preparation Example, aloe vera leaf juice was prepared by additionally mixing the composition of Table 1 below.
[비교예][Comparative Example]
상기 제조예에서 제조된 추출물 중, 링곤베리 추출물 및 씨벅손 추출물만을 1:1의 중량비로 배합하여 비교예의 항산화 조성물을 제조하였다.Among the extracts prepared in Preparation Example, only lingonberry extract and seabuckthorn extract were mixed in a weight ratio of 1:1 to prepare the antioxidant composition of the comparative example.
[실험예 1: 농도별 항산화 활성 평가][Experimental Example 1: Evaluation of antioxidant activity by concentration]
상기 실시예 2 내지 실시예 5에서 제조된 항산화 조성물 농도를 각각 0.1, 0.3, 0.5, 0.75, 및 1.5 mg/ml로 하여 DPPH(1, 1-diphenyl-2-picrylhy drazyl, Sigma-Aldrich, St. Louis, MO, USA) 라디칼 소거 활성을 측정하여 농도별 항산화 활성의 변화 정도를 확인하였다. 평가 방법은 Blois (1958)변법에 의해 측정하였으며, 구체적으로 각 농도별로 제조한 시료 100 μL에 1.5 × 10-4 M DPPH 용액 100 μL을 가하여 실온의 암실에서 30 분간 정치한 후, 517 nm에서 흡광도를 측정하였으며, 측정한 DPPH 라디칼 소거능 측정 결과는 도 1 내지 도 4에 나타내었다.The concentration of the antioxidant composition prepared in Examples 2 to 5 was 0.1, 0.3, 0.5, 0.75, and 1.5 mg/ml, respectively, and DPPH (1, 1-diphenyl-2-picrylhy drazyl, Sigma-Aldrich, St. Louis, MO, USA) Radical scavenging activity was measured to determine the degree of change in antioxidant activity by concentration. The evaluation method was measured by the Blois (1958) variant. Specifically, 100 μL of a 1.5 × 10 -4 M DPPH solution was added to 100 μL of a sample prepared for each concentration and allowed to stand for 30 minutes in a dark room at room temperature, and then absorbance at 517 nm. Was measured, and the measured DPPH radical scavenging ability measurement results are shown in FIGS. 1 to 4.
측정 결과, 농도가 증가함에 따라 DPPH 라디칼 소거 활성이 증가하되, 본 발명에 따른 농도를 초과할 경우 오히려 DPPH 라디칼 소거 활성이 감소하는 것을 확인할 수 있었다.As a result of the measurement, it was confirmed that the DPPH radical scavenging activity increased as the concentration increased, but if the concentration according to the present invention was exceeded, the DPPH radical scavenging activity decreased.
뿐만 아니라, 항산화 조성물이 구성성분으로서 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물 외에 마늘 추출물, 아귀 추출물, 및/또는 알로에베라잎즙을 추가 포함할 경우, DPPH 라디칼 소거 활성이 유의하게 증가하였음을 확인하였다.In addition, when the antioxidant composition further includes garlic extract, hornbeam extract, and/or aloe vera leaf juice in addition to blackcurrant extract, lingonberry extract, and seabuckthorn extract as constituents, DPPH radical scavenging activity was significantly increased. Confirmed.
[실험예 2: 총 폴리페놀 함량 측정][Experimental Example 2: Measurement of total polyphenol content]
상기 실시예 1 내지 실시예 5, 및 비교예에서 제조된 각각의 항산화 조성물의 총 폴리페놀 함량을 F-C 시약을 사용하는 Singleton 및 Rossi(1965)의 방법을 변형하여 측정하였다. 측정 방법은 탄닌산(tannic acid)을 이용하여 작성한 표준 곡선으로 구하여 표 2에 나타내었다. 하기 표 2에서, TAE는 탄닌산 당량을 나타낸다.The total polyphenol content of each of the antioxidant compositions prepared in Examples 1 to 5 and Comparative Examples was measured by modifying the method of Singleton and Rossi (1965) using an F-C reagent. The measurement method was obtained by using a standard curve prepared using tannic acid and is shown in Table 2. In Table 2 below, TAE represents the tannic acid equivalent.
상기 표 2에 나타낸 바와 같이, 본 발명에 따른 조건으로 제조되는 메추리알 빵의 경우 맛, 향, 및 기호도 모든 부분에서 상당히 우수한 평가를 받았으며, 특히 실시예 4의 메추리알 빵의 경우 가장 높은 점수를 나타내었다.As shown in Table 2, in the case of quail roe bread prepared under the conditions according to the present invention, taste, aroma, and preference were also significantly excellent in all parts, and in particular, the quail roe bread of Example 4 had the highest score. Indicated.
상기 표 2에 나타낸 바와 같이, 실시예 1 내지 실시예 5의 항산화 조성물과 비교하여, 비교예의 항산화 조성물의 경우 총 폴리페놀 함량이 가장 낮게 나타났다. 또한, 구성성분으로서 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물 외에 마늘 추출물, 아귀 추출물, 및/또는 알로에베라잎즙을 추가 포함할 경우, 더욱 높은 총 폴리페놀 함량을 나타냈다.As shown in Table 2, compared with the antioxidant compositions of Examples 1 to 5, the antioxidant compositions of Comparative Examples showed the lowest total polyphenol content. In addition, in the case of further including garlic extract, anglerfish extract, and/or aloe vera leaf juice in addition to blackcurrant extract, lingonberry extract, and seabuckthorn extract as constituents, a higher total polyphenol content was exhibited.
[실험예 3: 항비만 효과 측정][Experimental Example 3: Measurement of anti-obesity effect]
상기 실시예 1 내지 실시예 5, 및 비교예에서 제조된 각각의 항산화 조성물을 하기 5개의 식이그룹(군당 n=8)으로 나눈 6주령의 수컷 C57BL/6J 마우스(orient-biolink Co, 한국, 성남시)에 나누어 공급하였다. 공급은 8 주간 정해진 시간에 공급되었으며, 실험 환경은 온도 25℃, 점멸시간 12 시간, 습도 50%로 유지되는 동물 사육 챔버에서 사육되었다. 식이그룹은 다음과 같이 나누었다.6-week-old male C57BL/6J mice (orient-biolink Co, Korea, Seongnam-si, dividing each of the antioxidant compositions prepared in Examples 1 to 5, and Comparative Examples into the following five dietary groups (n=8 per group) ) And supplied. The supply was supplied at a fixed time for 8 weeks, and the experimental environment was bred in an animal breeding chamber maintained at a temperature of 25°C, a blinking time of 12 hours, and a humidity of 50%. The diet group was divided as follows.
식이그룹 1: 기준 사료+식염수(대조군)Dietary group 1: standard feed + saline solution (control group)
식이그룹 2: 고지방식+식염수Diet Group 2: High Fat Diet + Saline
식이그룹 3: 고지방식+실시예 1의 항산화 조성물Dietary Group 3: High Fat Diet + Antioxidant Composition of Example 1
식이그룹 4: 고지방식+실시예 2의 항산화 조성물Dietary Group 4: High Fat Diet + Antioxidant Composition of Example 2
식이그룹 5: 고지방식+실시예 3의 항산화 조성물Dietary Group 5: High Fat Diet + Antioxidant Composition of Example 3
식이그룹 6: 고지방식+실시예 4의 항산화 조성물Diet Group 6: High Fat Diet + Antioxidant Composition of Example 4
식이그룹 7: 고지방식+실시예 5의 항산화 조성물Dietary Group 7: High Fat Diet + Antioxidant Composition of Example 5
식이그룹 8: 고지방식+비교예의 항산화 조성물.Dietary Group 8: High Fat Diet + Antioxidant Composition of Comparative Example.
실험 경과 8 주 후, 마우스를 희생시켜 몸무게를 측정하였으며, 그 결과를 하기 표 3에 나타내었다.Eight weeks after the experiment, the mice were sacrificed to measure their weight, and the results are shown in Table 3 below.
상기 표 3에 나타낸 바와 같이, 고지방식이로 인한 마우스의 몸무게 증가를 본 발명의 따른 항산화 조성물이 저감시켜줌을 확인할 수 있었다. 또한, 구성성분으로서 블랙커런트 추출물, 링곤베리 추출물, 및 씨벅손 추출물 외에 마늘 추출물, 아귀 추출물, 및/또는 알로에베라잎즙을 추가 포함할 경우, 더욱 높은 항비만 효과를 나타내었다.As shown in Table 3, it was confirmed that the antioxidant composition according to the present invention reduced the weight increase of the mouse due to a high fat diet. In addition, when a garlic extract, an earmuff extract, and/or aloe vera leaf juice were added in addition to the blackcurrant extract, lingonberry extract, and seabuckthorn extract as constituents, a higher anti-obesity effect was exhibited.
[실험예 4: 관절염 개선 효과 측정][Experimental Example 4: Measurement of arthritis improvement effect]
상기 실시예 1 내지 5, 및 비교예에서 제조된 항산화 조성물의 관절염 개선 효과를 확인하기 위하여, MIA(monosodium iodocatate)로 유도한 관절염 모델 실험을 문헌에 기재된 방법을 이용하여 하기와 같이 실시하였다(James D, Pomonis et al., Pain, 114, pp339-346, 2005).In order to confirm the arthritis improvement effect of the antioxidant compositions prepared in Examples 1 to 5 and Comparative Examples, an arthritis model experiment induced by MIA (monosodium iodocatate) was conducted as follows using the method described in the literature (James D, Pomonis et al., Pain , 114, pp339-346, 2005).
실험동물로는 체중 200 내지 220 g의 수컷 랫(오리엔트바이오, 일본)을 수일관 순화시킨 후 MIA(시그마, St. Loius, MO; cat #I2512)를 식염수에 녹여 왼쪽 뒷발 무릎 관절강 내에 주사하여 관절염을 유발시키고 1주간 회복기간을 두었다. 1주 후, 관절염이 유발된 개체만을 선별하고 선별된 개체만으로 각 군당 8마리씩을 구성하였다. 군 분리 후 관절염 유발 8일째부터 매일 같은 시간대에 상기 항산화 조성물을 경구 투여하고, 약물 투여를 시작한 지 1주일 후부터 incapacitance tester로 측정하여 3 주간 주 1회 실시하였다. 왼쪽 뒷다리의 무게 측정치(%)는 양쪽 뒷다리의 무게합에 대한 왼쪽 뒷다리의 무게를 측정하여 계산하였으며, 억제율(%)은 실시예 5의 평균 측정값을 100으로 기준하였을 시의 상대수치로 나타내었다.As experimental animals, male rats (Orient Bio, Japan) weighing 200 to 220 g were purified for several days, then MIA (Sigma, St. Loius, MO; cat #I2512) was dissolved in saline and injected into the joint cavity of the knee of the left hind paw. And a recovery period for 1 week. One week later, only the subjects with arthritis were selected, and 8 animals were formed for each group with only the selected subjects. After group separation, the antioxidant composition was orally administered at the same time every day from the 8th day of arthritis induction, and measured with an incapacitance tester from 1 week after starting the drug administration and performed once a week for 3 weeks. The weight measurement value (%) of the left hind leg was calculated by measuring the weight of the left hind leg to the sum of the weights of both hind legs, and the inhibition rate (%) was expressed as a relative value based on the average measured value of Example 5 as 100. .
상기 표 4에 나타낸 바와 같이, 본 발명에 따른 항산화 조성물의 경우, 모두 비교예에 비해 관절염 진통 억제율이 뛰어난 것을 확인할 수 있었다.As shown in Table 4, in the case of the antioxidant composition according to the present invention, it was confirmed that all of the antioxidant compositions had superior arthritis analgesic inhibition rate compared to the comparative examples.
본 명세서에서는 본 발명자들이 수행한 다양한 실시예 가운데 몇 개의 예만을 들어 설명하는 것이나 본 발명의 기술적 사상은 이에 한정하거나 제한되지 않고, 당업자에 의해 변형되어 다양하게 실시될 수 있음은 물론이다.In the present specification, only a few examples of various embodiments performed by the present inventors are described, but the technical idea of the present invention is not limited or limited thereto, and it is obvious that it may be modified and variously implemented by those skilled in the art.
Claims (3)
상기 블랙커런트 추출물은, 블랙커런트 열매를 추출 용매로서 30% 내지 60% 함량(v/v)의 에탄올을 포함하는 에탄올 수용액을 이용하여 질소를 퍼징하면서 추출한 것이며,
상기 링곤베리 추출물은, 링곤베리를 팬자임으로 1 시간 내지 8 시간 동안 효소 반응시켜 착즙 및 저온살균하여 수득한 것이고,
상기 씨벅손 추출물은, 씨벅손으로부터 채취된 열매를 20℃ 내지 40℃까지 가열하여 착즙 및 저온살균하여 수득한 것이며,
상기 마늘 추출물은, 마늘을 스페자임으로 1 시간 내지 6 시간 동안 효소 반응시켜 착즙 및 저온살균하여 수득한 것이고,
상기 아귀 추출물은, 수분량이 10% 이하가 될 때까지 건조한 아귀를 추출 용매로서 30% 내지 60% 함량(v/v)의 에탄올을 포함하는 에탄올 수용액을 이용하여 추출한 것인,
항산화 식품 조성물.
As an antioxidant food composition comprising a blackcurrant extract, a lingonberry extract, a seabuckthorn extract, a garlic extract, and an anglerfish extract in a weight ratio of 1 to 2: 1 to 2: 1 to 2: 0.1 to 1: 0.1 to 1,
The blackcurrant extract is extracted while purging nitrogen using an aqueous ethanol solution containing 30% to 60% ethanol (v/v) of the blackcurrant fruit as an extraction solvent,
The lingonberry extract is obtained by enzymatic reaction of lingonberry with panzyme for 1 to 8 hours to juice and pasteurize,
The sea buckthorn extract is obtained by heating the fruit collected from sea buckthorn to 20 ℃ to 40 ℃ juice and pasteurization,
The garlic extract is obtained by enzymatic reaction of garlic with spezyme for 1 to 6 hours, juiced and pasteurized,
The anglerfish extract is extracted by using an aqueous ethanol solution containing 30% to 60% content (v/v) of ethanol as an extraction solvent of dried anglerfish until the moisture content is 10% or less,
Antioxidant food composition.
상기 항산화 식품 조성물의 농도는 0.25 내지 1 mg/ml로 포함되는 것을 특징으로 하는, 항산화 식품 조성물.The method of claim 1,
The concentration of the antioxidant food composition is characterized in that contained in 0.25 to 1 mg / ml, antioxidant food composition.
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| US20100215783A1 (en) * | 2009-02-23 | 2010-08-26 | Nutragenesis, Llc | Antioxidant Compositions, Beverage Formulations Thereof, and Methods of Increasing Antioxidant Capability |
| KR101540515B1 (en) | 2013-09-27 | 2015-07-31 | 영남대학교 산학협력단 | Composition for functional beverage having antioxidative effect comprising black Doraji, apple and jujube extract |
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| KR102070701B1 (en) * | 2019-05-02 | 2020-01-29 | (주)오르나 | Composition for antioxidant comprising bilberry juice, sea buckthorn juice, lingonberry juice |
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