KR101958969B1 - A composition for improving, preventing and treating of alcoholic gastrointestinal diseases comprising a complex extract of seaweed and complex extract of plant - Google Patents
A composition for improving, preventing and treating of alcoholic gastrointestinal diseases comprising a complex extract of seaweed and complex extract of plant Download PDFInfo
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- KR101958969B1 KR101958969B1 KR1020170163116A KR20170163116A KR101958969B1 KR 101958969 B1 KR101958969 B1 KR 101958969B1 KR 1020170163116 A KR1020170163116 A KR 1020170163116A KR 20170163116 A KR20170163116 A KR 20170163116A KR 101958969 B1 KR101958969 B1 KR 101958969B1
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- extract
- seaweed
- alcoholic
- plant
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Abstract
Description
본 발명은 알코올성 위장질환을 개선, 예방 또는 치료할 수 있도록 해조류 복합추출물 및 식물 복합추출물을 유효성분으로 함유하는 조성물에 관한 것이다.The present invention relates to a composition containing an algae extract and a plant complex extract as active ingredients so as to improve, prevent or treat an alcoholic gastrointestinal disorder.
숙취란 취할 때까지 술을 마신 사람들이 경험하는 현상으로 빈번히 나타나면서도 유쾌하지 못한 신체적, 정신적 증상을 말한다. 원인으로는 알코올 및 그 중간 대사산물인 아세트알데히드의 독성, 탈수, 흡수 장애로 인한 영양소의 결핍(혈당, 무기질 및 비타민 결핍)으로 알려져 있다. 숙취의 정도는 개인에 따른 편차(유전적 소양), 환경상태(영양상태, 운동상태, 탈수 정도, 건강상태 등)에 따라 그 차이가 매우 심하게 나타난다. 대표적인 증상으로는 목마름, 구토, 피로, 현기증, 두통 등이 있고, 이러한 요소들이 복합적으로 작용하기도 한다.Hangover is a phenomenon experienced by people who have drunk until they are drunk, but it often refers to unpleasant physical and mental symptoms. The cause is known as the lack of nutrients (blood sugar, minerals and vitamin deficiencies) due to the toxicity, dehydration and absorption of alcohol and its intermediate metabolite, acetaldehyde. The degree of hangover is very different according to individual variation (genetic inheritance), environmental condition (nutrition status, exercise status, degree of dehydration, health status, etc.). Typical symptoms include thirst, vomiting, fatigue, dizziness, and headache.
알코올은 간에서 알코올 데하이드로게나제 (ADH)와 조효소인 NAD+에 의해 숙취의 원인물질로 알려진 아세트알데히드로 산화되며, 알데히드 데하이드로게나제 (ALDH)와 NAD+에 의해서 아세트산으로 분해된다.Alcohol is oxidized to acetaldehyde, known as the causative agent of hangover, by the alcoholic dehydrogenase (ADH) and coenzyme NAD + in the liver, and is degraded to acetic acid by aldehyde dehydrogenase (ALDH) and NAD +.
또한, 사이토크롬 P-450 type 2E1(CYP2E1)과 카탈라아제에 의해서도 아세트알데히드로 산화되는데, 아세트알데히드와 아세트산은 지질 과산화반응 등을 통해 세포독성, 두통이나 복통, 삼투압 변화에 따른 탈수현상 등을 일으킨다. In addition, cytochrome P-450 type 2E1 (CYP2E1) and catalase also oxidize to acetaldehyde. Acetaldehyde and acetic acid cause cytotoxicity through lipid peroxidation, dehydration due to headache, abdominal pain, and osmotic changes.
또한, 현대인의 주요 질환 중 하나인 소화성 위궤양(peptic ulcers)은 점막이 위산(gastric HCl)과 펩신에 잠겨 있는 부위의 손상을 의미하는 것으로, 이 부위는 정상적으로 점막 세포가 분비하는 뮤신에 의해 덮여있다. 따라서 위산 분비 촉진, 펩신의 침습에 대항하는 뮤신 층의 약화 혹은 고갈, 국소 혈액순환 장애, 세포손상 및 염증반응 등 다양한 원인에 의해 위 점막 미란(erosions)과 궤양이 유발된다.In addition, peptic ulcers, one of the major diseases of modern humans, imply that the mucosa is damaged by gastric HCl and pepsin, which is normally covered by mucin secreted by mucous cells . Therefore, gastric mucosal erosions and ulcers are caused by various causes such as stimulation of gastric acid secretion, weakening or depletion of mucin layer against pepsin invasion, disturbance of blood circulation, cell damage and inflammation reaction.
그러므로 위궤양을 일으키는 원인물질로는 뮤신 층을 강화시키고 국소 혈행을 원활하게 해 주는 PGs을 생성하는 효소인 사이클로옥시게나제(COX)를 억제하는 비스테로이드성 소염제(NSAIDs) 등의 약물, 심리적 스트레스, 위산과다분비 및 저류, 위장운동성 증가 및 아세트산 축적, 헬리코박터 파이로리와 같은 세균감염 등을 들 수 있다.Therefore, gastric ulcers are caused by drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX), an enzyme that produces PGs that strengthens the mucin layer and smoothes local blood circulation, Gastric acid secretion and accumulation, bacterial infections such as Helicobacter pylori, and the like.
특히, 고농도의 알코올은 위 점막의 울혈을 초래하여 직접적인 출혈 및 괴사를 유발함은 물론 라디칼 반응에 따른 지질 과산화반응도 관여하는 것으로 알려져 있다.In particular, high concentrations of alcohol are known to cause congestion of the gastric mucosa, leading to direct hemorrhage and necrosis, as well as lipid peroxidation through radical reactions.
위궤양 치료제로는 벽세포로부터의 산 분비를 차단하는 수소 이온 펌프 억제제, 제산제(antacids), 산 분비를 촉진시키는 히스타민의 수용체 차단제(H2-antagonists), 뮤신층 강화제인 PGs와 그 유도체, 그리고 헬리코박터파이로리를 근절할 수 있는 항생제류가 대표적이다(Wallace와 Granger, 1996; Neal, 2003).Anti-gastric ulcers include hydrogen ion pump inhibitors, antacids, and H2-antagonists to block acid secretion from wall cells, histamine (H2-antagonists) that promote acid secretion, PGs and their derivatives as a mucin-layer enhancer, and Helicobacter pylori (Wallace and Granger, 1996; Neal, 2003).
알코올성 숙취와 위궤양은 현대인에 있어 빼놓을 수 없는 질환 중 하나로 많은 사람들이 겪고 있다. 특히 사회적 스트레스에 더해 빈번한 알코올의 섭취는 심각한 위궤양과 함께 간질환을 동반하는 경우가 많아 이를 개선하기 위한 많은 의약품과 건강기능성식품들이 판매되고 있다. 즉, ADH 및 ALDH를 활성화시켜 알코올 혈중농도를 낮추기 위한 노력이 집중적으로 이루어지고 있다. 하지만 단기간의 복용으로 효소를 활성화시켜 유의한 해독효과를 나타내는 효과적인 물질은 거의 찾아 볼 수 없다. Alcoholic hangover and stomach ulcers are one of the most common diseases in modern people. Especially, frequent consumption of alcohol in addition to social stress is accompanied with severe gastric ulcer and liver disease, and many medicines and health functional food products are being sold to improve it. That is, efforts to lower the alcohol blood concentration by activating ADH and ALDH have been intensively performed. However, there are few effective substances that activate the enzyme by a short-term dose and thus exhibit significant detoxifying effects.
특히, 수소 이온 펌프 억제제인 판토프라졸과 같은 위궤양 치료제의 경우에도 다른 원인에 의한 위궤양에는 효과적이지만 알코올성 위궤양에는 효과가 미약한 것으로 알려져 있다(Cao 등, 2004).In particular, the treatment of gastric ulcer, such as pantoprazole, which is a hydrogen ion pump inhibitor, is effective for gastric ulcers caused by other causes, but it is not effective for alcohol ulcers (Cao et al., 2004).
따라서, 생약 추출물 또는 인공제제 원료를 이용한 알코올성 위장질환용 식품이나 의약품이 개발되어 유통되고 있으나, 이들은 약효가 다소 인정되기는 해도 만족할만한 수준에 미치지 못하므로 부작용이 없으면서 효과가 충분히 인정되는 새로운 알코올성 위장질환 개선, 예방 또는 치료가 가능한 물질의 개발이 요구되고 있다.Therefore, foods or medicines for alcoholic gastrointestinal diseases using herbal medicine extracts or artificial preparations have been developed and distributed. However, they have not been satisfactorily satisfactory even though their efficacy is somewhat recognized. Therefore, new alcoholic gastrointestinal diseases There is a demand for development of a substance capable of improving, preventing, or treating cancer.
본 발명의 목적은 해조류 복합추출물 및 식물 복합추출물을 유효성분으로 함유하여 알코올성 위장질환을 예방 또는 치료할 수 있는 약학 조성물을 제공하는데 있다.It is an object of the present invention to provide a pharmaceutical composition containing an algae complex extract and a plant complex extract as an active ingredient to prevent or treat alcoholic gastrointestinal diseases.
또한, 본 발명의 다른 목적은 해조류 복합추출물 및 식물 복합추출물을 유효성분으로 함유하여 알코올성 위장질환을 개선 또는 예방할 수 있는 식품 조성물을 제공하는데 있다.Another object of the present invention is to provide a food composition containing as an active ingredient an algae complex extract and a plant complex extract capable of alleviating or preventing an alcoholic gastrointestinal disorder.
상기한 목적을 달성하기 위한 본 발명의 알코올성 위장질환을 예방 또는 치료할 수 있는 약학 조성물은 감태 추출물, 우뭇가사리 추출물, 톳 추출물, 모자반 추출물 및 돌미역 추출물을 포함하는 해조류 복합추출물; 및 In order to accomplish the above object, the present invention provides a pharmaceutical composition capable of preventing or treating alcoholic gastrointestinal diseases, which comprises at least one extract selected from the group consisting of Ganoderma lucidum extract, Mugwort extract, Capsicum annuum extract, And
황칠 추출물 및 녹차 추출물을 포함하는 식물 복합추출물;을 포함하는 혼합물을 유효성분으로 함유할 수 있다.An extract of a plant complex containing a green tea extract and a green tea extract, as an active ingredient.
상기 해조류 복합추출물은 감태 추출물 25 내지 40 중량%, 우뭇가사리 추출물 1 내지 10 중량%, 톳 추출물 25 내지 40 중량%, 모자반 추출물 25 내지 35 중량% 및 돌미역 추출물 1 내지 10 중량%를 포함할 수 있다.The seaweed complex extract may contain 25 to 40 wt% of a gentian extract, 1 to 10 wt% of a mugwort extract, 25 to 40 wt% of a mugwort extract, 25 to 35 wt% of a mugwort extract, and 1 to 10 wt% of a mugwort extract .
상기 식물 복합추출물은 황칠 추출물과 녹차 추출물은 1 : 0.7-1.3의 중량비로 혼합될 수 있다.The plant complex extract may be mixed with a mixture of Huangchil extract and green tea extract at a weight ratio of 1: 0.7-1.3.
상기 해조류 복합추출물과 식물 복합추출물은 1 : 5 내지 90의 중량비로 혼합될 수 있다.The algae complex extract and the plant complex extract may be mixed at a weight ratio of 1: 5 to 90.
상기 감태 추출물, 우뭇가사리 추출물, 톳 추출물, 모자반 추출물, 돌미역 추출물, 황칠 추출물 및 녹차 추출물은 물, 탄소수 1 내지 4의 저급알코올 또는 이들의 혼합용매로 추출된 것일 수 있다.The mint extract, mugwort extract, mangosteen extract, manganese manganese extract, dolomite extract, Huangchil extract and green tea extract may be extracted with water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof.
상기 알코올성 위장질환은 알코올에 의한 메스꺼움, 구토, 복통, 소화불량, 알코올성 위염 및 알코올성 위궤양 중에서 선택된 하나 이상인 것일 수 있다.The alcoholic gastrointestinal disorder may be one or more selected from nausea, vomiting, abdominal pain, indigestion, alcoholic gastritis and alcoholic gastric ulcer caused by alcohol.
또한, 상기한 다른 목적을 달성하기 위한 본 발명의 알코올성 위장질환을 개선 또는 예방할 수 있는 식품 조성물은 감태 추출물, 우뭇가사리 추출물, 톳 추출물, 모자반 추출물 및 돌미역 추출물을 포함하는 해조류 복합추출물; 및 In another aspect of the present invention, there is provided a food composition capable of improving or preventing alcoholic gastrointestinal diseases, which comprises at least one of algae extracts including Ganoderma lucidum extract, Mugwort extract, Top extract, Mungbean extract, And
황칠 추출물 및 녹차 추출물을 포함하는 식물 복합추출물;을 포함하는 혼합물을 유효성분으로 함유할 수 있다.An extract of a plant complex containing a green tea extract and a green tea extract, as an active ingredient.
본 발명의 알코올성 위장질환의 개선, 예방 또는 치료용 조성물은 알코올성 위장질환으로 인한 병리학적 소견을 완화시킬 수 있으므로 알코올성 위장질환의 예방 또는 치료에 현저한 효과가 있다.The composition for improving, preventing or treating alcoholic gastrointestinal diseases of the present invention can alleviate the pathological findings due to alcoholic gastrointestinal diseases and thus has a remarkable effect in the prevention or treatment of alcoholic gastrointestinal diseases.
또한, 본 발명은 천연물질인 해조류 복합추출물 및 식물 복합추출물을 유효성분으로 포함하여 부작용이 없으며 저렴하므로 알코올성 위장질환에 장기적으로 사용할 수 있다.In addition, the present invention can be used for alcoholic gastrointestinal diseases for a long period of time because it has no side effects and contains a natural extract of a seaweed compound complex and a plant complex extract as effective ingredients.
도 1은 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 궤양 인덱스를 나타낸 그래프이다.
도 2는 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군을 촬영한 사진이다.
도 3은 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 히스타민(Histamine) 농도를 나타낸 그래프이다.
도 4는 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 가스트린(Gastrin) 농도를 나타낸 그래프이다.
도 5는 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 IL-1β 농도를 나타낸 그래프이다.
도 6은 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 TNF-α 농도를 나타낸 그래프이다.FIG. 1 is a graph showing the ulcer indexes of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
FIG. 2 is a photograph of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
FIG. 3 is a graph showing the histamine concentrations of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
FIG. 4 is a graph showing the concentration of Gastrin in the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
FIG. 5 is a graph showing the IL-1? Concentrations in the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
FIG. 6 is a graph showing the TNF-.alpha. Concentrations of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
본 발명은 알코올성 위장질환을 개선, 예방 또는 치료할 수 있도록 해조류 복합추출물 및 식물 복합추출물을 유효성분으로 함유하는 조성물에 관한 것이다.
The present invention relates to a composition containing an algae extract and a plant complex extract as active ingredients so as to improve, prevent or treat an alcoholic gastrointestinal disorder.
이하, 본 발명을 상세하게 설명한다. Hereinafter, the present invention will be described in detail.
본 발명의 알코올성 위장질환을 개선, 예방 또는 치료할 수 있는 조성물은 해조류 복합추출물 및 식물 복합추출물을 유효성분으로 함유한다.The composition capable of improving, preventing or treating the alcoholic gastrointestinal disease of the present invention contains the seaweed complex extract and the plant complex extract as an active ingredient.
상기 해조류 복합추출물은 감태 추출물, 우뭇가사리 추출물, 톳 추출물, 모자반 추출물 및 돌미역 추출물을 포함하며; 상기 식물 복합추출물은 황칠 추출물 및 녹차 추출물을 포함한다.The above-mentioned seaweed compound complex extracts include Ganoderma lucidum extract, Mugwort extract, Chrysanthemum morifolium extract, Mulberry leaf extract and Strawberry Seed Extract; The plant complex extract includes Huangchil extract and green tea extract.
상기 감태(Ecklonia cava)는 갈조식물 다시마목 미역과의 해조류로, 한국, 일본 등지에 분포한다. 상기 감태는 후코이단과 플로로탄닌 성분을 함유하고 있으며, 상기 성분들은 항산화, 항암, 항염, 노화억제 및 고혈압억제 등에 우수한 것으로 알려져 있다. Ecklonia cava is a marine algae with brown algae, and is distributed in Korea and Japan. The above menthol contains fucoidan and phlorotannin components, and these components are known to be superior to antioxidants, anti-cancer, anti-inflammation, anti-aging and hypertension inhibition.
상기 감태는 추출물 형태로서 25 내지 40 중량%, 바람직하게는 30 내지 35 중량%로 사용된다. 감태 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다. The menthol is used in the form of an extract in an amount of 25 to 40% by weight, preferably 30 to 35% by weight. If the content of gentian extract is out of the above range, the efficacy against alcoholic gastrointestinal diseases may be deteriorated.
또한, 상기 우뭇가사리(Gelidium amansii)는 우뭇가사리과에 속하는 홍조류로서, 단백질 4.2%, 지방 0.2%, 탄수화물 18.5%, 섬유질 3.0%, 무기질 3.8%를 함유한다. 상기 우뭇가사리는 식용, 약용, 연구용, 공업용 등의 용도로 다양하게 활용되고 있으며, 식용 첨가물로서 영양적으로 많은 양의 탄수화물을 지니고 있고, 철분과 칼슘을 상당량 함유하고 있으며, 비타민A가 특히 많다.The above-mentioned Gelidium amansii is a red alga belonging to the mugwort family. It contains 4.2% protein, 0.2% fat, 18.5% carbohydrate, 3.0% fiber and 3.8% inorganic. The mugwort is widely used for various purposes such as edible, medicinal, research, and industrial applications. It has a nutritious amount of carbohydrate as an edible additive, contains a large amount of iron and calcium, and has a particularly large amount of vitamin A.
상기 우뭇가사리는 추출물 형태로서 1 내지 10 중량%, 바람직하게는 2 내지 5 중량%로 사용된다. 우뭇가사리 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다. The extract is used in an amount of 1 to 10% by weight, preferably 2 to 5% by weight. If the content of Leucocephalus extract is out of the above range, the efficacy against alcoholic gastrointestinal diseases may be deteriorated.
또한, 상기 톳(Hizikia fusiforme)은 모자반과에 속하는 갈조류로, 뿌리는 나뭇가지 모양이고 줄기는 원주형이며 잎은 베 짜는 북 또는 방망이 모양이고 곁가지는 엽액에 붙어서 난다. 우리나라의 중부 이남에 분포하고 특히 제주도와 서남해안에서 많이 생산되며, 칼슘, 요오드, 철 등의 무기염류가 많이 포함되어 있다.In addition, Hizikia fusiforme is a brown algae belonging to the moth, and its roots are in the shape of branches, the stem is columnar, the leaves are in the shape of a drum or bat, and the branches are attached to the leaf. It is distributed in the southern part of Korea, especially in Jeju and South western coasts. It contains many inorganic salts such as calcium, iodine and iron.
상기 톳은 추출물 형태로서 25 내지 40 중량%, 바람직하게는 30 내지 35 중량%로 사용된다. 톳 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다. The extract is used in an amount of 25 to 40% by weight, preferably 30 to 35% by weight. If the content of the top extract is out of the above range, the efficacy against alcoholic gastrointestinal diseases may be deteriorated.
또한, 상기 모자반(Sargassum fulvellum)은 모자반과에 속하는 갈조류의 하나로, 연안에 나며 녹갈색으로 톳과 비슷한 모양을 하고 있다. 일반성분은 단백질 1.85%, 지방 0.2%, 탄수화물 5.2%, 섬유 1.5%, 무기질 5.1%이며, 이중 칼슘의 함량이 많다.In addition, Sargassum fulvellum is one of the brown algae belonging to the mulberry family and has a shape similar to a greenish brown color in the coast. The general ingredients are 1.85% protein, 0.2% fat, 5.2% carbohydrate, 1.5% fiber and 5.1% inorganic, with a high content of calcium.
상기 모자반은 추출물 형태로서 25 내지 35 중량%, 바람직하게는 30 내지 35 중량%로 사용된다. 모자반 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다. The moth is used in the form of an extract in an amount of 25 to 35% by weight, preferably 30 to 35% by weight. If the content of mung bean extract is out of the above range, the efficacy against alcoholic gastrointestinal diseases may be decreased.
또한, 상기 돌미역은 다시마목(Laminariales) 미역과(Alariaceae)에 속하는 1년생 대형 조류로서 울릉도 청정해역 해안가 바위에서 자연 생산되며, 풍부한 단백질, 비타민, 미네랄, 칼슘, 요오드 등의 영양소가 다양하게 함유되어 있다. In addition, the dolm is the one year old algae belonging to the Laminariales seaweed (Alariaceae). It is naturally produced in the coastal rocks of Ulleungdo's coastal waters, and rich in nutrients such as protein, vitamins, minerals, calcium and iodine .
상기 돌미역은 추출물 형태로서 1 내지 10 중량%, 바람직하게는 2 내지 5 중량%로 사용된다. 돌미역 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다. The above-mentioned seaweed is used as an extract form in an amount of 1 to 10% by weight, preferably 2 to 5% by weight. If the content of the extract of the stalwil waxy is outside the above range, the efficacy against alcoholic gastrointestinal diseases may be deteriorated.
상기 감태, 우뭇가사리, 톳, 모자반 및 돌미역은 각각 추출용매와 1 : 5 내지 25, 바람직하게는 1 : 8 내지 15의 중량비로 혼합하여 80 내지 110 ℃에서 추출함으로써 추출물을 제조한다. 상기 감태, 우뭇가사리, 톳, 모자반 및 돌미역 각각과 추출용매의 중량비가 상기 범위를 벗어나는 경우에는 추출물에 유효성분이 적은 양으로 추출될 수 있다. 또한, 추출온도가 상기 하한치 미만인 경우에는 유효성분이 추출되지 않을 수 있으며, 상기 상한치 초과인 경우에는 유효성분이 적은 양으로 추출될 수 있다.The extracts are prepared by mixing the extracts with the extraction solvent at a weight ratio of 1: 5 to 25, preferably 1: 8 to 15, and extracting at 80 to 110 ° C. When the weight ratio of each of the above extracts, extracts, mosses, mosses, and seaweed extracts and the extraction solvent is out of the above range, the extract may be extracted in a small amount with an effective amount. If the extraction temperature is lower than the lower limit value, the effective ingredient may not be extracted. If the extraction temperature is higher than the upper limit value, the effective ingredient may be extracted in a smaller amount.
상기 추출물을 추출하는 추출용매로는 알코올성 위장질환의 개선, 예방 또는 치료에 바람직하게 작용할 수 있도록 물, 탄소수 1 내지 4의 저급알코올, 또는 이들의 혼합용매를 사용할 수 있다. 상기 혼합용매로는 특별히 한정하는 것은 아니지만, 바람직하게는 20 내지 80 부피%의 메탄올, 에탄올, 부탄올 또는 프로판올 수용액, 더욱 바람직하게는 60 내지 80 부피%의 에탄올 수용액으로 추출된 추출물을 들 수 있다.As the extraction solvent for extracting the extract, water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof may be used so as to favorably improve, prevent or treat alcoholic gastrointestinal diseases. The mixed solvent is not particularly limited, but an extract obtained by extracting with 20 to 80% by volume of an aqueous solution of methanol, ethanol, butanol or propanol, more preferably 60 to 80% by volume of ethanol is preferable.
또한, 상기 황칠(Dendropanax morbifera LEV.)은 두릅나무과에 속하는 난대성 상록교목으로, 우리나라의 남부 해안 지역과 제주도에서 자생하며, 겨울에도 낙엽이 지지 않는 수종으로 수피에 상처를 주면 황색의 수지액이 나오는데 이것을 황칠이라고 한다. 황칠 안에 들어 있는 정유의 주성분은 세스퀴테르펜(sesqui-terpene)이며, 그밖에 알코올, 에스테르 등이 함유되어 있다. 또한, 황칠나무는 번열 제거, 술 해독, 안질 및 황달 치료, 나병에 효과가 있으며 인체에 무해하다는 기록도 전해지고 있다 (이시진, 본초강목, 중국문광도서, 1590).The dandelion (Dendropanax morbifera LEV.) Is an evergreen tree belonging to Araliaceae. It is native to the southern coast of Korea and Jeju Island. It is a species that does not fall down in winter. If it bruises the bark, This is called Huangchil. The main ingredient of the essential oil contained in Huangchil is sesqui-terpene, and other alcohol and ester. In addition, it has been reported that Hwangchil is effective in eliminating burning, alcoholic detoxification, treatment of eye and jaundice, leprosy and harmless to the human body (Ishinjin, Bascho Gangmok, Munkwang Book, 1590).
상기 황칠은 추출물 형태로서 40 내지 60 중량%로 사용된다. 황칠 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다. The yellowing is used in an amount of 40 to 60% by weight in the form of an extract. If the content of Huangchil extract is out of the above range, the efficacy against alcoholic gastrointestinal diseases may be deteriorated.
또한, 상기 녹차(Camellia sinensis O.Kuntge)는 경남, 전남의 남해안지역의 비교적 따뜻한 곳에서 자라는 여러해살이 상록교목으로, 잎은 단단하고 약간 두꺼우며 표면에 광택이 있다. 콜레스테롤과 혈당을 낮추는 효과가 있으며, 항산화작용을 한다.Also, the green tea (Camellia sinensis O.Kuntge) is a perennial evergreen arboreous tree that grows in a relatively warm place on the southern coast of Kyungnam and Jeonnam. Its leaves are hard, slightly thick and glossy on the surface. It lowers cholesterol and blood sugar and has antioxidant activity.
상기 녹차는 추출물 형태로서 40 내지 60 중량%로 사용된다. 녹차 추출물의 함량이 상기 범위를 벗어난 경우에는 알코올성 위장질환에 대한 효능이 저하될 수 있다.The green tea is used in an amount of 40 to 60% by weight as an extract. If the content of green tea extract is out of the above range, the efficacy against alcoholic gastrointestinal diseases may be decreased.
바람직하게, 상기 황칠 추출물과 녹차 추출물은 1 : 0.7-1.3의 중량비로 혼합되는데, 상기 황칠 추출물을 기준으로 녹차 추출물의 함량이 상기 하한치 미만인 경우에는 효능이 저하될 수 있으며, 상기 상한치 초과인 경우에는 관능성이 저하될 수 있다. Preferably, the green tea extract and the green tea extract are mixed at a weight ratio of 1: 0.7-1.3. When the content of the green tea extract is lower than the lower limit, the efficacy may be lowered. If the content is higher than the upper limit, The functionality may be lowered.
상기 황칠 및 녹차는 각각 상기 해조류 복합추출물을 추출하는 방법과 동일한 방법으로 추출될 수 있다.The above yellowtail and green tea can be extracted in the same manner as the method of extracting the above-mentioned seaweed complex extract.
본 발명의 해조류 복합추출물과 식물 복합추출물은 1 : 5 내지 90의 중량비, 바람직하게는 1 : 11 내지 80의 중량비로 혼합된다. 해조류 복합추출물을 기준으로 식물 복합추출물의 함량이 상기 하한치 미만인 경우에는 알코올성 위장질환에 대한 개선, 예방 또는 치료 효과가 저하될 수 있으며, 상기 상한치 초과인 경우에는 텁텁하고 관능성이 저하될 수 있다.The seaweed extract of the present invention and the plant combination extract of the present invention are mixed at a weight ratio of 1: 5 to 90, preferably 1: 11 to 80. If the content of the plant complex extract is lower than the lower limit, the effect of improving, preventing or treating alcoholic gastrointestinal diseases may be deteriorated. If the content of the plant complex extract is lower than the upper limit, it may be deteriorated.
본 명세서에서 감태, 우뭇가사리, 톳, 모자반, 돌미역, 황칠 및 녹차를 언급하면서 사용되는 용어 '추출물'은 추출용매를 처리하여 얻은 조추출물뿐만 아니라 추출물의 가공물도 포함한다. 예를 들어, 본 발명의 추출물은 감압 증류 및 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말 상태로 제조될 수 있다.The term "extract" used in the present specification refers to the extracts of the extract as well as the crude extract obtained by treating the extraction solvent. For example, the extract of the present invention can be prepared in a powder state by an additional process such as vacuum distillation and freeze-drying or spray-drying.
또한, 본 발명의 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물은 광의로는 해조류 복합추출물 및 식물 복합추출물이 혼합된 혼합물을 동물에게 투여할 수 있도록 제형화된 해조류 복합추출물 및 식물 복합추출물이 혼합된 혼합물의 가공물, 예컨대, 해조류 복합추출물 및 식물 복합추출물이 혼합된 혼합물 분말도 포함하는 의미를 갖는다. 비록 본 발명에서 해조류 복합추출물 및 식물 복합추출물이 혼합된 혼합물의 추출물로 실험을 진행하긴 하였으나, 해조류 복합추출물 및 식물 복합추출물이 혼합된 혼합물의 가공물과 같은 형태로도 목적하는 효과를 달성할 수 있음은 당업자라면 예상 가능할 것이다.In addition, the extract of the seaweed complex extract and the plant complex extract of the present invention may be mixed with the seaweed complex extract and the plant complex extract formulated so that a mixture of the seaweed complex extract and the plant complex extract may be administered to the animal But also a mixture powder of a mixture of the mixture, for example, a seaweed complex extract and a plant complex extract. Although the present invention has been carried out with an extract of a mixture of a seaweed compound complex and a plant complex extract, the desired effect can be achieved even in the form of a mixture of a mixture of a seaweed compound complex and a plant complex extract Would be predictable by those skilled in the art.
한편, 본 명세서에서 용어 '유효성분으로 함유하는'이란 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물의 효능 또는 활성을 달성하는 데 충분한 양을 포함하는 것을 의미한다. 일예로, 상기 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물은 10 내지 1500 ㎍/㎖, 바람직하게는 100 내지 1000 ㎍/㎖의 농도로 사용된다. 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물은 천연물로서 과량 투여하여도 인체에 부작용이 없으므로 본 발명의 조성물 내에 포함되는 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물의 양적 상한은 당업자가 적절한 범위 내에서 선택하여 실시할 수 있다.
As used herein, the term " comprising as an active ingredient " means an amount sufficient to attain the efficacy or activity of the extract mixed with the seaweed complex extract and the plant complex extract. For example, the extract obtained by mixing the seaweed complex extract and the plant complex extract is used at a concentration of 10 to 1500 μg / ml, preferably 100 to 1000 μg / ml. Since the extracts mixed with seaweed extracts and plant complex extracts have no adverse effects on the human body even when they are administered in an excessive amount as natural products, the quantitative upper limit of the extracts obtained by mixing the seaweeds complex extract and plant combination extract contained in the composition of the present invention As shown in FIG.
본 발명의 약제학적 조성물은 상기 유효 성분 이외에 약제학적으로 적합하고 생리학적으로 허용되는 보조제를 사용하여 제조될 수 있으며, 상기 보조제로는 부형제, 붕해제, 감미제, 결합제, 피복제, 팽창제, 윤활제, 활택제 또는 향미제 등을 사용할 수 있다.The pharmaceutical composition of the present invention can be prepared by using pharmaceutically acceptable and physiologically acceptable adjuvants in addition to the above-mentioned active ingredients. Examples of the adjuvants include excipients, disintegrants, sweeteners, binders, coating agents, swelling agents, lubricants, A lubricant or a flavoring agent can be used.
상기 약제학적 조성물은 투여를 위해서 상기 기재한 유효 성분 이외에 추가로 약제학적으로 허용 가능한 담체를 1종 이상 포함하여 약제학적 조성물로 바람직하게 제제화할 수 있다.The pharmaceutical composition may be formulated into a pharmaceutical composition containing at least one pharmaceutically acceptable carrier in addition to the above-described active ingredients for administration.
상기 약제학적 조성물의 제제 형태는 과립제, 산제, 정제, 피복정, 캡슐제, 좌제, 액제, 시럽, 즙, 현탁제, 유제, 점적제 또는 주사 가능한 액제 등이 될 수 있다. 예를 들어, 정제 또는 캡슐제의 형태로의 제제화를 위해, 유효 성분은 에탄올, 글리세롤, 물 등과 같은 경구, 무독성의 약제학적으로 허용 가능한 불활성 담체와 결합될 수 있다. 또한, 원하거나 필요한 경우, 적합한 결합제, 윤활제, 붕해제 및 발색제 또한 혼합물로 포함될 수 있다. 적합한 결합제는 이에 제한되는 것은 아니나, 녹말, 젤라틴, 글루코스 또는 베타-락토오스와 같은 천연 당, 옥수수 감미제, 아카시아, 트래커캔스 또는 소듐올레이트와 같은 천연 및 합성 검, 소듐 스테아레이트, 마그네슘 스테아레이트, 소듐 벤조에이트, 소듐 아세테이트, 소듐 클로라이드 등을 포함한다. 붕해제는 이에 제한되는 것은 아니나, 녹말, 메틸 셀룰로스, 아가, 벤토니트, 잔탄 검 등을 포함한다.The pharmaceutical composition may be in the form of granules, powders, tablets, coated tablets, capsules, suppositories, liquids, syrups, juices, suspensions, emulsions, drops or injectable solutions. For example, for formulation into tablets or capsules, the active ingredient may be combined with an oral, non-toxic pharmaceutically acceptable inert carrier such as ethanol, glycerol, water, and the like. Also, if desired or necessary, suitable binders, lubricants, disintegrants and coloring agents may also be included as a mixture. Suitable binders include, but are not limited to, natural sugars such as starch, gelatin, glucose or beta-lactose, natural and synthetic gums such as corn sweeteners, acacia, tracker candles or sodium oleate, sodium stearate, magnesium stearate, sodium Benzoate, sodium acetate, sodium chloride, and the like. Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum and the like.
액상 용액으로 제제화되는 조성물에 있어서 허용 가능한 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로즈 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.Acceptable pharmaceutical carriers for compositions that are formulated into a liquid solution include sterile water and sterile water suitable for the living body such as saline, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, One or more of these components may be mixed and used. If necessary, other conventional additives such as an antioxidant, a buffer, and a bacteriostatic agent may be added. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to formulate into injectable solutions, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like.
더 나아가 해당분야의 적절한 방법으로 Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA에 개시되어 있는 방법을 이용하여 각 질환에 따라 또는 성분에 따라 바람직하게 제제화 할 수 있다.Further, it can be suitably formulated according to each disease or ingredient, using the method disclosed in Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA as an appropriate method in the field.
본 발명의 약제학적 조성물은 경구 또는 비경구로 투여할 수 있고, 비경구 투여인 경우에는 정맥내 주입, 피하 주입, 근육 주입, 복강 주입, 경피 투여 등으로 투여할 수 있으며, 바람직하게는 경구 투여이다.The pharmaceutical composition of the present invention can be administered orally or parenterally. In the case of parenteral administration, the composition can be administered by intravenous injection, subcutaneous injection, muscle injection, intraperitoneal injection, transdermal administration, etc., .
본 발명의 약제학적 조성물의 적합한 투여량은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성, 병적 상태, 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사는 소망하는 치료 또는 예방에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다. 본 발명의 바람직한 구현예에 따르면, 본 발명의 약제학적 조성물의 1일 투여량은 0.001-10 g/㎏이다.The appropriate dosage of the pharmaceutical composition of the present invention varies depending on factors such as the formulation method, administration method, age, body weight, sex, pathological condition, food, administration time, administration route, excretion rate and responsiveness of the patient, Usually, a skilled physician can readily determine and prescribe dosages effective for the desired treatment or prophylaxis. According to a preferred embodiment of the present invention, the daily dosage of the pharmaceutical composition of the present invention is 0.001-10 g / kg.
본 발명의 약제학적 조성물은 약제학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화함으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수 있다. 이때 제형은 오일 또는 수성 매질중의 용액, 현탁액 또는 유화액 형태이거나 엑스제, 분말제, 과립제, 정제 또는 캅셀제 형태일 수도 있으며, 분산제 또는 안정화제를 추가적으로 포함할 수 있다.The pharmaceutical composition of the present invention can be prepared in unit dose form by formulating it with a pharmaceutically acceptable carrier and / or excipient or can be manufactured by inserting it into a multi-dose container. The formulations may be in the form of solutions, suspensions or emulsions in oils or aqueous media, or in the form of excipients, powders, granules, tablets or capsules, and may additionally contain dispersing or stabilizing agents.
또한, 본 발명은 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물을 유효성분으로 함유하는 알코올성 위장질환의 개선, 예방 또는 치료용 식품 조성물을 제공한다.The present invention also provides a food composition for improving, preventing or treating an alcoholic gastrointestinal disorder, which comprises an extract of a mixture of a seaweed compound complex and a plant complex extract as an active ingredient.
본 발명에 따른 식품 조성물은 상기 약제학적 조성물과 동일한 방식으로 제제화되어 기능성 식품으로 이용하거나, 각종 식품에 첨가할 수 있다. 본 발명의 조성물을 첨가할 수 있는 식품으로는 예를 들어, 음료류, 알코올 음료류, 과자류, 다이어트바, 유제품, 육류, 초코렛, 피자, 라면, 기타 면류, 껌류, 아이스크림류, 비타민 복합제, 건강보조식품류 등이 있다.The food composition according to the present invention can be formulated in the same manner as the above pharmaceutical composition and used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, beverages, alcoholic beverages, confectioneries, diet bars, dairy products, meat, chocolates, pizza, ram noodles, other noodles, gums, ice cream, .
본 발명의 식품 조성물은 유효성분으로서 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물뿐만 아니라, 식품 제조 시에 통상적으로 첨가되는 성분을 포함할 수 있으며, 예를 들어, 단백질, 탄수화물, 지방, 영양소, 조미제 및 향미제를 포함한다. 상술한 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등; 디사카라이드, 예를 들어 말토스, 슈크로스, 올리고당 등; 및 폴리사카라이드, 예를 들어 덱스트린, 사이클로덱스트린 등과 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 향미제로서 천연 향미제 [타우마틴, 스테비아 추출물 (예를 들어 레바우디오시드 A, 글리시르히진 등]) 및 합성 향미제(사카린, 아스파르탐 등)를 사용할 수 있다. 예컨대, 본 발명의 식품 조성물이 드링크제와 음료류로 제조되는 경우에는 본 발명의 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물 이외에 구연산, 액상과당, 설탕, 포도당, 초산, 사과산, 과즙, 및 각종 식물 추출액 등을 추가로 포함시킬 수 있다.The food composition of the present invention may contain, as an active ingredient, not only an extract obtained by mixing a seaweed complex extract and a plant complex extract but also a component that is ordinarily added during the manufacture of a food, for example, a protein, a carbohydrate, a fat, Seasoning and flavoring agents. Examples of the above-mentioned carbohydrates are monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And polysaccharides such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavorings such as tau martin and stevia extract (e.g., rebaudioside A and glycyrrhizin) and synthetic flavorings (saccharine, aspartame, etc.) can be used as flavorings. For example, when the food composition of the present invention is prepared as a drink and a beverage, the extract of the seaweed complex and the plant complex extract of the present invention may contain citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, And the like.
본 발명은 상기 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물을 유효성분으로 포함하는 알코올성 위장질환의 개선, 예방 또는 치료용 식품 조성물을 포함하는 건강기능식품을 제공한다. 건강기능식품이란, 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물을 음료, 차류, 향신료, 껌, 과자류 등의 식품소재에 첨가하거나, 캡슐화, 분말화, 현탁액 등으로 제조한 식품으로, 이를 섭취할 경우 건강상 특정한 효과를 가져오는 것을 의미하나, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용시 발생할 수 있는 부작용 등이 없는 장점이 있다. 이와 같이 하여 얻어지는 본 발명의 건강기능식품은, 일상적으로 섭취하는 것이 가능하기 때문에 매우 유용하다. 이와 같은 건강기능식품에 있어서의 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물의 첨가량은, 대상인 건강기능식품의 종류에 따라 달라 일률적으로 규정할 수 없지만, 식품 본래의 맛을 손상시키지 않는 범위에서 첨가하면 되며, 대상 식품에 대하여 통상 0.01 내지 50 중량%, 바람직하기로는 0.1 내지 20 중량%의 범위이다. 또한, 환제, 과립제, 정제 또는 캡슐제 형태의 건강기능식품의 경우에는 통상 0.1 내지 100 중량% 바람직하기로는 0.5 내지 80 중량%의 범위에서 첨가하면 된다. 한 구체예에서, 본 발명의 건강기능식품은 환제, 정제, 캡슐제 또는 음료의 형태일 수 있다.The present invention provides a health functional food comprising a food composition for improving, preventing or treating an alcoholic gastrointestinal disorder, which comprises an extract obtained by mixing the above-mentioned seaweed complex extract and plant complex extract as an active ingredient. The health functional food refers to a food prepared by adding an extract obtained by mixing a seaweed compound complex and a plant complex extract to a food material such as a beverage, a tea, a spice, a gum or a confectionery, or by encapsulating, pulverizing or suspending However, unlike general medicines, it has the advantage that there are no side effects that may occur when a drug is taken for a long time using the food as a raw material. The health functional food of the present invention thus obtained is very useful because it can be ingested routinely. The amount of the extract of the combination of the seaweed compound complex and the plant complex extract in such a health functional food can not be uniformly determined depending on the kind of the health functional food to which it is added but may be added within a range that does not deteriorate the original taste of the food And is usually in the range of 0.01 to 50% by weight, preferably 0.1 to 20% by weight based on the target food. In the case of health functional foods in the form of pills, granules, tablets or capsules, they may be added usually in the range of 0.1 to 100% by weight, preferably 0.5 to 80% by weight. In one embodiment, the health functional food of the present invention may be in the form of a pill, tablet, capsule or beverage.
또한, 본 발명은 알코올성 위장질환의 개선, 예방 또는 치료용 의약 또는 식품의 제조를 위한 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물의 용도를 제공한다. 상기한 바와 같이 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물은 알코올성 위장질환의 개선, 예방 또는 치료를 위한 용도로 이용될 수 있다.In addition, the present invention provides the use of an extract obtained by mixing a seaweed complex extract and a plant complex extract for the production of a medicament or food for the improvement, prevention or treatment of alcoholic gastrointestinal diseases. As described above, the extract obtained by mixing the seaweed compound complex and the plant complex extract can be used for the improvement, prevention or treatment of alcoholic gastrointestinal diseases.
또한, 본 발명은 포유동물에게 유효량의 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물을 투여하는 것을 포함하는 알코올성 위장질환의 개선, 예방 또는 치료 방법을 제공한다.The present invention also provides a method of improving, preventing or treating an alcoholic gastrointestinal disorder, comprising administering to a mammal an effective amount of an extract of a combination of a seaweed compound extract and a plant complex extract.
여기에서 사용된 용어 "포유동물"은 치료, 관찰 또는 실험의 대상인 포유동물을 말하며, 바람직하게는 인간을 말한다.The term " mammal " as used herein refers to a mammal that is the subject of treatment, observation or experimentation, preferably a human.
여기에서 사용된 용어 "유효량"은 연구자, 수의사, 의사 또는 기타 임상의에 의해 생각되는 조직계, 동물 또는 인간에서 생물학적 또는 의학적 반응을 유도하는 유효 성분 또는 약학적 조성물의 양을 의미하는 것으로, 이는 해당 질환 또는 장애의 증상의 완화를 유도하는 양을 포함한다. 본 발명의 유효 성분에 대한 유효량 및 투여횟수는 원하는 효과에 따라 변화될 수 있다. 그러므로, 투여될 최적의 투여량은 당업자에 의해 쉽게 결정될 수 있으며, 질환의 종류, 질환의 중증도, 조성물에 함유된 유효성분 및 다른 성분의 함량, 제형의 종류, 및 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여 시간, 투여 경로 및 조성물의 분비율, 치료기간, 동시 사용되는 약물을 비롯한 다양한 인자에 따라 조절될 수 있다. 본 발명의 예방, 치료 또는 개선 방법에 있어서, 성인의 경우, 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물을 1일 1회 내지 수회 투여시, 0.001 g/kg 내지 10 g/kg의 용량으로 투여하는 것이 바람직하다.As used herein, the term " effective amount " refers to the amount of active ingredient or pharmaceutical composition that elicits a biological or medical response in a tissue system, animal, or human, as contemplated by a researcher, veterinarian, physician or other clinician, ≪ / RTI > inducing a reduction of the symptoms of the disease or disorder. The effective amount and the administration frequency for the active ingredient of the present invention can be changed according to the desired effect. Thus, the optimal dosage to be administered can be readily determined by those skilled in the art and will vary with the nature of the disease, the severity of the disease, the amount of active and other ingredients contained in the composition, the type of formulation, and the age, The age, body weight, sex, diet, time of administration, route of administration and fraction of the composition, duration of treatment, concurrent medication, and the like. In the prevention, treatment or improvement method of the present invention, in the case of an adult, the extract mixed with seaweed extract and plant complex extract is administered at a dose of 0.001 g / kg to 10 g / kg once or several times a day .
본 발명의 치료방법에서 해조류 복합추출물 및 식물 복합추출물이 혼합된 추출물을 유효 성분으로 포함하는 조성물은 경구, 직장, 정맥내, 동맥내, 복강내, 근육내, 흉골내, 경피, 국소, 안구내 또는 피내 경로를 통해 통상적인 방식으로 투여할 수 있다.
In the therapeutic method of the present invention, the composition comprising the extract of the seaweed compound complex and the plant complex extract as an active ingredient can be administered orally, rectally, intravenously, intraarterially, intraperitoneally, intramuscularly, intrasternally, transdermally, Or via the intradermal route in a conventional manner.
이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시하나, 하기 실시예는 본 발명을 예시하는 것일 뿐 본 발명의 범주 및 기술사상 범위 내에서 다양한 변경 및 수정이 가능함은 당업자에게 있어서 명백한 것이며, 이러한 변형 및 수정이 첨부된 특허청구범위에 속하는 것도 당연한 것이다.It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention. Such variations and modifications are intended to be within the scope of the appended claims.
실시예Example 1 내지 20. 해조류 복합추출물+식물 복합추출물 1 to 20. Seaweed complex extract + plant complex extract
감태 추출물, 우뭇가사리 추출물, 톳 추출물, 모자반 추출물, 돌미역 추출물을 포함하는 해조류 복합추출물;과 황칠 추출물 및 녹차 추출물을 포함하는 식물 복합추출물;을 포함하는 조성물을 하기 표 1의 제조 비율에 따라 제조하였다. 이때 식물 복합추출물은 황칠 추출물과 녹차 추출물을 50 중량%씩 동일한 양으로 첨가하였다.A composition comprising a seaweed extract, a green tea extract, a green tea extract, and a green tea extract, was prepared according to the production ratios shown in Table 1 below . At this time, the plant complex extract was added in an amount of 50 wt% each of Huangchil extract and green tea extract.
<시험예><Test Example>
시험예 1. 항산화 측정Test Example 1. Antioxidant measurement
상기 실시예 1 내지 20에 따라 제조된 조성물에 대한 DPPH 자유 라디칼 소거능 측정을 통해 항산화 효과를 평가함으로써 유효성분의 배합비율을 선정하였다.DPPH free radical scavenging activity of the compositions prepared according to Examples 1 to 20 was measured to determine the compounding ratio of the active ingredients by evaluating the antioxidative effect.
에탄올에 용해시킨 0.2 mM DPPH(1,1-diphenyl-2-picrylhydrazyl) 용액 950 ㎖에 상기 실시예 1 내지 20의 조성물을 각각 DMSO(dimethylsulfoxide)에 100 ㎕/㎖로 희석한 용액 50 ㎕를 가한 후 실온에서 30분간 incubation 후 517 ㎚에서 흡광도를 측정하였다. 항산화 활성은 하기 [수학식 1]로 계산하였다.50 μl of a solution prepared by diluting each of the compositions of Examples 1 to 20 with 100 μl / ml of DMSO (dimethyl sulfoxide) was added to 950 ml of a 0.2 mM DPPH (1,1-diphenyl-2-picrylhydrazyl) solution dissolved in ethanol After incubation at room temperature for 30 minutes, the absorbance was measured at 517 nm. The antioxidant activity was calculated by the following formula (1).
[수학식 1][Equation 1]
항산화 활성(%) = {1-(시료 첨가군 흡광도/시료 무첨가군 흡광도)}X00 (%)Antioxidant activity (%) = {1- (absorbance of sample group / absorbance of group without sample)} X00 (%)
위 표 2에 나타낸 바와 같이, 본 발명의 실시예 6, 7, 10, 11, 14 및 15의 조성물은 항산화 활성이 대략 80% 내외로 우수하며, 그외 조성물의 경우에는 이에 비해 낮은 항산화 활성을 보이는 것을 확인하였다. As shown in Table 2 above, the compositions of Examples 6, 7, 10, 11, 14 and 15 of the present invention exhibited antioxidative activity of about 80% Respectively.
또한, 식물 복합추출물:해조류 복합추출물의 혼합비율이 6:1 또는 85:1일 경우 항산화 활성이 낮은 것을 확인하였다.
Also, it was confirmed that the antioxidative activity was low when the mixing ratio of the plant complex extract: seaweed complex was 6: 1 or 85: 1.
시험예 2. 동물실험Test Example 2. Animal experiment
본 시험은 수컷 SD rat에게 7일 동안 실험물질을 공급한 후 알코올성 위장질환을 유도하며 시험물질인 실시예 7의 조성물을 액상 또는 고상 형태로 경구투여 한 후, 궤양 인덱스(Ulcer index) 측정, 혈장 내 히스타민(Histamine), 가스트린(Gastrin), 위 조직 내 IL-1β, TNF-α 농도를 측정하여 시험물질이 알코올성 위장질환의 개선 효과를 평가하고자 실시하였다. This test was conducted in male SD rats for 7 days after induction of alcoholic gastrointestinal disease. After oral administration of the composition of Example 7 as a liquid or solid form, ulcer index measurement, plasma Histamine, Gastrin, IL-1β and TNF-α levels in the stomach tissues were measured to evaluate the improvement effect of alcoholic gastrointestinal diseases.
200~230 g의 Sprague-Dawley 랫트(오리엔트바이오, Korea, 숫컷)를 실험에 사용하였다. 폴리카보네이트제 케이지(280W X 420D X 180H mm)에서 사육되었으며, 충분한 사료와 물이 공급되며 적절한 인공조도로 12시간의 낮, 밤을 조절하였다(am 7:00부터 낮). 그리고 일정한 온도(20~24 ℃) 및 습도(40~60%)를 유지시켜 주었다. 바뀐 환경에 적응하도록 일주일간 살펴보며 수면주기를 유지하고, 이상행동을 확인하였다. 또한, 식이로는 사울사료의 실험동물용 고형사료를 이용하였다.200-230 g of Sprague-Dawley rats (Orient Bio, Korea, male) were used in the experiment. The animals were housed in a polycarbonate cage (280W X 420D X 180H mm), fed with sufficient feed and water, and adjusted for 12 hours of daytime and night with appropriate artificial illumination (from 7 am onwards). It maintained a constant temperature (20 ~ 24 ℃) and humidity (40 ~ 60%). We observed for a week to adjust to the changed environment, maintained the sleep cycle, and confirmed abnormal behavior. As a diet, a solid feed for experimental animals of a sole diet was used.
실험동물은 체중변화가 일정하고 건강한 동물만을 선별하여 임의 배치법에 의해 생리식염수를 투여한 정상군, 에탄올+생리식염수 음성 대조군, 에탄올+실시예 7의 추출물을 액상으로 200 mg/kg 투여한 시료 투여군, 에탄올+실시예 7의 추출물을 고상으로 200 mg/kg으로 투여한 시료 투여군 및 에탄올+Ranitidine(광동제약) 50 mg/kg으로 투여한 양성 대조군으로 나누었으며 실험군마다 6마리씩 사용하였다. The experimental animals were divided into a normal group in which physiological saline was administered according to a random arrangement with a constant weight change and healthy animals, a negative control group of ethanol + physiological saline, ethanol + a sample administered with 200 mg / kg of the extract of Example 7 , Ethanol + the extract of Example 7 at a dose of 200 mg / kg as a solid phase, and a positive control group administered with ethanol + Ranitidine (Guangdong Pharmaceutical) at a dose of 50 mg / kg.
이때 시험물질을 일회용 주사기를 이용하여 투여 개시일부터 1일 1회, 7일 동안 총 7회 위 내에 강제 투여하였다.At this time, the test substance was forcibly administered in a disposable syringe 7 times a day for 7 days once a day from the start of administration.
실시예 7의 추출물은 액상으로 200 mg/kg 및 고상으로 200 mg/kg을 식염수에 녹여 4 ml/kg 경구 투여하였으며, Ranitidine 역시 50 mg/kg을 식염수에 녹여 4 ml/kg 경구 투여하였다.The extract of Example 7 was orally administered at a dose of 200 mg / kg in a liquid phase and 200 mg / kg in a solid phase at a dose of 4 ml / kg, and Ranitidine was dissolved in saline at a dose of 4 ml / kg.
-5개 군의 마우스--5 mice -
정상군: 생리식염수 7일 투여 6마리Normal group: 6 mice given saline solution for 7 days
음성 대조군: 에탄올 및 생리식염수 7일 투여 6마리Negative control group: Ethanol and saline solution for 6 days for 7 days
실시예 7(액상): 에탄올 및 실시예 7의 추출물(액상) 7일 투여 6마리Example 7 (Liquid Phase): Ethanol and the extract of Example 7 (liquid phase) 7 days Administration Six dogs
실시예 7(고상): 에탄올 및 실시예 7의 추출물(고상) 7일 투여 6마리Example 7 (solid phase): Ethanol and extract of Example 7 (solid phase) 7 days administration Six dogs
양성 대조군: 에탄올 및 Ranitidine 7일 투여 6마리
Positive control: 6 rats of ethanol and Ranitidine for 7 days
효능평가Efficacy evaluation
시험물질 투여 6일날 시험동물을 24시간 이상 절식시킨 후 시험물질을 투여하고 30분 후 무수 에탄올 10 ml/kg(음성 대조군, 투여군(액상), 투여군(고상), 양성 대조군)을 경구 투여한 이후 절식, 절수하여 1시간 방치한 다음 에테르로 마취하여 위를 적출하였다. 위의 대만부를 절개하여 펼친 후 사진촬영하고 냉동 보관하였다. 이미지 프로그램을 사용하여 위궤양(출혈부위) 길이를 측정한 후 궤양 인덱스(Ulcer index)(mm)로 표시하였다(점상출혈인 경우 5개를 1 mm로 계산).After the test animals were fasted for more than 24 hours on the 6th day of the test substance administration, the test substance was administered and oral administration of
동물을 희생하기에 앞서 복부대동맥에서 혈액을 체취하여 EDTA가 처리된 튜브에 넣고 롤러에서 5분 동안 반응시킨 후 3,000 rpm에서 20분 동안 원심분리하여 혈장을 체취하고 췌위한 혈장은 ??20 ℃에서 보관하며 시험에 사용하였다.Before sacrificing animals, blood was taken from the abdominal aorta, placed in EDTA-treated tubes, reacted for 5 minutes on a roller, centrifuged at 3,000 rpm for 20 minutes to collect plasma, and plasma for pancreas was stored at -20 ° C And stored for testing.
상기 혈장 내 히스타민(Histamine), 가스트린(Gastrin); 위 조직 내 IL-1β, TNF-α 농도는 각각의 ELISA Kit 메뉴얼대로 분석하였다.Histamine in the plasma, Gastrin; IL-1β and TNF-α concentrations in stomach tissues were analyzed according to the respective ELISA Kit manuals.
위 손상을 시키는 요인으로 알코올 과다섭취는 위에 위산의 분비와 출혈, 염증발생을 유발시켜 급성위궤양을 일으킨다.As a cause of gastric injuries, excessive alcohol intake causes gastric acid secretion, hemorrhage, inflammation and causes acute gastric ulcer.
위산 분비의 경로 중 히스타민(Histamine), 가스트린(Gastrin)의 활성은 위벽세포를 자극시켜 결국 위산의 분비를 증가시켜 위장 점막의 손상을 일으키게 된다. 또한, 위 조직의 손상으로 조직 내 염증이 유발되면 염증성 사이토카인 IL-1β, TNF-α가 증가하게 된다.
The activity of histamine and gastrin in the pathway of gastric acid secretion stimulates the gastric wall cells, which in turn increases the secretion of gastric acid and causes gastric mucosal damage. In addition, inflammation of the stomach due to damage to the stomach causes inflammatory cytokines such as IL-1β and TNF-α.
2-1. 궤양 인덱스(Ulcer index) 측정2-1. Ulcer index measurement
도 1은 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 궤양 인덱스를 나타낸 그래프이며; 도 2는 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군을 촬영한 사진이다.1 is a graph showing the ulcer indexes of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention; FIG. 2 is a photograph of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
도 1에 도시된 바와 같이, 음성 대조군의 UI는 평균 24.67 mm로, 정상군에 비하여 통계적으로 유의하게 증가하였다. As shown in FIG. 1, the UI of the negative control group was 24.67 mm, which was statistically significantly higher than that of the normal group.
또한, 실시예 7(액상)의 UI는 평균 13.52 mm이며, 실시예 7(고상)의 UI는 평균 14.28 mm로서, 음성 대조군에 비하여 통계학적으로 유의하게 감소하였다.In addition, the UI of Example 7 (liquid phase) was 13.52 mm on average, and the UI of Example 7 (solid phase) was 14.28 mm on average, which was statistically lower than that of negative control.
또한, 양성 대조군의 UI는 평균 13.78 mm로서, 음성 대조군에 비하여 통계학적으로 유의하게 감소하였다.The mean UI of the positive control group was 13.78 mm, which was statistically significantly lower than that of the negative control group.
또한 도 2에 도시된 바와 같이, 음성 대조군는 출혈부위가 다수 관찰되었으나 실시예 7(액상), 실시예 7(고상) 및 양성 대조군은 출혈부위가 관찰되지 않거나 적은 부위로 관찰되었다.
As shown in FIG. 2, the bleeding sites were observed in the negative control group, but the bleeding sites were not observed or observed in Example 7 (liquid phase), Example 7 (solid phase) and the positive control group.
2-2. 혈장 내 히스타민(Histamine) 농도2-2. Histamine concentration in plasma
도 3은 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 히스타민(Histamine) 농도를 나타낸 그래프이다.FIG. 3 is a graph showing the histamine concentrations of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
도 3에 도시된 바와 같이, 정상군의 혈액 중 히스타민(Histamine) 농도는 평균 21.26 ng/ml이며, 음성 대조군의 혈액 중 히스타민(Histamine) 농도는 26.14 ng/ml로 정상군에 비하여 증가하였으나 통계학적으로 유의한 차이가 나타나지 않았다.As shown in FIG. 3, histamine (Histamine) concentration in the normal group was 21.26 ng / ml, and the histamine concentration in the negative control group was 26.14 ng / ml, There was no significant difference.
또한, 실시예 7(액상)의 혈액 중 히스타민(Histamine) 농도는 25.37 ng/ml이며, 실시예 7(고상)의 혈액 중 히스타민(Histamine) 농도는 24.11 ng/ml로서, 음성 대조군에 비하여 차이를 보이지 않았다.The histamine concentration in the blood of Example 7 (liquid phase) was 25.37 ng / ml, and the concentration of histamine in the blood of Example 7 (solid phase) was 24.11 ng / ml, I did not see it.
또한, 양성 대조군의 혈액 중 히스타민(Histamine) 농도는 19.22 ng/ml로서, 음성 대조군에 비하여 통계학적으로 유의하게 감소하였다.
Histamine concentration in the blood of the positive control group was 19.22 ng / ml, which was statistically lower than that of the negative control group.
2-3. 혈장 내 가스트린(Gastrin) 농도2-3. Plasma Gastrin concentration
도 4는 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 가스트린(Gastrin) 농도를 나타낸 그래프이다.FIG. 4 is a graph showing the concentration of Gastrin in the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
도 4에 도시된 바와 같이, 정상군의 혈액 중 가스트린(Gastrin) 농도는 평균 211.30 pg/ml이며, 음성 대조군의 혈액 중 가스트린(Gastrin) 농도는 345.87 pg/ml로 정상군에 비하여 통계학적으로 유의하게 증가하였다.As shown in FIG. 4, the average concentration of gastrin in the blood of the normal group was 211.30 pg / ml, and the concentration of gastrin in the blood of the negative control group was 345.87 pg / ml, which was statistically significant Respectively.
또한, 실시예 7(액상)의 혈액 중 가스트린(Gastrin) 농도는 282.38 pg/ml로서, 음성 대조군에 비하여 감소하였으나 통계학적으로 차이가 나타나지 않았다.In addition, the concentration of gastrin in the blood of Example 7 (liquid phase) was 282.38 pg / ml, which was lower than that of negative control but not statistically different.
또한, 실시예 7(고상)의 혈액 중 가스트린(Gastrin) 농도는 270.15 pg/ml이며, 양성 대조군의 혈액 중 가스트린(Gastrin) 농도는 242.42 pg/ml로서, 음성 대조군에 비하여 통계학적으로 유의하게 감소하였다.
In addition, the concentration of gastrin in the blood of Example 7 (solid phase) was 270.15 pg / ml, and the concentration of gastrin in the blood of the positive control group was 242.42 pg / ml, which was statistically decreased Respectively.
2-4. 위 조직 내 IL-1β 농도2-4. IL-1β levels in stomach tissues
도 5는 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 IL-1β 농도를 나타낸 그래프이다.FIG. 5 is a graph showing the IL-1? Concentrations in the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
도 5에 도시된 바와 같이, 정상군의 위 조직 내 IL-1β 농도는 평균 194.64 pg/mg protein이며, 음성 대조군의 위 조직 내 IL-1β 농도는 276.68 pg/mg protein로 정상군에 비하여 통계학적으로 유의하게 증가하였다.As shown in FIG. 5, the IL-1β concentration in the stomach tissues of the normal group was 194.64 pg / mg protein and the IL-1β concentration in the stomach tissues of the negative control group was 276.68 pg / Respectively.
또한, 실시예 7(액상)의 위 조직 내 IL-1β 농도는 평균 220.97 pg/mg protein이며, 실시예 7(고상)의 위 조직 내 IL-1β 농도는 평균 224.91 pg/mg protein이고, 양성 대조군의 위 조직 내 IL-1β 농도는 평균 235.08 pg/mg protein으로서, 모두 음성 대조군에 비하여 통계학적으로 유의하게 감소하였다.
In addition, the IL-1? Concentration in the gastric tissues of Example 7 (liquid phase) was 220.97 pg / mg protein on average, the IL-1? Concentration in the stomach tissues of Example 7 (solid phase) was 224.91 pg / mg protein on average, The levels of IL-1β in the gastric tissues were 235.08 pg / mg protein, which was significantly lower than that of the negative control.
2-4. 위 조직 내 TNF-α 농도2-4. TNF-a concentration in stomach tissue
도 6은 본 발명의 정상군, 음성 대조군, 투여군(실시예 7_액상, 실시예 7_고상) 및 양성 대조군에 대한 TNF-α 농도를 나타낸 그래프이다.FIG. 6 is a graph showing the TNF-.alpha. Concentrations of the normal group, the negative control group, the administration group (Example 7 liquid phase, Example 7 solid phase) and the positive control group of the present invention.
도 6에 도시된 바와 같이, 정상군의 위 조직 내 TNF-α 농도는 평균 109.39 pg/mg protein이며, 음성 대조군의 위 조직 내 TNF-α 농도는 134.58 pg/mg protein로 정상군에 비하여 통계학적으로 유의하게 증가하였다.As shown in FIG. 6, the TNF-α concentration in the gastric tissues of the normal group was 109.39 pg / mg protein and the TNF-α concentration in the gastric tissues of the negative control group was 134.58 pg / Respectively.
또한, 실시예 7(액상)의 위 조직 내 TNF-α 농도는 평균 110.64 pg/mg protein로서, 음성 대조군에 비하여 통계학적으로 유의하게 감소하였다.In addition, the TNF-alpha concentration in the stomach tissues of Example 7 (liquid phase) was 110.64 pg / mg protein on average, which was statistically significantly lower than that of the negative control.
또한, 실시예 7(고상)의 위 조직 내 TNF-α 농도는 평균 130.57 pg/mg protein이고, 양성 대조군의 위 조직 내 TNF-α 농도는 평균 122.23 pg/mg protein으로서, 음성 대조군에 비하여 차이를 보이지 않았다.
In addition, the TNF-α concentration in the stomach tissues of Example 7 (solid phase) was 130.57 pg / mg protein on average and the TNF-α concentration in the stomach tissues of the positive control group was 122.23 pg / I did not see it.
2-9. 체중 측정2-9. Weight measurement
정상군의 체중은 투여개시일부터 투여 7일까지 평균 210.6-229.3 g의 변동을 나타내었으며, 음성 대조군의 체중은 평균 209.7-226.0 g의 변동을 나타내어 정상군에 비하여 통계학적으로 유의한 차이가 나타나지 않았다.The body weight of the normal group showed an average change of 210.6-229.3 g from the start of administration to the 7th day of administration, and the weight of the negative control group showed an average change of 209.7-226.0 g, which was not statistically different from that of the normal group .
또한, 실시예 7(액상)군의 체중, 실시예 7(고상)의 체중 및 양성 대조군의 체중은 각각 평균 210.4-227.5 g, 209.9-228.7 g 및 211.0-228.7 g으로서 음성 대조군과 통계학적으로 유의한 차이가 나타나지 않았다.
In addition, the body weight of the Example 7 (liquid) group, the body weight of Example 7 (solid) and the body weight of the positive control group were 210.4-227.5 g, 209.9-228.7 g and 211.0-228.7 g, respectively, There was no difference.
결론적으로, 수컷 SD rat에 시험물질을 투여한 후 알코올로 위궤양을 유도한 결과, 액상 및 고상(투여군) 모두 위궤양 유발억제를 보이는 것을 확인하였다. 또한, 위산분비를 활성화시키는 가스트린(Gastrin)의 경우 액상 및 고상의 시험물질을 투여 시 혈중 가스트린(Gastrin) 농도가 감소되는 것을 확인하였다. 염증성 지표인 IL-1β, TNF-α는 위 조직에서 액상 및 고상의 시험물질을 투여 시 감소하는 것을 보여 염증 유발을 억제시키는 것을 확인하였다.
In conclusion, the test substance was administered to male SD rats and the gastric ulcer was induced with alcohol. As a result, it was confirmed that both the liquid and solid phase (control group) showed gastric ulcer induction inhibition. In addition, in the case of gastrin which activates gastric acid secretion, it was confirmed that the blood gastrin concentration was decreased when the liquid and solid test substances were administered. IL-1β and TNF-α, which are inflammatory markers, decreased in the stomach tissues when administered with liquid and solid phase test substances, thus confirming the inhibition of inflammation induction.
하기에 본 발명의 분말을 함유하는 조성물의 제제예를 설명하나, 본 발명은 이를 한정하고자 함이 아닌 단지 구체적으로 설명하고자 함이다.Hereinafter, formulation examples of the composition containing the powder of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically described.
제제예 1. 산제의 제조Preparation Example 1. Preparation of powder
실시예 7에서 얻은 추출물 분말 500 mg500 mg of the extract powder obtained in Example 7
유당 100 mg
탈크 10 mg
상기의 성분들을 혼합하고 기밀포에 충진하여 산제를 제조한다.
The above components are mixed and filled in airtight bags to prepare powders.
제제예 2. 정제의 제조Formulation Example 2. Preparation of tablets
실시예 7에서 얻은 추출물 분말 300 mg300 mg of the extract powder obtained in Example 7
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mgMagnesium stearate 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.
제제예 3. 캅셀제의 제조Formulation Example 3. Preparation of capsules
실시예 7에서 얻은 추출물 분말 200 mg200 mg of the extract powder obtained in Example 7
결정성 셀룰로오스 3 mgCrystalline cellulose 3 mg
락토오스 14.8 mgLactose 14.8 mg
마그네슘 스테아레이트 0.2 mgMagnesium stearate 0.2 mg
통상의 캡슐제 제조방법에 따라 상기의 성분을 혼합하고 젤라틴 캡슐에 충전하여 캡슐제를 제조한다.
The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.
제제예 4. 주사제의 제조Formulation Example 4. Preparation of injection
실시예 7에서 얻은 추출물 분말 600 mg600 mg of the extract powder obtained in Example 7
만니톨 180 mg180 mg mannitol
주사용 멸균 증류수 2974 mgSterile sterilized water for injection 2974 mg
Na2HPO4,12H2O 26 mgNa 2 HPO 4, 12H 2 O 26 mg
통상의 주사제의 제조방법에 따라 1 앰플 당 상기의 성분 함량으로 제조한다.
It is prepared by the above-mentioned component content per ampoule according to the usual injection preparation method.
제제예 5. 액제의 제조Formulation Example 5. Preparation of a liquid preparation
실시예 7에서 얻은 추출물 분말 4 g4 g of the extract powder obtained in Example 7
이성화당 10 g10 g per isomer
만니톨 5 g5 g mannitol
정제수 적량Purified water quantity
통상의 액제의 제조방법에 따라 정제수에 각각의 성분을 가하여 용해시키고 레몬향을 적량 가한 다음 상기의 성분을 혼합한 다음 정제수를 가하여 전체를 정제수를 가하여 전체 100g으로 조절한 후 갈색병에 충진하여 멸균시켜 액제를 제조한다.
Each component was added and dissolved in purified water according to the usual liquid preparation method, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was adjusted to 100 g with purified water, To prepare a liquid agent.
제제예 6. 과립제의 제조Preparation Example 6 Preparation of Granules
실시예 7에서 얻은 추출물 분말 1,000 mg1,000 mg of the extract powder obtained in Example 7
비타민 혼합물 적량Vitamin mixture quantity
비타민 A 아세테이트 70 ㎍70 [mu] g of vitamin A acetate
비타민 E 1.0 mgVitamin E 1.0 mg
비타민 B1 0.13 mgVitamin B1 0.13 mg
비타민 B2 0.15 mg0.15 mg of vitamin B2
비타민 B6 0.5 mgVitamin B6 0.5 mg
비타민 B12 0.2 ㎍0.2 [mu] g vitamin B12
비타민 C 10 mg
비오틴 10 ㎍Biotin 10 μg
니코틴산아미드 1.7 mgNicotinic acid amide 1.7 mg
엽산 50 ㎍50 ㎍ of folic acid
판토텐산 칼슘 0.5 mgCalcium pantothenate 0.5 mg
무기질 혼합물 적량Mineral mixture quantity
황산제1철 1.75 mg1.75 mg of ferrous sulfate
산화아연 0.82 mg0.82 mg of zinc oxide
탄산마그네슘 25.3 mgMagnesium carbonate 25.3 mg
제1인산칼륨 15 mgPotassium monophosphate 15 mg
제2인산칼슘 55 mgSecondary calcium phosphate 55 mg
구연산칼륨 90 mgPotassium citrate 90 mg
탄산칼슘 100 mg
염화마그네슘 24.8 mgMagnesium chloride 24.8 mg
상기의 비타민 및 미네랄 혼합물의 조성비는 비교적 과립제에 적합한 성분을 바람직한 실시예로 혼합 조성하였지만, 그 배합비를 임의로 변형 실시하여도 무방하며, 통상의 과립제 제조방법에 따라 상기의 성분을 혼합한 다음, 과립을 제조하고, 통상의 방법에 따라 건강기능식품 조성물 제조에 사용할 수 있다.
The composition ratio of the above-mentioned vitamins and minerals is comparatively comparatively mixed with the granules according to the preferred embodiment. However, the blending ratio may be arbitrarily changed, and the above components are mixed according to the ordinary granule preparation method, Can be prepared and used in the manufacture of a health functional food composition according to a conventional method.
제제예 7. 기능성 음료의 제조Preparation Example 7. Preparation of functional beverage
실시예 7에서 얻은 추출물 분말 1,000 mg 1,000 mg of the extract powder obtained in Example 7
구연산 1,000 mgCitric acid 1,000 mg
올리고당 100 g100 g of oligosaccharide
매실농축액 2 gPlum concentrate 2 g
타우린 1 gTaurine 1 g
정제수를 가하여 전체 900 mLPurified water was added to the flask to obtain a total of 900 mL
통상의 건강음료 제조방법에 따라 상기의 성분을 혼합한 다음, 약 1 시간 동안 85 ℃에서 교반 가열한 후, 만들어진 용액을 여과하여 멸균된 2 L 용기에 취득하여 밀봉 멸균한 뒤 냉장 보관한 다음 본 발명의 기능성 음료 조성물 제조에 사용한다. The above components were mixed according to a conventional health drink manufacturing method, and the mixture was stirred and heated at 85 DEG C for about 1 hour. The solution thus prepared was filtered and sterilized in a sterilized 2 L container, It is used in the production of the functional beverage composition of the invention.
상기 조성비는 비교적 기호음료에 적합한 성분을 바람직한 실시예로 혼합 조성하였지만, 수요계층, 수요국가, 사용용도 등 지역적, 민족적 기호도에 따라서 그 배합비를 임의로 변형 실시하여도 무방하다.
Although the composition ratio is a mixture of the components suitable for the preferred beverage as a preferred embodiment, the blending ratio may be arbitrarily varied according to the regional and national preferences such as the demand level, the demanding country, and the intended use.
Claims (7)
황칠 추출물 및 녹차 추출물을 포함하는 식물 복합추출물;을 포함하는 혼합물을 유효성분으로 함유하는 알코올성 위장질환의 예방 또는 치료용 약학 조성물.Extracts of seaweeds including Ganoderma lucidum extract, Mugwort extract, Mugwort extract, Mulberry leaf extract and Strawberry seaweed extract; And
A plant complex extract comprising an extract of a plant including green tea extract and a green tea extract as an active ingredient; and a pharmaceutical composition for preventing or treating an alcoholic gastrointestinal disorder.
황칠 추출물 및 녹차 추출물을 포함하는 식물 복합추출물;을 포함하는 혼합물을 유효성분으로 함유하는 알코올성 위장질환의 개선 또는 예방용 식품 조성물.Extracts of seaweeds including Ganoderma lucidum extract, Mugwort extract, Mugwort extract, Mulberry leaf extract and Strawberry seaweed extract; And
Wherein the composition contains a mixture comprising a plant extract of Huangchil and a green tea extract, as an active ingredient, for improving or preventing an alcoholic gastrointestinal disorder.
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