KR102129409B1 - Composition for treating hair loss and promoting hair growth - Google Patents
Composition for treating hair loss and promoting hair growth Download PDFInfo
- Publication number
- KR102129409B1 KR102129409B1 KR1020180006439A KR20180006439A KR102129409B1 KR 102129409 B1 KR102129409 B1 KR 102129409B1 KR 1020180006439 A KR1020180006439 A KR 1020180006439A KR 20180006439 A KR20180006439 A KR 20180006439A KR 102129409 B1 KR102129409 B1 KR 102129409B1
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- hair
- hair loss
- astragalus
- broiler
- Prior art date
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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Abstract
본 발명은 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 조성물에 대한 것이다. 본 발명의 조성물은 모발의 생성 및 성장을 촉진하므로, 탈모의 예방, 개선, 치료, 및 발모 촉진용으로 사용될 수 있다.The present invention relates to a composition comprising a broiler extract and astragalus extract as active ingredients. Since the composition of the present invention promotes hair growth and growth, it can be used for preventing, improving, treating, and promoting hair growth.
Description
본 발명은 탈모의 예방, 개선 또는 치료용 약제학적 조성물 및 식품 조성물, 그리고 발모 촉진용 조성물에 대한 것이다.The present invention relates to a pharmaceutical composition and a food composition for preventing, improving or treating hair loss, and a composition for promoting hair growth.
탈모란 정상적으로 모발이 있어야 할 곳에 모발이 없는 상태를 말하며 유전적 요인이 주요한 원인으로 알려져 있다. 최근에는 사회적 스트레스의 증가와 더불어 환경오염 및 인스턴트 식품 등 서구화된 식습관, 잦은 파마와 염색, 잘못된 두피관리들로 인하여 탈모 인구가 점차 증가하고 있는 추세이다. 그러나 아직까지 탈모에 대한 명확한 원인은 규명되고 있지 않고, 최근 들어 오히려 탈모증으로 고민하는 사람이 점점 늘고 있으며 그 연령층도 낮아지고 있는 실정이다. Hair loss refers to a condition in which there is no hair where the hair should normally be, and a genetic factor is known as a major cause. In recent years, with the increase in social stress, the population has been gradually increasing due to westernized eating habits such as environmental pollution and instant food, frequent perm and dyeing, and poor scalp management. However, a clear cause for hair loss has not been identified, and recently, more and more people are suffering from alopecia, and the age group is also decreasing.
탈모증의 치료법에 관해서도 아직까지 뚜렷한 효과를 지닌 것은 없으며, 동의보감에서는 신응양진단 등 탈모에 관계되는 몇몇 복용하는 처방들이 있고, 호마유(참깨) 등을 탈모 부위에 마사지한다든지, 특정 한약처방을 주침해서 바르는 방법과 특정 혈위를 자극하는 방법 등이 있지만 효과에 있어서는 개인적 차이가 많다고 알려져 있다. There is no clear effect on the treatment of alopecia, and Donguibogam has several prescriptions related to hair loss, such as diagnosing kidney disease, and massages horse oil (sesame) into the hair loss area, or heals certain Chinese medicine prescriptions. There are methods of applying and stimulating specific blood levels, but there are many personal differences in effectiveness.
종래의 탈모증 치료방법으로는, 호르몬설과 관련하여 여성 호르몬을 주재로 한 제제가 있으나 피부 염증 발생, 호르몬 투여에 의한 부작용 발생 등의 보고가 있어 현재는 사용이 중단되고 있다. 최근 사용되고 있는 대표적인 발모제로는, 처음에는 혈액 순환 촉진을 위한 용도로 개발되어 사용되다가 이를 사용하는 환자들 사이에서 부작용으로 발모 효과를 나타내는 것으로 알려져, 이후, 발모용 원료로 미국식품의약품안전청(FDA)에서 승인받아 발모 치료제로 사용되고 있는 미국특허 제3,382,247호의 미녹시딜(6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidine)및 미국특허 제 5,215,894 호에서 언급된 머크사의 피나스테라이드(finasteride)가 있다. As a conventional treatment method for alopecia, there are preparations based on female hormones in connection with hormonal theory, but there are reports of skin inflammation and side effects caused by hormone administration, which are currently discontinued. As a representative hair growth agent that has recently been used, it is first developed and used for promoting blood circulation, and is known to exhibit a hair growth effect as a side effect among patients who use it, and thereafter, as a raw material for hair growth, the United States Food and Drug Administration (FDA) Minoxidil (6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidine) of U.S. Patent No. 3,382,247, which has been approved and used as a treatment for hair growth, and finasteride of Merck of U.S. Patent No. 5,215,894 ( finasteride).
그러나, 미녹시딜의 경우 끈적이는 사용감과 피부에 자극을 유발하는 부작용이 보고된 바 있으며, 피나스테라이드의 경우 현재 경구 투여용 제제로 사용되고 있으나, 이의 섭취에 따라 성기능 장애 등의 부작용이 보고된 일도 있을 뿐 아니라, 탈모에 대해서도 꾸준한 복용이 이루어져야만 효과가 있다는 단점이 있다. However, in the case of minoxidil, sticky feeling and side effects that cause irritation to the skin have been reported, and in the case of finasteride, it is currently used as a formulation for oral administration, but side effects such as sexual dysfunction have been reported depending on its intake. There is also a drawback that hair loss is effective only when consistently taken.
따라서, 기존 약물의 부작용을 개선할 수 있는 새로운 약물에 대한 요구는 꾸준히 늘어나고 있다.Therefore, the demand for new drugs that can improve the side effects of existing drugs is steadily increasing.
한편, 육계(Cinnamomi Cortex)는 녹나무과(Lauraceae)에 속하는 육계나무(Cinnamomum cassia) 또는 그밖의 동속 근연식물의 줄기껍질로, 주피를 다소 제거하여 사용하기도 한다. 육계는 통 모양 또는 말려 들어간 통 모양이고, 길이 5 cm 내지 50 cm, 지름 1.5 cm 내지 5 cm, 두께 0.1 cm 내지 0.5 cm이다. 바깥 면은 어두운 적갈색, 안쪽 면은 적갈색을 띠며 매끈하다. 꺾이기 쉬우며 꺾인 면은 적갈색을 띠고 연한 갈색의 얇은 층이 있으며 약간 섬유성이다. On the other hand, broiler (Cinnamomi Cortex) is a stem bark of Cinnamomum cassia or other related plants belonging to the family Lauraceae, and is also used to remove some of the skin. Broilers are tubular or rolled tubular, 5 cm to 50 cm long, 1.5 cm to 5 cm in diameter, and 0.1 cm to 0.5 cm thick. The outer side is dark reddish brown, and the inner side is reddish brown. It is easy to bend and the bent side is reddish brown, has a light brown thin layer and is slightly fibrous.
황기(Astragali Radix)는 콩과(Leguminosae)에 속하는 황기(Astragalus membranaceus) 또는 그밖의 동속 근연식물의 뿌리 부위를 지칭하며, 주피를 벗겨 사용할 때가 많다. 황기는 가늘고 긴 원주형을 이루고 길이 30 cm 내지 100 cm, 지름 7 mm 내지 20 mm 이며, 드문드문 작은 가지뿌리가 붙어있으나 분지되는 일은 없고 근두부 가까이에서는 약간 꼬여지고 줄기의 잔기가 남아있다. 바깥면은 엷은 회황색-엷은 황갈색이며 회갈색의 코르크층이 군데군데 남아 있고 불규칙한 거친 세로의 주룸과 가로로 피목같은 모양이 보인다. 질은 치밀하고 꺾기 힘들며 꺾은 면은 섬유성이다.Astragali Radix refers to the root region of Astragalus membranaceus belonging to the legumes (Leguminosae) or other related plants, and is often peeled off. Astragalus is elongated columnar, 30 cm to 100 cm long, 7 mm to 20 mm in diameter, with sparse small roots attached, but not branched, slightly twisted near the roots and residues of the stem remaining. The outer surface is pale grayish yellow to pale yellowish brown, and there are gray corked layers. The irregular rough vertical main room and horizontal cortical look are seen. The vagina is dense, hard to bend, and the bent side is fibrous.
본 발명의 목적은 탈모의 예방 또는 치료용 약제학적 조성물을 제공하는 것이다.An object of the present invention is to provide a pharmaceutical composition for the prevention or treatment of hair loss.
본 발명의 다른 목적은 탈모의 예방 또는 개선용 식품 조성물을 제공하는 것이다.Another object of the present invention is to provide a food composition for preventing or improving hair loss.
본 발명의 또 다른 목적은 발모 촉진용 조성물을 제공하는 것이다.Another object of the present invention is to provide a composition for promoting hair growth.
상기 목적을 달성하기 위하여, 본 발명자들은 기존의 탈모 치료제 및 발모제를 대체할 수 있는 새로운 물질에 관하여 연구를 계속하던 중, 육계 추출물 및 황기 추출물을 함유하는 복합 추출물이 탈모를 치료하고, 발모를 촉진할 수 있음을 확인하고 본 발명을 완성하였다.In order to achieve the above object, the present inventors continued research on new substances that can replace existing hair loss treatment agents and hair growth agents, while complex extracts containing broiler extracts and astragalus extracts treat hair loss and promote hair growth After confirming that it can be done, the present invention was completed.
본 발명은 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 탈모의 예방 또는 치료용 약제학적 조성물을 제공한다.The present invention provides a pharmaceutical composition for preventing or treating hair loss comprising broiler extract and astragalus extract as active ingredients.
본 발명에서, 육계(Cinnamomi Cortex)는 Cinnamomum cassia 또는 그밖의 동속 근연식물의 줄기껍질을 의미한다. 상기 Cinnamomum cassia 또는 그밖의 동속 근연식물은 구체적으로, Cinnamomum cassia, Cinnamomum loureiroi, Cinnamomum verum, Cinnamomum burmannii, Cinnamomum wilsonii, Cinnamomum chingii, Cinnamomum japonicum, Cinnamomum zeylanicum, Cinnamomum obtusifolim 및 Cinnamomum sieboldii을 들 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 구체적인 구현예에서, 육계는 Cinnamomum verum의 줄기껍질일 수 있다.In the present invention, broiler (Cinnamomi Cortex) refers to the stem bark of Cinnamomum cassia or other related root plants. The Cinnamomum cassia or other related plants are specifically Cinnamomum cassia , Cinnamomum loureiroi , Cinnamomum verum , Cinnamomum burmannii , Cinnamomum wilsonii , Cinnamomum chingii , Cinnamomum japonicum , Cinnamomum zeylanicum , Cinnamomum obtusifolim and Cinnamomum obtusifolim It is not. In a specific embodiment of the present invention, broiler may be the stem bark of Cinnamomum verum .
본 발명에서, 황기(Astragali Radix)는 Astragalus membranaceus 또는 그밖의 동속 근연식물의 뿌리를 의미한다. 상기 Astragalus membranaceus 또는 그밖의 동속 근연식물은 구체적으로, Astragalus mongholicus, Astragalus uliginosus 및 Astragalus membranaceus var. mongholicus를 들 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 구체적인 구현예에서, 황기는 Astragalus membranaceus의 뿌리일 수 있다.In the present invention, astragalus (Astragali Radix) refers to the root of Astragalus membranaceus or other related plants. The Astragalus membranaceus or other related plants are specifically, Astragalus mongholicus , Astragalus uliginosus and Astragalus membranaceus var. mongholicus , but is not limited thereto. In a specific embodiment of the present invention, astragalus may be the root of Astragalus membranaceus .
본 발명에서, 육계 및 황기는 자연 상태 그대로인 것뿐만 아니라, 반건조, 건조 등의 가공된 것을 포함한다.In the present invention, broiler and astragalus include not only the natural state, but also semi-dried and dried.
본 발명에서, 추출물(extract)은 천연물을 추출 처리하여 얻어지는 추출액, 상기 추출액의 분획물, 상기 추출액 또는 분획물의 조정제물이나 정제물, 또는 이들의 희석액, 농축액, 건조물, 또는 이들의 혼합물 등, 육계 및 황기로부터 형성가능한 모든 제형의 추출물을 포함한다.In the present invention, the extract (extract) is an extract obtained by extracting a natural product, a fraction of the extract, a crude or refined product of the extract or fraction, or a dilution, concentrate, dried product, or a mixture thereof, broiler and Contains extracts of all formulations formable from astragalus.
본 발명에서 추출물은 이 분야에 공지된 일반적 제조방법을 사용하여 제조될 수 있으며, 특별히 제한되지 않는다. 예를 들어, 초음파 추출법(sonication extraction), 초임계 추출법(supercritical extraction), 감압 추출법(vacumn extraction), 환류 추출법(reflux extraction), 열수 추출법(hot-water extraction), 고온 가압 추출법(autoclave extraction), 초고압 추출법(high-pressure extraction), 효소 추출법(enzyme extraction), 또는 추출 용매를 사용하여 공지의 방법에 의해 제조하는 방법일 수 있으나, 이에 한정되는 것은 아니다.In the present invention, the extract may be prepared using a general manufacturing method known in the art, and is not particularly limited. For example, ultrasonic extraction, supercritical extraction, vacuum extraction, reflux extraction, hot-water extraction, autoclave extraction, High-pressure extraction (high-pressure extraction), enzyme extraction (enzyme extraction), or may be a method prepared by a known method using an extraction solvent, but is not limited thereto.
본 발명에서, 추출물은 물, 유기용매 또는 이들의 혼합물을 추출 용매로 하여 추출액으로 제조될 수 있다. 상기 물은 예를 들어, 증류수, 정제수, 무균수를 들 수 있으나, 이에 한정되는 것은 아니다. 상기 유기용매는 예를 들어, 알코올, 글리세린, 부틸렌글리콜, 프로필렌글리콜, 메틸아세테이트, 에틸아세테이트, 아세톤, 벤젠, 헥산, 디에틸에테르 및 디클로로메탄를 들 수 있으나, 이에 한정되는 것은 아니다. In the present invention, the extract may be prepared as an extract using water, an organic solvent or a mixture thereof as an extraction solvent. The water may be, for example, distilled water, purified water, sterile water, but is not limited thereto. The organic solvent may include, for example, alcohol, glycerin, butylene glycol, propylene glycol, methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane, but is not limited thereto.
본 발명에서, 추출물은 바람직하게는 물, 탄소수 1 내지 4의 저가 알코올(메탄올, 에탄올, 프로판올 또는 부탄올) 또는 이들의 혼합물로 이루어진 군에서 선택된 용매를 추출 용매로 하여 추출된 것일 수 있다. 상기 탄소수 1 내지 4의 저가 알코올의 농도는 10 % 내지 90 %일 수 있고, 바람직하게는 20 % 내지 70 % 일 수 있고, 더 바람직하게는 25 % 내지 50 % 일 수 있다. 본 발명의 구체적인 구현예에서, 육계 추출물은 증류수를 추출 용매로 하여 추출된 것일 수 있다. 본 발명의 구체적인 구현예에서, 황기 추출물은 증류수를 추출 용매로 하여 추출된 것일 수 있다.In the present invention, the extract may be extracted by using a solvent selected from the group consisting of water, low-cost alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol or butanol) or a mixture thereof. The concentration of the low alcohol having 1 to 4 carbon atoms may be 10% to 90%, preferably 20% to 70%, and more preferably 25% to 50%. In a specific embodiment of the present invention, the broiler extract may be extracted using distilled water as an extraction solvent. In a specific embodiment of the present invention, the astragalus extract may be extracted using distilled water as an extraction solvent.
본 발명에서, 분획물은 여러 다양한 구성 성분들을 포함하는 혼합물로부터 특정 성분 또는 특정 성분 그룹을 분리하기 위하여 분획을 수행하여 수득된 결과물을 의미한다. 본 발명에서, 분획물은 추출액을 분획하여 제조될 수 있다.In the present invention, a fraction refers to a product obtained by performing a fraction to separate a specific component or a specific component group from a mixture containing various various components. In the present invention, the fraction can be prepared by fractionating the extract.
본 발명에서, 상기 분획물의 제조에 사용되는 분획 용매의 종류는 특별히 제한되지 않으며, 본 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 분획 용매는 예를 들어, 물, 탄소수 1 내지 4의 알코올, 헥산, 에틸 아세테이트, 클로로포름, 디클로로메탄 또는 이들의 혼합물 등을 들 수 있으나, 이에 한정되는 것은 아니다. 상기 분획 용매는 단독으로 사용되거나 2종 이상을 혼합하여 사용될 수 있으며, 용매의 극성에 따라 순차적으로 사용하여 각 용매의 분획물을 제조할 수 있다.In the present invention, the type of fractional solvent used in the preparation of the fraction is not particularly limited, and any solvent known in the art may be used. The fractional solvent may include, for example, water, alcohol having 1 to 4 carbon atoms, hexane, ethyl acetate, chloroform, dichloromethane, or a mixture thereof, but is not limited thereto. The fractional solvent may be used alone or in combination of two or more, and may be sequentially used according to the polarity of the solvent to prepare fractions of each solvent.
본 발명에서, 정제물은 추출액 또는 분획물에 추가의 정제 과정을 더 수행하여 수득된 결과물을 의미한다. 상기 정제는 이 분야에 공지된 일반적인 방법을 사용할 수 있으며, 예를 들어, 실리카겔 컬럼 크로마토그래피(silica gel column chromatography), 박층 크로마토그래피(thin layer chromatography), 고성능 액체 크로마토그래피(high performance liquid chromatography) 등과 같은 다양한 크로마토그래피를 들 수 있으나, 이에 한정되는 것은 아니다.In the present invention, the purified product means the result obtained by further performing an additional purification process to the extract or fraction. The purification may use a general method known in the art, for example, silica gel column chromatography, thin layer chromatography, high performance liquid chromatography, etc. The same variety of chromatography may be mentioned, but is not limited thereto.
본 발명에서, 추출물은 여과, 농축 또는 건조과정을 수행하여 용매가 제거되거나, 여과, 농축 및 건조를 모두 수행한 것일 수 있다. 상기 여과는 예를 들어, 여과지 또는 감압여과기를 이용할 수 있다. 상기 농축은 예를 들어, 감압 농축기 또는 회전 증발기를 이용할 수 있다. 상기 건조는 예를 들어, 분무건조법 또는 동결건조법으로 수행할 수 있다. In the present invention, the solvent may be removed by performing a filtration, concentration, or drying process, or all of filtration, concentration, and drying. The filtration may be, for example, filter paper or a vacuum filter. The concentration may be, for example, a reduced pressure concentrator or a rotary evaporator. The drying may be performed, for example, by spray drying or freeze drying.
또한, 본 발명에서, 추출물은 사용 시까지 급속 냉동 냉장고(deep freezer)에 보관할 수 있고, 농축 및 동결건조를 통하여 수분을 완전히 제거시킬 수 있으며, 수분을 완전히 제거시킨 추출물은 분말형태로 사용하거나 상기 분말을 증류수 또는 통상의 용매에 녹여 사용할 수 있다.In addition, in the present invention, the extract can be stored in a deep freezer until use, and can be completely removed through concentration and freeze-drying, and the extract that completely removes water is used in powder form or the The powder can be used by dissolving it in distilled water or a conventional solvent.
본 발명에서, 육계 추출물 및 황기 추출물은 육계와 황기를 각각 별도로 추출한 후 혼합한 것, 또는 육계와 황기를 추출 전 혼합하여 추출한 것을 모두 포함한다. 본 발명의 구체적인 구현예에서, 육계 추출물 및 황기 추출물은 육계와 황기를 각각 별도로 추출한 후 혼합한 것일 수 있다. In the present invention, the broiler extract and the astragalus extract include both a broiler and astragalus separately extracted and mixed, or a mixture of a broiler and astragalus before extraction. In a specific embodiment of the present invention, the broiler extract and the astragalus extract may be mixed after separately extracting the broiler and the astragalus.
본 발명에서, "육계 및 황기 복합 추출물"은 육계와 황기를 각각 별도로 추출한 후 혼합한 것, 또는 육계와 황기를 추출 전 혼합하여 추출한 것을 지칭하는 용어로 사용된다.In the present invention, "the broiler and astragalus complex extract" is used as a term referring to a mixture after extracting broiler and astragalus separately, or mixing and extracting broiler and astragalus before extraction.
본 발명의 약제학적 조성물에서, 육계 추출물 및 황기 추출물의 함량비는 1 : 0.5 내지 1 : 100, 바람직하게는 1 : 1 내지 1 : 10 일 수 있다. 본 발명의 구체적인 구현예에서, 육계 추출물 및 황기 추출물의 함량비는 1 : 4 일 수 있다. In the pharmaceutical composition of the present invention, the content ratio of broiler extract and astragalus extract may be 1: 0.5 to 1: 100, preferably 1: 1 to 1: 10. In a specific embodiment of the present invention, the content ratio of broiler extract and astragalus extract may be 1:4.
본 발명에서, 탈모는 피부로부터 모발이 탈락하는 현상 또는 모발이 성기거나 가늘어지는 상태를 의미하며, 탈모증과 혼용되어 사용될 수 있는 용어이다. In the present invention, hair loss refers to a phenomenon in which hair is removed from the skin or a state in which hair is sparse or thin, and is a term that can be used interchangeably with alopecia.
본 발명에서, 모발은 머리의 모근 및 모낭, 머리카락 및 속눈썹과 겉눈썹, 수염, 겨드랑이, 음모, 신체 전반에 모근 및 모낭이 있는 모든 부위를 포함한다.In the present invention, hair includes all hair follicles and hair follicles, hair and eyelashes and lashes, beards, armpits, pubic hair, and hair follicles and hair follicles throughout the body.
본 발명에서, 탈모는 구체적으로 안드로겐성 탈모, 휴지기 탈모, 약제성 탈모, 기계적 탈모, 외상성 탈모, 압박성 탈모, 생장기 탈모, 비강성 탈모, 매독성 탈모, 지루 탈모, 증후성 탈모, 반흔성 탈모, 선천성 탈모, 원형 탈모, 머리 백선, 전두 탈모, 감모증, 유전성 단순 감모증 및 전신 탈모로 이루어진 군에서 선택되는 하나 이상일 수 있다. 그러나 탈모는 발생의 직간접적인 원인을 불문하고 이 분야에서 탈모로 분류되는 모든 증상을 포함하는 의미로서 이해되어야 한다.In the present invention, hair loss is specifically androgenic hair loss, resting hair loss, pharmaceutical hair loss, mechanical hair loss, traumatic hair loss, compressive hair loss, growth phase hair loss, non-rigid hair loss, syphilis hair loss, seborrheic hair loss, symptomatic hair loss, scarring hair loss , Congenital alopecia, circular alopecia, hair ringworm, frontal alopecia, alopecia, hereditary simple alopecia and systemic alopecia. However, hair loss should be understood as meaning including all symptoms classified as hair loss in this field, regardless of the direct or indirect cause of the occurrence.
본 발명의 구체적인 실시예에 따르면, 육계 추출물 및 황기 추출물을 포함하는 조성물은 모발이 제거된 상태에서 모발의 생성 및 성장을 촉진한다. 또한, 본 발명의 육계 추출물 및 황기 추출물을 포함하는 조성물은 5α-리덕타아제의 발현을 억제할 수 있다. 따라서 본 발명의 약제학적 조성물은 탈모의 예방 또는 치료용으로 효과적으로 사용될 수 있다.According to a specific embodiment of the present invention, a composition comprising a broiler extract and astragalus extract promotes the production and growth of hair in a state in which the hair is removed. In addition, the composition comprising the broiler extract and the astragalus extract of the present invention can suppress the expression of 5α-reductase. Therefore, the pharmaceutical composition of the present invention can be effectively used for the prevention or treatment of hair loss.
본 발명에서, "유효성분"은 단독으로 목적하는 활성을 나타내거나, 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In the present invention, "active ingredient" refers to a component that can exhibit the desired activity alone, or itself can exhibit activity with an inactive carrier.
본 발명에서, "예방"은 본 발명의 약제학적 조성물의 투여에 의해 탈모와 연관된 하나 이상의 증상의 발생 또는 발병이 억제되거나 지연되는 모든 행위를 의미하며, 반드시 탈모의 완전한 발병 억제를 의미하는 것은 아니다. In the present invention, "prophylaxis" refers to all actions in which the occurrence or development of one or more symptoms associated with hair loss is inhibited or delayed by administration of the pharmaceutical composition of the present invention, and does not necessarily mean the complete suppression of hair loss. .
본 발명에서, "치료"는 본 발명의 약제학적 조성물의 투여에 의해 탈모와 연관된 하나 이상의 증상을 나타내고 있거나, 이전에 나타냈던 개체의 증상이 억제되거나, 감소되거나 또는 호전되는 모든 행위를 의미한다. 상기 개체는 인간을 포함하는 포유류일 수 있으며, 바람직하게는 인간이다.In the present invention, "treatment" refers to any action that exhibits one or more symptoms associated with hair loss by administering the pharmaceutical composition of the present invention, or suppresses, reduces or ameliorates the symptoms of an individual who has previously manifested it. The subject may be a mammal, including a human being, and is preferably a human being.
본 발명에서, "투여"는 어떠한 적절한 방법으로 개체에 본 발명의 약제학적 조성물을 도입하는 것을 의미한다. 투여 경로는 목적 조직에 도달할 수 있는 한 어떠한 일반적인 경로를 통하여 경구 또는 비경구 투여될 수 있다. 또한, 본 발명의 약제학적 조성물이 표적 세포로 이동할 수 있도록 하는 임의의 장치에 의해 투여될 수 있다.In the present invention, "administration" means introducing the pharmaceutical composition of the present invention to an individual in any suitable way. The route of administration can be administered orally or parenterally through any general route as long as the target tissue can be reached. In addition, the pharmaceutical composition of the present invention can be administered by any device that allows it to migrate to target cells.
본 발명의 약제학적 조성물은 본 발명의 효과를 해치지 않는 범위에서 약제학적으로 허용되는 담체를 추가로 포함할 수 있다. 본 발명에서 사용될 수 있는 약제학적으로 허용되는 담체의 종류는 특별히 제한되지 아니하며, 이 기술 분야에서 통상적으로 사용되는 담체라면 어느 것이든 사용할 수 있다. 상기 담체는 예를 들어, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사 용액, 락토오스, 덱스트로오스, 수크로오스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 말토 덱스트린, 글리세롤, 에탄올 등을 들 수 있으나, 이에 한정되는 것은 아니다. 상기 담체는 단독으로 사용되거나 2 종 이상을 혼합하여 사용될 수 있다.The pharmaceutical composition of the present invention may further include a pharmaceutically acceptable carrier in a range that does not impair the effects of the present invention. The type of the pharmaceutically acceptable carrier that can be used in the present invention is not particularly limited, and any carrier commonly used in the art can be used. Examples of the carrier include saline, sterile water, Ringer's solution, buffered saline, albumin injection solution, lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, maltodextrin, glycerol, ethanol, etc. , But is not limited thereto. The carrier may be used alone or in combination of two or more.
본 발명의 약제학적 조성물은 본 발명의 효과를 해치지 않는 범위에서 약제학적으로 허용되는 첨가제를 추가로 포함할 수 있다. 본 발명에서 사용될 수 있는 약제학적으로 허용되는 첨가제의 종류는 특별히 제한되지 아니하며 이 기술 분야에서 통상적으로 사용되는 첨가제라면 어느 것이든 사용할 수 있다. 상기 첨가제는 예를 들어, 충전제, 결합제, 붕해제, 윤활제, 현탁화제, 용제, 산화방지제, pH 조절제, 습윤제, 감미제 및 보존제를 들 수 있으나, 이에 한정되지는 것은 아니다. 상기 첨가제는 단독으로 사용되거나 2 종 이상을 혼합하여 사용될 수 있다.The pharmaceutical composition of the present invention may further include a pharmaceutically acceptable additive in a range that does not impair the effects of the present invention. The types of pharmaceutically acceptable additives that can be used in the present invention are not particularly limited, and any additives commonly used in the art can be used. Examples of the additives include, but are not limited to, fillers, binders, disintegrants, lubricants, suspending agents, solvents, antioxidants, pH adjusting agents, wetting agents, sweeteners and preservatives. The additives may be used alone or in combination of two or more.
본 발명의 약제학적 조성물은 경구 투여 또는 비경구 투여를 위한 적합하고 다양한 제형이 될 수 있다. 본 발명에서, 경구 투여용 제형은 예를 들어, 정제, 환제, 분말, 산제, 과립, 펠렛, 캡슐, 트로키(troches), 로젠지(lozenge), 현탁액, 에멀젼, 시럽 및 엘릭시르제 등을 들 수 있으나, 이에 한정되는 것은 아니다. 본 발명에서, 비경구 투여용 제형은 예를 들어, 주사제, 좌제, 호흡기 흡입제, 에어로졸제, 연고, 도포용 분말, 오일, 크림, 겔 및 샴푸 등을 들 수 있으나, 이에 한정되는 것은 아니다.The pharmaceutical composition of the present invention may be suitable and various formulations for oral administration or parenteral administration. In the present invention, oral dosage forms include, for example, tablets, pills, powders, powders, granules, pellets, capsules, troches, lozenges, suspensions, emulsions, syrups and elixirs. However, it is not limited thereto. In the present invention, the formulation for parenteral administration may include, for example, injections, suppositories, respiratory inhalers, aerosols, ointments, powders for application, oils, creams, gels, and shampoos, but is not limited thereto.
본 발명의 약제학적 조성물은 목적에 따라 경구 투여하거나 비경구 투여할 수 있다. 본 발명에서, 비경구 투여는 예를 들어, 복강 투여, 직장 투여, 피하 투여, 정맥 투여, 근육 투여, 흉부 투여, 경피 투여 및 모발 투여를 들 수 있고, 조성물을 질환 부위에 도포하거나 분무, 흡입하는 것도 들 수 있으나. 이에 한정되는 것은 아니다. 본 발명의 구체적인 구현예에서, 본 발명의 약제학적 조성물은 경구 투여될 수 있다.The pharmaceutical composition of the present invention may be administered orally or parenterally depending on the purpose. In the present invention, parenteral administration includes, for example, intraperitoneal administration, rectal administration, subcutaneous administration, intravenous administration, intramuscular administration, thoracic administration, transdermal administration and hair administration, and the composition is applied to a diseased site or sprayed or inhaled. It can also be done. It is not limited to this. In a specific embodiment of the invention, the pharmaceutical composition of the invention can be administered orally.
본 발명의 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에서, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효한 양의 수준은 환자의 상태, 체중, 성별, 연령, 건강상태, 질병의 정도, 약물에 대한 민감도, 투여 시간, 투여 경로, 배출 비율, 치료 기간, 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다. 본 발명의 약제학적 조성물의 투여량은 통상의 기술자에 의해 적절하게 선택될 수 있다. 본 발명의 약제학적 조성물의 투여량은 육계 추출물 및 황기 추출물의 함량을 기준으로 1일 0.1 mg/kg 내지 2,000 mg/kg 일 수 있고, 보다 바람직하게는 1 mg/kg 내지 500 mg/kg 일 수 있으나, 이에 제한되는 것은 아니다. 또한, 상기 투여량의 본 발명의 범위를 한정하는 것은 아니다.The pharmaceutical composition of the present invention is administered in a pharmaceutically effective amount. In the present invention, "a pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit/risk ratio applicable to medical treatment, and the effective amount level is the patient's condition, weight, sex, age, and health It can be determined according to the condition, the degree of disease, the sensitivity to the drug, the time of administration, the route of administration, the rate of excretion, the duration of treatment, factors including drugs used concurrently, and other factors well known in the medical field. The dosage of the pharmaceutical composition of the present invention can be appropriately selected by a person skilled in the art. The dosage of the pharmaceutical composition of the present invention may be 0.1 mg/kg to 2,000 mg/kg per day based on the content of broiler extract and astragalus extract, and more preferably 1 mg/kg to 500 mg/kg per day. However, it is not limited thereto. In addition, the scope of the present invention is not limited to the above dosage.
본 발명의 약제학적 조성물의 투여는 하루에 한 번 투여할 수도 있고, 수회 나누어 투여할 수도 있으며, 수일에 한 번 투여할 수도 있다. The pharmaceutical composition of the present invention may be administered once a day, may be administered several times, or may be administered once every several days.
본 발명의 약제학적 조성물은 탈모의 예방 및 치료를 위하여 단독으로, 또는 다른 예방 또는 치료제와 병용하여 투여될 수 있고, 다른 예방 또는 치료제와 동시에 또는 순차적으로 투여될 수 있다. 또한, 본 발명의 약제학적 조성물은 수술, 호르몬 치료, 화학 치료 및 생물학적 반응 조절제를 사용하는 방법들과 병용하여 사용될 수 있다.The pharmaceutical composition of the present invention may be administered alone or in combination with other prophylactic or therapeutic agents for the prevention and treatment of hair loss, and may be administered simultaneously or sequentially with other prophylactic or therapeutic agents. In addition, the pharmaceutical composition of the present invention can be used in combination with methods using surgery, hormone therapy, chemotherapy, and biological response modifiers.
본 발명은 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 탈모의 예방 또는 개선용 식품 조성물을 제공한다.The present invention provides a food composition for preventing or improving hair loss comprising broiler extract and astragalus extract as active ingredients.
본 발명의 식품 조성물에서, 육계, 황기, 추출물, 유효성분 및 탈모는 앞서 본 발명의 약제학적 조성물에 대해 상세하게 기재한 바와 동일하다.In the food composition of the present invention, broiler, astragalus, extract, active ingredient and hair loss are the same as described in detail for the pharmaceutical composition of the present invention.
본 발명의 구체적인 실시예에 따르면, 육계 추출물 및 황기 추출물을 포함하는 조성물은 모발이 제거된 상태에서 모발의 생성 및 성장을 촉진한다. 따라서 본 발명의 식품 조성물은 탈모의 예방 또는 개선용으로 효과적으로 사용될 수 있다.According to a specific embodiment of the present invention, a composition comprising a broiler extract and astragalus extract promotes the production and growth of hair in a state in which the hair is removed. Therefore, the food composition of the present invention can be effectively used for preventing or improving hair loss.
본 발명에서, "예방"은 본 발명의 식품 조성물의 섭취에 의해 탈모와 연관된 하나 이상의 증상의 발생 또는 발병이 억제되거나 지연되는 모든 행위를 의미하며, 반드시 탈모의 완전한 발병 억제를 의미하는 것은 아니다. In the present invention, "prevention" refers to all actions in which the occurrence or development of one or more symptoms associated with hair loss is suppressed or delayed by ingestion of the food composition of the present invention, and does not necessarily mean the complete suppression of hair loss.
본 발명에서, "개선"은 본 발명의 식품 조성물의 섭취에 의해 탈모와 연관된 하나 이상의 증상의 정도가 감소되거나 호전되거나 진행이 지연되는 모든 행위를 의미한다.In the present invention, "improvement" means any action in which the intake of the food composition of the present invention reduces, improves or delays progression of one or more symptoms associated with hair loss.
본 발명의 식품 조성물은 육계 추출물 및 황기 추출물을 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. The food composition of the present invention may be added as a broiler extract and astragalus extract as it is or may be used together with other food or food ingredients, and may be suitably used according to conventional methods.
본 발명의 식품 조성물은 육계 추출물 및 황기 추출물을 유효성분으로 포함하며, 유효성분의 함량은 사용 목적에 따라 적합하게 결정될 수 있다. 일반적으로, 육계 추출물 및 황기 추출물은 식품 조성물의 총중량에 대하여 0.0001 내지 100 중량%로 첨가될 수 있다.Food composition of the present invention includes a broiler extract and astragalus extract as an active ingredient, the content of the active ingredient may be appropriately determined according to the purpose of use. In general, broiler extract and astragalus extract may be added at 0.0001 to 100% by weight based on the total weight of the food composition.
본 발명에서, 식품 조성물의 형태에는 특별한 제한이 없으며, 통상적인 의미에서의 식품을 모두 포함한다. 본 발명이 적용될 수 있는 식품으로는, 예를 들어, 음료, 드링크제, 건강기능식품 등이 있다.In the present invention, the form of the food composition is not particularly limited, and includes all foods in the ordinary sense. Foods to which the present invention can be applied include, for example, beverages, drinks, and health functional foods.
본 발명에서, "건강기능식품"은 인체에 유용한 기능성을 가진 원료나 성분을 사용하여, 영양 공급 외에도 생체조절기능이 효율적으로 나타나도록 제조 및 가공한 식품을 의미한다. 상기 건강기능식품은 경우에 따라, 기능성식품, 건강식품 또는 건강보조식품 등의 용어와 호용된다. 또한, 본 발명에서, "기능"이란 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적인 작용으로 보건 용도에 유용한 효과를 의미할 수 있다.In the present invention, "health functional food" means a food prepared and processed so that a bio-control function is efficiently displayed in addition to nutritional supply, by using a raw material or a component having useful functionality for the human body. The health functional food is used interchangeably with terms such as a functional food, a health food, or a health supplement, as the case may be. In addition, in the present invention, "function" may mean an effect useful for health use by controlling nutrients or physiological action on the structure and function of the human body.
본 발명의 식품 조성물은 통상적으로 식품의 냄새, 맛 또는 시각 등을 향상시킬 수 있는 식품 첨가제를 추가로 더 포함할 수 있다. 상기 식품 첨가제는 예를 들어, 풍미제, 증진제, 탄산화제 방부제(소르빈산 칼륨, 벤조산나트륨, 살리실산, 디히드로초산나트륨 등), 살균제(표백분과 고도 표백분, 차아염소산나트륨 등), 산화방지제(부틸히드록시아니졸, 부틸히드록시톨루엔등), 착색제(타르색소 등), 발색제(아질산 나트륨, 아초산 나트륨 등), 표백제(아황산나트륨), 조미료(MSG 글루타민산나트륨 등), 감미료(둘신, 사이클레메이트, 사카린, 나트륨 등), 향료(바닐린, 락톤류 등), 팽창제(명반, D-주석산수소칼륨 등), 강화제, 유화제, 증점제(호료), 피막제, 검기초제, 거품억제제, 용제 및 개량제를 들 수 있으나, 이에 한정되는 것은 아니다. 상기 첨가물은 식품의 종류에 따라 선별되고 적절한 양으로 사용될 수 있다.The food composition of the present invention may further include a food additive that can generally improve the odor, taste, or vision of the food. The food additives include, for example, flavoring agents, enhancers, preservatives for carbonation agents (potassium sorbate, sodium benzoate, salicylic acid, sodium dihydroacetate, etc.), fungicides (bleaching and highly bleaching, sodium hypochlorite, etc.), antioxidants (butyl hydride) Roxyanisol, butylhydroxytoluene, etc.), colorants (such as tar color), colorants (sodium nitrite, sodium nitrite, etc.), bleach (sodium sulfite), seasonings (such as MSG sodium glutamate), sweeteners (dulcin, cyclate) , Saccharin, sodium, etc.), fragrances (vanillin, lactones, etc.), swelling agents (alum, D-potassium hydrogen sulphate, etc.), strengthening agents, emulsifiers, thickeners (foams), coating agents, gum starting agents, foam inhibitors, solvents and improvers However, it is not limited thereto. The additive may be selected according to the type of food and used in an appropriate amount.
본 발명의 식품 조성물은 식품의 기능성을 향상시킬 수 있는 추가의 성분을 더 포함할 수 있다. 예들 들어, 비타민(vitamin), 니아신(niacin), 비오틴(biotin), 폴레이트(folate), 판토텐산(panthotenic acid) 등을 포함할 수 있다. 또한, 아연(Zn), 철(Fe), 칼슘(Ca), 크롬(Cr), 마그네슘(Mg), 망간(Mn), 구리(Cu) 등의 미네랄을 포함할 수 있다. 또한, 라이신, 트립토판, 시스테인, 발린 등의 아미노산을 포함할 수 있다. The food composition of the present invention may further include additional ingredients that can improve the functionality of the food. For example, vitamins (vitamin), niacin (niacin), biotin (biotin), folate (folate), may include pantotenic acid (panthotenic acid). In addition, minerals such as zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (Mg), manganese (Mn), and copper (Cu) may be included. In addition, amino acids such as lysine, tryptophan, cysteine, and valine may be included.
본 발명의 식품 조성물은 식품 첨가물로 사용할 수 있으며, 이를 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다.The food composition of the present invention can be used as a food additive, it can be added as it is or used with other food or food ingredients, it can be suitably used according to a conventional method.
본 발명의 식품 조성물이 음료 또는 드링크제인 경우, 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상기 향미제는 예를 들어, 사카린, 아스파르탐 등을 들 수 있다. 상기 천연 탄수화물은 예를 들어, 모노사카라이드(포도당, 과당 등), 디사카라이드(말토스, 수크로스 등), 및 폴리사카라이드(덱스트린, 시클로덱스트린 등)와 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리스리톨 등의 당알코올을 들 수 있다. 그 밖에 본 발명의 식품 조성물은 천연 과일주스, 과일주스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 혼합하여 사용할 수 있다.When the food composition of the present invention is a beverage or drink, various flavors or natural carbohydrates and the like may be added as additional components, as in a conventional beverage. Examples of the flavoring agent include saccharin and aspartame. The natural carbohydrates include, for example, conventional sugars such as monosaccharides (glucose, fructose, etc.), disaccharides (maltose, sucrose, etc.), and polysaccharides (dextrin, cyclodextrin, etc.), and xylitol, And sugar alcohols such as sorbitol and erythritol. In addition, the food composition of the present invention may contain flesh for the preparation of natural fruit juice, fruit juice beverage and vegetable beverage. These ingredients may be used independently or in combination.
본 발명은 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 발모 촉진용 조성물을 제공한다.The present invention provides a composition for promoting hair growth, comprising broiler extract and astragalus extract as active ingredients.
본 발명의 발모 촉진용 조성물에서, 육계, 황기, 추출물 및 유효성분 은 앞서 본 발명의 약제학적 및 식품 조성물에 대해 상세하게 기재한 바와 동일하다.In the composition for promoting hair growth of the present invention, broiler, astragalus, extract and active ingredient are the same as those described in detail for the pharmaceutical and food composition of the present invention.
본 발명에서, "발모"는 모발의 생성 및 성장을 의미하며, 이 분야에서 사용되는 용어 양모 또는 육모의 의미를 포함하는 광의의 개념이다.In the present invention, "hair growth" refers to the generation and growth of hair, and is a broad concept including the term wool or hair growth as used in this field.
본 발명의 구체적인 실시예에 따르면, 육계 추출물 및 황기 추출물을 포함하는 조성물은 모발이 제거된 상태에서 모발의 생성 및 성장을 촉진한다. 따라서 본 발명의 조성물은 발모 촉진용으로 효과적으로 사용될 수 있다.According to a specific embodiment of the present invention, a composition comprising a broiler extract and astragalus extract promotes the production and growth of hair in a state in which the hair is removed. Therefore, the composition of the present invention can be effectively used for promoting hair growth.
본 발명의 발모 촉진용 조성물은 화장료 조성물로 사용될 수 있다. 상기 화장료 조성물은 예를 들어, 용액, 솔젤, 현탁액, 에멀젼, 페이스트, 마이크로캡슐, 오일, 왁스, 에어졸의 형태로 제형화 될 수 있으나, 이에 한정되는 것은 아니다. 상기 화장료 조성물의 구체적인 제형은 예를 들어, 헤어토닉, 헤어크림, 헤어팩, 헤어로션, 헤어샴푸, 헤어린스, 헤어비누, 헤어컨디셔너, 헤어스프레이, 헤어에어졸, 헤어 왁스, 헤어젤, 포마드 및 분말 등을 들 수 있으나, 이에 한정되는 것은 아니다. 상기 화장료 조성물은 화장료 조성물에 통상적으로 사용되는 보조제를 추가로 더 포함할 수 있다. 상기 보조제는 예를 들어, 겔화제, 활성제, 보존제, 항산화제, 용매, 방향제, 충전제, 차단제, 안료, 흡취제 및 염료 등을 들 수 있으나, 이에 한정되는 것은 아니다. 상기 화장료 조성물은 모발 또는 두피에 직접 도포 또는 산포하는 등의 방법에 의해 사용될 수 있다.The composition for promoting hair growth of the present invention may be used as a cosmetic composition. The cosmetic composition may be formulated in the form of, for example, a solution, sol gel, suspension, emulsion, paste, microcapsule, oil, wax, aerosol, but is not limited thereto. Specific formulations of the cosmetic composition, for example, hair tonic, hair cream, hair pack, hair lotion, hair shampoo, hair rinse, hair soap, hair conditioner, hair spray, hair aerosol, hair wax, hair gel, pomade and powder, etc. However, it is not limited to this. The cosmetic composition may further include an auxiliary agent commonly used in the cosmetic composition. Examples of the adjuvant include, but are not limited to, gelling agents, active agents, preservatives, antioxidants, solvents, fragrances, fillers, blockers, pigments, odorants and dyes. The cosmetic composition may be used by a method such as applying or spreading directly on the hair or scalp.
본 발명의 발모 촉진용 조성물은 목적에 따라 경구 투여하거나 비경구 투여할 수 있다. 본 발명에서, 비경구 투여는 예를 들어, 복강 투여, 직장 투여, 피하 투여, 정맥 투여, 근육 투여, 흉부 투여, 경피 투여를 들 수 있고, 조성물을 두피 또는 모발에 도포하거나 분무, 흡입하는 것도 들 수 있으나. 이에 한정되는 것은 아니다. The composition for promoting hair growth of the present invention may be administered orally or parenterally depending on the purpose. In the present invention, parenteral administration includes, for example, intraperitoneal administration, rectal administration, subcutaneous administration, intravenous administration, intramuscular administration, chest administration, and transdermal administration, and the composition is applied to the scalp or hair, sprayed, or inhaled. I can lift it. It is not limited to this.
본 발명의 발모 촉진용 조성물은 모발성장 촉진 보조성분을 추가로 포함할 수 있다. 모발성장 촉진 보조성분은 5알파-환원효소 억제 성분, 모근 및 모낭세포 활성 성분, 모낭세포 혈류 증강 성분, 살균 성분, 비듬방지제, 각질 연화제, 청량제, 보습제 등을 포함하나, 이에 한정되는 것은 아니다.The composition for promoting hair growth of the present invention may further include an auxiliary component for promoting hair growth. Auxiliary ingredients for promoting hair growth include, but are not limited to, 5 alpha-reductase inhibitory ingredients, hair root and follicular cell active ingredients, follicular cell blood flow enhancing ingredients, sterilizing ingredients, anti-dandruff agents, keratin softeners, refreshing agents, moisturizers, and the like.
육계 추출물 및 황기 추출물을 포함하는 조성물은 모발이 제거된 상태에서 모발의 생성 및 성장을 촉진한다. 또한, 본 발명의 육계 추출물 및 황기 추출물을 포함하는 조성물은 5α-리덕타아제의 발현을 억제할 수 있다. 따라서 본 발명의 식품 조성물은 탈모의 예방, 치료 또는 개선용, 및 발모 촉진용으로 효과적으로 사용될 수 있다.The composition comprising a broiler extract and astragalus extract promotes the production and growth of hair with the hair removed. In addition, the composition comprising the broiler extract and the astragalus extract of the present invention can suppress the expression of 5α-reductase. Therefore, the food composition of the present invention can be effectively used for preventing, treating or improving hair loss, and for promoting hair growth.
도 1은 실시예 1에서 정상대조군(NC), 음성대조군(AGA) 및 실험군(Sample group)의 피부를 관찰한 사진이다.
도 2는 실시예 1에서 정상대조군(NC), 음성대조군(AGA) 및 실험군(Sample group)의 피부를 더모스코프로 관찰한 사진이다.
도 3은 실시예 2에서 정상대조군(NC), 음성대조군(AGA) 및 실험군(Sample group)의 조직을 염색하여 광학 현미경으로 관찰한 것을 나타낸 것이다.
도 4는 실시예 3에서 정상대조군(NC), 음성대조군(AGA) 및 실험군(Sample group)의 카스파아제-8(caspase-8) 발현 정도를 웨스턴 블롯으로 확인한 결과를 나타낸 사진 및 그래프이다.
도 5는 실시예 3에서 정상대조군(NC), 음성대조군(AGA) 및 실험군(Sample group)의 카스파아제-9(caspase-9) 발현 정도를 웨스턴 블롯으로 확인한 결과를 나타낸 사진 및 그래프이다.
도 6은 실시예 3에서 정상대조군(NC), 음성대조군(AGA) 및 실험군(Sample group)의 p53 발현 정도를 웨스턴 블롯으로 확인한 결과를 나타낸 사진 및 그래프이다.1 is a photograph of the skin of the normal control group (NC), the negative control group (AGA) and the experimental group (Sample group) in Example 1.
FIG. 2 is a photograph of the skin of the normal control group (NC), the negative control group (AGA), and the experimental group (Sample group) observed in Example 1.
Figure 3 shows that observed in the optical microscope by staining the tissue of the normal control group (NC), negative control group (AGA) and experimental group (Sample group) in Example 2.
Figure 4 is a photograph and graph showing the results of confirming the expression level of caspase-8 (caspase-8) of the normal control group (NC), negative control group (AGA) and experimental group (Sample group) in Example 3.
5 is a photograph and graph showing the results of confirming the expression level of caspase-9 (caspase-9) of the normal control group (NC), the negative control group (AGA), and the experimental group in Example 3 by Western blot.
6 is a photo and graph showing the results of the p53 expression level of the normal control group (NC), the negative control group (AGA) and the experimental group (Sample group) in Example 3 confirmed by Western blot.
이하에서, 본 발명을 구체적인 제조예 및 실시예를 통하여 보다 상세히 설명한다. 그러나 하기 실시예는 본 발명의 이해를 돕기 위하여 제공되는 것일 뿐, 실시예에 의하여 본 발명의 범위가 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail through specific production examples and examples. However, the following examples are provided only to help understanding of the present invention, and the scope of the present invention is not limited by the examples.
<제조예><Production Example>
제조예 1: 육계 추출물의 제조Preparation Example 1: Preparation of broiler extract
육계(500 g)에 3차 증류수(3.75 L)를 가하여 100 ℃에서 2시간 열수 추출한 후 여과하였다. 여과액을 55 ± 2 ℃에서 회전 감압농축기(rotary vacuum evaporator, EYELA, Tokyo, Japan)로 감압 농축 후, 동결 건조하여 20.1 g 파우더 상태의 육계 열수 추출물(수율: 4%)을 수득하였다.Tertiary distilled water (3.75 L) was added to broiler (500 g), followed by extraction with hot water at 100° C. for 2 hours, followed by filtration. The filtrate was concentrated under reduced pressure with a rotary vacuum evaporator (EYELA, Tokyo, Japan) at 55±2° C., and then freeze-dried to obtain a 20.1 g powder broiler hot water extract (yield: 4%).
제조예 2: 황기 추출물의 제조Preparation Example 2: Preparation of astragalus extract
황기는 정도 생약국(Seoul, Korea)에서 건조된 뿌리 형태로 구입한 후 경희대학교 한의과대학 융합한의과학교실에서 형태학적 및 화학적으로 동정하여 사용하였다. 황기(150 g)에 증류수(1.5 L)을 가하여 100 ℃에서 2시간 열수 추출 한 후 여과하였다. 여과액을 55 ± 2 ℃에서 회전 감압농축기(rotary vacuum evaporator, EYELA, Tokyo, Japan)로 감압 농축 후, 동결 건조하여 24.3 g 파우더 상태의 황기 열수 추출물(수율: 16.2%)을 수득하였다.Hwanggi was purchased in the form of dried roots from the Soyak, Korea, and was used for morphological and chemical identification in the Department of Convergence Medicine, College of Oriental Medicine, Kyunghee University. Distilled water (1.5 L) was added to sulfuric acid (150 g), followed by extraction with hot water at 100° C. for 2 hours, followed by filtration. The filtrate was concentrated under reduced pressure with a rotary vacuum evaporator (EYELA, Tokyo, Japan) at 55±2° C., and then freeze-dried to obtain a 24.3 g powdered astragalus hot water extract (yield: 16.2%).
제조예 3: 육계 및 황기 복합 추출물의 제조Preparation Example 3: Preparation of broiler and astragalus complex extract
제조예 1에서 수득한 육계 추출물 및 제조예 2에서 수득한 황기 추출물을 1 : 4 의 중량 비율로 혼합하여 육계 및 황기 복합 추출물을 수득하였다.The broiler extract obtained in Preparation Example 1 and the astragalus extract obtained in Preparation Example 2 were mixed at a weight ratio of 1: 4 to obtain a broiler and astragalus complex extract.
<실시예> 육계 및 황기 복합 추출물을 포함하는 조성물의 탈모 예방, 치료, 개선 효과, 및 발모 촉진 효과 확인<Example> Prevention of hair loss, treatment, improvement effect, and hair growth promotion effect of a composition containing a broiler and astragalus complex extract
실험 동물Experimental animals
실시예 1 내지 3에서 실험동물은 체중 20 g 내외의 암컷 7주령의 C57BL/6J 정상 생쥐를 이용하였다. 모든 생쥐는 대한바이오링크(충북, 음성)로부터 구매하여 일주일 동안의 적응기를 통해 본 실험에 사용되었다. 전 실험 기간 동안 모든 생쥐들은 표준화된 고형사료와 물을 공급받았으며, 사육실의 온도는 23 ± 2°C, 습도 50 ± 10%, 광주기와 암주기(light-dark cycle)는 12시간-12시간으로 유지되었다. In Examples 1 to 3, the experimental animals used C57BL/6J normal mice of 7 weeks of age and females with a body weight of about 20 g. All mice were purchased from Daehan Biolink (Chungbuk, Eumseong) and used in this experiment through an adaptive period of one week. During the entire experimental period, all mice were supplied with standardized solid feed and water, the temperature in the breeding room is 23 ± 2°C, humidity is 50 ± 10%, photoperiod and light-dark cycle are 12 hours-12 hours. Was maintained.
실험 모델 유발 및 약물 처리Experimental model triggering and drug treatment
각 군의 생쥐(n = 6)는 정상대조군(NC, normal control group), 등 부위의 털을 제모한 음성대조군(AGA, negative control group), 등 부위의 털을 제모하고 제조예 3의 복합 추출물을 처리한 실험군(sample group)으로 나뉘어졌다. 발모효과를 관찰하기 위하여 전기제모기(electric clipper)를 사용하여 실험 시작 후 마우스의 등 부위의 털을 제거한 후 제모제를 발라 완전한 제모를 하였다. 정상대조군과 음성대조군에는 비히클(증류수)을 처리하였으며, 제조예 3의 복합 추출물은 100 mg/kg의 양으로 처리하였으며, 증류수에 녹여 100 μL씩 구강투여 하였다. 매일 1회씩 총 14일간 반복하였으며, 15일 째 되는 날 실험 목적에 따라 생쥐를 희생하였다. 분석을 위하여 병변 부위의 피부 조직을 적출하였다. 적출된 피부 조직을 이하의 실시예 2 및 3에 사용하였다.In each group of mice (n = 6), a normal control group (NC), a negative control group (AGA, epilation of hair on the back area), a hair removal on the back area, and a complex extract of Preparation Example 3 It was divided into the experimental group (sample group). In order to observe the hair growth effect, the hair was removed from the back of the mouse after the start of the experiment using an electric clipper, and the hair removal agent was applied to complete hair removal. The normal control group and the negative control group were treated with vehicle (distilled water), and the complex extract of Preparation Example 3 was treated in an amount of 100 mg/kg, dissolved in distilled water and administered orally by 100 μL. It was repeated once a day for a total of 14 days, and mice were sacrificed according to the purpose of the experiment on the 15th day. Skin tissue at the lesion site was extracted for analysis. The extracted skin tissue was used in Examples 2 and 3 below.
통계처리Statistics processing
실시예 1 내지 3에서 실험 결과는 평균 ± 표준오차(mean ± S.E.M) 값으로 표시하였으며, 집단 간 평균치 차이는 각 실험 결과를 통하여 ANOVA (analysis of variance)를 구한 후 던칸 다중 범위 검정(Duncan's multiple range test)을 이용하여 p < 0.05 수준에서 검증하였다.In Examples 1 to 3, the experimental results were expressed as mean ± standard error (mean ± SEM) values, and the mean difference between groups was calculated through ANOVA (analysis of variance) through each experimental result, followed by Duncan's multiple range test. test) at p <0.05 level.
실시예 1: 육안 관찰Example 1: Visual observation
육계 및 황기 복합 추출물의 발모 효능을 관찰하기 위하여 실험 시작 15일 째 되는 날 생쥐를 희생하기 전 졸레틸과 럼푼이 1:1로 혼합된 마취제를 희석하여 복강 투여하였다. 마취된 생쥐의 등 부위를 카메라(Sony, Tokyo, Japan)와 더모스코프(dermoscope) (Smart Microscope Pro; Kangjin Technology, Ltd., Seoul, Korea)로 촬영한 후 정상대조군 및 음성대조군과 비교 관찰하였다. 카메라로 촬영한 결과를 도 1에 나타내었으며, 더모스코프로 촬영한 결과를 도 2에 나타내었다.In order to observe the hair growth efficacy of the broiler and astragalus complex extracts, an anesthetic mixed with zoletyl and rumpoon 1:1 was diluted and administered intraperitoneally before sacrificing mice on the 15th day of the experiment. The back part of the anesthetized mouse was photographed with a camera (Sony, Tokyo, Japan) and a dermoscope (Smart Microscope Pro; Kangjin Technology, Ltd., Seoul, Korea), and then compared with the normal control group and the negative control group. The results taken with the camera are shown in FIG. 1, and the results taken with the Dermoscope are shown in FIG. 2.
도 1 및 2에 나타낸 바와 같이, 육계 및 황기 복합 추출물을 처리한 군에서 음성대조군 대비 모발의 성장이 월등히 우수한 것을 확인할 수 있다. 따라서, 본 발명의 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 조성물은 탈모의 예방, 치료, 개선, 및 발모 촉진용으로 효과적으로 사용될 수 있다.As shown in Figures 1 and 2, it can be seen that the growth of hair was significantly superior to the negative control group in the group treated with the broiler and astragalus complex extracts. Therefore, the composition containing the broiler extract and the astragalus extract of the present invention as an active ingredient can be effectively used for preventing, treating, improving, and promoting hair growth.
실시예 2: 조직학적 평가Example 2: Histological evaluation
적출한 등 피부 조직을 24시간 동안 4% 포르말린에 고정한 후, 조직의 탈수를 위해 순서대로 저농도의 70% 에탄올부터 80% 에탄올, 90% 에탄올, 95% 에탄올 및 고농도 100% 알코올까지 탈수하고, 자일렌에 투명과정을 거친 다음 파라핀 블록을 제작하였다. 제작된 블록은 4 μm 두께로 박절하여 탈파라핀 및 100% 에탄올에서 70% 에탄올을 거쳐 함수시켰다. 증류수에 수세시킨 조직 슬라이드를 헤마토실린(hematoxylin) & 에오신(eosin) (H&E)으로 각각 염색하여 퍼마운트(permount)로 봉입하였다. 염색된 조직은 광학현미경(Leica Microsystems Inc., IL, USA)에서 × 200 배율로 관찰하였으며, 그 결과를 도 3에 나타내었다.After fixing the extracted back skin tissue in 4% formalin for 24 hours, in order to dehydrate the tissue, dehydrate from 70% ethanol to 80% ethanol, 90% ethanol, 95% ethanol, and high concentration 100% alcohol in order. After undergoing a transparent process on the len, a paraffin block was produced. The produced block was sliced to a thickness of 4 μm, and then dehydrated through deparaffin and 100% ethanol to 70% ethanol. Tissue slides washed with distilled water were stained with hematoxylin & eosin (H&E), respectively, and sealed with a permount. The stained tissue was observed under an optical microscope (Leica Microsystems Inc., IL, USA) at a magnification of 200, and the results are shown in FIG. 3.
도 3에 나타낸 바와 같이, 육계 및 황기 복합 추출물을 처리한 군에서 음성대조군 대비 모낭의 형태가 안정되고, 모발의 형성이 촉진된 것을 확인할 수 있다. 따라서, 본 발명의 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 조성물은 탈모의 예방, 치료, 개선, 및 발모 촉진용으로 효과적으로 사용될 수 있다.As shown in FIG. 3, it can be seen that in the group treated with the broiler and astragalus complex extract, the morphology of the hair follicle was stabilized compared to the negative control group, and hair formation was promoted. Therefore, the composition containing the broiler extract and the astragalus extract of the present invention as an active ingredient can be effectively used for preventing, treating, improving, and promoting hair growth.
실시예 3: 탈모 관련 단백질 발현 억제 확인 (웨스턴 블롯)Example 3: Hair loss related protein expression inhibition confirmation (Western Blot)
적출된 피부 조직의 단백질을 추출하기 위하여 프로테아제 억제제 칵테일(protease inhibitors cocktail)이 포함된 단백질 추출 버퍼(protein extraction buffer) (50 mM Tris-HCl, 150 mM NaCl, 1% 트리톤 X-100, 1% 디옥시콜산 나트륨, 0.1% 도데실 황산 나트륨(SDS), 2 mM 에틸렌디아민테트라 아세트산(EDTA))를 넣어 분쇄하였다. 얻어진 단백질은 브래드포드(bradford) 법을 사용하여 정량하였다. 정량된 단백질 30 μg을 SDS 12% 폴리아크릴아미드 젤(polyacrylamide gel)에 전기영동하여 분리한 후 폴리비닐리덴 디플루오라이드(PVDF) 멤브레인으로 이동시켰다. 1차 항체를 반응시킨 후, 호스래디시 퍼옥시다아제(HRP) goat anti-rabbit을 처리하여 2차 반응을 유도시켰다. 발현된 단백질 밴드는 강화된 화학발광 분석 키트(enhanced chemiluminescence assay kit)를 이용하여 LAS 이미지 게이지(LAS Image Gauge) 프로그램에서 측정하였으며, 그 결과를 도 4 내지 6에 나타내었다.Protein extraction buffer (50 mM Tris-HCl, 150 mM NaCl, 1% Triton X-100, 1% D) containing protease inhibitors cocktail to extract the protein of the extracted skin tissue. Sodium oxycholate, 0.1% sodium dodecyl sulfate (SDS) and 2 mM ethylenediaminetetraacetic acid (EDTA) were added and pulverized. The obtained protein was quantified using the Bradford method. 30 μg of the quantified protein was separated by electrophoresis on SDS 12% polyacrylamide gel, and then transferred to a polyvinylidene difluoride (PVDF) membrane. After reacting the primary antibody, a secondary reaction was induced by treating horseradish peroxidase (HRP) goat anti-rabbit. The expressed protein band was measured in a LAS Image Gauge program using an enhanced chemiluminescence assay kit, and the results are shown in FIGS. 4 to 6.
도 4 내지 6에 나타낸 바와 같이, 음성 대조군의 경우 카스파아제-8(caspase-8), 카스파아제-9(caspase-9) 및 p53의 발현이 크게 증가하여 모발 퇴화기에 모낭 내 세포사멸이 일어났으나, 육계 및 황기 복합 추출물을 투여한 실험군의 경우 상기 단백질들의 발현 증가가 크게 완화되는 것으로 보아 육계 및 황기 복합 추출물이 모낭 내 항-세포사멸 효과를 가짐을 확인할 수 있다. 따라서, 본 발명의 육계 추출물 및 황기 추출물을 유효성분으로 포함하는 조성물은 탈모의 예방, 치료, 개선, 및 발모 촉진용으로 효과적으로 사용될 수 있다.4 to 6, in the case of the negative control group, caspase-8, caspase-9, and p53 expression increased significantly, resulting in apoptosis in the hair follicle during hair degeneration. B, in the experimental group in which the broiler and astragalus complex extracts were administered, it was confirmed that the increase in expression of the proteins was significantly alleviated, and the broiler and astragalus complex extracts had anti-apoptotic effects in hair follicles. Therefore, the composition comprising the broiler extract and the astragalus extract of the present invention as an active ingredient can be effectively used for preventing, treating, improving and promoting hair growth.
이상의 설명으로부터, 본 발명이 속하는 기술분야의 통상의 기술자는 본 발명이 그 기술적 사상이나 필수적 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다. 이와 관련하여, 이상에서 기술한 예들은 모든 면에서 예시적인 것이며 한정적인 것이 아닌 것으로서 이해되어야 한다. 본 발명의 범위는 상기 상세한 설명보다는 후술하는 특허 청구범위의 의미 및 범위 그리고 그 등가 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.From the above description, those skilled in the art to which the present invention pertains will appreciate that the present invention may be implemented in other specific forms without changing its technical spirit or essential characteristics. In this regard, the examples described above should be understood as illustrative in all respects and not restrictive. The scope of the present invention should be construed as including all changes or modifications derived from the meaning and scope of the following claims rather than the detailed description and equivalent concepts thereof.
Claims (8)
상기 육계 추출물 및 황기 추출물은 모낭 내 세포사멸 억제 효과를 갖는 것을 특징으로 하는 탈모의 예방 또는 치료용 약제학적 조성물.Contains broiler extract and astragalus extract as active ingredients,
The broiler extract and astragalus extract is a pharmaceutical composition for preventing or treating hair loss, characterized in that it has the effect of inhibiting apoptosis in hair follicles.
상기 육계 추출물 및 황기 추출물은 모낭 내 세포사멸 억제 효과를 갖는 것을 특징으로 하는 탈모의 예방 또는 개선용 식품 조성물.Contains broiler extract and astragalus extract,
The broiler extract and astragalus extract is a food composition for preventing or improving hair loss, characterized in that it has the effect of inhibiting apoptosis in hair follicles.
상기 육계 추출물 및 황기 추출물은 모낭 내 세포사멸 억제 효과를 갖는 것을 특징으로 하는 발모 촉진용 조성물.Contains broiler extract and astragalus extract as active ingredients,
The broiler extract and astragalus extract is a composition for promoting hair growth, characterized in that it has an effect of inhibiting apoptosis in hair follicles.
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| KR100762413B1 (en) | 2006-03-27 | 2007-10-04 | 한국미용화장품(주) | Compositon for prevention of hair loss and stimulation of hair growth |
| KR101547758B1 (en) * | 2014-03-05 | 2015-08-26 | 주식회사 크라운진 | Composition for preventing hair loss and promoting hair growth |
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| JP3027302B2 (en) * | 1994-09-06 | 2000-04-04 | 花王株式会社 | Hair restoration / hair restoration |
| JPH10203933A (en) * | 1997-01-27 | 1998-08-04 | Kao Corp | Hair-restoring and growing agent |
| KR20010018668A (en) * | 1999-08-20 | 2001-03-15 | 유상옥 | A cosmetic composition containing Cinnamomi Cortex extracts |
| KR100583158B1 (en) * | 2004-07-21 | 2006-05-23 | 김은선 | Composition comprising an extract of astragalusmembranaceus for hair growing promotor |
| KR20080081393A (en) * | 2007-03-05 | 2008-09-10 | 주식회사 에이치비비지니스 | Hair growth promoting composition having extract of pogostemon cablin, sunflower, cinnamomum cassia blume |
| KR100973248B1 (en) * | 2008-10-24 | 2010-07-30 | 호서대학교 산학협력단 | Soap with finely milled natural cinnamon powder and method for fabricating the same |
| KR101231582B1 (en) * | 2010-05-14 | 2013-02-08 | 김수근 | Composition for Moisturizing Skin and Composition for Preventing Hair Loss or Promoting Hair Generation Having the Extract of Cinnamomum camphora Sieb |
| KR101810139B1 (en) | 2011-10-19 | 2017-12-19 | (주)아모레퍼시픽 | Composition for promoting hair growth and restoration |
| KR101908360B1 (en) * | 2011-11-29 | 2018-10-17 | (주)아모레퍼시픽 | Composition Containing essential oil for relieving seborrheic dermatitis |
| KR101332803B1 (en) * | 2012-02-07 | 2013-11-27 | 계명대학교 산학협력단 | Method for Preparing Supercritical Fluid Extract of Cinnamomum verum and Its Use |
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| KR101797667B1 (en) | 2017-07-24 | 2017-12-12 | 최기남 | Composition for preventing, improving or treating hair loss and method for preparing the same |
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| KR100762413B1 (en) | 2006-03-27 | 2007-10-04 | 한국미용화장품(주) | Compositon for prevention of hair loss and stimulation of hair growth |
| KR101547758B1 (en) * | 2014-03-05 | 2015-08-26 | 주식회사 크라운진 | Composition for preventing hair loss and promoting hair growth |
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